Search results:


General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
TLR8 51311 toll-like receptor 8  XCD288 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
25547486   2014Cell line : -

Source : Chang Gung Memorial Hospital-Kaohsiung Medical Center, were investigated in this study.

Sample Type : CRC tumor and normal tissue

No. of Sample : 26

Stage : TNM Stage I-IV

Real-time PCR, immunohistochemistry and Western blotting Up-regulation-TLR1, TLR2, TLR4 and TLR8 gene expression induce downstream IL-6 and IL-8 gene expression; detection of these expression levels can serve as a CRC marker.


Gene Details



NC_000023.10 (12924739..12941288)

View Larger Image
   
Gene Type protein coding
Gene Family CD molecules
Description The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung and peripheral blood leukocytes, and lies in close proximity to another family member, TLR7, on chromosome X. [provided by RefSeq, Jul 2008]  
Chromosome X
Location Xp22
Start 12924739  
End 12941288  
Strand +  
Gene Sequence

   Download   Select all

Length 16550  
OMIM ID 300366   
HGNC ID HGNC:15632   
Unigene ID Hs.660543   
Ensembl ID ENSG00000101916   
PharmGKB ID PA38009   

mRNA Information


mRNA ID ?NM_016610.3
Exon  
mRNA Sequence

   Download   Select all

Length  



CDS Information


   
Location
CDS Sequence

   Download   Select all

CCDS ID CCDS14152.1



Protein Information


      
Protein IDNP_057694.2
Protein Nametoll-like receptor 8
Molecular Wt. (Da)0
Protein Sequence

   Download   Select all

Length 1041  
Uniprot IDQ9NQR4
Ensembl Protein ID ENSP00000377696  



Post-translational Modification Information (Source : HPRD)


No matching records could be found.

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

               
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
4615MYD883703NP_002459.2yeast 2-hybrid16482509   


Pathway Information


      
Pathway Name Pathway ID
Toll-like receptor signaling pathway hsa04620


Structure Information


No matching records could be found.

Domain Information




ID Location Description
pfam01582882-1020  TIR
cl22869882-1020  TIR_2 superfamily
smart00255880-1022  TIR
cd00116486-701  LRR_RI
cl23707486-701  LRR_RI superfamily
cd00116505-750  LRR_RI
cd00116529-746  LRR_RI
smart00082772-817  LRRCT
cl15307772-817  LRRCT superfamily
cd00116561-773  LRR_RI
pfam13676883-983  TIR_2
pfam13855688-748  LRR_8
pfam1385565-137  LRR_8
pfam13855287-349  LRR_8
pfam13855609-676  LRR_8
pfam13855222-299  LRR_8
pfam13855530-596  LRR_8
pfam13855484-542  LRR_8
PLN00113283-772  PLN00113
PLN00113309-774  PLN00113
PLN0011365-597  PLN00113
PLN00113220-676  PLN00113
PRK15370512-748  PRK15370
pfam13855712-774  LRR_8
TIGR00864742-829  PCC
PRK15370639-751  PRK15370
pfam13855277-323  LRR_8
pfam13855665-724  LRR_8
COG4886484-669  LRR
COG4886585-766  LRR
PRK15370123-266  PRK15370
PLN03150286-354  PLN03150
PLN03150266-376  PLN03150
COG488671-363  LRR
PRK1537023-175  PRK15370
PRK15370125-362  PRK15370
PLN03150523-594  PLN03150
pfam13855510-565  LRR_8
pfam13855311-376  LRR_8
PRK1537053-239  PRK15370
pfam13855394-431  LRR_8


Ontology Information


   
HPRD ID5271
Molecular ClassCell surface receptor
Molecular FunctionCatalytic activity (GO:0003824)
Biological ProcessMetabolism (GO:0008152); Energy pathways (GO:0006091)  



SNP Information


View SNP Geneview Report   

Drug Information


Uniprot ID DrugBank ID Name Type
Q9NR97DB00724ImiquimodSmallMoleculeDrug

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO