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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| TEAD4 | 7004 | TEA domain family member 4 | 12 | TEF-3, TEFR-1, EFTR-2, RTEF-1 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 26387538 | 2015 | Cell line : - Source : Department of Colorectal Surgery, XinHua Hospital. Sample Type : CRC tumor and normal tissue No. of Sample : - Stage : TNM Stage I-IV | Immunohistochemistry,Cell culture, transwell migration, cell proliferation, qPCR, luciferase assays and chromatin immunoprecipitation,Microarray | Up-regulation | - | TEAD4 nuclear expression can serve as a biomarker for CRC progression and poor prognosis. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain. It is preferentially expressed in the skeletal muscle, and binds to the M-CAT regulatory element found in promoters of muscle-specific genes to direct their gene expression. Alternatively spliced transcripts encoding distinct isoforms, some of which are translated through the use of a non-AUG (UUG) initiation codon, have been described for this gene. [provided by RefSeq, Jul 2008] | Chromosome | 12 |
| Location | 12p13.3-p1 |
| Start | 3068478 |
| End | 3149842 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 81365 |
| OMIM ID | 601714 |
| HGNC ID | HGNC:11717 |
| Unigene ID | Hs.94865 |
| Ensembl ID | - |
| PharmGKB ID | PA36435 |
mRNA Information
| mRNA ID | ?NM_003213.3 |
|---|---|
| Exon | join(1..170,637..729,35427..35681,51693..51757, 52859..52921,58087..58215,59234..59277,59804..59859, 61323..61462,62533..62706,78657..78797,80796..80948, 81054..81365) | mRNA Sequence | Download Select all |
| Length | 1798 |
Protein Information
| Protein ID | NP_003204.2 |
|---|---|
| Protein Name | TEA domain family member 4 |
| Molecular Wt. (Da) | 42225 |
| Protein Sequence | Download Select all |
| Length | 434 |
| Uniprot ID | Q86WJ1 |
| Ensembl Protein ID | ENSP00000358262 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 11007 | CCDC85B | 16101 | NP_006839.2 | yeast 2-hybrid | 16189514 |
| 25937 | WWTR1 | 9580 | NP_056287.1 | yeast 2-hybrid | 16189514 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Hippo signaling pathway | hsa04390 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam01285 | 11-426 | TEA |
| cl02603 | 11-426 | TEA superfamily |
| smart00426 | 38-105 | TEA |
Ontology Information
| HPRD ID | 5263 |
|---|---|
| Molecular Class | Transcription factor |
| Molecular Function | Cytoskeletal anchoring activity (GO:0016343) |
| Biological Process | Cell growth and/or maintenance (GO:0008151) |
Drug Information
No matching records could be found.