Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| TM4SF1 | 4071 | transmembrane 4 L six family member 1 | 3 | L6 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24968843 | 2014 | Cell line : HCT116, DLD1 Source : - Sample Type : - No. of Sample : - Stage : - | RT-PCR,Western blotting and immunocytochemistry, Transfection, migration and invasion assay | Up-regulation | - | TM4SF1 is closely related to the invasion and metastasis of colorectal cancer cells in vitro. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface antigen and is highly expressed in different carcinomas. [provided by RefSeq, Jul 2008] | Chromosome | 3 |
| Location | 3q21-q25 |
| Start | 149086805 |
| End | 149095647 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 8843 |
| OMIM ID | 191155 |
| HGNC ID | HGNC:11853 |
| Unigene ID | Hs.351316 |
| Ensembl ID | ENSG00000169908 |
| PharmGKB ID | PA36554 |
mRNA Information
| mRNA ID | NM_014220.2 |
|---|---|
| Exon | join(80..490,2092..2181,2273..2418,5994..6174,7981..8843) | mRNA Sequence | Download Select all |
| Length | 1712 |
Protein Information
| Protein ID | NP_055035.1 |
|---|---|
| Protein Name | transmembrane 4 L six family member 1 |
| Molecular Wt. (Da) | 31424 |
| Protein Sequence | Download Select all |
| Length | 202 |
| Uniprot ID | P24468 |
| Ensembl Protein ID | ENSP00000377721 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 780 | DDR1 | 2678 | NP_054700.2 | yeast 2-hybrid | 16169070 |
| 7277 | TUBA4A | 1851 | NP_005991.1 | yeast 2-hybrid | 16169070 |
| 27111 | SDCBP2 | 18032 | NP_536737.3 | in vitro;in vivo;yeast 2-hybrid | 11102519 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam05805 | 1-195 | L6_membrane |
| cl05399 | 1-195 | L6_membrane superfamily |
Ontology Information
| HPRD ID | 2797 |
|---|---|
| Molecular Class | Integral membrane protein |
| Molecular Function | Defense/immunity protein activity (GO:0003793) |
| Biological Process | Immune response (GO:0006955) |
Drug Information
No matching records could be found.