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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| TCF4 | 6925 | Transcription factor 4 | 18 | E2-2; ITF2; PTHS; SEF2; ITF-2; SEF-2; TCF-4; SEF2-1; SEF2-1A; SEF2-1B; bHLHb19 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 21132538 | 2011 | Cell line : - Source : Lund University Hospital in Sweden (n = 35) and from the HNPCC-register at Hvidovre Hospital in Denmark (n = 83). Sample Type : CRC tumor and normal tissue No. of Sample : 122 colorectal cancers from 118 HNPCC patients with disease-causing mutations in MLH1 (n = 60), MSH2 (n = 47), and MSH6 (n = 11) Stage : - | Immunohistochemistry | Up-regulation | - | TCF-4 belongs to the TCF/LEF transcription complex, which is activated by b-catenin.
|
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Basic helix-loop-helix proteins |
| Description | This gene encodes transcription factor 4, a basic helix-loop-helix transcription factor. The encoded protein recognizes an Ephrussi-box ('E-box') binding site ('CANNTG') - a motif first identified in immunoglobulin enhancers. This gene is broadly expressed, and may play an important role in nervous system development. Defects in this gene are a cause of Pitt-Hopkins syndrome. Multiple alternatively spliced transcript variants that encode different proteins have been described. [provided by RefSeq, Aug 2011] | Chromosome | 18 |
| Location | 18q21.1 |
| Start | 55222331 |
| End | 55635993 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 413663 |
| OMIM ID | 602272 |
| HGNC ID | HGNC:11634 |
| Unigene ID | Hs.644653 |
| Ensembl ID | ENSG00000196628 |
| PharmGKB ID | PA36389 |
mRNA Information
| mRNA ID | NM_001243226.2 |
|---|---|
| Exon | join(1..291,4606..4696,48858..48949,50642..50714, 171857..171918,174879..174975,232476..232540, 284991..285120,285586..285635,356338..356443, 360242..360375,366031..366163,374461..374528, 375967..376045,378603..378679,381294..381497, 401311..401446,403323..403485,406918..407147, 407633..407773,407964..413663) | mRNA Sequence | Download Select all |
| Length | 8122 |
CDS Information
| Location | join(97..291,4606..4696,48858..48949,50642..50714, 171857..171918,174879..174975,232476..232540, 284994..285120,285586..285635,356338..356443, 360242..360375,366031..366163,374461..374528, 375967..376045,378603..378679,381294..381497, 401311..401446,403323..403473,406918..407147, 407633..407769) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | - |
Protein Information
| Protein ID | NP_001230155.2 |
|---|---|
| Protein Name | Transcription factor 4 |
| Molecular Wt. (Da) | 83295 |
| Protein Sequence | Download Select all |
| Length | 773 |
| Uniprot ID | P24522 |
| Ensembl Protein ID | ENSP00000360024 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 481 |
| S | Phosphorylation | 481 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 142 | PARP1 | 1435 | NP_001609.2 | in vivo | 17283121 |
| 429 | ASCL1 | 11 | NP_004307.2 | in vitro;in vivo;yeast 2-hybrid | 10903890 |
| 801 | CALM1 | 241 | NP_008819.1 | in vitro | 10757985 |
| 805 | CALM2 | 242 | NP_001734.1 | in vitro | 10757985 |
| 808 | CALM3 | 243 | NP_005175.2 | in vitro | 10757985 |
| 1499 | CTNNB1 | 286 | NP_001895.1 | in vitro;in vivo | 16 724 116 160 070 700 000 000 000 000 000 |
| 2033 | EP300 | 4078 | NP_001420.2 | in vitro | 17410209 |
| 2547 | XRCC6 | 1071 | NP_001460.1 | in vivo | 17283121 |
| 3398 | ID2 | 2664 | NP_002157.2 | in vivo;yeast 2-hybrid | 115 916 539 242 638 |
| 3399 | ID3 | 2608 | NP_002158.3 | in vitro;in vivo;yeast 2-hybrid | 115 916 538 999 959 |
| 3728 | JUP | 1414 | NP_002221.1 | in vitro;in vivo | 16306047 |
| 4654 | MYOD1 | 1166 | NP_002469.2 | in vitro;yeast 2-hybrid | 85 762 418 999 959 |
| 4760 | NEUROD1 | 3428 | NP_002491.2 | in vivo | 11591653 |
| 7520 | XRCC5 | 8935 | NP_066964.1 | in vivo | 17283121 |
| 26959 | HBP1 | 13634 | NP_036389.2 | in vivo | 11500377 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00083 | 562-622 | HLH |
| cl00081 | 562-622 | HLH superfamily |
| smart00353 | 570-623 | HLH |
| pfam00010 | 565-618 | HLH |
Ontology Information
| HPRD ID | 2996 |
|---|---|
| Molecular Class | Transcription factor |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Biological_process unknown (GO:0000004) |
Drug Information
No matching records could be found.