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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| TGFBR3 | 7049 | transforming growth factor, beta receptor III | 1 | betaglycan, BGCAN |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 21847367 | 2011 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | - | Up-regulation | - | These data support a model whereby T?RIII mediates TGF-? superfamily ligand-induced colon cancer progression and support a context-dependent role for T?RIII in regulating cancer progression. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Proteoglycans / Cell surface : Other |
| Description | This locus encodes the transforming growth factor (TGF)-beta type III receptor. The encoded receptor is a membrane proteoglycan that often functions as a co-receptor with other TGF-beta receptor superfamily members. Ectodomain shedding produces soluble TGFBR3, which may inhibit TGFB signaling. Decreased expression of this receptor has been observed in various cancers. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.[provided by RefSeq, Sep 2010] | Chromosome | 1 |
| Location | 1p33-p32 |
| Start | 92145900 |
| End | 92371559 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 225660 |
| OMIM ID | 600742 |
| HGNC ID | HGNC:11774 |
| Unigene ID | Hs.482390 |
| Ensembl ID | ENSG00000069702 |
| PharmGKB ID | PA36487 |
mRNA Information
| mRNA ID | ?NM_001195683.1 |
|---|---|
| Exon | join(1..177,6306..6366,44359..44532,108532..108716, 147253..147390,171044..171227,176030..176198, 178197..178344,183859..184048,185776..186110, 186539..186691,189295..189435,189609..189767, 193461..193760,197220..197340,207873..207914, 210224..210331,222146..225660) | mRNA Sequence | Download Select all |
| Length | 6308 |
Protein Information
| Protein ID | NP_001182612.1 |
|---|---|
| Protein Name | transforming growth factor, beta receptor III |
| Molecular Wt. (Da) | 77198 |
| Protein Sequence | Download Select all |
| Length | 851 |
| Uniprot ID | P50748 |
| Ensembl Protein ID | ENSP00000328236 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 92 | ACVR2A | 25 | NP_001607.1 | in vivo | 10746731 |
| 409 | ARRB2 | 147 | NP_004304.1 | in vivo | 12958365 |
| 2022 | ENG | 565 | NP_001108225.1 | in vivo | 12568406 |
| 3623 | INHA | 933 | NP_002182.1 | in vivo | 10746731 |
| 3624 | INHBA | 929 | NP_002183.1 | in vivo | 10746731 |
| 7040 | TGFB1 | 1821 | NP_000651.3 | in vivo | 7935686 |
| 7042 | TGFB2 | 1828 | AAA50404.1 | in vivo | 11157754 |
| 7043 | TGFB3 | 1829 | NP_003230.1 | in vitro | 11382746 |
| 7048 | TGFBR2 | 1823 | NP_001020018.1 | in vivo | 11323414 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| smart00241 | 455-725 | ZP |
| cl02523 | 455-725 | Zona_pellucida superfamily |
| pfam00100 | 455-712 | Zona_pellucida |
Ontology Information
| HPRD ID | 10010 |
|---|---|
| Molecular Class | Cell surface receptor |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Biological_process unknown (GO:0000004) |
Drug Information
No matching records could be found.