CoReCG

Search results:

General Information

Gene_Symbol	Gene_ID	Gene_Name	Chromosome	Alias
TGFB1	7040	transforming growth factor, beta 1	19	CED, TGFbeta

Evidence
Gene
mRNA
CDS
Protein
PTM
Enzyme
PPi
Pathway
Structural
Domain
Ontology
SNP
Drug
External Links

Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
12174377	2002	Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 50 patients with colorectal cancer and 30 healthy volunteers Stage : Biomarker	ELISA, immunohistochemistry	Up-regulation	-	TGFbeta1 may be used as a possible biomarker. Serum levels of TGFbeta1 in patients with colorectal cancer(40+/-18 microg.L(-1)) were significantly higher than those in the healthy control group(19+/-8 microg.L(-1)), P<0.05.
12046078	2002	Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 98 colorectal cancer Stage : -	Immunohistochemistry	Up-regulation	-	TGF beta(1) might be associated with tumor progression by modulating the angiogenesis in colorectal cancer and TGF beta(1) may be used as a possible biomarker.

Gene Details

Chromosome 19 - NC_000019.10 (41330531..41353933, complement)
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Gene Type	protein coding
Gene Family	Endogenous ligands
Description	This gene encodes a member of the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types. Many cells have TGFB receptors, and the protein positively and negatively regulates many other growth factors. The secreted protein is cleaved into a latency-associated peptide (LAP) and a mature TGFB1 peptide, and is found in either a latent form composed of a TGFB1 homodimer, a LAP homodimer, and a latent TGFB1-binding protein, or in an active form composed of a TGFB1 homodimer. The mature peptide may also form heterodimers with other TGFB family members. This gene is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease.
Chromosome	19
Location	19q13.1
Start	41330531
End	41353933
Strand	-
Gene Sequence	>gi\|568815579:c41353933-41330531 Homo sapiens chromosome 19, GRCh38.p2 Primary Assembly AGCCGGTCCCCGCCGCCGCCGCCCTTCGCGCCCTGGGCCATCTCCCTCCCACCTCCCTCCGCGGAGCAGC CAGACAGCGAGGGCCCCGGCCGGGGGCAGGGGGGACGCCCCGTCCGGGGCACCCCCCCGGCTCTGAGCCG CCCGCGGGGCCGGCCTCGGCCCGGAGCGGAGGAAGGAGTCGCCGAGGAGCAGCCTGAGGCCCCAGAGTCT GAGACGAGCCGCCGCCGCCCCCGCCACTGCGGGGAGGAGGGGGAGGAGGAGCGGGAGGAGGGACGAGCTG GTCGGGAGAAGAGGAAAAAAACTTTTGAGACTTTTCCGTTGCCGCTGGGAGCCGGAGGCGCGGGGACCTC TTGGCGCGACGCTGCCCCGCGAGGAGGCAGGACTTGGGGACCCCAGACCGCCTCCCTTTGCCGCCGGGGA CGCTTGCTCCCTCCCTGCCCCCTACACGGCGTCCCTCAGGCGCCCCCATTCCGGACCAGCCCTCGGGAGT CGCCGACCCGGCCTCCCGCAAAGACTTTTCCCCAGACCTCGGGCGCACCCCCTGCACGCCGCCTTCATCC CCGGCCTGTCTCCTGAGCCCCCGCGCATCCTAGACCCTTTCTCCTCCAGGAGACGGATCTCTCTCCGACC TGCCACAGATCCCCTATTCAAGACCACCCACCTTCTGGTACCAGATCGCGCCCATCTAGGTTATTTCCGT GGGATACTGAGACACCCCCGGTCCAAGCCTCCCCTCCACCACTGCGCCCTTCTCCCTGAGGACCTCAGCT TTCCCTCGAGGCCCTCCTACCTTTTGCCGGGAGACCCCCAGCCCCTGCAGGGGCGGGGCCTCCCCACCAC ACCAGCCCTGTTCGCGCTCTCGGCAGTGCCGGGGGGCGCCGCCTCCCCCATGCCGCCCTCCGGGCTGCGG CTGCTGCCGCTGCTGCTACCGCTGCTGTGGCTACTGGTGCTGACGCCTGGCCGGCCGGCCGCGGGACTAT CCACCTGCAAGACTATCGACATGGAGCTGGTGAAGCGGAAGCGCATCGAGGCCATCCGCGGCCAGATCCT GTCCAAGCTGCGGCTCGCCAGCCCCCCGAGCCAGGGGGAGGTGCCGCCCGGCCCGCTGCCCGAGGCCGTG CTCGCCCTGTACAACAGCACCCGCGACCGGGTGGCCGGGGAGAGTGCAGAACCGGAGCCCGAGCCTGAGG CCGACTACTACGCCAAGGAGGTCACCCGCGTGCTAATGGTGGAAACCCACAACGGTGAGCTCGGAGGGGC AGGGGAGCCGGGAGGGGGGCCCCCAGGGGGCGCCGGAGTGCCGGGGCCACGGGTAGGAAGTGACTGGCAG AAGAAACTGGCTGGAGGAAGAGGACACCCCGGGGCAAAGGGAACGTGTGATGGTGGGAGGGGGGTGTCCG AAAGAGGATGGCACTGAGCCCCCTACCACCCAGGTGTCTGGTCTTGGAGAGGAGGAGATAGCGAAGTGGA CCGCTTCTAGAGTGCGACAGAAACATGCGGGGTCGTGGGGGCAGTCCCCTAGAGGGAGACAAGCAATAGG GGGAGGGTAGAAGGCTCCCTCTTCCAGGACGCGTTGAATGGGGGGGGGGGTCGTGGGGTGCCAGGTGCAG AGAAGGGAGCCTGGTGTGGGAGAAGCGAAGACCCCAGCATTTGGGAAAGGAGAGGCGCTGGAGAAAGTTG ACCCAGAGCTTGGGGGTCCTGAGGTGGAAAGATTCAAGAAGGACAGAAAAGCTAGATGAAGGCAACCCCA GAGGGTGCCAGGAAAGTGAGAGCGGACCCACTTCCAGAGGCTGCCAGGAACACGCGGGATGCGGGGGTGG GGGAGAGTCGTAGAAAGAGAAACAGAGGTGCGTGTGATAAATGTGGGGAGAAAGGGACGGGAGGTTATTG GAAGGAGGAGGCAAGCGGGAGAGGAGCGGAGACTCGGGAGGGCGCCCGGGATGCAGAGGTGTCCTCGGTG TTTCACACAGGGACGTGAGGGACAGAGTGGGGAGCCCAGCGGAGGAATCGAGCTTCCAGAAGACCTAGAG TCCTGGGTCATGGGAAGGGCTTTACCGAGAGGGGAGACAGGCGTGGGAAAGGTGGTGTGAGCGGGGAGGA GGAGAGATACCCAGCGCCATCCACGCTGCATTCCCCGCAGGATGCAGGGGAATGGGCTGAGCGGAGTCCA GCCGCAGGGGAAGTGCTGGGTGGGGGGTGACTCTACAAGACCGAGGTGAGAAAACCAAGCTGGGAGGAGT GAGAAAGCCCCACGTGGGTGCCACGCGCGGGGGGAGGAGCCTGCGCTTCCACCAAGGGGCAGGAGGACCC CGCTGCGCTAAACGCTGGCAGTCTGGACCCCAAAGTCCCAGTTCCTCTCAGGGTGGCTGGGGAAACCCCA GCGTCCGGCGGCCTCATCCCCCTCCCTTCCCTTTCCTTCCCATGCCCCCGGCGGAGGCGGGGATCGCTCG CGGAGCCCGGGGCGAGACGGGGCAGGTCTGGTCCCCGCCCTCCTGGCTGCGGCGCCTCCCGCCCTCCTCA CCCCAGCTACGGGCGGGGCTCCCACTCAGCCGGCCCCGTCGGCATCCATGCGAGGACCCAGGCGTCCCGC GTGGTTCAGAGCCTTGGGGAAGATCCCTCAGGTTTCACTGACTCTTGGGCGGTGTGGGCTTGCGGGTTCC CTGCCCATTTCTGCGCCAGTTTACAGCTCCAGCCCAATGACGCGCACTCCGCACCCAAGTCTCAGCCTTA CCTTATCTTCCGTGGCTTCACCTTCGTTGTAGAGGTTCCTTTAACACTGACACCTCCAATCCTCTTCTCC CCAACAAATGCACATGTGTCTCGTCTCGCACGTGTCTCCCCATCTGCCTCTTTCTTTTCGTCTCCGTTAG TCTTTCTGTCCACGCATGGGTCTCCTGGTTTTTGTCTCTCCGACTATTTTCTCTCCCTTTCTATTTTTCT CCTCCACGGTCCTGTTGCCTCGTCTCCGTCTCTGACATCTCCCCGCCTCTCCCTCTCTGCATCACCCTCC AACCCTTCCTCTCCCTCCTCTCTGTCTTCCTCCCTATCTGTCTTCCCCAGCCAAGGCTCTGCCTTTCCTT TGGGGTTTGCTGAGTAACCTCCGGGCCAAGAATAGGGCTTACTGGGGCTGGGTGGGGAGGGAGACTGGGG AGGAGGAGGAGGATCGAAGGGGGCCGTAGGGGAGGGGTTTCCTCTGCCTTTCTCACCAGTCTCTTTTCAC ACCCCCACTATGGGAGGCTGGAAGCAGTTGCCCCAGTTGATCCAGCAGTTCATGGCCTGTTCCCTCATCC CCATCCCCAAACTTTTCCTAAACTAGAAAATACCTTGGCTGGGCGCGGTGGCTCACGCCTGTAATCCCAG CACTTTGGGAGGCCAAGGTGGGTGGACCACCTGAGGTCAGGAGTTGGAGACCAGCCTGGCCAACATGGTG AAACCCGGTCTCTACTAAAAATACAAAAATTAGCTGGGCGGGGTGGCGGGCGGCGCCTGTAATCCCAGCT ACTTGGGAGGCTGAGGCAGGAGAATCGCTTGAACCTGGGAGGCAGAGGTTGCTATGAGCCAAGATCGCGC CACTGCACTCCAGCCTGGGCGACAGAAACTCCATCTCAAAAAAAAAAAAAAAAAAAGAAAAGAAAACACC TTAATTCCTTTTCTCCCCACTACAGCCATTCCTACCCAGAATGAACTTCACTTTCCCTAACCAGCTGGGG AAGGGAGTTAAGGGTGGAAAACTAATAATAAAAATAAGTAGAAGAATCACTTAGGGGTTAAGAGCACAGT CTCTAGCTGGGTGGGTGTGGTGGCTCATGCCTGTGATCTCAACATATTGGGAGGCTGAGGCGTGAGGATC CCTTGAGCCCAGGAGTTCCAGCCTGCCGTGAGCCATGGTTGTGCTACTGCACTTCCGTCTGGGGGACAGA GTGAGACCCTGTCTCTTGGGGGAAGAAAAAAAAAAAGCACAGTCTCTGGAATGAGACAGCTTGAGTTTGA ATCCCAGTCTGCAGCTATGTGACCTTGGGGCAAATTACTTAATCTCGGTGCCTCAGTTTCTCATCTATTA AACGGGTATAATAATAGTATAAGGTTGTGAGGTTTAAATGTCTTCATCTTTGTAAAGTGCTTTAGATAGC ATCTGGTAAATAGCGCTGTTTTGTGGTTTTTTGTTGTTGTTGTTTTTGAGACAGAGTCTTACTCTGTCAC CCAGGCTGGAGTGCAGTGGCGCAATCTCGGCACACTATAACCTCTGCCTCTCAGGTTCAAGCGATTCTCA TGCCTCAACCTCCCAAGTAGCTGGGATTAGAGCCGTCCGGCACCATGCCTGGCCAATTTTTGTATTTTTA GTAGAAACGGGGTTTCACCATGTTGGCCAGGCTGGTCTCGAACTCCCGACCTCAAGTAATCAATCCACCT CGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTGCGCCCAGCCAGCACTCTTAGACGTATACAT GATTGAGTGACCAGTGTATGCAGAATTGGTGCCACATGGCTTGACCTGGGTCATCTAATTTCCCACTATA ATACTGGAATGGGTTCTAGAGTCACTCTGTCTTGTCTTACACCTGGCTCAGAGAGAGGAATTCACTTGCC CAAGGTTACACAGCGCTTAAATTAGGAGAGTCTGTGTGGGAATGCAGGGAGCTTAATGTTATTGCTGTTT TTCAAAGAATAACAGGAAACTGACATTCAGAAAGAGGGTGTTAACTGCCCATGGTCACACAGCCAAGAGG CAGCAGAGGCACTATCTGAGTCCAAAGCCTGTGCCTTTGATCCTTACTCTGCATTTTAGGGGCTCTTGCA TTTGGGGCAAGGAAGGCCAGAGCAAACAGAGTGGTTCCCCTTGGTGCCAGCCTTAGTCGACTTGAGAGAT GATGCTACATGAGAGAGGAATGTGGTTAGGACCTATTTTACAGAGGAGGAAACAAACCTAGGGGGAGAAA CCACTTCCTCAAGGTCACACAGCTAAAAAGTATCACAGTCAGGGCTGGGCGTGGTGGCTCACACCTGTAA TCCCAGCACTTTGGGAGGCCGAGGCGGGTGGATCACGAGGTCAGGAGATCGAGACCATCCTGGCCAACAT GGTGAAACCCCATCTCTACTAAAAATACAAAAATTAGCTGGGCATGGTGGCATGAGCCTTTAGTCCCAGC TGCTCGGGAGGCTGAGGCAGGAGAATTGCTTGAACCCTGGAGGCGGAGGTTGCAGTGAGCAGAGATTGCG CCACTGCACTCCAAGCCTGGGTGACAGAGCGAGTCTCCGTCTCAAAAAAAAAAAAAAATTCATTTAAATA AATAAATAAATAAATAAATAAATAAATAAATAAATAAAAGGTATCAGAGACTGACTCCACCCCAGAGCTG TCAGCTCCAAAACTCCTAGAGTTGGGAGCACCAGCTCCCCTCACCTCTGCCAAACCCCTGATCGCCTCCC TTCATTTCTCCCTGCTAGAAATCTATGACAAGTTCAAGCAGAGTACACACAGCATATATATGTTCTTCAA CACATCAGAGCTCCGAGAAGCGGTACCTGAACCCGTGTTGCTCTCCCGGGCAGAGCTGCGTCTGCTGAGG CTCAAGTTAAAAGTGGAGCAGCACGTGGAGCTGTACCAGGTGAGGACATGAGCCAGAAGGAAGGTCAGGG CATGGGCTGGAGAGGGTGAGCTGTGACCAAGGGGGTGGCTGTGGGTCGGCTGGTTACAAGGTCCACCTAG ATGGTCCCTGAAGGATAGAAGAACACAAACCATACAATCCTAGAACGCTTTTTTTTTTTTTTTGAGACAG TGTCTCACTCTGTTGCCAAGCTGGAGTGCAGTGGTATGACCTCAGCTCACTGCAATCTCCGCCTCCTGGG TTCCAGTGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGTGTGCGCCACCACGCCCAGCTA ATTTTTGTATTTTTGGTAGAGATGGGGTTTTACCATGTTGGCCAGGATGGTCTCGATCTCCTGACCTCGT GATCCACCTGCCTCGGTCTCCCAAAGTGCTCAGATTACAGGCGTGAGCCACTGCGCCTGGCCTCTTTTTT TTTTTTTTTTTTTTTTGAGATGGAGTCTTGCTCTGTCGCCCAGGCTGGAGTACAATGGGGTGATCTCGGC TCACTGCAACCTCCGCCTCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCACCCGAGTAGCTGGGATTACA GGCATGTGCCAACACGCTGGGCTAATTTTTGTATTTTTAGTAGAGACAGAGTTTTATCATGTTGGCCAGG CTTGTCTCAAACTCCTGCCCTCAAGTGATTCTCCTACCTGAGCCTCCCAGAGTGCTGGGATTACAGGTGT GAGCCACTGCACCCGGAACCTAGAGCACTTTTAAATGTTCAGACTCTTTGCATCCTAGGATGTTAAACAC TTAGAAGGCTGGAATCTTAGGAGTTGGACTCTTTAAGGACACAGGATTCTTGAAAGTTGGAATCTCTGAA