Search results:


General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
TLR9 54106 toll-like receptor 9  3CD289 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
24154870   2013Cell line : Mouse B16 and CT26

Source : ATCC

Sample Type : -

No. of Sample : -

Stage : -

Immunofluorescent staining,Western blotting,real time RT-PCR,Flow cytometryUp-regulation-Unique set of TLR9/STAT3-regulated genes involved in tumor-promoting inflammation and revascularization.


Gene Details



NC_000003.11 (52255096..52260179, complement)

View Larger Image
   
Gene Type protein coding
Gene Family CD molecules
Description The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is preferentially expressed in immune cell rich tissues, such as spleen, lymph node, bone marrow and peripheral blood leukocytes. Studies in mice and human indicate that this receptor mediates cellular response to unmethylated CpG dinucleotides in bacterial DNA to mount an innate immune response. [provided by RefSeq, Jul 2008]  
Chromosome 3
Location 3p21.3
Start 52255096  
End 52260179  
Strand -  
Gene Sequence

   Download   Select all

Length 5084  
OMIM ID 605474   
HGNC ID HGNC:15633   
Unigene ID Hs.87968   
Ensembl ID ENSG00000239732   
PharmGKB ID PA38010   

mRNA Information


mRNA ID ?NM_017442.3
Exon  
mRNA Sequence

   Download   Select all

Length  



CDS Information


   
Location
CDS Sequence

   Download   Select all

CCDS ID CCDS2848.1



Protein Information


      
Protein IDNP_059138.1
Protein Nametoll-like receptor 9
Molecular Wt. (Da)0
Protein Sequence

   Download   Select all

Length 1032  
Uniprot IDQ8NFD5
Ensembl Protein ID ENSP00000344546  



Post-translational Modification Information (Source : HPRD)


No matching records could be found.

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

               
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
23162MAPK8IP312014NP_055948.2in vivo12941697   


Pathway Information


                                          
Pathway Name Pathway ID
African trypanosomiasis hsa05143
Chagas disease (American trypanosomiasis) hsa05142
Herpes simplex infection hsa05168
Malaria hsa05144
Measles hsa05162
Toll-like receptor signaling pathway hsa04620
Tuberculosis hsa05152


Structure Information


No matching records could be found.

Domain Information




ID Location Description
pfam01582872-1009  TIR
cl22869872-1009  TIR_2 superfamily
smart00255870-1009  TIR
cd00116476-739  LRR_RI
cl23707476-739  LRR_RI superfamily
cd00116599-777  LRR_RI
pfam13855496-556  LRR_8
pfam13855284-344  LRR_8
pfam13855701-762  LRR_8
pfam1385564-135  LRR_8
pfam13855628-689  LRR_8
pfam13855200-254  LRR_8
pfam13855123-177  LRR_8
PLN00113200-737  PLN00113
PLN0011365-588  PLN00113
PLN00113401-737  PLN00113
PLN0011365-647  PLN00113
PRK1537024-240  PRK15370
pfam13855476-533  LRR_8
COG488633-254  LRR
COG4886476-760  LRR
pfam13855677-737  LRR_8
PRK15370127-318  PRK15370
COG4886108-437  LRR
COG4886472-714  LRR
PLN03150477-556  PLN03150
pfam13855521-587  LRR_8
COG4886386-608  LRR
pfam13855598-665  LRR_8
pfam13855654-713  LRR_8
COG4886309-559  LRR
pfam13855169-232  LRR_8
pfam13855275-318  LRR_8
PLN03150633-719  PLN03150
pfam13855144-211  LRR_8
pfam13855220-296  LRR_8
PLN03150198-254  PLN03150
PLN03150600-666  PLN03150


Ontology Information


   
HPRD ID6385
Molecular ClassCell surface receptor
Molecular FunctionTransporter activity (GO:0005215)
Biological ProcessTransport (GO:0006810)  



SNP Information


View SNP Geneview Report   

Drug Information


Uniprot ID DrugBank ID Name Type
Q9NR96DB00608ChloroquineSmallMoleculeDrug
Q9NR96DB01611HydroxychloroquineSmallMoleculeDrug

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO