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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| TCF7L2 | 6934 | Transcription factor 7-like 2 (T-cell specific, HMG-box)  | 10 | TCF4; TCF-4  |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22895193    | 2012 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 72 pair of CRC and normal tissue Stage : - | Next-generation sequencing, RNAseq and SNP array analysis | Mutation | - | - |
Gene Details

| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. The protein has been implicated in blood glucose homeostasis. Genetic variants of this gene are associated with increased risk of type 2 diabetes. Several transcript variants encoding multiple different isoforms have been found for this gene.[provided by RefSeq, Oct 2010]   | Chromosome | 10 |
| Location | 10q25.3 |
| Start | 112950219   |
| End | 113167678   |
| Strand | -   |
| Gene Sequence |    Download   Select all |
| Length | 217460   |
| OMIM ID | 602228    |
| HGNC ID | HGNC:11641    |
| Unigene ID | Hs.593995     |
| Ensembl ID | ENSG00000148737    |
| PharmGKB ID | -    |
mRNA Information
| mRNA ID | XM_005270071.1 |
|---|---|
| Exon | join(1..727,989..1055,1265..1389,14338..14406, 89807..89908,139179..139322,190966..191098,193705..193807, 195793..195879,200765..200905,201507..201666, 202115..202222,207803..207851,208449..208499, 209702..209774,215337..217460)   | mRNA Sequence |    Download   Select all |
| Length | 4263   |
CDS Information
| Location | join(539..727,989..1055,1265..1389,14338..14406, 89807..89908,139179..139322,190966..191098,193705..193807, 195793..195879,200765..200905,201507..201666, 202115..202222,207803..207851,208449..208499, 209702..209774,215337..215754) |
|---|---|
| CDS Sequence |    Download   Select all |
| CCDS ID | - |    
Protein Information
| Protein ID | NP_001139746.1 |
|---|---|
| Protein Name | Transcription factor 7-like 2 (T-cell specific, HMG-box) |
| Molecular Wt. (Da) | 65963 |
| Protein Sequence |    Download   Select all |
| Length | 602   |
| Uniprot ID | P17661 |    
| Ensembl Protein ID | ENSP00000363071   |    
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| K | Sumoylation | 297 |
| S | Phosphorylation | 58 |
| S | Phosphorylation | 59 |
| S | Phosphorylation | 60 |
| S | Phosphorylation | 58 |
| S | Phosphorylation | 59 |
| S | Phosphorylation | 60 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING)      View   
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1499 |    CTNNB1 |    286 |    NP_001895.1 |    in vitro;in vivo |    11   713   476   128   610   200   000   000   000   000   000    |
| 2033 |    EP300 |    4078 |    NP_001420.2 |    in vitro;in vivo |    12861022    |
| 3728 |    JUP |    1414 |    NP_002221.1 |    in vitro |    11711551    |
| 5663 |    PSEN1 |    87 |    NP_000012.1 |    in vitro;in vivo |    1   150   472   616   306   040    |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Acute myeloid leukemia |    hsa05221 |    
| Adherens junction |    hsa04520 |    
| Arrhythmogenic right ventricular cardiomyopathy (ARVC) |    hsa05412 |    
| Basal cell carcinoma |    hsa05217 |    
| Colorectal cancer |    hsa05210 |    
| Endometrial cancer |    hsa05213 |    
| Hippo signaling pathway |    hsa04390 |    
| Melanogenesis |    hsa04916 |    
| Pathways in cancer |    hsa05200 |    
| Prostate cancer |    hsa05215 |    
| Thyroid cancer |    hsa05216 |    
| Wnt signaling pathway |    hsa04310 |    
Structure Information
| PDB ID | 1JDH |
|---|---|
| Resolution | 1.9 |
| Method | X-RAY DIFFRACTION |
| Chains | A   |
| Molecule | BETA-CATENIN   |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| cd01388 | 353-420  | SOX-TCF_HMG-box |
| cl00082 | 353-420  | HMG-box superfamily |
| pfam08347 | 1-259  | CTNNB1_binding |
| cl07093 | 1-259  | CTNNB1_binding superfamily |
| pfam00505 | 353-418  | HMG_box |
| cd00084 | 353-415  | HMG-box |
| smart00398 | 353-417  | HMG |
| cd01390 | 353-408  | HMGB-UBF_HMG-box |
| cd01389 | 353-416  | MATA_HMG-box |
| PTZ00199 | 354-407  | PTZ00199 |
| pfam09011 | 355-408  | HMG_box_2 |
| COG5648 | 353-410  | NHP6B |
| pfam05793 | 20-93  | TFIIF_alpha |
| COG3456 | 147-264  | COG3456 |
Ontology Information
| HPRD ID | 3575 |    
|---|---|
| Molecular Class | Transcription factor |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Immune response (GO:0006955)   |
Drug Information
No matching records could be found.
External Links
| ArrayExpress | GO |    
|---|---|
| ICGC | GO |    
| Cancer3D | GO |    
| COSMIC | GO |    
| NCG | GO |    
| TSGene | GO |    
| Tumor Gene Family of Databases | GO |    
| CCDB | GO |    
| G2SBC | GO |    
| Osteosarcoma Database | GO |    
| RCDB | GO |    
