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General Information
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 19956069 | 2010 | Cell line : - Source : - Sample Type : CRC tumor and adjacent normal tissue No. of Sample : 204 Stage : - | Immunohistochemical analysis | Up-regulation | - | p73 expression should be considered as a valuable poor prognostic marker. Our data also suggest that TP73 gene may play a role in colorectal carcinoma development. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a member of the p53 family of transcription factors involved in cellular responses to stress and development. It maps to a region on chromosome 1p36 that is frequently deleted in neuroblastoma and other tumors, and thought to contain multiple tumor suppressor genes. The demonstration that this gene is monoallelically expressed (likely from the maternal allele), supports the notion that it is a candidate gene for neuroblastoma. Many transcript variants resulting from alternative splicing and/or use of alternate promoters have been found for this gene, but the biological validity and the full-length nature of some variants have not been determined. [provided by RefSeq, Feb 2011] | Chromosome | 1 |
| Location | 1p36.3 |
| Start | 3569129 |
| End | 3652765 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 83637 |
| OMIM ID | 601990 |
| HGNC ID | HGNC:12003 |
| Unigene ID | Hs.192132 |
| Ensembl ID | ENSG00000078900 |
| PharmGKB ID | PA36684 |
mRNA Information
| mRNA ID | ?NM_001126240.2 |
|---|---|
| Exon | join(1..77,29769..29866,30496..30616,54985..55227, 69457..69643,70790..70905,74551..74660,75064..75206, 75565..75653,76763..76884,77436..77584,78363..78501, 78899..78992,80183..83637) | mRNA Sequence | Download Select all |
| Length | 5154 |
Protein Information
| Protein ID | NP_001119712.1 |
|---|---|
| Protein Name | tumor protein p73 |
| Molecular Wt. (Da) | 15889 |
| Protein Sequence | Download Select all |
| Length | 636 |
| Uniprot ID | Q9UQC2 |
| Ensembl Protein ID | ENSP00000343959 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| Y | Phosphorylation | 99 |
| K | Sumoylation | 627 |
| T | Phosphorylation | 86 |
| T | Phosphorylation | 86 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 274 | BIN1 | 3150 | NP_647593.1 | in vitro;in vivo;yeast 2-hybrid | 11709703 |
| 1387 | CREBBP | 2534 | NP_004371.2 | in vitro | 11279015 |
| 3146 | HMGB1 | 1228 | NP_002119.1 | in vitro | 11748232 |
| 3265 | HRAS | 1813 | NP_005334.1 | in vitro;in vivo;yeast 2-hybrid | 16436381 |
| 4088 | SMAD3 | 4380 | NP_005893.1 | in vitro | 12732139 |
| 4193 | MDM2 | 1272 | NP_002383.2 | in vitro;in vivo | 102 070 511 043 561 000 000 000 |
| 4609 | MYC | 1818 | NP_002458.2 | in vitro;in vivo;yeast 2-hybrid | 1 208 004 311 844 790 |
| 4734 | NEDD4 | 3786 | NP_940682.2 | in vivo | 15678106 |
| 4801 | NFYB | 1794 | NP_006157.1 | in vitro;in vivo | 12167641 |
| 5371 | PML | 23 | NP_150241.2 | in vivo | 11832207 |
| 5599 | MAPK8 | 3100 | NP_620637.1 | in vitro;in vivo | 15483136 |
| 7157 | TP53 | 1859 | NP_000537.3 | in vitro;in vivo | 112 389 249 891 077 |
| 7341 | SUMO1 | 3554 | NP_003343.1 | in vivo;yeast 2-hybrid | 10961991 |
| 8850 | KAT2B | 6780 | NP_003875.3 | in vitro;in vivo;yeast 2-hybrid | 14614455 |
| 10399 | GNB2L1 | 1503 | NP_006089.1 | in vitro;yeast 2-hybrid | 12761493 |
| 83737 | ITCH | 7565 | Q96J02 | in vitro;in vivo;yeast 2-hybrid | 15678106 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Hippo signaling pathway | hsa04390 |
| Measles | hsa05162 |
| Neurotrophin signaling pathway | hsa04722 |
| p53 signaling pathway | hsa04115 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd08367 | 127-306 | P53 |
| cl14608 | 127-306 | P53 superfamily |
| cd09571 | 487-551 | SAM_tumor-p73 |
| cl15755 | 487-551 | SAM_superfamily superfamily |
| pfam00870 | 113-309 | P53 |
| cd09503 | 487-551 | SAM_tumor-p63,p73 |
| cd09572 | 487-550 | SAM_tumor-p63 |
| pfam07710 | 351-386 | P53_tetramer |
| cl06653 | 351-386 | P53_tetramer superfamily |
| pfam07647 | 485-549 | SAM_2 |
| cd09487 | 492-547 | SAM_superfamily |
| smart00454 | 491-550 | SAM |
Ontology Information
| HPRD ID | 6299 |
|---|---|
| Molecular Class | Transcription factor |
| Molecular Function | GTPase activity (GO:0003924) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.