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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
THBS1 7057 thrombospondin 1  15TSP1, THBS, TSP, THBS-1, TSP-1 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
11410779   2001Cell line : -

Source : -

Sample Type : -

No. of Sample : -

Stage : -

-Down-regulation-TSP-1 is an important negative-regulator of tumor angiogenesis, and TSP-1 may be useful for predicting recurrence in patients with colon�cancer.

16166434   2005Cell line : -

Source : University Hospitals of Leicester and the Royal Liverpool Hospital

Sample Type : CRC tumor and adjacent normal tissue

No. of Sample : 182

Stage : -

ImmunohistochemistryDown-regulation-TSP-1 is a negatively prognostic factor for survival in resected colorectal liver metastases.


Gene Details



NC_000015.9 (39873280..39889668)

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Gene Type protein coding
Gene Family -
Description The protein encoded by this gene is a subunit of a disulfide-linked homotrimeric protein. This protein is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1. This protein has been shown to play roles in platelet aggregation, angiogenesis, and tumorigenesis. [provided by RefSeq, Jul 2008]  
Chromosome 15
Location 15q15
Start 39873280  
End 39889668  
Strand +  
Gene Sequence

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Length 16389  
OMIM ID 188060   
HGNC ID HGNC:11785   
Unigene ID Hs.164226   
Ensembl ID ENSG00000137801   
PharmGKB ID PA36497   

mRNA Information


mRNA ID ?NM_003246.3
Exon join(1..150,751..846,1115..1674,2539..2614,2910..3109, 3222..3344,4392..4485,6269..6442,6964..7140,7448..7621, 7881..8008,8124..8276,8727..8945,9438..9545,10113..10272, 10427..10545,11490..11724,11922..12149,12319..12590, 13021..13118,13223..13362,14284..16389)  
mRNA Sequence

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Length 7253  



CDS Information


   
Location 180..3692
CDS Sequence

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CCDS ID CCDS32194.1



Protein Information


      
Protein IDNP_003237.2
Protein Namethrombospondin 1
Molecular Wt. (Da)177378
Protein Sequence

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Length 1170  
Uniprot IDQ92537
Ensembl Protein ID ENSP00000344424  



Post-translational Modification Information (Source : HPRD)


Residue Type site
WGlycosylation385
SGlycosylation394
WGlycosylation438
WGlycosylation441
CDisulfide Bridge447;484
TGlycosylation450
CDisulfide Bridge451;489
CDisulfide Bridge462;474
WGlycosylation498
TGlycosylation507
NGlycosylation1067

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                                                                                                                                                                                                                                                        
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
811CALR169NP_004334.1in vitro12147682   
948CD361430NP_000063.2in vivo1   077   296   110   487   970   
1277COL1A1362NP_000079.2in vitro3571333   
1280COL2A1361NP_001835.3in vitro3571333   
1281COL3A1365NP_000081.1in vitro3571333   
1289COL5A1368NP_000084.3in vivo66   935   019   840   442   
1294COL7A1358NP_000085.1yeast 2-hybrid9840442   
1511CTSG289NP_001902.1in vitro8408036   
1634DCN501NP_001911.1in vitro;in vivo93   288   411   550   960   
1719DHFR519NP_000782.1in vitro10749676   
1991ELANE554NP_001963.1in vitro8463250   
2147F21488NP_000497.1in vivo2435757   
2243FGA619NP_000499.1in vitro9867861   
2335FN1626NP_997647.1in vitro11773026   
3273HRG812NP_000403.1in vivo6438154   
3488IGFBP5901NP_000590.1in vivo10698186   
3690ITGB31428NP_000203.2in vitro2478219   
3914LAMB31032NP_000219.2in vivo;yeast 2-hybrid9840442   
4035LRP1138NP_002323.2in vitro;in vivo904   571   214   991   768   
4313MMP2386NP_004521.1in vitro;in vivo;yeast 2-hybrid10900205   
4318MMP9387NP_004985.2in vitro;in vivo;yeast 2-hybrid1   090   020   511   606   710   
5340PLG1417NP_000292.1in vitro2522013   
6678SPARC1631NP_003109.1in vitro2745554   
7035TFPI1064NP_006278.1in vitro10922378   


Pathway Information


                                                                  
Pathway Name Pathway ID
Bladder cancer hsa05219
ECM-receptor interaction hsa04512
Focal adhesion hsa04510
Malaria hsa05144
MicroRNAs in cancer hsa05206
p53 signaling pathway hsa04115
Phagosome hsa04145
PI3K-Akt signaling pathway hsa04151
Proteoglycans in cancer hsa05205
Rap1 signaling pathway hsa04015
TGF-beta signaling pathway hsa04350


Structure Information


No matching records could be found.

Domain Information




ID Location Description
pfam05735972-1169  TSP_C
cl05347972-1169  TSP_C superfamily
smart0021026-221  TSPN
cl2286126-221  LamG superfamily
smart00209438-490  TSP1
cl15278438-490  TSP_1 superfamily
smart00209495-547  TSP1
cl15278495-547  TSP_1 superfamily
pfam00093318-372  VWC
cl17735318-372  VWC superfamily
pfam00090439-489  TSP_1
pfam00090496-546  TSP_1
smart00214318-372  VWC
pfam00090383-428  TSP_1
cl15278383-428  TSP_1 superfamily
smart00209382-429  TSP1
pfam02412846-882  TSP_3
cl15981846-882  TSP_3 superfamily
pfam02412787-821  TSP_3
cl15981787-821  TSP_3 superfamily
pfam02412920-952  TSP_3
cl15981920-952  TSP_3 superfamily
pfam12947650-689  EGF_3
cl21504650-689  EGF_CA superfamily
smart00215318-385  VWC_out
cd00110124-217  LamG
smart0028299-217  LamG
PTZ00087433-492  PTZ00087
PTZ00441496-517  PTZ00441
PTZ00441384-428  PTZ00441


Ontology Information


   
HPRD ID12243
Molecular ClassExtracellular matrix protein
Molecular FunctionCytoskeletal protein binding (GO:0008092)
Biological ProcessCell growth and/or maintenance (GO:0008151)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO