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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
TNFRSF19 55504 tumor necrosis factor receptor superfamily, member 19  13TAJ-alpha, TROY, TAJ, TRADE 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
23142137   2013Cell line : -

Source : -

Sample Type : -

No. of Sample : -

Stage : -

Chromatin immunoprecipitation with DNA microarray analysis and immunohistochemistryUp-regulation-TROY is up-regulated in human colorectal cancer cell lines and in intestinal tumors in mice. It functions as a negative modulator of the Wnt pathway in LGR5-positive stem cells.


Gene Details



Chromosome 13 - NC_000013.11 (23570370..23676105)

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Gene Type protein coding
Gene Family Tumor necrosis factor receptor superfamily
Description The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is highly expressed during embryonic development. It has been shown to interact with TRAF family members, and to activate JNK signaling pathway when overexpressed in cells. This receptor is capable of inducing apoptosis by a caspase-independent mechanism, and it is thought to play an essential role in embryonic development. Alternatively spliced transcript variants encoding distinct isoforms have been described.  
Chromosome 13
Location 13q12.11-q
Start 23570370  
End 23676105  
Strand +  
Gene Sequence

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Length 105736  
OMIM ID 606122   
HGNC ID HGNC:11915   
Unigene ID Hs.149168   
Ensembl ID ENSG00000127863   
PharmGKB ID -   

mRNA Information


mRNA ID NM_148957.3
Exon join(1..479,19781..19883,22976..23086,45498..45676, 56338..56423,88681..88845,89996..90121,97611..97713, 98323..98728,103003..105736)  
mRNA Sequence

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Length 4214  



CDS Information


   
Location join(19815..19883,22976..23086,45498..45676,56338..56423, 88681..88845,89996..90121,97611..97713,103003..103150)
CDS Sequence

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CCDS ID -



Protein Information


      
Protein IDNP_061117.2
Protein Nametumor necrosis factor receptor superfamily, member 19
Molecular Wt. (Da)42728
Protein Sequence

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Length 423  
Uniprot IDP11047
Ensembl Protein ID ENSP00000258341  



Post-translational Modification Information (Source : HPRD)


No matching records could be found.

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                           
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
7185TRAF13418NP_005649.1in vivo10809768   
7186TRAF23538NP_066961.2in vivo10809768   
7187TRAF33539NP_663777.1in vivo10809768   
7188TRAF53834NP_004610.1in vivo10809768   
7189TRAF63833NP_665802.1in vivo12060722   


Pathway Information


      
Pathway Name Pathway ID
Cytokine-cytokine receptor interaction hsa04060


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd1341833-149  TNFRSF19
cl2285533-149  TNFRSF superfamily
cd1583834-149  TNFRSF27
cd1341946-138  TNFRSF19L
cd0018549-138  TNFRSF
cd1342116-143  TNFRSF_EDAR
cd1583434-141  TNFRSF1A_teleost
cd1342437-121  TNFRSF9_teleost
cd1341229-137  TNFRSF11B_teleost
cd1057830-147  TNFRSF3
cd1057541-124  TNFRSF6B
cd1340649-140  TNFRSF4
cd1583549-139  TNFRSF1B_teleost
cd1058149-122  TNFRSF11B


Ontology Information


   
HPRD ID1031
Molecular ClassCell surface receptor
Molecular FunctionStructural molecule activity (GO:0005198)
Biological ProcessCell growth and/or maintenance (GO:0008151)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO