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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
TERF1 7013 Telomeric repeat binding factor (NIMA-interacting) 1  8TRF; PIN2; TRF1; TRBF1; t-TRF1; hTRF1-AS 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
17848589   2007Cell line : -

Source : Tumor Bank Network established at the Centro Nacional de Investigaciones Oncolo' gicas (CNIO).

Sample Type : -

No. of Sample : -

Stage : -

Antibody Microarrays,Protein Labeling and Microarray Assay,Tissue Microarray Design and ImmunohistochemistryUnknown1.54-


Gene Details



Chromosome: 8; NC_000008.10 (73921097..73959987)

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Gene Type protein coding
Gene Family -
Description This gene encodes a telomere specific protein which is a component of the telomere nucleoprotein complex. This protein is present at telomeres throughout the cell cycle and functions as an inhibitor of telomerase, acting in cis to limit the elongation of individual chromosome ends. The protein structure contains a C-terminal Myb motif, a dimerization domain near its N-terminus and an acidic N-terminus. Two transcripts of this gene are alternatively spliced products. [provided by RefSeq, Jul 2008]  
Chromosome 8
Location 8q21.11
Start 73008862  
End 73048123  
Strand -  
Gene Sequence

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Length 39262  
OMIM ID 600951   
HGNC ID HGNC:11728   
Unigene ID Hs.442707    
Ensembl ID ENSG00000147601   
PharmGKB ID PA36445   

mRNA Information


mRNA ID NM_017489.2
Exon join(1..344,5034..5129,11823..11944,13355..13441, 15961..16110,18079..18191,21475..21534,23181..23272, 30255..30358,37100..38891)  
mRNA Sequence

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Length 2960  



CDS Information


   
Locationjoin(26..344,5034..5129,11823..11944,13355..13441, 15961..16110,18079..18191,21475..21534,23181..23272, 29845..29934,30255..30358,37100..37276)
CDS Sequence

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CCDS ID -



Protein Information


      
Protein IDNP_003209.2
Protein NameTelomeric repeat binding factor (NIMA-interacting) 1
Molecular Wt. (Da)48108
Protein Sequence

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Length 419  
Uniprot IDP15559
Ensembl Protein ID ENSP00000319788  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation219
SPhosphorylation219
SPhosphorylation11;-
SPhosphorylation11;-
SPhosphorylation434
SPhosphorylation435
SPhosphorylation437
SPhosphorylation414
SPhosphorylation415
SPhosphorylation417

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                                      
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
472ATM6347NP_000042.3in vitro;in vivo1   137   597   615   314   650   
4093SMAD94484BAA21128.1yeast 2-hybrid15231748   
7704ZBTB1611762NP_005997.2yeast 2-hybrid16169070   
9231DLG54972NP_004738.3yeast 2-hybrid16169070   
10813UTP14A6712NP_006640.2yeast 2-hybrid16169070   
11244ZHX110379NP_009153.3yeast 2-hybrid16169070   
26272FBXO49949NP_036308.1in vitro;in vivo16275645   
28964GIT16577NP_001078923.1yeast 2-hybrid16169070   
60626RIC8A12373NP_068751.4yeast 2-hybrid16169070   
80351TNKS26182NP_079511.1in vitro;in vivo;yeast 2-hybrid114   548   731   173   974   000   000   000   


Pathway Information


No matching records could be found.

Structure Information


PDB ID1BA5
Resolution-
MethodSOLUTION NMR
Chains A  
Molecule HTRF1  
Model View



Domain Information




ID Location Description
cd0028076-264  TRFH
cl0277976-264  TRFH superfamily
cd11660381-429  SANT_TRF
cl21498381-429  SANT superfamily
pfam0855877-264  TRF
pfam00249380-428  Myb_DNA-binding
cd00167382-428  SANT
smart00717380-429  SANT


Ontology Information


   
HPRD ID509
Molecular ClassDNA binding protein
Molecular FunctionDeoxyribonuclease activity (GO:0004536)
Biological ProcessRegulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO