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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
TCF7L2 6934 Transcription factor 7-like 2 (T-cell specific, HMG-box)  10TCF4; TCF-4 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
22895193   2012Cell line : -

Source : -

Sample Type : CRC tumor and normal tissue

No. of Sample : 72 pair of CRC and normal tissue

Stage : -

Next-generation sequencing, RNAseq and SNP array analysisMutation--


Gene Details



Chromosome: 10; NC_000010.10 (114710009..114927437)

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Gene Type protein coding
Gene Family -
Description This gene encodes a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. The protein has been implicated in blood glucose homeostasis. Genetic variants of this gene are associated with increased risk of type 2 diabetes. Several transcript variants encoding multiple different isoforms have been found for this gene.[provided by RefSeq, Oct 2010]  
Chromosome 10
Location 10q25.3
Start 112950219  
End 113167678  
Strand -  
Gene Sequence

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Length 217460  
OMIM ID 602228   
HGNC ID HGNC:11641   
Unigene ID Hs.593995    
Ensembl ID ENSG00000148737   
PharmGKB ID -   

mRNA Information


mRNA ID XM_005270071.1
Exon join(1..727,989..1055,1265..1389,14338..14406, 89807..89908,139179..139322,190966..191098,193705..193807, 195793..195879,200765..200905,201507..201666, 202115..202222,207803..207851,208449..208499, 209702..209774,215337..217460)  
mRNA Sequence

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Length 4263  



CDS Information


   
Locationjoin(539..727,989..1055,1265..1389,14338..14406, 89807..89908,139179..139322,190966..191098,193705..193807, 195793..195879,200765..200905,201507..201666, 202115..202222,207803..207851,208449..208499, 209702..209774,215337..215754)
CDS Sequence

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CCDS ID -



Protein Information


      
Protein IDNP_001139746.1
Protein NameTranscription factor 7-like 2 (T-cell specific, HMG-box)
Molecular Wt. (Da)65963
Protein Sequence

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Length 602  
Uniprot IDP17661
Ensembl Protein ID ENSP00000363071  



Post-translational Modification Information (Source : HPRD)


Residue Type site
KSumoylation297
SPhosphorylation58
SPhosphorylation59
SPhosphorylation60
SPhosphorylation58
SPhosphorylation59
SPhosphorylation60

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                            
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
1499CTNNB1286NP_001895.1in vitro;in vivo11   713   476   128   610   200   000   000   000   000   000   
2033EP3004078NP_001420.2in vitro;in vivo12861022   
3728JUP1414NP_002221.1in vitro11711551   
5663PSEN187NP_000012.1in vitro;in vivo1   150   472   616   306   040   


Pathway Information


                                                                        
Pathway Name Pathway ID
Acute myeloid leukemia hsa05221
Adherens junction hsa04520
Arrhythmogenic right ventricular cardiomyopathy (ARVC) hsa05412
Basal cell carcinoma hsa05217
Colorectal cancer hsa05210
Endometrial cancer hsa05213
Hippo signaling pathway hsa04390
Melanogenesis hsa04916
Pathways in cancer hsa05200
Prostate cancer hsa05215
Thyroid cancer hsa05216
Wnt signaling pathway hsa04310


Structure Information


PDB ID1JDH
Resolution1.9
MethodX-RAY DIFFRACTION
Chains A  
Molecule BETA-CATENIN  
Model View



Domain Information




ID Location Description
cd01388353-420  SOX-TCF_HMG-box
cl00082353-420  HMG-box superfamily
pfam083471-259  CTNNB1_binding
cl070931-259  CTNNB1_binding superfamily
pfam00505353-418  HMG_box
cd00084353-415  HMG-box
smart00398353-417  HMG
cd01390353-408  HMGB-UBF_HMG-box
cd01389353-416  MATA_HMG-box
PTZ00199354-407  PTZ00199
pfam09011355-408  HMG_box_2
COG5648353-410  NHP6B
pfam0579320-93  TFIIF_alpha
COG3456147-264  COG3456


Ontology Information


   
HPRD ID3575
Molecular ClassTranscription factor
Molecular FunctionMolecular function unknown (GO:0005554)
Biological ProcessImmune response (GO:0006955)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO