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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| TMEFF2 | 23671 | transmembrane protein with EGF-like and two follistatin-like domains 2 | 2 | TENB2, HPP1, TR, TPEF, CT120.2 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 26291085 | 2015 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : (LGD 17), adenoma with high-grade dysplasia 6, CRC 17, metastatic CRC (MCRC, n = 7), active UC (UCa, n = 4), inactive and long-standing UC (UCi, n = 4). Stage : - | DNA isolation and methylation-sensitive restriction enzyme methylation array analysis,Bisulfite PCR analysis and validation studies,microarray analysis. | Methylation | - | More than 85% of tumor samples showed hypermethylation in 10 genes (SFRP1, SST, BNC1, MAL, SLIT2, SFRP2, SLIT3, ALDH1A3, TMEFF2, WIF1) |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a member of the tomoregulin family of transmembrane proteins. This protein has been shown to function as both an oncogene and a tumor suppressor depending on the cellular context and may regulate prostate cancer cell invasion. Multiple soluble forms of this protein have been identified that arise from both an alternative splice variant and ectodomain shedding. Additionally, this gene has been found to be hypermethylated in multiple cancer types. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015] | Chromosome | 2 |
| Location | 2q32.3 |
| Start | 192770615 |
| End | 193059645 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 289031 |
| OMIM ID | 605734 |
| HGNC ID | HGNC:11867 |
| Unigene ID | Hs.144513 |
| Ensembl ID | ENSG00000144339 |
| PharmGKB ID | PA36568 |
Protein Information
| Protein ID | NP_001292063.1 |
|---|---|
| Protein Name | transmembrane protein with EGF-like and two follistatin-like domains 2 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 374 |
| Uniprot ID | P19224 |
| Ensembl Protein ID | ENSP00000303174 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00104 | 95-135 | KAZAL_FS |
| cl00097 | 95-135 | KAZAL_FS superfamily |
| cd00104 | 189-227 | KAZAL_FS |
| cl00097 | 189-227 | KAZAL_FS superfamily |
| smart00280 | 90-135 | KAZAL |
| smart00280 | 181-227 | KAZAL |
| PHA02887 | 236-301 | PHA02887 |
| cl20100 | 236-301 | PHA02887 superfamily |
| pfam07648 | 95-135 | Kazal_2 |
| cd01327 | 92-135 | KAZAL_PSTI |
| pfam00050 | 94-135 | Kazal_1 |
| pfam07648 | 192-227 | Kazal_2 |
| PHA03099 | 247-301 | PHA03099 |
| cl20104 | 247-301 | PHA03099 superfamily |
| pfam00050 | 190-227 | Kazal_1 |
Ontology Information
| HPRD ID | 8933 |
|---|---|
| Molecular Class | Integral membrane protein |
| Molecular Function | Transferase activity (GO:0016740) |
| Biological Process | Metabolism (GO:0008152); Energy pathways (GO:0006091) |
Drug Information
No matching records could be found.