Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| TDGF1 | 6997 | teratocarcinoma-derived growth factor 1 | 3 | CRIPTO, CR, Cripto-1 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 20126975 | 2010 | Cell line : - Source : - Sample Type : CRC Tumor No. of Sample : 55 Stage : - | - | Up-regulation | - | The present data strongly suggest the usefulness of TDGF1 as a predictive marker for metachronous metastasis in CRC patients. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes an epidermal growth factor-related protein that contains a cripto, FRL-1, and cryptic domain. The encoded protein is an extracellular, membrane-bound signaling protein that plays an essential role in embryonic development and tumor growth. Mutations in this gene are associated with forebrain defects. Pseudogenes of this gene are found on chromosomes 2, 3, 6, 8, 19 and X. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010] | Chromosome | 3 |
| Location | 3p21.31 |
| Start | 46616045 |
| End | 46623953 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 7909 |
| OMIM ID | 187395 |
| HGNC ID | HGNC:11701 |
| Unigene ID | Hs.385870 |
| Ensembl ID | ENSG00000241186 |
| PharmGKB ID | PA36420 |
mRNA Information
| mRNA ID | ?NM_001174136.1 |
|---|---|
| Exon | complement(5383..5506) | mRNA Sequence | Download Select all |
| Length | 4888 |
Protein Information
| Protein ID | NP_001167607.1 |
|---|---|
| Protein Name | teratocarcinoma-derived growth factor 1 |
| Molecular Wt. (Da) | 21761 |
| Protein Sequence | Download Select all |
| Length | 188 |
| Uniprot ID | O95817 |
| Ensembl Protein ID | ENSP00000358081 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 7917 | BAT3 | 808 | NP_004630.3 | yeast 2-hybrid | 16169070 |
| 10980 | COPS6 | 16735 | NP_006824.2 | yeast 2-hybrid | 16169070 |
| 55791 | C1orf103 | 17975 | NP_060842.3 | yeast 2-hybrid | 16169070 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00054 | 83-107 | EGF_CA |
| cl21504 | 83-107 | EGF_CA superfamily |
| pfam09443 | 115-150 | CFC |
| cl09683 | 115-150 | CFC superfamily |
| cd07783 | 147-183 | FGGY_CarbK-RPE_like |
| cl17037 | 147-183 | NBD_sugar-kinase_HSP70_actin superfamily |
Ontology Information
| HPRD ID | 13624 |
|---|---|
| Molecular Class | Growth factor |
| Molecular Function | DNA binding (GO:0003677) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.