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General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22895193 | 2012 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | Exome sequencing, RNAseq and SNP array analysis. | Mutation | - | - |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The protein encoded by this gene is a methylcytosine dioxygenase that catalyzes the conversion of methylcytosine to 5-hydroxymethylcytosine. The encoded protein is involved in myelopoiesis, and defects in this gene have been associated with several myeloproliferative disorders. Two variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011] | Chromosome | 4 |
| Location | 4q24 |
| Start | 105145875 |
| End | 105279803 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 133929 |
| OMIM ID | 612839 |
| HGNC ID | HGNC:25941 |
| Unigene ID | Hs.367639 |
| Ensembl ID | ENSG00000168769 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_017628.4 |
|---|---|
| Exon | join(1..212,44486..44631,88023..96897) | mRNA Sequence | Download Select all |
| Length | 9236 |
CDS Information
| Location | join(88069..91477,95465..95555,96960..97053,97696..97904, 113745..113895,115885..115974,123736..123873, 126690..127044,129174..130645) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS47120.1 |
Protein Information
| Protein ID | NP_001120680.1 |
|---|---|
| Protein Name | KIAA1546 |
| Molecular Wt. (Da) | 223681 |
| Protein Sequence | Download Select all |
| Length | 2002 |
| Uniprot ID | P31371 |
| Ensembl Protein ID | ENSP00000371790 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 99 |
| S | Phosphorylation | 1107 |
| K | Acetylation | 53 |
| T | Phosphorylation | 97 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam12851 | 1290-1424 | Tet_JBP |
| cl21496 | 1290-1424 | 2OG-FeII_Oxy superfamily |
| pfam12851 | 1850-1905 | Tet_JBP |
| cl21496 | 1850-1905 | 2OG-FeII_Oxy superfamily |
| pfam05109 | 1561-1741 | Herpes_BLLF1 |
Ontology Information
| HPRD ID | 624 |
|---|---|
| Molecular Class | Unclassified |
| Molecular Function | Transmembrane receptor protein tyrosine kinase activity (GO:0004714) |
| Biological Process | Enzyme linked receptor protein signaling pathway (GO:0007167); Cellular morphogenesis during differentiation (GO:0000904) |
Drug Information
No matching records could be found.