Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| TCF7L1 | 83439 | transcription factor 7-like 1 (T-cell specific, HMG-box) | 2 | - |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24811787 | 2014 | Cell line : - Source : Nationwide Children�s Hospital Biospecimen Core Resource. Sample Type : CRC Tumor and adjecent normal tissue No. of Sample : 276 Stage : - | Methylation-specific PCR | Methylation | - | Significantly aberrant methylation in 23 genes (NEIL1, NEIL3, DCLRE1C, NHEJ1, GTF2H5, CCNH, CTNNB1, DKK2, DKK3, FZD5 LRP5, TLE3, WNT2, WNT3A, WNT6, TCF7L1, CASP8, EDNRB1, GPC6, KIAA1804, MYO1B, SMAD2 and TTN). |
| 22810696 | 2012 | Cell line : - Source : - Sample Type : CRC tumors and adjacent tissues. No. of Sample : 12 Stage : - | Exome-sequencing | Mutation | - | Recurrent chromosomal translocations include the fusion of NAV2 and WNT pathway member TCF7L1 were found. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a member of the T cell factor/lymphoid enhancer factor family of transcription factors. These transcription factors are activated by beta catenin, mediate the Wnt signaling pathway and are antagonized by the transforming growth factor beta signaling pathway. The encoded protein contains a high mobility group-box DNA binding domain and participates in the regulation of cell cycle genes and cellular senescence. [provided by RefSeq, Nov 2010] | Chromosome | 2 |
| Location | 2p11.2 |
| Start | 85360583 |
| End | 85537511 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 176929 |
| OMIM ID | 604652 |
| HGNC ID | HGNC:11640 |
| Unigene ID | Hs.516297 |
| Ensembl ID | ENSG00000152284 |
| PharmGKB ID | PA36393 |
Protein Information
| Protein ID | NP_112573.1 |
|---|---|
| Protein Name | transcription factor 7-like 1 (T-cell specific, HMG-box) |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 588 |
| Uniprot ID | Q8IVF7 |
| Ensembl Protein ID | ENSP00000335655 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1499 | CTNNB1 | 286 | NP_001895.1 | in vivo | 11266540 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Acute myeloid leukemia | hsa05221 |
| Adherens junction | hsa04520 |
| Arrhythmogenic right ventricular cardiomyopathy (ARVC) | hsa05412 |
| Basal cell carcinoma | hsa05217 |
| Colorectal cancer | hsa05210 |
| Endometrial cancer | hsa05213 |
| Hippo signaling pathway | hsa04390 |
| Melanogenesis | hsa04916 |
| Pathways in cancer | hsa05200 |
| Prostate cancer | hsa05215 |
| Thyroid cancer | hsa05216 |
| Wnt signaling pathway | hsa04310 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd01388 | 345-416 | SOX-TCF_HMG-box |
| cl00082 | 345-416 | HMG-box superfamily |
| pfam08347 | 30-250 | CTNNB1_binding |
| cl07093 | 30-250 | CTNNB1_binding superfamily |
| pfam00505 | 346-414 | HMG_box |
| cd00084 | 346-411 | HMG-box |
| smart00398 | 345-413 | HMG |
| cd01390 | 347-404 | HMGB-UBF_HMG-box |
| cd01389 | 345-411 | MATA_HMG-box |
| PTZ00199 | 331-403 | PTZ00199 |
| pfam09011 | 342-413 | HMG_box_2 |
| COG5648 | 316-406 | NHP6B |
| PHA03247 | 86-333 | PHA03247 |
Ontology Information
| HPRD ID | 17459 |
|---|---|
| Molecular Class | Transcription regulatory protein |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Biological_process unknown (GO:0000004) |
Drug Information
No matching records could be found.