AAGGTTGGGGGCTCTAGAATCATTCTGTCCAATATGACAGCCACTAGTCACATTTAGCTTGATTAAAATT TAAATTGTTTAAAATTAAATTAAAAATTTAGGGCCAGGCATAGTGGCTCACACCTCTAATCCCAGAACTT TGGGAAGCCGAGGCAGGCAGATTGCTTGAGCCCAGGAGTCCGAGACCAGTCTGGGCAACATGTTGAAACT TCGTCTCTACAAAAAATACTAAAATTAGCCTGTTATGGTGATGCGTGCCTCTAGTCCCAGCTACTCAGTA GTCTGAGGTGGGAGGATTGATTGAGCCCAGGAGGTCGAGGCTGTAGTGAACTGTGATTGCACCACTGCAT TCCAGCCTGGGTGATGGAGCGAGACCGTCTCAAAAATATATATATATAGGCCAGGCGTGGTGGCTCATGC CTGCAATCCCAGCACTTTGGGAGGCCAGGGTGGGTGGATCACTTGAGGTCAGGAGTTCAAGACCAGCCTG GCCAACATGACGAAACTCCATCTCTACTAAAAATACAAAAATTAGCCAGGTGTGGTGGCAGGCACCTGTA ATCCCAGCTACTTGGGAGGCTGAGGTGGGAGAATCGCTTGACCCCAGGAGGTGGAGACTGCAGTGAGCGG AGATCATACCACTGCACTCCAGCCTGGGCAACAGAGCGAGACTCTGTCTCAAAAAAATAAAAATGAAAAA GAAATCCTCATTCTCACTGGCCATATTTCTAGTACTCTATAGTCACATGTGGTTAGCAGCTACTATTTTG GATGTTGCAGATAAAGCACATTTCCAGAAAGTTCTTTAGGACAGCACTGCTCTAGAAGATAGGGAGCTTC CAAGAGGACTGGGGCATCTGGAAGGGCTGGAGGCTCTAGCAGTTTCTATGAGCTAGAATCCATATCAGAG GGAATGTTAACTCATAGGATGGTAGATTTCAGACTTTCACAGTGAGAGAACTTTGTCCTATGTTAGCTTG GCTTCTTGGAGTCTGGGGAATTCAGCTTTATTCTGCAGTCCCTGGAGTGGACTATCCAGCCCCAGAAAAT TCTTCTTTTTTTTGTGTGTGTGTGTGATGGAGTTTTGCTCCTGTTGCCCAGGCTGGAGTGCAATGGCACC ATCTTGGCTCACCACAACCTTTGCTTCCTGGGTTCAAGCGATTCTCCTGCCTCAGCCACCCGAGCAGCTG GGATTACAGGCATGCACCACCACACCTAGCTAATTTTGTATTTTTAGTAGAGACGGTGTTTCTCCATATT GGTCAGGCTGGTCTCGAACTTCTGACCTCTGGTGATCCACCCTCCTCGGCCTCCCAAAGTGCTGGGATTA CAAGCGTGAGCGACTGTGCCTGGCCCAGAAAATTATTCTACACAGATGTTGGGTACCTGCAGCATCTAGG TGCGGCATGGCAGACTCTTGGGTTTATAGAACATTAGTCTTCTAAAGCTTCTCAGGCTCTAGAAGTGGAA ATCTTGGGATATTATCAAACATTTGAATCACAAAATGACTTTTTTTTTTTTTGAGACAGAGTCTCACTCT GTCACCCTGGCTAGAGTGCAGTGGTGCAATCTCGGCTCACTGCAACCTCTGTGTCTTGGGTTCAAGTGAT TCTCCTGCCTCAGCCTCCTGAGTAGCTGGGATTACAGGCGTGTGCCACCACGCCTGGCTAATTTTTGTAT TTTTAGTAGAGACGAGGTTTCACTTTGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGAGATCCACC CGCCTTGGCCTCCCAAAGTGCTGGGATAACAGGCGTGAGCCACCGTGCCCAGCCGGAATCATTAGAAATG ACTTCTAAGTTACTGAGAATTCAGGGTGTCAAATTTGCAGAACCGTATGCTCAGTAAACCCCAGAATGTT TGCAGCAGAATTTTATTTTATTTATTATTATTATTTTGAGACGAAGTCTCGTCCTGTCGCCCAGGCTGGA GTGCAGTGGCGTGATCTTGGCTCACTGCAGTCTGTGTCTCCCGGGCTCAAGCAATTCTCCTGCCTCAGCC TCCCAAATAGTGGCGACTACAGGCGTGTGCCACCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGATGG GGTTTCACTATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAAGTGATCCACCCACCTTGGGCTCCCA AAGTGCTGGGATTACAGGCGTGAGCCACTGCGCCCGGCCCAGAATGTTAGCAGCAGAATTTTAGCATTGT GGGCTGTCCACGCTGAGTGGGGCTTAGCATTTCACCAATGAGGAAACAGGCCTCGAGAAGGCAAGAAAAC ACCTTCGGCTGAGCTGTGTGAAGGTGACTTGACCGCAGCCTGAGCTTTTTCTCCACCCCTCCTCTCATGG GTACTGTTGGGGAGGATGGGTGCCACAGGACCACACAGGTGGCTGTCTGAGAGGGTAGTGCCTGGGAACT TTCTGGAAGCCTGTTTGGGGAAGCAGATGGGGTGAAGGATTCAGTTAGTGTATGTGGGGTCGTGACACCA TCTACCCACTGTCTCTCTCCTGCCTTCATCATCCTCTAGAAATACAGCAACAATTCCTGGCGATACCTCA GCAACCGGCTGCTGGCACCCAGCGACTCGCCAGAGTGGTTATCTTTTGATGTCACCGGAGTTGTGCGGCA GTGGTTGAGCCGTGGAGGTGAGGATTACTTGTGTGTCCCACCCCTGTTTCTCCCTGGGGTCCACCCCATT GTTTGTCCTGGGGTCACTTTGCCTAGGACCCCTCTCCGCCCCATACTGGTGTGAAAGTGCTGAGACCTGG CTCCCCTCTGTGGCATGGAAACCTGAGTGATTGGCTAATCTGTTTCCTGAGCACCTCTCTGCCCTGCCCT GTGATGGGTGATGCCAAGGACACAGCAATGACCAAAACAGCCCCATCCTTGCCCTCACAGAGCTCATATA GTCCATTGGCTAGGTAGCTGGGGAACAGACCTGTAAGGCAGTGATGACCCAGAGTGGGTGGGACTGGGAT GGGGAGCCCAAAGGAGGTACCTGACCCAGCCCAGAATCAGGGAGGGCTTCCTGGAGGAGGGGCACCATAG CTGATGTTGAAGGGATGAGTAGAATGGTCAGGAAAAGGAGAGGTGTAAGAGTATTCTGGGGCTGGGCATG GTGGCTTATGCCTATAATCCCAGCACTTTTGAAGGCCAAGGAGGATGGATCACTGGAGCTCAGGAGTTTT GAGAGCAGCCTGGGCAACATGGCGAAACCCGGTCTCTACACAAAAATACAAAAATTAGCCATGCATGCTG TTACGTGCCTGTAGTTCCAGCTGCTTGGGAGACTGAGGTGGGAGAATCACCTGAGCCTGGGAGGTCGAGG CTGCAGTGAGTCATAATCACACTACTGCAATCCAGCCTACATGAAAGAGTGAGATCCCATCTCAAAAAAA AAAAAAAAAAAAAGATTCCAGGCAAAGGGAACAGCCTGTGCAAAGGCCTGGAGGCCAGGGAGAGCCTAAC TAACTCATTTGATCTGTCCAGGAGATGATTGTCTCTGTCTGGTTTCTGGCAGGGCCCATGGTGCCCCTAT CTCTCTCCCTCACCTCCCTCTCATTTATGCTTTTATTCAATAATTGCCCACAGGTTCCTGCTGTGTGCCT GGCCATGTGCTGGGTGGTGTGGGGGACATAGTGATAACCAAGACAGCCCTCAGTTCTGCCCTCATGGGGC CCACAGTCACTTCTGGACACCTAAGAGATCTTGTCAAGGCCCCACCAGGCAGGAATGACCTAGAATGATC AAGAATGGGATGGGGAGGCACCAGCAGGGAGGACAAGGCTGGGACAGGGAGGCATGCAGGATGGGGGAAC GCCCTAAGTGCTGTTGGGAGCCCAGAGAAGGCACCTGGACCCATCTGGGGAGTCTAGGAGGGCTTGCTGG GTGAGGGTGATTGTGTGGAGACTCACAGGATAAATAGTAGTTTGGCCACATGAAAAAAAAGGGATTAGGG GGCCTGGCATGGTGGCTCACGCCTGTAATCCCAGCACTTTGAGAGGCCGAGGTGGGTGGATCACCTGAGA TCGGGAGTTCGAGACCAGCCTGACCAACATGGAGAAACCCCGTCTCTACTAAAAATACATAATTAGCTCG GCGTGGTGATGCATGCCTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATTGCTTGAACCCAGGA GGTGGAGGTTTCAGTGAGCCAAGATCGTGCCATTGCACTCCAGCCTGGGCAACAACAGTGAAACTCCGTC