CoReCG

Search results:

General Information

Gene_Symbol	Gene_ID	Gene_Name	Chromosome	Alias
TPM1	7168	Tropomyosin 1 (alpha)	15	CMH3; TMSA; CMD1Y; C15orf13; HTM-alpha

Evidence
Gene
mRNA
CDS
Protein
PTM
Enzyme
PPi
Pathway
Structural
Domain
Ontology
SNP
Drug
External Links

Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
19678923	2009	Cell line : - Source : Department for Surgery at Jesenice hospital. Sample Type : CRC tumor and normal tissue No. of Sample : 16 samples of colorectal adenocarcinoma (CRC) and corresponding normal tissue Stage : -	Microarray, RT-PCR, mutation detection	Down-regulation	-	Underexpression of the TPM1 gene in a case of CRCs without KRAS mutations, showing that TPM1 might serve as an alternative path of development of CRC. This downregulation could in some cases be mediated by deletion of the TPM1 gene.
20812987	2010	Cell line : - Source : Nanfang Hospital tumour tissue bank. Sample Type : - No. of Sample : 150 CRC patients Stage : -	2-D Gel electrophoresis, and mass spectrometry,Western blotting , Immunohistochemistry	Up-regulation	-	This gene differentially expressed in between normal colorectal tissue and colorectal cancer tissue experiment done by 2-D Gel eclectrophotesis.

Gene Details

Chromosome: 15; NC_000015.9 (63334838..63364114)
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Gene Type	protein coding
Gene Family	Tropomyosins
Description	This gene is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. The encoded protein is one type of alpha helical chain that forms the predominant tropomyosin of striated muscle, where it also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and myosin during muscle contraction. In smooth muscle and non-muscle cells, alternatively spliced transcript variants encoding a range of isoforms have been described. Mutations in this gene are associated with type 3 familial hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008]
Chromosome	15
Location	15q22.1
Start	63042639
End	63071915
Strand	-
Gene Sequence	>gi\|568815583:63042639-63071915 Homo sapiens chromosome 15, GRCh38.p2 Primary Assembly GGAAGGGGGGCAGGAGAAAAAAGCTTTTCCAAAAAAGTATTGGCTGTCTTGAGGAATGCGGTCGCCCCCT TGGGAAAGTACATATCTGGGAGAAGCAGGCGGCTCCGCGCTCGCACTCCCGCTCCTCCGCCCGACCGCGC GCTCGCCCCGCCGCTCCTGCTGCAGCCCCAGGGCCCCTCGCCGCCGCCACCATGGACGCCATCAAGAAGA AGATGCAGATGCTGAAGCTCGACAAGGAGAACGCCTTGGATCGAGCTGAGCAGGCGGAGGCCGACAAGAA GGCGGCGGAAGACAGGAGCAAGCAGGTCTGCGCCTCCCCGGCCCTGCGCCCGCGCCCAGAGCGCCGGGAC TCGAGCCTGGCACCCCCGGCTGGATCCCCACCCCGAGGACTCGGGGAGCCACCACCCTACCCCCACCACC ACCCAGGGCGGCCAGGGCGCGCGTCTGGAAAGAAGGAAGGGAAACGCAAGAGCCAGGCTTAGTCTAACTT AGTCTGGTCTGAGGACGCTTATTTCCCTTCTCTGGTTCCCATGGCCCGCGAAATCAAGTCCTAGAGGCGC TTTATTCTCAGGACTGGGAATCAGTTTGGGGGAGGGAGGAGGACACCCGGTTCCTGGGGACGTTTGAAGG AAGGGCGAGGGATGGAGAAAGGGGGTCGAGTAACTCAAGTGTTAGAAGTTCGTTGACTTTTGACTGGGGA GAAAGGAACCTTAAACTTGGGGAGGAGAAGGGAGTCCTGGAGTTGTTACCTAAGAACAAAGATGGGGCGG AATGGAGGCTACAGCCCGAAAGCCAGGCCAGCAGTGGCGTTCTTCTGTGTCCCCAAGTAGTGGACTTGAG CCCGCTGAGACCTCGGCAGGAGTCTCGTCCCAGGGCAGGTGGGTGTGCGGGGTGAGCCGCGGAGCGGTTC CAGCTCGGGTAAAGAGGAAGTTACCTCGGGTCCTTTGCACTCCAACTCGGCGGCGCCCCGAGCCCGAGGG GCCCCAGCCAACCCGACGCCCGTGTGTTGTGTGTGTCTAACACCCGGTCCGTGCCGGCCGCCCGCGCCCG CCCGCCGCTGCCCCCAGCTCGAGGAGGACATCGCGGCCAAGGAGAAGTTGCTGCGGGTGTCGGAGGACGA GCGGGACCGGGTGCTGGAGGAGCTGCACAAGGCGGAGGACAGCCTCCTGGCCGCCGAAGAGGCCGCCGCC AAGGTACCCGGGGCGCGCGGCACGGCGTGGCGCACGAATGGCTAACTCTTTCTCTTTCTCTCTCTCCCTC CCTGTCTTTCCCTCTGTCTCTCCCGCTGTCCCTGTCCTTCTGGTTCTGTGCACCCACACCCCTCCCCTTC GGGATCACGCTGCCTGCTGCACCCCCCTCCCTCCCTGTACCCCCTGGCCAACTCCCAGCTGGAAGATGAG CTGGTGTCACTGCAAAAGAAACTCAAGGGCACCGAAGATGAACTGGACAAATACTCTGAGGCTCTCAAAG ATGCCCAGGAGAAGCTGGAGCTGGCAGAGAAAAAGGCCACCGATGTAAGTGCACGCTCACACTGCTTCCC TCACCTCTTGCCTGCGTGGCCACTCCGGGGTCACCACAGGGCTGGAGAGCAATGAAGGAAGTTTACCTTT TCCTGCTGGACACCTGCACACAGCCCTGCCATGGCCCAGAGCATTGGATGCCGCCTCTGACTGCTACTGC ACACATTCATTTATATTTCATCCACTCCTCTCTTCTTCTCCTTTCCTTTACCTCCCTGGGGGTGGAGGTG GGTGGATGAGAGGCTGGGAGAATAGAGCAGCTGAAATTGGACTCTGGAGGTGAACTTCACCTCCCTGGTG GCAGAAAACCCTTGAGGTGTCATCACCAAGGTTTGTGTAGAGAATGCCAGGTTTTCTTCACTTTCTTTCC TTTTGCCGTTTCCAGTGGGTGGGAAGTTCTGGGTTTGGTGGTGGGTCTAGTCAGGGTTCAGAGAACCTGG CCTCTAAATGAAAGAAATGACACAGCGGTACCTTTACTTAGATGGCTGCACTTCATGGTGGGGCACAGAG ACACTTTGAGGCTTCCTTTCTCATTAGTGTAAGCCTTAATCCACCCCTTAAGATCTGCCTGGGAAGATGA TACTTGCTTGGGTCTGCAGTCTGAAGGCACTAGATCCAGAAAGTAAGCTGTGAGTTATATATAGCTCAGT GCTTTATATGGTATAGTGAGCTAGCTGCCCCCTGCCCCTCCTGCTGGCCCCGCCCCCACCTGTCAGCCTT CTGACAACCACCACATAGTTGCAGGGGTGATGCACACAGCTAAGGCTCTCCTAAGCTCTTTGTCCACTGC CCTTTGGAAGCTTTTTAATTGATAGCTTGCCTCTTCTGCCTCGGAAAGTCAAGCCAAAGGACCAACTTCT TTTCACACCGTTGGATTCCATTCTAAAAGCTAATTAAGCCTAGAGGCCCAATTAGAAAAGAATTCCTTGG