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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| TERF1 | 7013 | Telomeric repeat binding factor (NIMA-interacting) 1  | 8 | TRF; PIN2; TRF1; TRBF1; t-TRF1; hTRF1-AS  |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 17848589    | 2007 | Cell line : - Source : Tumor Bank Network established at the Centro Nacional de Investigaciones Oncolo' gicas (CNIO). Sample Type : - No. of Sample : - Stage : - | Antibody Microarrays,Protein Labeling and Microarray Assay,Tissue Microarray Design and Immunohistochemistry | Unknown | 1.54 | - |
Gene Details

| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a telomere specific protein which is a component of the telomere nucleoprotein complex. This protein is present at telomeres throughout the cell cycle and functions as an inhibitor of telomerase, acting in cis to limit the elongation of individual chromosome ends. The protein structure contains a C-terminal Myb motif, a dimerization domain near its N-terminus and an acidic N-terminus. Two transcripts of this gene are alternatively spliced products. [provided by RefSeq, Jul 2008]   | Chromosome | 8 |
| Location | 8q21.11 |
| Start | 73008862   |
| End | 73048123   |
| Strand | -   |
| Gene Sequence |    Download   Select all |
| Length | 39262   |
| OMIM ID | 600951    |
| HGNC ID | HGNC:11728    |
| Unigene ID | Hs.442707     |
| Ensembl ID | ENSG00000147601    |
| PharmGKB ID | PA36445    |
mRNA Information
| mRNA ID | NM_017489.2 |
|---|---|
| Exon | join(1..344,5034..5129,11823..11944,13355..13441, 15961..16110,18079..18191,21475..21534,23181..23272, 30255..30358,37100..38891)   | mRNA Sequence |    Download   Select all |
| Length | 2960   |
CDS Information
| Location | join(26..344,5034..5129,11823..11944,13355..13441, 15961..16110,18079..18191,21475..21534,23181..23272, 29845..29934,30255..30358,37100..37276) |
|---|---|
| CDS Sequence |    Download   Select all |
| CCDS ID | - |    
Protein Information
| Protein ID | NP_003209.2 |
|---|---|
| Protein Name | Telomeric repeat binding factor (NIMA-interacting) 1 |
| Molecular Wt. (Da) | 48108 |
| Protein Sequence |    Download   Select all |
| Length | 419   |
| Uniprot ID | P15559 |    
| Ensembl Protein ID | ENSP00000319788   |    
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 219 |
| S | Phosphorylation | 219 |
| S | Phosphorylation | 11;- |
| S | Phosphorylation | 11;- |
| S | Phosphorylation | 434 |
| S | Phosphorylation | 435 |
| S | Phosphorylation | 437 |
| S | Phosphorylation | 414 |
| S | Phosphorylation | 415 |
| S | Phosphorylation | 417 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING)      View   
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 472 |    ATM |    6347 |    NP_000042.3 |    in vitro;in vivo |    1   137   597   615   314   650    |
| 4093 |    SMAD9 |    4484 |    BAA21128.1 |    yeast 2-hybrid |    15231748    |
| 7704 |    ZBTB16 |    11762 |    NP_005997.2 |    yeast 2-hybrid |    16169070    |
| 9231 |    DLG5 |    4972 |    NP_004738.3 |    yeast 2-hybrid |    16169070    |
| 10813 |    UTP14A |    6712 |    NP_006640.2 |    yeast 2-hybrid |    16169070    |
| 11244 |    ZHX1 |    10379 |    NP_009153.3 |    yeast 2-hybrid |    16169070    |
| 26272 |    FBXO4 |    9949 |    NP_036308.1 |    in vitro;in vivo |    16275645    |
| 28964 |    GIT1 |    6577 |    NP_001078923.1 |    yeast 2-hybrid |    16169070    |
| 60626 |    RIC8A |    12373 |    NP_068751.4 |    yeast 2-hybrid |    16169070    |
| 80351 |    TNKS2 |    6182 |    NP_079511.1 |    in vitro;in vivo;yeast 2-hybrid |    114   548   731   173   974   000   000   000    |
Pathway Information
No matching records could be found.
Structure Information
| PDB ID | 1BA5 |
|---|---|
| Resolution | - |
| Method | SOLUTION NMR |
| Chains | A   |
| Molecule | HTRF1   |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00280 | 76-264  | TRFH |
| cl02779 | 76-264  | TRFH superfamily |
| cd11660 | 381-429  | SANT_TRF |
| cl21498 | 381-429  | SANT superfamily |
| pfam08558 | 77-264  | TRF |
| pfam00249 | 380-428  | Myb_DNA-binding |
| cd00167 | 382-428  | SANT |
| smart00717 | 380-429  | SANT |
Ontology Information
| HPRD ID | 509 |    
|---|---|
| Molecular Class | DNA binding protein |
| Molecular Function | Deoxyribonuclease activity (GO:0004536) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)   |
Drug Information
No matching records could be found.
External Links
| ArrayExpress | GO |    
|---|---|
| ICGC | GO |    
| Cancer3D | GO |    
| COSMIC | GO |    
| NCG | GO |    
| TSGene | GO |    
| Tumor Gene Family of Databases | GO |    
| CCDB | GO |    
| G2SBC | GO |    
| Osteosarcoma Database | GO |    
| RCDB | GO |    
