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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
TCF12 6938 transcription factor 12  15HEB, HTF4, HsT17266, bHLHb20 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
21999571   2011Cell line : -

Source : Department of Molecular Medicine, Aarhus University Hospital, Skejby, 8200 Aarhus N, Denmark.

Sample Type : CRC tumor and normal tissue

No. of Sample : 108

Stage : TNM Stage I,II,III

real time RT-PCR,Transcription factor binding analysis,Exon array data analysis,TMA staining Up-regulation-TCF12 protein expression was upregulated in cancer samples and correlated with progression free survival.

22130667   2012Cell line : SW620, SW480, HCT 8, HCT116

Source : Taipei Veterans General Hospital

Sample Type : CRC tumor and normal tissue

No. of Sample : 140

Stage : TNM Stage I,II,III,IV

Gene Expression Array Analysis,PCR,Immunoblotting,Nuclear Extraction Immunoprecipitation,Cancer Cell Migration and Invasion Assays,Chromatin immunoprecepetationUp-regulation- TCF12 functioned as a transcriptional repressor of E-cadherin and its overexpression was significantly correlated with the occurrence of CRC metastasis.

23386606   2013Cell line : HCT 115, SW480, SW620

Source : Taipei Veterans General Hospital .

Sample Type : CRC tumor and normal tissue

No. of Sample : 60

Stage : -

RT-PCR,Assay of Gap Junction Activity,Cell Migration and Invasion Assays,Immunoblotting ,Chromatin Immunoprecipitation,Proximity Ligation AssayUp-regulation-CD91/IKK/NF-?B signaling cascade is involved in secreted HSP90?-induced TCF12 expression, leading to E-cadherin down-regulation and enhanced CRC cell migration/invasion.


Gene Details



NC_000015.9 (57210833..57580716)

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Gene Type protein coding
Gene Family Basic helix-loop-helix proteins
Description The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH) E-protein family that recognizes the consensus binding site (E-box) CANNTG. This encoded protein is expressed in many tissues, among them skeletal muscle, thymus, B- and T-cells, and may participate in regulating lineage-specific gene expression through the formation of heterodimers with other bHLH E-proteins. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]  
Chromosome 15
Location 15q21
Start 57210833  
End 57580716  
Strand +  
Gene Sequence

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Length 369884  
OMIM ID 600480   
HGNC ID HGNC:11623   
Unigene ID Hs.511504   
Ensembl ID ENSG00000140262   
PharmGKB ID PA36381   

mRNA Information


mRNA ID ?NM_001306219.1
Exon join(1..618,1604..1700,2738..2810,83061..83096, 145462..145535,173501..173603,248114..248178, 273870..274005,279485..279537,312864..312969, 314003..314142,314424..314568,315755..315819, 325184..325262,333062..333135,334133..334204, 334974..335180,343806..343920,344824..344986, 354742..354974,364157..364310,372541..372841)  
mRNA Sequence

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Length 3109  



CDS Information


   
Location 641..2797
CDS Sequence

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CCDS ID CCDS10159.1



Protein Information


      
Protein IDNP_001293148.1
Protein Nametranscription factor 12
Molecular Wt. (Da)19584
Protein Sequence

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Length 682  
Uniprot IDQ9UHI8
Ensembl Protein ID ENSP00000284984  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation333;-
SPhosphorylation333;-
SPhosphorylation333;-
SPhosphorylation333;-
SPhosphorylation163;-
SPhosphorylation83
SPhosphorylation89
SPhosphorylation83
SPhosphorylation89
SPhosphorylation83
SPhosphorylation89
SPhosphorylation83
SPhosphorylation89
SPhosphorylation305
TPhosphorylation313
SPhosphorylation305
TPhosphorylation313
SPhosphorylation305
TPhosphorylation313
SPhosphorylation305
TPhosphorylation313
SPhosphorylation135
TPhosphorylation143
SPhosphorylation559
SPhosphorylation583
SPhosphorylation583
SPhosphorylation559
SPhosphorylation389
SPhosphorylation540
SPhosphorylation564
SPhosphorylation564
SPhosphorylation540
SPhosphorylation370
SPhosphorylation79
SPhosphorylation79
SPhosphorylation79
SPhosphorylation79
TPhosphorylation557
TPhosphorylation581
TPhosphorylation581
TPhosphorylation557
TPhosphorylation387
SPhosphorylation558
SPhosphorylation582
SPhosphorylation582
SPhosphorylation558
SPhosphorylation388
SPhosphorylation386
SPhosphorylation386
SPhosphorylation216
SPhosphorylation67
SPhosphorylation67
SPhosphorylation67
SPhosphorylation67
SPhosphorylation534
SPhosphorylation558
SPhosphorylation558
SPhosphorylation534
SPhosphorylation364
SPhosphorylation552
SPhosphorylation576
SPhosphorylation576
SPhosphorylation552
SPhosphorylation382

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                          
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
1387CREBBP2534NP_004371.2in vitro;in vivo15333839   
2033EP3004078NP_001420.2in vitro11755530   
3397ID18980NP_002156.2yeast 2-hybrid9242638   
3398ID22664NP_002157.2yeast 2-hybrid9242638   
6929TCF3918NP_003191.1in vivo144   607   512   566   462   
11098PRSS237149NP_009104.1yeast 2-hybrid16169070   


Pathway Information


No matching records could be found.

Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd00083575-635  HLH
cl00081575-635  HLH superfamily
smart00353583-636  HLH
pfam00010578-631  HLH


Ontology Information


   
HPRD ID9272
Molecular ClassTranscription factor
Molecular FunctionTranscription factor activity (GO:0003700)
Biological ProcessRegulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO