Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| TP53RK | 112858 | TP53 regulating kinase | 20 | dJ101A2.2, prpk, Nori-2p, BUD32 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 26263387 | 2015 | Cell line : Ls174T, SW480, HCT116, SW837, HR8348, and HT29 Source : Cell Bank of Type Culture Collection (Shanghai City, China) Sample Type : - No. of Sample : - Stage : - | Overexpression and loss-of-function analyses,Dual-luciferase assay and Western blotting, Chromatin immunoprecipitation assay,real time RT-PCR | Down-regulation | - | CREB-miR-630-BCL2L2 and TP53RK comprise a novel signaling cascade regulating radiosensitivity in CRC cell lines by inducing cell apoptosis and death. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | - | Chromosome | 20 |
| Location | 20q13.2 |
| Start | 45313004 |
| End | 45318301 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 5298 |
| OMIM ID | 608679 |
| HGNC ID | HGNC:16197 |
| Unigene ID | Hs.440263 |
| Ensembl ID | ENSG00000172315 |
| PharmGKB ID | PA25774 |
Protein Information
| Protein ID | NP_291028.3 |
|---|---|
| Protein Name | TP53 regulating kinase |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 253 |
| Uniprot ID | Q96DX5 |
| Ensembl Protein ID | ENSP00000369850 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| T | Phosphorylation | 7 |
| T | Phosphorylation | 135 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 7157 | TP53 | 1859 | NP_000537.3 | in vitro;in vivo | 11546806 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00180 | 41-196 | PKc |
| cl21453 | 41-196 | PKc_like superfamily |
| COG3642 | 36-253 | Bud32 |
| TIGR03724 | 38-247 | arch_bud32 |
| PRK14879 | 36-247 | PRK14879 |
| pfam06293 | 39-225 | Kdo |
| cd13968 | 40-185 | PKc_like |
| cd14014 | 36-187 | STKc_PknB_like |
| cd05120 | 75-189 | APH_ChoK_like |
| cd05145 | 39-185 | RIO1_like |
| cd13996 | 29-199 | STKc_EIF2AK |
| cd05117 | 140-187 | STKc_CAMK |
| cd13999 | 41-191 | STKc_MAP3K-like |
| cd14001 | 108-205 | PKc_TOPK |
| pfam01163 | 84-185 | RIO1 |
| cd14154 | 111-187 | STKc_LIMK |
| cd05118 | 133-187 | STKc_CMGC |
| cd14210 | 137-187 | PKc_DYRK |
| cd14146 | 38-187 | STKc_MLK4 |
| cd14077 | 49-187 | STKc_Kin1_2 |
| cd14020 | 107-188 | STKc_KIS |
| cd14169 | 111-191 | STKc_CaMKI_beta |
| cd14221 | 114-196 | STKc_LIMK1 |
| cd14015 | 141-188 | STKc_VRK |
| cd14222 | 101-187 | STKc_LIMK2 |
| cd14166 | 36-198 | STKc_CaMKI_gamma |
| cd14083 | 146-198 | STKc_CaMKI |
| PRK01723 | 75-184 | PRK01723 |
| cd05121 | 82-186 | ABC1_ADCK3-like |
| cd05038 | 108-197 | PTKc_Jak_rpt2 |
| cd14016 | 148-187 | STKc_CK1 |
| cd14065 | 78-187 | PKc_LIMK_like |
| cd14148 | 42-187 | STKc_MLK2 |
| cd14061 | 42-187 | STKc_MLK |
| cd14174 | 37-186 | STKc_Mnk1 |
| smart00090 | 62-187 | RIO |
| cd06637 | 36-187 | STKc_TNIK |
| cd14078 | 150-186 | STKc_MELK |
| cd14085 | 144-189 | STKc_CaMKIV |
| cd14070 | 153-187 | STKc_HUNK |
| cd13969 | 82-186 | ADCK1-like |
| cd14225 | 137-187 | PKc_DYRK4 |
| cd13994 | 144-196 | STKc_HAL4_like |
| cd14063 | 141-192 | PK_KSR |
| cd14093 | 124-196 | STKc_PhKG |
| cd14097 | 141-187 | STKc_STK33 |
| cd14212 | 138-202 | PKc_YAK1 |
| cd08220 | 113-189 | STKc_Nek8 |
| cd14106 | 142-187 | STKc_DRAK |
| cd14164 | 110-194 | STKc_TSSK6-like |
| cd14095 | 111-186 | STKc_DCKL |
| cd14005 | 111-185 | STKc_PIM |
| cd14003 | 153-187 | STKc_AMPK-like |
| cd14037 | 54-185 | STKc_NAK_like |
| PRK09605 | 37-247 | PRK09605 |
| COG0515 | 36-187 | SPS1 |
| pfam00069 | 36-187 | Pkinase |
| smart00220 | 36-187 | S_TKc |
| COG1718 | 39-185 | RIO1 |
| pfam01636 | 36-177 | APH |
| COG0478 | 42-184 | RIO2 |
Ontology Information
| HPRD ID | 17029 |
|---|---|
| Molecular Class | Serine/threonine kinase |
| Molecular Function | Transcription factor activity (GO:0003700) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.