TCAAAAAAAAAAAAGAAAAGAAAAAGAAAAAATAGGGATTAGGGAGCAGGTGGGCACTGGGAGGAGTGTC CTGGGCTGTTCGACAAAGGCCTAGAAGGAGCTCATCTGTCTTGGTCAATGCTGAGTCCCAAGCACACAGC ACAGGCTTCGGCACATTGTAGGAGCCTAGAAAACATCATTCACTCATTCATTCAAGAGATTGATGCTGGC TGGGTGCAGTGGCTCATGCCTGTAATCCCAGCACTTCGGGAGGCCAGGGCAGGAGGATTGCTTGAGCCCA GCCTGGGCAACATAGTGAGACCTCTGTCTCTACAGAGAATTTAAAAAGTAGCCGTGTAGGCCGGATGCAG TGGCTCAAGCCTGTAATCCCAGCACTTTGGGATGCCAAGGCAGGCGGATCACCTGAGGTCAGGAGTTTGA GACCAGCCTGGCCAGCATGGTGAAACCCCATCTCTACTAAAAATACAAAAAATTAGCCGGGTGTGGTGGC GCATGCCTGTTATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCGTTTGAACCTGGGAGGTGGAGGTT GCAGTGAGCTGATATCACGCCACTGAACTCCAGCCTGGGCAACAGAGCCAGACTCCATCTCAAAAAAAAA AAAAAAATTAGCCATGCGTGGTAGCACGCGCCTGTGGTCCCAGCTACTCGGGAGGCTGAGATGGGAGGAT TGCTTGGGCCTTGGAGATTGAGGCTGCGAGACCTTGTCTCAAAAAAAAAAAAAAAAAAAAAAAGAGAGAG CTGCAGTGAGAGGGCAGAGTGGGGTGGGTGGGGGAGGCAGGAAGGAAGCCCCTGGGGTTTGCTCCTTCCT TCCTCTTCCTCCAGGGGCTGGGTGAGCTGCACTCTCAGACTGGCTTCCCTCTCGCCACTCCTACAGGGGA AATTGAGGGCTTTCGCCTTAGCGCCCACTGCTCCTGTGACAGCAGGGATAACACACTGCAAGTGGACATC AACGGTGAGGCCTGCTTCCCCGGCCATGCCCAGTTGTGACGTGTGTGCGTGTGTGTGTTCCCATCTGCCC CACGCCCCACTTATCTATCCCTCTGAGAGTGTGTGTGTATGTCCCCTATCCCCTGACTCCCACACCAAAG CAGGGTTCACTACCGGCCGCCGAGGTGACCTGGCCACCATTCATGGCATGAACCGGCCTTTCCTGCTTCT CATGGCCACCCCGCTGGAGAGGGCCCAGCATCTGCAAAGCTCCCGGCACCGCCGAGCCCTGGACACCAAC TATTGCTTCAGGTGAGCCTTGTAGCCTGGATGGAGGCCTTCCAGGCTGGGGGCATGACTGCCATCTGCTG ACCAGGTGCTCCAGGTTGGACACCTGGCTGCTGCTGTGCTTGGGCTGAGCATCTGTCTCCTTTAGCTTGG AGGGCTCAGGGGATGAGGTCTGGGTGTAAGAACCAGGAGTCTTGTGCCAGGTGCGGTGGCTCACGCCTGT AATCCCAACACTTTGGGAGGCTGAGGCAGGTGGATCACCTGAAGTGAGGAGTTTGAGACCTGTCTGGCCA ACATGGTGAAACCCGTCTCTACTAAAAATCCAAAAATTAGCCAGGCGTGGTGGGCGCCTATAATCCCAGC CACAAAAAACAAAAAAAGAACTGGGAGTCTTGTAATGTTGGGATCAGGTTCCTTTTTTTTTTTTTTTTTT TTTTTTTGAGACAGAGTCTCGCTCTGTCACCTGGGCTGGAGTGCAGTGGCGCTATCTTGATTCACTGCAA GCTCCACCTCCCGGGTTCACACGATTCTCCTGTCTCAGCCTCCCGAGTAGCTAGGACTACAGGCACGTGC CACCACGCCCAGCTAATTTTTTTGTATTTTTAGTAGAGATGGGGTTTCACTGTGTTAGCCAGGATGGTCT CCATCTCCTGACCTCGTGATACACCCACCTCAGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCAACG CGCCCGGCCTAATTTTTTGTATCTTTAGTAGAGACTGGGTTTCACCATGTTAGCCAGGATGGTCTTGATC TCCTGACCTCGTGATCCGCCTGCCTCAGCCTCCCGAAGTGCTGGGATTACAGGTGTGAGCCACCACGCCC AGCCTTGCTTTCTTGCTGGAGTGTTGGAATCACAGAATGTTAGAAAGTTGAACCCTGTGATTGTTGGAAT TCAAAGTTGGAAGGTCACCATCTTGAATCCCTAAATTGTTGGCAGGTTGAGGTTCTAGAATGCTGGGATT CTAGAATGCTAGAATTTGGTGTTAATTACTGAAATGGAAAATGTCGGACTCAAGGAAAGCTGAAACATTG GAATCCTAGAATTTGGGGATTCAAAATGGGAAGATGGCCCATGTGGAATTCCTGCACCACTGGCCAATTG TGGATACCAGTGTTGGCAGATTGGAGTCCTTGAATATTGGGCTCACAGTGGTAGAATTCTGTTTTGAAAT ATTCACATCCACAAATGTTGGAGTTGGAGAAAGCAGAATATTGGTATCTCAGCATGTTGGAACTCAGTGT TGGAATGTTAGAATATTAGAATGCTGGGATTTTATTAATAGAAAGTGGCAGCAGGCTGGGCGCGGTGGCT CACGCCTATAATTCCAGCACTTTGGGAGGCTGAGGTGGGCGGATCCCTGAGGTCTGGAGTTCAAGACCAG CCTGGCCAACATGGTGAAACCCCATCTCTATTAAAAATACAAAAATTAGCCAGGTGTGGTGGCTGGCACC TGTAATCCCAGCTACTCGGCTGGGATTACGGCTATCCAGGTACCCAGGCTGGGGCAGGAGAATCACTGGA ACCTCGGGGGTGGAGGTTGCAGTGAACCGAGATCGCGCCACTGCACTCCGGCCTGGGCAATGATGCGAGA CTCCATCTAAAAAAAAAAAAAAAAAAAAAAAAGAAAGAAAGTGTCAGTTTGAACCTCTTGAGTGATGGCT CAGAACTTTGGAATGTTGGGATGCAATACTGGCATACTGGAATTCAGGAATGCCAAGATCCTCAAAGGTT GGAAAGGGGGAATCCTAGAGAGTTGAAGATGCTGTCAGAATGTTAGAATCATAAGATGCTGGAATGCTAA TACTGCAATCTAAGAAAGCTGAAATGTTGGATTCCTAGAAAGTTGAAATGGAGAGTTAGAATGTTGTAAA TTTAGAGTGATCATCTGACCTTATTCCTCCCTTGCTTAAAATATTTTGGTCCTGTCTCTGGGCTTTGTTA CCGGCTGTTTCCCTGCCAGAAAATCAGCCCTGCTCCCAGGCTCCTTCACCACCAGATCTTAGCGCCATCA GCCCAGCAACGCTGTCAATGAACAAATTGAGGTCTTTTTTGAGACAGAGTCTCGCTCTGTTGCCCAGGCT GGAGTGCAGTGGCGTGATCTCGGCTCACTGCAACCTCCGCCTCCCAGGTTCAAGTGATTCTCCTGCCTCA GCCTCCTGAGTAGCTGGGATTACAGGCGTGTGCCACCACACCCGGCTAATTTTTGGTTTTTTTAGTAGAC ACTGGGTTTCACCATGTTGGTCAGGCTGGTCTCGAACTCCTGACCTCGTGATCCACCCGCCTCGGCCTCC CAAAGTGCTGGGATTACAGGCATGAACCACTGCGCCCGGCCACAAATTGAGGTCTTGAGTGCCAACAGCT CCTGACATTACAAAGGGAGATAGCCAGCCATGTCAGCCTCCGTAGGGAGGGACCCAATGTTGCCTAGGAA GTCTTGGCAAAAAATCAAACCTGAAGGCCAGGTGCGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAG GCCAAGGCAGGCAGATCGCTTGAGCTTAGGAGTTCAAGACCAGCTTGTGCAACATGTTAAAACCCTGCCT CTGTACAAGAAATACAAAAAAACTAGCTGGCTGGGTGGTGTGTGCCTGTAGTCCCAGCTACTTGGGAGGC TGAGGCAGGAGTGCTTGAGCCTAGGAGGTTGTGGCTGCAGTCAGCCAGGATCACGCCACTGCATTTCAGG ACAGAGCAGGACCTTGTCTCAGGAAAAAAAAAAAAAAATCAAACCTGAATCTGATCAGGACTGTAGATCC TAACAGTTTTCTAGAAAGACAGGAACAGAGGAAATGGTCAGCAAAACTCAGACTGCAAGAAACCTCACCC AGTTTCTTCATCAAATACAATGCAAAGAAGGGGAAAGCACACACACACACACACGTACCCCCCATGCAAC CAAAAATTCACATACAAGTTTTGACTCCCCAAAAACTTAACTATTAATAGCCTACTGTGGACTGGAATTC TGCTTTATCCACAACATAAACAGTTGATTAATACTTTTTTTTTTTTTTGGAGACAGAGTCTCTGTCATTC AGGCTGGAGTGCAGTGGTGCGGTCTCGGCTCACTGCAGCTTCTGCCTCCCGGGTTCAAGTGATTCTCTTG CTTCAGCCTCCCGAGTAGCTGGGACCACAGGTGCCCACCGCCACGCCCAGCTAATTTTTTGTATTTTAGT AGAGATGGGGTTTCACCGTATTGCCCAGGCTGGTCTTGAACTCCTGAGGTCAGGCAATCCGCCCACCTCA GCCTCCCAAAGTGCTAGGATTACAGGCATGAGCCACTGCTCCCGGCCGAATAATACATATTTTGCATGTT TTATGTATTATGTCCTATATCCCCTTTTTTTTTTTTTGAGACGGAGTTTCGCTGTTGTCACTCAGGCTGG AGTGTAATGGCACAATCTCAGCTCACGGCAACCTCCACCTCCCGGGGGTTCAAGCAATTCTCCTGCTTCA GCCTCCTGAGTAGTTGGGATTATAGGCACCTGCCACCATGCCCGGCTAACTTTTGTATTTTTAGTAGAGG TGGGGTTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAAGTGATCTACCCGCCTCAGCCTC CCAAAGTGCTGGGATTGCAGGGGTGAGCCACGCACCCGGCCGTATTCTTTGTTTTTTTTTTTGAGACAGA GTCTAGCTGTGTCACCCAGGCTGGAGTGCAGTGAAGTGATCTCAGCTCACTGCAACCTCCGCCTCCCAGG TTCAAGCAATTCTCCTGCCTCAGTCTCCCAAATAGCTGTGATTTCAGGCATCCGCCATCGCACCCGGGTA ATTTTTGTATTTTTAGTAGAGACGGGGTTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAG GTGATCCATCAGCCTCGGCCTCCCAAAGTGCTGGCCTTACAGGCTTGAACCACTGCTCCCGGCCTATGCC TGCATTTTAAAAATAAGATAGAGAAAAGAAAATGTCCTTAAGAAAATCATAAGGAAGAGGAAGTATATTT TCCATTCATTGAGTGGAAGTGGCTTATCATAAAGGTCTTCATGTTGAGTAGGCTGAGGAGGAGGAAGAAA AGGTGTTGGTCTTGCTGTCTCAGGGCAGAGGTGGAAGAAAAATTCACCTGTAAGTGGTGAATTTTGTAAG AGGACCCATGTAGTTCAAACCCATGTCCAAGGGTCAGTCTATATATAGTTGACCCTGAATATATATACAG AGAGAGAGAGAGATGATTTTGTAGATTTTGAAAAAAGTCCTAAGAGAGGCCAGGTATGGTAGCTCACACC CGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGTGGATCACTTGAGGTCAGGAGTTGGAGACCAGCCTGG CCAACATGGTGAAACCCTGTCTGTACTAAAAATACAAAAATCAGGCCAGCTGTCGTGGCTCACACCTGTA ATCCCAGCACTTTGGGAGGCCAAGGTGGGTGGACCACCTGAGGTCAGGAGTTCGAGACCAGTCTGGCCAA CGTGGTGAAACCTCCTCTCTACTAAAAATTCAAAAATGAGCCAGGCGTGGTGGCGGGCCCTGTAATCCCA GCTACTCTTGAGGCTGAGGCAGGAGAACTGCTTGAACCCAGGAAGTGGAGGTTGCAGTGAGCCGAGGTCG CGCCATTGCACTCCAGCCTGGGCAACAAGAGTGAGACTCCCGTCTCAAAAAAATAAATAAATAATTAAAA ATACAAAAATTAGCAGGGTATGGTGGCAGGCGCCTGTAGTCTTAGCTACTTGGGAGACTGAGGCAGGAGA ATCACTTGAACCTGGGAGGCACAGGTTGCAGTGACCCGAGATTGCACCACTTCACTGCATCCTGGGTGAC AGAGTGAGACTCCATCTCAAAAATTAAAAAAAAAAAAAAATCCTAAGAGACATATCAACCAATTGCAATG TGTAGACCTTACTTGAATCCTTATTTACACAGGCTTAAAAAAAAAAGATATTTATGAGACAGTTGGGTAA ATGTGAACTCTGTCTAGATATTCCTCTAGATATCAAGGAATTGTTAATTTTCTTACATGGTATTGTGACT GTGTTTTAAAGTAGTCTTAATTAGAGATACATTTGAAATATTTATGGATGAAGCAACACGGTGGATTGCA TGTGCTTTGAGATAAACCATTGTCGGCTGGCTGCAGTGGCTCACAGCTATAATCCCACCACTTTGGGAGG CCAAGGCAGGAGGATTGCTTGAGCCTAAGAGTTGGAGACCAGCCTGGGCAATATGGTGAAACCCCATCTC CCAAAAAAAAAAATATGAAAAGTAGCTGGGCCTGGTGGTGTGTACCTTTTGTCCCAGCTACTCAGGAGGC TGAGGTGGGAGGTTGGCTTGAGCCCCAGGAGCTGGAGGCCACAGTGAGCTGTGATTGCACCACTGCACTC CAGCCTGGGTGACAGAGTGAGATCCTGTCTCAAAAAAAAAAAAAAAAGAGATAGTGGATAGGGGTAGAGA TGCAATGGAAATTGGCCATGAGTTGGTCATTGTTGAAGCTGCTTTTGTGTACATCTGAAACTTTCCAGCT GGACGCGGTGGCTCACACCTGTAATCCCAGCACTTTGGAAGGCTGAGGCGGGTGGATCACATGAGGTCAG GAGTTCGAGACCAGCCTGTCCAACATGGTGAAACCCTGTCTCTACTAAAAATACAGAAAAATTAGCTGGG TATGGTGGTGTGTGCCTGTAATCCCAGCTACTTGGGAGGCTGAGCCAGGAGAATTGCTTGAACTTGGGAC ATGGAGGTTGCAGTGAGCCAAGATTGCACCACTGCACTCCAGCCTGGGGCAACAGAGCAAGACTCCATCT CAAAAAAAAAAAAAAAAAACTTTCATAGGAAAATTTGTTCTTAAGGCAGCTCGAACACTACCTCCTTCCT AACCCCTTTCTCCAACATCCAAGATGGATGTGAGGCCTCTGGGCTCCCCTGGGGCCCTAAGTAGATCTTT GACTCAACAAACAGTCTCTGTTGGGTCTTTTATTTATAAAAAGTTTTGTAGCGACAGGGTCTCACTATGC TCCCCAGGCTGGTCTTAAACTCCTTGGGCTCAAGCGATTCACCGGTCTTGGCTTCCCAAAGTGCTGAGAT TACAGGCGTGAGTCACTGCACCTGGCCTAGGTCTTGAGAGACTGGACGGAAGAGGCTTGGCAAGGGCAAG GGCTGTGGGTATCCCAAGGCCCGGTGCAGGGTAGGCCCCGAATGTGTGCTGAAAAAATGAGTCAGAGGAT CACCTAGACGGCTTGTTCAACACGGACTGTTGTTCCCAGTCCTGCACACAATTTCTGATTTCAGTGGCCT GGGGTGCCACCTGAGAATCTGCATTTCCCATAGTTCCCAGGTGATGCTGCCGCTGGTCCTGGGAGCTCAC GTGGAGAGCTGCTGACTTGGATAACAGTATCACAGATTGTTCAAATCCTAGGATCTCAGAACCCCAGCTA GGGTTGAACTGCATATTAAAGATGATTCTGAGCCGGGTGCGGTGGCTCATGCCTGTAATCCCAGCACTTT GGGAGGCCGAGGTGGGTGGGTCACCTGAGGTCAGGAGTTTGAGACCAGCCTGACCAACATGGTGAAACCC AGCCTCTACTAAAAATACAAAAAATTAGCCAGGCATGGTGGCACATGCCTGTAATCCCAGGTACTTGAGA GGCTGAGGCAGGAGAATTGCTTGAACCCGGGAGACGGAGGTTGCAGTGAGCTGAGATCACACCATCGCAC TCCAGCCTGGGCAACAGGAGGGAAACTCCATCTCAAAAAAAAAAAAAGATTCCGGACACTAGTTCTTCCC CTTTTGTGAGTTCAGAACTTCCTGTGAGAAAGTGAAAGCCAGGACTCTTTTTCCCAGAAATACATGCATA CATACACACATGTGCATATGATCTCAGGCACTCATGGCCCTCCCTAAGCCTGCCCATGATGGCCCCTTGG CCCTCAGCTTAACACCTTATTTTATCTAGTAGCTCCTACCTCTGAACAGATGAGGAAACTGAGGTCCAAC CAAATTGGGTGGTACGGGCTGAGTTCACAGGGATCTCAGTTTCTTGACTTCCTTCTCAGGCTTCTGTGGC TCTTGGAAAGGCTTTATCTTGCCTCTAGGTTATCCGGTGCCACTTGAAGTTGGGTTCAAGCGATTCTCCT GCCTCAGACTCCCCAGTAGCTGGGATTACAGGTGCCCGCCACCAGGTCCAGCTAATTTTTGAATTTTTAG TAAAGACAGGGTCCTCAAGTCTGCCTGCCCTAGCCTCCCAAAGTGCCGGGATGACAGGCGTGAGCCACCG TGCCTGGCTGGCCCCACCAATCTATGAGCAGAGGTTGCAGTGAGCCAAGATTGCACCACTGCACTCCAGC CTGGGTGACGGAGCAAGACTCTGTCTCAAAAAAAAAAAAAAAAAAAAAAGGCATTGTCAACTTTTTCTTT TCTTTTCTTTCTTTTTTCTTTTCTTTTCAAGACAGAGTCTCACCCTGTTGCCCTGGGTGGAGTGCAGTGG CACGATCTTGGCTCACTGCAACCTCTGCTTCTTGGGTTCAAGCAGATTCTTGTGCCTCAGCCTCCTGAGT AGCTGGGATTACAGACAAGCACCGCCACACCCAGCTAATTTTTGTATTTTTAGTAGAGACGGGGTTTCGC CATGTTGGTCAGGCTGGTCTCAATCTCCTGATCTCAGGTGATCCACCCGCCTTGGCCTCCCAAAGTGCTG GGATTACAGGCGTGAGCCACTGCACCCGGCCTCTTTGACAGTTCTAAGAAGTAAAATAAACCAGAAGAAG GCAGGCAGAGAGTAATAGATATTGGGAACTGTTATTTTTCCTATTCTGATTTAAATTCCTTTATTATGGA AAATTTCAAATGTATACAAAAGCAATGAAGATAATGAATGCCCGTAAACTCTCATCCAGCGTCATCGGTA ATTAAGATTTTGCCCCATTTCAAATGCAGACATTTTTATATTTTCTTGCATAACTGCAATACCGTATTGC ACTAAATGGAACTAACAGTCACTTGGATATTTTGGAAAGGATGGCTCAGAAAGGTATCTCTGAGGAGGTG ATGTTCAGTCATGTAACTGATATTTACTAGTACCTACTGCATTCCAGACACTGCTTTAGGAGTTAAGGGT CCCTGAGTGAAGGACATTTGAGCTAAGGTTTAAATGAAGTGAAGGGGCCAGGTGTGGTGGCTCATGCCAG TAATCCCAATGCTTTGGGAGGCCGAGGCGTGCGGATCGTTTGAGCCCAAGTTCGACACCAGCCTCAGCAA CATAGTGAGACCGTGTCTCTAAAAAGAATAACAAATTAAAAAGAATAAATAGGCCAGATGCAGTGGCTCA GGTCTGTAATACCAGCACTTTGGGAGGCTGAGGTGGGCGGATCACAAGGTCAGGAGTTCGAGACCAGCCT GGCCAACATGGTGAAACCCTGTCTCTACTAAAAAGACAAAAAAATTAGCCGGGCATGGTGGCACACGCCT GTAATCCCAGCTACTCGGAAGGCTGAGGCAGGAGAATCGCTTGAACCTGGGAGGCGGAGGTTGCAGTGAG CCGAGATCATGCCACTGCACTCCAGCCTGGCAGACAGAGTGAGACTCTGTCTCAAAAAAAAAAAAAAAAA AAAATAGAAAAAAAAAGAAGAAATGAAGTGAAGGAACAAGCTGGAGTGGGTATCTGTGGGACTAGCAAGG CAGGCAGAGGGAACAGCAGATGCAGGAGCCCCGAAATAAGACTGTCTGAGGAACAGACAGGACGCCAGTG TGGCTGGAGTGGAGTAGGCGTGAGAGAGGGAGTTGAGATCAGCCAGATTTGATAGCACCTTGTGGCTCAC GGTGAGGACTTGGGCATTTGCCGTGAGATGGAGCCAGGTTCAGAGCAGAGGAGTGACAAGACAATTTATA GCATGCCCATGGAGGGCAGAGATTTCTGTCTCTTTTTTAAAAAAATTGAAAAAAAATTTTGTAGAGACAG GGTCTTGCACTTTGTTGTCCAGGCTGGCATGCAGTGGTGTTATCATAGTTCACTGCAACCTCGAACTCCT CGACTCCAGCGATCCTCCCACTTCATCCTCCCAAAGTGCTGGGATTAAAGGTGTGAGCCACCATGCCTAG CCTATTTCTATCTGTTTCATTTGTCCTCAGTCCACAGTAGATCCCAGCCCAGCACACAGTAGTAGTTCAA TAAACATTTGTTGCACAAATAGAGCAGATCAGTTTACATGGAGCTGTGTTATTTTGTATGTTCCAGGGTG TGGCATGCCATGATTTATTTAGCCCCCCCGTGGATGGTCATCTGGCTTCTTACAGGCTTGTCTTAAGCAT TGCGTGAAATTAATTATTACATTGCTCTTAGCACTGGAGGAAGTGCTTAATCTGTGTTAGTGATTATCAT GACTATTTGTGTTGTTATTAACACAGTGGGTGCAAGGGAGACCCAGATGGAGATAGGGCTGGGGGGGCAA CCTAGGGTGACACACGCACCTGGGGAGGAGGGGCATGTGGCTTCTATGGTGGTAGCCCCTCCCTGCCCCT GACGCGTCTCTCCTGCCTGCAGCTCCACGGAGAAGAACTGCTGCGTGCGGCAGCTGTACATTGACTTCCG CAAGGACCTCGGCTGGAAGTGGATCCACGAGCCCAAGGGCTACCATGCCAACTTCTGCCTCGGGCCCTGC CCCTACATTTGGAGCCTGGACACGCAGTACAGCAAGGTACGTCTGGCCCACCGGGCTACGAGATGCGCTT GGGGGGAGCCAGGACGGAGGAAGAGGAGAGAGAAAGAGAAGTAAAGTCAGAGAGGTGAGTTGGCAGGATG GGGAGAAAGAGAGGGATGGGGTGGGGAGGGGAATGAATAAAGAGATGGGGAGAGAGGCAGGAAGCTAGAG AGGGGCTCTGAGCAGGGGCCAGAGGGAGATGAGCTATGAAGACCCACAGAGTGAAGTAACAGAGGGATGG GGGTGAAGGGGAGAAGAGAGACAGGGAGATGGAAGGAAAAACGCAGAAATGGAGAGACAAAATGAGAGAG ACAGATACAGACACAGAGTTAGGCCAAGGAGAGACAAAGACAGATACACAACAAGGCAAGAGGCGAAGAT GAGGAGGGACAGAGACTGAGAAAGAAAATCAGGCGGGCGCGGCGGCTCACGATGGTAATACCAACACTTT GGGACGCTGAAGCAGGAGGATCGCTTGAGCCCAGGAGTTCGAGAGTAGCCCAGGCAGCAGACTGAGATCC CATCTCTACCAAAAAAAAAAAAAAAAAAAAAAAAAAAGCTAGGAGTGGTGGCGCTTGCCTGTGGTTGGAG CTACTCCGGAGGCTGAGGCGGGAGGATGGCTTGCGCTCAGGAGGTTGAGGCTGCAGCGAGCCATGATCGT GCCACTATACTCCAGCCTGGGTGGCAGAGCGAGACCCAGTCTCAAAACAAAAAGAAAATCAGACAGGTGG GGAGAGACAGAATAAGATAGGATGTTAGAAGATAAGAGAGACCGAATTGGAGATGGGAAGAGGGGATGCG GGGAGAGACGAAGTGAGAGAGGCTGGCGCGGTAGCGGGTGGGGGATGGGGCAGTGGAGGGCCGTTTTCCT CCCTCCACGAGCCCTGAGCCCTGACCCCGCCCGCCGCCCGCAGGTCCTGGCCCTGTACAACCAGCATAAC CCGGGCGCCTCGGCGGCGCCGTGCTGCGTGCCGCAGGCGCTGGAGCCGCTGCCCATCGTGTACTACGTGG GCCGCAAGCCCAAGGTGGAGCAGCTGTCCAACATGATCGTGCGCTCCTGCAAGTGCAGCTGAGGTCCCGC CCCGCCCCGCCCCGCCCCGGCAGGCCCGGCCCCACCCCGCCCCGCCCCCGCTGCCTTGCCCATGGGGGCT GTATTTAAGGACACCCGTGCCCCAAGCCCACCTGGGGCCCCATTAAAGATGGAGAGAGGACTGCGGATCT CTGTGTCATTGGGCGCCTGCCTGGGGTCTCCATCCCTGACGTTCCCCCACTCCCACTCCCTCTCTCTCCC TCTCTGCCTCCTCCTGCCTGTCTGCACTATTCCTTTGCCCGGCATCAAGGCACAGGGGACCAGTGGGGAA CACTACTGTAGTTAGATCTATTTATTGAGCACCTTGGGCACTGTTGAAGTGCCTTACATTAATGAACTCA TTCAGTCACCATAGCAACACTCTGAGATGCAGGGACTCTGATAACACCCATTTTAAAGGTGAGGAAACAA GCCCAGAGAGGTTAAGGGAGGAGTTCCTGCCCACCAGGAACCTGCTTTAGTGGGGGATAGTGAAGAAGAC AATAAAAGATAGTAGTTCAGGCC Download Select all
Length	23403
OMIM ID	190180
HGNC ID	HGNC:11766
Unigene ID	Hs.645227
Ensembl ID	ENSG00000105329
PharmGKB ID	-

