Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| TNFRSF19 | 55504 | tumor necrosis factor receptor superfamily, member 19  | 13 | TAJ-alpha, TROY, TAJ, TRADE  |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23142137    | 2013 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | Chromatin immunoprecipitation with DNA microarray analysis and immunohistochemistry | Up-regulation | - | TROY is up-regulated in human colorectal cancer cell lines and in intestinal tumors in mice. It functions as a negative modulator of the Wnt pathway in LGR5-positive stem cells. |
Gene Details

| Gene Type | protein coding |
|---|---|
| Gene Family | Tumor necrosis factor receptor superfamily |
| Description | The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is highly expressed during embryonic development. It has been shown to interact with TRAF family members, and to activate JNK signaling pathway when overexpressed in cells. This receptor is capable of inducing apoptosis by a caspase-independent mechanism, and it is thought to play an essential role in embryonic development. Alternatively spliced transcript variants encoding distinct isoforms have been described.   | Chromosome | 13 |
| Location | 13q12.11-q |
| Start | 23570370   |
| End | 23676105   |
| Strand | +   |
| Gene Sequence |    Download   Select all |
| Length | 105736   |
| OMIM ID | 606122    |
| HGNC ID | HGNC:11915    |
| Unigene ID | Hs.149168    |
| Ensembl ID | ENSG00000127863    |
| PharmGKB ID | -    |
mRNA Information
| mRNA ID | NM_148957.3 |
|---|---|
| Exon | join(1..479,19781..19883,22976..23086,45498..45676, 56338..56423,88681..88845,89996..90121,97611..97713, 98323..98728,103003..105736)   | mRNA Sequence |    Download   Select all |
| Length | 4214   |
CDS Information
| Location | join(19815..19883,22976..23086,45498..45676,56338..56423, 88681..88845,89996..90121,97611..97713,103003..103150) |
|---|---|
| CDS Sequence |    Download   Select all |
| CCDS ID | - |    
Protein Information
| Protein ID | NP_061117.2 |
|---|---|
| Protein Name | tumor necrosis factor receptor superfamily, member 19 |
| Molecular Wt. (Da) | 42728 |
| Protein Sequence |    Download   Select all |
| Length | 423   |
| Uniprot ID | P11047 |    
| Ensembl Protein ID | ENSP00000258341   |    
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING)      View   
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 7185 |    TRAF1 |    3418 |    NP_005649.1 |    in vivo |    10809768    |
| 7186 |    TRAF2 |    3538 |    NP_066961.2 |    in vivo |    10809768    |
| 7187 |    TRAF3 |    3539 |    NP_663777.1 |    in vivo |    10809768    |
| 7188 |    TRAF5 |    3834 |    NP_004610.1 |    in vivo |    10809768    |
| 7189 |    TRAF6 |    3833 |    NP_665802.1 |    in vivo |    12060722    |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Cytokine-cytokine receptor interaction |    hsa04060 |    
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd13418 | 33-149  | TNFRSF19 |
| cl22855 | 33-149  | TNFRSF superfamily |
| cd15838 | 34-149  | TNFRSF27 |
| cd13419 | 46-138  | TNFRSF19L |
| cd00185 | 49-138  | TNFRSF |
| cd13421 | 16-143  | TNFRSF_EDAR |
| cd15834 | 34-141  | TNFRSF1A_teleost |
| cd13424 | 37-121  | TNFRSF9_teleost |
| cd13412 | 29-137  | TNFRSF11B_teleost |
| cd10578 | 30-147  | TNFRSF3 |
| cd10575 | 41-124  | TNFRSF6B |
| cd13406 | 49-140  | TNFRSF4 |
| cd15835 | 49-139  | TNFRSF1B_teleost |
| cd10581 | 49-122  | TNFRSF11B |
Ontology Information
| HPRD ID | 1031 |    
|---|---|
| Molecular Class | Cell surface receptor |
| Molecular Function | Structural molecule activity (GO:0005198) |
| Biological Process | Cell growth and/or maintenance (GO:0008151)   |
Drug Information
No matching records could be found.
External Links
| ArrayExpress | GO |    
|---|---|
| ICGC | GO |    
| Cancer3D | GO |    
| COSMIC | GO |    
| NCG | GO |    
| TSGene | GO |    
| Tumor Gene Family of Databases | GO |    
| CCDB | GO |    
| G2SBC | GO |    
| Osteosarcoma Database | GO |    
| RCDB | GO |    
