Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| TCF7 | 6932 | transcription factor 7 (T-cell specific, HMG-box) | 5 | TCF-1 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 9259402 | 1997 | Cell line : SW480,SW620, COLO205,COLO201,HT29 Source : ATCC Sample Type : - No. of Sample : - Stage : - | CAT-assay,Northern blotting,real time RT-PCR,Western blotting | Up-regulation | - | - |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The protein encoded by this gene is a transcriptional activator that plays an important role in lymphocyte differentiation. This gene is expressed predominantly in T-cells. The encoded protein can bind an enhancer element and activate the CD3E gene, and it also may repress the CTNNB1 and TCF7L2 genes through a feedback mechanism. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] | Chromosome | 5 |
| Location | 5q31 |
| Start | 133450402 |
| End | 133483920 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 33519 |
| OMIM ID | 189908 |
| HGNC ID | HGNC:11639 |
| Unigene ID | Hs.573153 |
| Ensembl ID | ENSG00000081059 |
| PharmGKB ID | PA36392 |
mRNA Information
| mRNA ID | ?NM_001134851.2 |
|---|---|
| Exon | join(1..453,619..685,1207..1331,23357..23462,24249..24336, 26094..26186,27483..27602,28019..28181,28291..28398, 28890..28938,31499..33527) | mRNA Sequence | Download Select all |
| Length | 3401 |
Protein Information
| Protein ID | NP_001128323.2 |
|---|---|
| Protein Name | transcription factor 7 (T-cell specific, HMG-box) |
| Molecular Wt. (Da) | 77132 |
| Protein Sequence | Download Select all |
| Length | 384 |
| Uniprot ID | O60829 |
| Ensembl Protein ID | ENSP00000218068 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Acute myeloid leukemia | hsa05221 |
| Adherens junction | hsa04520 |
| Arrhythmogenic right ventricular cardiomyopathy (ARVC) | hsa05412 |
| Basal cell carcinoma | hsa05217 |
| Colorectal cancer | hsa05210 |
| Endometrial cancer | hsa05213 |
| Hippo signaling pathway | hsa04390 |
| Melanogenesis | hsa04916 |
| Pathways in cancer | hsa05200 |
| Prostate cancer | hsa05215 |
| Thyroid cancer | hsa05216 |
| Wnt signaling pathway | hsa04310 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd01388 | 269-339 | SOX-TCF_HMG-box |
| cl00082 | 269-339 | HMG-box superfamily |
| pfam08347 | 1-212 | CTNNB1_binding |
| cl07093 | 1-212 | CTNNB1_binding superfamily |
| pfam00505 | 269-337 | HMG_box |
| cd00084 | 269-334 | HMG-box |
| smart00398 | 269-336 | HMG |
| cd01389 | 269-335 | MATA_HMG-box |
| cd01390 | 270-327 | HMGB-UBF_HMG-box |
| PTZ00199 | 259-326 | PTZ00199 |
| pfam09011 | 264-327 | HMG_box_2 |
| COG5648 | 252-346 | NHP6B |
Ontology Information
| HPRD ID | 5608 |
|---|---|
| Molecular Class | Transcription factor |
| Molecular Function | Growth factor activity (GO:0008083) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.