mRNA Information

mRNA ID	NM_000660.5
Exon	join(1..1244,5479..5639,9070..9187,11687..11764, 11904..12051,21653..21806,22724..23403)
mRNA Sequence	>7040 AGCCGGTCCCCGCCGCCGCCGCCCTTCGCGCCCTGGGCCATCTCCCTCCCACCTCCCTCCGCGG AGCAGCCAGACAGCGAGGGCCCCGGCCGGGGGCAGGGGGGACGCCCCGTCCGGGGCACCCCCCC GGCTCTGAGCCGCCCGCGGGGCCGGCCTCGGCCCGGAGCGGAGGAAGGAGTCGCCGAGGAGCAG CCTGAGGCCCCAGAGTCTGAGACGAGCCGCCGCCGCCCCCGCCACTGCGGGGAGGAGGGGGAGG AGGAGCGGGAGGAGGGACGAGCTGGTCGGGAGAAGAGGAAAAAAACTTTTGAGACTTTTCCGTT GCCGCTGGGAGCCGGAGGCGCGGGGACCTCTTGGCGCGACGCTGCCCCGCGAGGAGGCAGGACT TGGGGACCCCAGACCGCCTCCCTTTGCCGCCGGGGACGCTTGCTCCCTCCCTGCCCCCTACACG GCGTCCCTCAGGCGCCCCCATTCCGGACCAGCCCTCGGGAGTCGCCGACCCGGCCTCCCGCAAA GACTTTTCCCCAGACCTCGGGCGCACCCCCTGCACGCCGCCTTCATCCCCGGCCTGTCTCCTGA GCCCCCGCGCATCCTAGACCCTTTCTCCTCCAGGAGACGGATCTCTCTCCGACCTGCCACAGAT CCCCTATTCAAGACCACCCACCTTCTGGTACCAGATCGCGCCCATCTAGGTTATTTCCGTGGGA TACTGAGACACCCCCGGTCCAAGCCTCCCCTCCACCACTGCGCCCTTCTCCCTGAGGACCTCAG CTTTCCCTCGAGGCCCTCCTACCTTTTGCCGGGAGACCCCCAGCCCCTGCAGGGGCGGGGCCTC CCCACCACACCAGCCCTGTTCGCGCTCTCGGCAGTGCCGGGGGGCGCCGCCTCCCCCATGCCGC CCTCCGGGCTGCGGCTGCTGCCGCTGCTGCTACCGCTGCTGTGGCTACTGGTGCTGACGCCTGG CCGGCCGGCCGCGGGACTATCCACCTGCAAGACTATCGACATGGAGCTGGTGAAGCGGAAGCGC ATCGAGGCCATCCGCGGCCAGATCCTGTCCAAGCTGCGGCTCGCCAGCCCCCCGAGCCAGGGGG AGGTGCCGCCCGGCCCGCTGCCCGAGGCCGTGCTCGCCCTGTACAACAGCACCCGCGACCGGGT GGCCGGGGAGAGTGCAGAACCGGAGCCCGAGCCTGAGGCCGACTACTACGCCAAGGAGGTCACC CGCGTGCTAATGGTGGAAACCCACAACGAAATCTATGACAAGTTCAAGCAGAGTACACACAGCA TATATATGTTCTTCAACACATCAGAGCTCCGAGAAGCGGTACCTGAACCCGTGTTGCTCTCCCG GGCAGAGCTGCGTCTGCTGAGGCTCAAGTTAAAAGTGGAGCAGCACGTGGAGCTGTACCAGAAA TACAGCAACAATTCCTGGCGATACCTCAGCAACCGGCTGCTGGCACCCAGCGACTCGCCAGAGT GGTTATCTTTTGATGTCACCGGAGTTGTGCGGCAGTGGTTGAGCCGTGGAGGGGAAATTGAGGG CTTTCGCCTTAGCGCCCACTGCTCCTGTGACAGCAGGGATAACACACTGCAAGTGGACATCAAC GGGTTCACTACCGGCCGCCGAGGTGACCTGGCCACCATTCATGGCATGAACCGGCCTTTCCTGC TTCTCATGGCCACCCCGCTGGAGAGGGCCCAGCATCTGCAAAGCTCCCGGCACCGCCGAGCCCT GGACACCAACTATTGCTTCAGCTCCACGGAGAAGAACTGCTGCGTGCGGCAGCTGTACATTGAC TTCCGCAAGGACCTCGGCTGGAAGTGGATCCACGAGCCCAAGGGCTACCATGCCAACTTCTGCC TCGGGCCCTGCCCCTACATTTGGAGCCTGGACACGCAGTACAGCAAGGTCCTGGCCCTGTACAA CCAGCATAACCCGGGCGCCTCGGCGGCGCCGTGCTGCGTGCCGCAGGCGCTGGAGCCGCTGCCC ATCGTGTACTACGTGGGCCGCAAGCCCAAGGTGGAGCAGCTGTCCAACATGATCGTGCGCTCCT GCAAGTGCAGCTGAGGTCCCGCCCCGCCCCGCCCCGCCCCGGCAGGCCCGGCCCCACCCCGCCC CGCCCCCGCTGCCTTGCCCATGGGGGCTGTATTTAAGGACACCCGTGCCCCAAGCCCACCTGGG GCCCCATTAAAGATGGAGAGAGGACTGCGGATCTCTGTGTCATTGGGCGCCTGCCTGGGGTCTC CATCCCTGACGTTCCCCCACTCCCACTCCCTCTCTCTCCCTCTCTGCCTCCTCCTGCCTGTCTG CACTATTCCTTTGCCCGGCATCAAGGCACAGGGGACCAGTGGGGAACACTACTGTAGTTAGATC TATTTATTGAGCACCTTGGGCACTGTTGAAGTGCCTTACATTAATGAACTCATTCAGTCACCAT AGCAACACTCTGAGATGCAGGGACTCTGATAACACCCATTTTAAAGGTGAGGAAACAAGCCCAG AGAGGTTAAGGGAGGAGTTCCTGCCCACCAGGAACCTGCTTTAGTGGGGGATAGTGAAGAAGAC AATAAAAGATAGTAGTTCAGGCC Download Select all
Length	2583

