Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| TFPI | 7035 | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 2 | EPI, TFI, TFPI1 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 20062932 | 2010 | Cell line : - Source : - Sample Type : CRC tumor and adjacent normal tissue No. of Sample : 108 cancer tissues ( primary tumours and metastatic lymph nodes) Stage : - | Immunohistochemistry,real time RT-PCR, in situ hybridisation | Up-regulation | - | TFPI mRNA and protein are present in association with colon and breast cancer cells, suggesting that the protein may play a role in cancer biology. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation. The coagulation process initiates with the formation of a factor VIIa-TF complex, which proteolytically activates additional proteases (factors IX and X) and ultimately leads to the formation of a fibrin clot. The product of this gene inhibits the activated factor X and VIIa-TF proteases in an autoregulatory loop. The encoded protein is glycosylated and predominantly found in the vascular endothelium and plasma in both free forms and complexed with plasma lipoproteins. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been confirmed. [provided by RefSeq, Jul 2008] | Chromosome | 2 |
| Location | 2q32 |
| Start | 188328957 |
| End | 188419219 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 90263 |
| OMIM ID | 152310 |
| HGNC ID | HGNC:11760 |
| Unigene ID | Hs.516578 |
| Ensembl ID | ENSG00000003436 |
| PharmGKB ID | PA36475 |
mRNA Information
| mRNA ID | ?NM_001032281.2 |
|---|---|
| Exon | join(1..304,1966..2112,3328..3930) | mRNA Sequence | Download Select all |
| Length | 1054 |
Protein Information
| Protein ID | NP_001027452.1 |
|---|---|
| Protein Name | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 304 |
| Uniprot ID | Q6ZMQ8 |
| Ensembl Protein ID | ENSP00000324196 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| N | Glycosylation | 145 |
| N | Glycosylation | 195 |
| S | Glycosylation | 202 |
| T | Glycosylation | 203 |
| S | Proteolytic Cleavage | 202 |
| K | Proteolytic Cleavage | 48 |
| T | Proteolytic Cleavage | 115 |
| K | Proteolytic Cleavage | 48 |
| R | Proteolytic Cleavage | 111 |
| S | Proteolytic Cleavage | 202 |
| K | Proteolytic Cleavage | 48 |
| K | Proteolytic Cleavage | 48 |
| K | Proteolytic Cleavage | 48 |
| K | Proteolytic Cleavage | 48 |
| R | Proteolytic Cleavage | 111 |
| T | Proteolytic Cleavage | 115 |
| N | Glycosylation | 145 |
| N | Glycosylation | 195 |
| S | Glycosylation | 202 |
| S | Proteolytic Cleavage | 202 |
| S | Proteolytic Cleavage | 202 |
| T | Glycosylation | 203 |
| K | Proteolytic Cleavage | 48 |
| K | Proteolytic Cleavage | 48 |
| K | Proteolytic Cleavage | 48 |
| K | Proteolytic Cleavage | 48 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 4316 | MMP7 | 1525 | NP_002414.1 | in vitro | 10859319 |
| 4317 | MMP8 | 385 | NP_002415.1 | in vitro | 12117418 |
| 4321 | MMP12 | 3027 | NP_002417.2 | in vitro | 10859319 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Complement and coagulation cascades | hsa04610 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00109 | 123-175 | KU |
| cl00101 | 123-175 | KU superfamily |
| cd00109 | 52-104 | KU |
| cl00101 | 52-104 | KU superfamily |
| cd00109 | 217-268 | KU |
| cl00101 | 217-268 | KU superfamily |
| smart00131 | 123-175 | KU |
| pfam00014 | 124-175 | Kunitz_BPTI |
| smart00131 | 215-267 | KU |
| pfam00014 | 216-268 | Kunitz_BPTI |
| smart00131 | 52-104 | KU |
| pfam00014 | 53-104 | Kunitz_BPTI |
Ontology Information
| HPRD ID | 9212 |
|---|---|
| Molecular Class | Protease inhibitor |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Biological_process unknown (GO:0000004) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P10646 | DB00036 | Coagulation factor VIIa | BiotechDrug |
| P10646 | DB06779 | Dalteparin | SmallMoleculeDrug |