Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| TLR5 | 7100 | toll-like receptor 5 | 1 | TIL3, FLJ10052, MGC126430, MGC126431 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24154872 | 2013 | Cell line : - Source : Population-based PopGen project in Schleswig-Holstein Sample Type : Population based case control study No. of Sample : 613 Stage : - | SNP selection,Genotyping | Polymorhpism | - | In the TLR5 gene, rs5744174/F616L was associated with increased survival, whereas rs2072493/N592S was associated with decreased survival. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a member of the toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immune responses. These receptors recognize distinct pathogen-associated molecular patterns that are expressed on infectious agents. The protein encoded by this gene recognizes bacterial flagellin, the principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB, which in turn activates a host of inflammatory-related target genes. Mutations in this gene have been associated with both resistance and susceptibility to systemic lupus erythematosus, and susceptibility to Legionnaire disease.[provided by RefSeq, Dec 2009] | Chromosome | 1 |
| Location | 1q32.3-q42 |
| Start | 223282748 |
| End | 223316624 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 33877 |
| OMIM ID | 603031 |
| HGNC ID | HGNC:11851 |
| Unigene ID | Hs.604542 |
| Ensembl ID | ENSG00000187554 |
| PharmGKB ID | PA36553 |
mRNA Information
| mRNA ID | ?NM_003268.5 |
|---|---|
| Exon | join(3..87,1520..1635,8419..8601,8801..8894,10644..10808, 30248..33879) | mRNA Sequence | Download Select all |
| Length | 4275 |
Protein Information
| Protein ID | NP_003259.2 |
|---|---|
| Protein Name | toll-like receptor 5 |
| Molecular Wt. (Da) | 21265 |
| Protein Sequence | Download Select all |
| Length | 858 |
| Uniprot ID | Q12765 |
| Ensembl Protein ID | ENSP00000242059 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Inflammatory bowel disease (IBD) | hsa05321 |
| Legionellosis | hsa05134 |
| Pathogenic Escherichia coli infection | hsa05130 |
| Salmonella infection | hsa05132 |
| Toll-like receptor signaling pathway | hsa04620 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam01582 | 695-832 | TIR |
| cl22869 | 695-832 | TIR_2 superfamily |
| smart00255 | 692-827 | TIR |
| cd00116 | 328-581 | LRR_RI |
| cl23707 | 328-581 | LRR_RI superfamily |
| pfam13676 | 696-778 | TIR_2 |
| smart00082 | 579-630 | LRRCT |
| cl15307 | 579-630 | LRRCT superfamily |
| cd00116 | 89-208 | LRR_RI |
| cl23707 | 89-208 | LRR_RI superfamily |
| smart00370 | 501-524 | LRR |
| cl19480 | 501-524 | LRR superfamily |
| smart00369 | 501-524 | LRR_TYP |
| cl19479 | 501-524 | LRR_TYP superfamily |
| pfam12799 | 503-542 | LRR_4 |
| cl19302 | 503-542 | LRR_4 superfamily |
| pfam13855 | 314-372 | LRR_8 |
| pfam13855 | 473-538 | LRR_8 |
| pfam13855 | 360-415 | LRR_8 |
| pfam13855 | 95-182 | LRR_8 |
| PLN00113 | 90-581 | PLN00113 |
| pfam13855 | 288-348 | LRR_8 |
| PRK15370 | 383-580 | PRK15370 |
| COG4886 | 284-515 | LRR |
| pfam13855 | 502-560 | LRR_8 |
| pfam13855 | 337-396 | LRR_8 |
| COG4886 | 335-609 | LRR |
| COG4886 | 311-561 | LRR |
| COG4886 | 400-582 | LRR |
| PRK15370 | 490-583 | PRK15370 |
| pfam13855 | 85-131 | LRR_8 |
| TIGR00864 | 554-634 | PCC |
| PLN03210 | 324-534 | PLN03210 |
| pfam13306 | 322-399 | LRR_5 |
| PLN03150 | 501-550 | PLN03150 |
Ontology Information
| HPRD ID | 5780 |
|---|---|
| Molecular Class | Cell surface receptor |
| Molecular Function | Transcription regulator activity (GO:0030528) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.