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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| TEAD1 | 7003 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 11 | TEF-1 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 26435499 | 2015 | Cell line : 5 CRC cell lines Source : - Sample Type : CRC tumor and normal tissue No. of Sample : CRC tissues 151 normal colorectal mucosa 30 Stage : - | real time RT-PCR, methylation specific PCR and bisulfite sequencing PCR | Methylation | - | TCF21 may function as a tumor suppressor gene, which is downregulated through promoter hypermethylation in CRC development. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a ubiquitous transcriptional enhancer factor that is a member of the TEA/ATTS domain family. This protein directs the transactivation of a wide variety of genes and, in placental cells, also acts as a transcriptional repressor. Mutations in this gene cause Sveinsson's chorioretinal atrophy. Additional transcript variants have been described but their full-length natures have not been experimentally verified. [provided by RefSeq, May 2010] | Chromosome | 11 |
| Location | 11p15.4 |
| Start | 12695969 |
| End | 12966284 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 270316 |
| OMIM ID | 189967 |
| HGNC ID | HGNC:11714 |
| Unigene ID | Hs.655331 |
| Ensembl ID | - |
| PharmGKB ID | PA36432 |
mRNA Information
| mRNA ID | ?NM_021961.5 |
|---|---|
| Exon | join(1..413,988..1140,89758..90013,187829..187893, 190417..190479,205287..205421,206584..206630, 207475..207536,208580..208704,227519..227692, 250491..250631,255753..255905,262688..270316) | mRNA Sequence | Download Select all |
| Length | 9433 |
Protein Information
| Protein ID | NP_068780.2 |
|---|---|
| Protein Name | TEA domain family member 1 (SV40 transcriptional enhancer factor) |
| Molecular Wt. (Da) | 48198 |
| Protein Sequence | Download Select all |
| Length | 426 |
| Uniprot ID | O75367 |
| Ensembl Protein ID | ENSP00000302572 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 87 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 4149 | MAX | 1113 | NP_002373.3 | in vitro;in vivo | 9199327 |
| 4207 | MEF2B | 2808 | NP_005910.1 | in vitro | 12861002 |
| 4208 | MEF2C | 2809 | NP_002388.2 | in vitro | 12861002 |
| 4625 | MYH7 | 1175 | NP_000248.2 | in vitro;yeast 2-hybrid | 825 379 712 861 002 |
| 6908 | TBP | 2511 | NP_003185.1 | in vitro | 8423815 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Hippo signaling pathway | hsa04390 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam01285 | 6-418 | TEA |
| cl02603 | 6-418 | TEA superfamily |
| smart00426 | 30-97 | TEA |
Ontology Information
| HPRD ID | 9259 |
|---|---|
| Molecular Class | Transcription factor |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Biological_process unknown (GO:0000004) |
Drug Information
No matching records could be found.