Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| TLE3 | 7090 | transducin-like enhancer of split 3 | 15 | ESG, ESG3, KIAA1547, HsT18976, GRG3 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24811787 | 2014 | Cell line : - Source : - Sample Type : CRC tumor and normal tissues No. of Sample : 13 Stage : - | Illumina Infinium Human Methylation 450 BeadChip. | Methylation | - | - |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | WD repeat domain containing |
| Description | This gene encodes a transcriptional co-repressor protein that belongs to the transducin-like enhancer family of proteins. The members of this family function in the Notch signaling pathway that regulates determination of cell fate during development. Expression of this gene has been associated with a favorable outcome to chemotherapy with taxanes for ovarian carcinoma. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Sep 2013] | Chromosome | 15 |
| Location | 15q22 |
| Start | 70340129 |
| End | 70390274 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 50146 |
| OMIM ID | 600190 |
| HGNC ID | HGNC:11839 |
| Unigene ID | Hs.287362 |
| Ensembl ID | - |
| PharmGKB ID | PA36541 |
mRNA Information
| mRNA ID | ?NM_001105192.2 |
|---|---|
| Exon | join(1..1161,1675..1775,2295..2358,3360..3404, 21778..21840,23329..23403,37287..37406,38476..38526, 39121..39273,39645..39786,40278..40462,41562..41638, 42638..42887,43251..43498,44562..44709,45412..45562, 46469..46545,47732..50146) | mRNA Sequence | Download Select all |
| Length | 5526 |
Protein Information
| Protein ID | NP_001098662.1 |
|---|---|
| Protein Name | transducin-like enhancer of split 3 |
| Molecular Wt. (Da) | 97669 |
| Protein Sequence | Download Select all |
| Length | 772 |
| Uniprot ID | Q14140 |
| Ensembl Protein ID | ENSP00000326933 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 203 |
| S | Phosphorylation | 240 |
| S | Phosphorylation | 245 |
| S | Phosphorylation | 263 |
| S | Phosphorylation | 267 |
| S | Phosphorylation | 286 |
| S | Phosphorylation | 286;- |
| S | Phosphorylation | 203;- |
| S | Phosphorylation | 217;- |
| S | Phosphorylation | 267;- |
| S | Phosphorylation | 253;- |
| Y | Phosphorylation | 238;- |
| T | Phosphorylation | 259;- |
| S | Phosphorylation | 211;- |
| S | Phosphorylation | 207;- |
| T | Phosphorylation | 285 |
| S | Phosphorylation | 289 |
| S | Phosphorylation | 294 |
| T | Phosphorylation | 296 |
| S | Phosphorylation | 311 |
| S | Phosphorylation | 317 |
| T | Phosphorylation | 321 |
| T | Phosphorylation | 312 |
| T | Phosphorylation | 319 |
| T | Phosphorylation | 328 |
| T | Phosphorylation | 334 |
| S | Phosphorylation | 413 |
| S | Phosphorylation | 299 |
| S | Phosphorylation | 201 |
| S | Phosphorylation | 332 |
| S | Phosphorylation | 295 |
| S | Phosphorylation | 205 |
| S | Phosphorylation | 292 |
| T | Phosphorylation | 333 |
| T | Phosphorylation | 331 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 2290 | FOXG1 | 1283 | NP_005240.3 | in vivo | 11238932 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00200 | 484-769 | WD40 |
| cl02567 | 484-769 | WD40 superfamily |
| pfam03920 | 1-136 | TLE_N |
| cl08405 | 1-136 | TLE_N superfamily |
| cd00200 | 579-770 | WD40 |
| cd00200 | 610-770 | WD40 |
| pfam00400 | 609-646 | WD40 |
| smart00320 | 607-646 | WD40 |
| pfam00400 | 578-604 | WD40 |
| smart00320 | 565-604 | WD40 |
| COG2319 | 478-770 | WD40 |
| COG2319 | 484-770 | WD40 |
| COG2319 | 484-765 | WD40 |
| COG2319 | 519-770 | WD40 |
| PLN00181 | 506-768 | PLN00181 |
Ontology Information
| HPRD ID | 12079 |
|---|---|
| Molecular Class | Transcription regulatory protein |
| Molecular Function | Transcription regulator activity (GO:0030528) |
| Biological Process | Nucleobase, nucleoside, nucleotide and nucleic acid transport (GO:0015931) |
Drug Information
No matching records could be found.