CDS Information

Location	join(890..1244,5479..5639,9070..9187,11687..11764, 11904..12051,21653..21806,22724..22882)
CDS Sequence	>lcl\|NM_000660.5_cds_NP_000651.3_1 [gene=TGFB1] [protein=transforming growth factor beta-1 precursor] [protein_id=NP_000651.3] [location=890..2062] ATGCCGCCCTCCGGGCTGCGGCTGCTGCCGCTGCTGCTACCGCTGCTGTGGCTACTGGTGCTGACGCCTG GCCGGCCGGCCGCGGGACTATCCACCTGCAAGACTATCGACATGGAGCTGGTGAAGCGGAAGCGCATCGA GGCCATCCGCGGCCAGATCCTGTCCAAGCTGCGGCTCGCCAGCCCCCCGAGCCAGGGGGAGGTGCCGCCC GGCCCGCTGCCCGAGGCCGTGCTCGCCCTGTACAACAGCACCCGCGACCGGGTGGCCGGGGAGAGTGCAG AACCGGAGCCCGAGCCTGAGGCCGACTACTACGCCAAGGAGGTCACCCGCGTGCTAATGGTGGAAACCCA CAACGAAATCTATGACAAGTTCAAGCAGAGTACACACAGCATATATATGTTCTTCAACACATCAGAGCTC CGAGAAGCGGTACCTGAACCCGTGTTGCTCTCCCGGGCAGAGCTGCGTCTGCTGAGGCTCAAGTTAAAAG TGGAGCAGCACGTGGAGCTGTACCAGAAATACAGCAACAATTCCTGGCGATACCTCAGCAACCGGCTGCT GGCACCCAGCGACTCGCCAGAGTGGTTATCTTTTGATGTCACCGGAGTTGTGCGGCAGTGGTTGAGCCGT GGAGGGGAAATTGAGGGCTTTCGCCTTAGCGCCCACTGCTCCTGTGACAGCAGGGATAACACACTGCAAG TGGACATCAACGGGTTCACTACCGGCCGCCGAGGTGACCTGGCCACCATTCATGGCATGAACCGGCCTTT CCTGCTTCTCATGGCCACCCCGCTGGAGAGGGCCCAGCATCTGCAAAGCTCCCGGCACCGCCGAGCCCTG GACACCAACTATTGCTTCAGCTCCACGGAGAAGAACTGCTGCGTGCGGCAGCTGTACATTGACTTCCGCA AGGACCTCGGCTGGAAGTGGATCCACGAGCCCAAGGGCTACCATGCCAACTTCTGCCTCGGGCCCTGCCC CTACATTTGGAGCCTGGACACGCAGTACAGCAAGGTCCTGGCCCTGTACAACCAGCATAACCCGGGCGCC TCGGCGGCGCCGTGCTGCGTGCCGCAGGCGCTGGAGCCGCTGCCCATCGTGTACTACGTGGGCCGCAAGC CCAAGGTGGAGCAGCTGTCCAACATGATCGTGCGCTCCTGCAAGTGCAGCTGA Download Select all
CCDS ID	CCDS33031.1

Protein Information

Protein ID	NP_000651.3
Protein Name	transforming growth factor, beta 1
Molecular Wt. (Da)	28491
Protein Sequence	>7040 MPPSGLRLLPLLLPLLWLLVLTPGRPAAGLSTCKTIDMELVKRKRIEAIRGQILSKLRLASPPS QGEVPPGPLPEAVLALYNSTRDRVAGESAEPEPEPEADYYAKEVTRVLMVETHNEIYDKFKQST HSIYMFFNTSELREAVPEPVLLSRAELRLLRLKLKVEQHVELYQKYSNNSWRYLSNRLLAPSDS PEWLSFDVTGVVRQWLSRGGEIEGFRLSAHCSCDSRDNTLQVDINGFTTGRRGDLATIHGMNRP FLLLMATPLERAQHLQSSRHRRALDTNYCFSSTEKNCCVRQLYIDFRKDLGWKWIHEPKGYHAN FCLGPCPYIWSLDTQYSKVLALYNQHNPGASAAPCCVPQALEPLPIVYYVGRKPKVEQLSNMIV RSCKCS Download Select all
Length	390
Uniprot ID	P08833
Ensembl Protein ID	ENSP00000275525

Post-translational Modification Information (Source : HPRD)

Residue	Type	site
N	Glycosylation	82

Enzyme Information

No matching records could be found.

PPi Information

(Click to view network : Source STRING) View

Interactant Gene ID (Source: HPRD)	Gene Symbol	HPRD ID	Ref Seq ID	Technique	References
650	BMP2	206	NP_001191.1	in vivo	11456401
651	BMP3	208	NP_001192.2	in vivo	9434787
1280	COL2A1	361	NP_001835.3	in vitro	10085302
1490	CTGF	412	NP_001892.1	in vivo	10457363
1634	DCN	501	NP_001911.1	in vitro;in vivo	76 381 067 798 269
2022	ENG	565	NP_001108225.1	in vitro;in vivo	12015308
2339	FNTA	607	NP_002018.1	yeast 2-hybrid	8599089
3694	ITGB6	947	NP_000879.2	in vivo	10025398
4313	MMP2	386	NP_004521.1	in vitro;in vivo	10652271
6348	CCL3	1656	NP_002974.1	in vivo	8568261
6678	SPARC	1631	NP_003109.1	in vitro;in vivo	15034927
7057	THBS1	1765	NP_003237.2	in vivo	1550960

Pathway Information

Pathway Name	Pathway ID
AGE-RAGE signaling pathway in diabetic complications	hsa04933
Amoebiasis	hsa05146
Cell cycle	hsa04110
Chagas disease (American trypanosomiasis)	hsa05142
Chronic myeloid leukemia	hsa05220
Colorectal cancer	hsa05210
Cytokine-cytokine receptor interaction	hsa04060
Dilated cardiomyopathy	hsa05414
Endocytosis	hsa04144
FoxO signaling pathway	hsa04068
Hepatitis B	hsa05161
Hippo signaling pathway	hsa04390
HTLV-I infection	hsa05166
Hypertrophic cardiomyopathy (HCM)	hsa05410
Inflammatory bowel disease (IBD)	hsa05321
Intestinal immune network for IgA production	hsa04672
Leishmaniasis	hsa05140
Malaria	hsa05144
MAPK signaling pathway	hsa04010
Non-alcoholic fatty liver disease (NAFLD)	hsa04932
Osteoclast differentiation	hsa04380
Pancreatic cancer	hsa05212
Pathways in cancer	hsa05200
Proteoglycans in cancer	hsa05205
Renal cell carcinoma	hsa05211
Rheumatoid arthritis	hsa05323
TGF-beta signaling pathway	hsa04350
Toxoplasmosis	hsa05145
Tuberculosis	hsa05152

Structure Information

PDB ID	1KLA
Resolution
Method	SOLUTION NMR
Chains	A, B
Molecule	TRANSFORMING GROWTH FACTOR-BETA 1
Model	View

Domain Information

ID	Location	Description
pfam00019	290-390	TGF_beta
cl02510	290-390	TGF_beta superfamily
pfam00688	28-261	TGFb_propeptide
cl02928	28-261	TGFb_propeptide superfamily
smart00204	293-390	TGFB
PHA02913	293-389	PHA02913

Ontology Information

HPRD ID	4183
Molecular Class	Ligand
Molecular Function	Cell adhesion molecule activity (GO:0005194)
Biological Process	Cell communication (GO:0007154); Signal transduction (GO:0007165)

SNP Information

View SNP Geneview Report

Drug Information

Uniprot ID DrugBank ID Name Type
P01137 DB00070 Hyaluronidase BiotechDrug
P01137 DB06205 Hyaluronidase (Human Recombinant) BiotechDrug

External Links

ArrayExpress GO
ICGC GO
Cancer3D GO
COSMIC GO
NCG GO
TSGene GO
Tumor Gene Family of Databases GO
CCDB GO
G2SBC GO
Osteosarcoma Database GO
RCDB GO

Uniprot ID	DrugBank ID	Name	Type
P01137	DB00070	Hyaluronidase	BiotechDrug
P01137	DB06205	Hyaluronidase (Human Recombinant)	BiotechDrug

ArrayExpress	GO
ICGC	GO
Cancer3D	GO
COSMIC	GO
NCG	GO
TSGene	GO
Tumor Gene Family of Databases	GO
CCDB	GO
G2SBC	GO
Osteosarcoma Database	GO
RCDB	GO