GAAGTTGGTAACAATTCCAAGAATGTGTGAGCACCAGGGAAAGCTATGCCAGCAGTTGAAACACCGAGAG CAACAGCAGACTTTTTTATATGAAAGTAACATGCAAATAACTGAAGGGTCTCAGGTCTTGAAATTAGTGA AGTCTTTTGTAGCATGAAAGGCTTGAGATGTATATCCAGGTGTGCTTTGTAAATGAGAACTCCAGAGACG ACATTTAGGATCTGACAAAAAGAAATTTTCAGTGAAAATCAAGCTTCCTGGAAAGGGGATTTGGGGGGAA GCACTGATTTCGCTAAAACATTTAAATTCTAAACTACCTGGCTTTGGAAAAAGAGCCAAAAACCATATAT GACTCTGAGCCTACTTTGTATAATGCAGATCAGATGCCTGCTCTATATATGGCTAAATGGAAGATGCCTG CCTCCCGCAAATTCTCCAGCAGGACGTTTATTTAGCTTTTTCAAAAGAGCTGCTAATAGATCAAGGAAAG ATATTCCTTATAAGGAAAAGAATGCAGAGAATTTGAAAATAGCCCAGTAAGACTGAAGGCAAAAGAGGGA GAAAAAGGTTACTACAATTCTTAAGGGAAAAAAATAGGATAATAATTATTGTAACTATGTAGTGCTAACA TGTCTTTATTGAAAAGTCTTGTTGAAGGGAGCGCTGGAATGGGGTGGGGCAGAAATGGGAAAGAAGTTAT TTAAAGTCAGCTGGTGTGGGAAGCAGCAGGGGAGGGAGCTTCTTGAATCTTGTTTTGGTTATTTTTCCCA CCGGGAAACTGCCCCTAAATCTGGCATATATGGCTTTTTTGATAGTGTATTGATCACATTCCCTTTTAGG ACACTTTAGGTTGTCTGGAGTTTGGAGCCCGTAGGAATATTGAAGAAGTTAGTGAAGAAATGCTATACAG TCATTTGTTGATTAATGAAGGGGGATAAGGTCTGAGACATGTGTCGTTAGGTGATTTATTCATTGTGCAA ACACCATAGAGTGTATGGTACTTACACAAACCTAGAGGGTATAGCCTACTAAACACCTAGGCTACAAACT TGTACAGTGTGTTACTGTACTGAATACTGTCAACAATTGTAACACAAATCACCAGGCGATAGGAATTTTT TAGTTCTATTGTAATCTTATGAGGCTACTCTCATATATGCAGCCCCTCATTGACCAAAACATCATTATGC AGTGCATGACCATATTGAGAGTATTCGTTTTTTATTTACTAAAAAATAGTCAAAACTTGAGGAGGAAGAG ACAGATGTCACTAGAAAAAGGGAGAAGTCCGGTAAGGGAGAAGTCAGCTTCCTGAGGTGGAATCGTATTA CCTTTGGGATTAGGACATTTCATTGTCATTATTCACCAGTGTAAAACACTTTTACATTTTTCTACTATTA TTACTAAAAACATTTTTCTACTACTTTACAAATCCTATTCTGGAAGTGGGCTCTACCTAGCTTAGAAGAT TGTCATTCAGGAGTAGTATCCCTGATGGTCTTGTTTCGAATTTTGTGTTGTCTTTCCACCTAAGTCAAAA GTGAGGCTGAAGGGGATCGAAGACTCCATTTTTTTCTGGCCCCCAATCTCTTCCCCAGTAACTGTGATAT ATCTGATATTTATAGCATATGAGTCTTTATCCCTTTGTAGGTCTTTACTTCTTAACTTAGGGATTCTCAA CCTTCTCTAAACATAATCACTTAGGGAGCTTTTAAAACCCAAAGTTAGGATGCACCCAAAGCCAGTTAAA TCAGAATCCCTGGGGATGCAACCCAGGCGGCAGCATTTAAAAAATACCCAAGTGATTCCAACCTACAGAC AAGGATGAGAAAACTCTCCTAAACTCTTGTATAATGACATCGGCATGAAAATGAACTCACCTGAAACTGA CCTTCCCAGGACATTAAGTCACTAGTTGGCTGCTTATGGCACTTGCCAGTGTCCAGCAGTTTCCTGGCTG CTCCTGGAGGTTGCCAGACACCCGGTTCCCCCATTCTCAATGTTGGAGGCCCACAGTCTCTGCACTTAGG GGACCAGCTGTAACCTCCCCACCTGACCAGATGAACCGCGGGGAAACAAAGCGAGAAGCTCCCACCTACA GGATGCAAGGACCCAAGCTGGGATTTGTGAGAGTCTCAGCAGAGGCTGTGAGGAACTCCACAGAAAATGA GGCAGGAAAGCAAAAGTTCCTTGTTAGGGCTTGGAGGAGGAGAGGGTTGTCAAGCATGTTTTCTTTATTA TTCCCACACATAAGGGAGCTGGCTTTAAGAGCTTTCTGTGACAAACCTGAGGAGAAAAAGCCCTGAGACT TAGAAGGCATTTAAGAATACAGCTCAAGGGGGAAATCGGTGGAGACTGTATCTGCGGTGGTTTTCTCCAC CTGTAGCCAGAGGCTCTCTCATAGGGTTCTGTGGCTTTCCTTGGGGTGCCTTTTAAAGGCATCCCAGTCC AGCCCAGGACTGACTGGATTCCAGGAGATCTCAGAGGCTGGTCTGACACCAAAGAAGGCTGTAAAGAGAA GAGACCATTTGGATGACTGTTTTCATGGAAAGTGAGCCCCAGGGAGGCTGGCCTGAGATTACACAGCTGA TTATGGGCCTCAGCCTGACTCTTAAAACAATGCTTGTGTATTTCTTAATCGTAGCTATCATTTGAGTTTT TAACTATGTACAAGGTATTGTGCTAAGCGCTTTACAGTCCTTCATAATTCTCATAGCAGCCCCATGGGGA AAGTACTATTATTATTCCCACTTTTACAGATGACGCCCAGAGAAGACAGGTAATGTGTCCGAAGTCACGC AGCAGGAAACTAGGAGCCAGAGTCAACCTAGGAAAACTGCATTTAGAACAGGAGGTCTAACCACTGTGCT CTACACGCGGGTGGTTTTCACTTCGTGAAGTTTTGGGGAATGGGGGTAGTGCTTGGGTTATAATCTTGCG GTTGGGATCAGGCCCTTTAGGGCATATTCCGGCTCCAGACCCGCCGCTCAGCTTCTCTGGCTCCCGGGCA TGGGAATCTGGACTCGGGAGCGGAGCGCTCCCGCGGCCAGCAGGAGTCGCTATTGCCCTTAGCAGCCAGC TCCGTTACCCCGGGTCACCACCGCGCCGCGGAGGGGCCCTAGAAGTGGAAGCCAGAGCCCTAGTGCAGTG GCCTCCCGGAGCGCCCAGCTCACCAGGTACCCCCGCAGCGCGCCGGGAGCGCCTTTCTCCCCGCCGCCGC GAGCATGCGCAGTGCCCCCAGCCAGTCCCGGGATCCACGGCGCGCGCCCCTCCCAGCCGCGCGCGCCCGC CTGCGGTTTGTCTGCGCAGCCCTGGAGGCTGCGACTTCCGGACTGCTCCTGGCCGCAGGGGGCGCCGCCA TCGCACAGAGAGGCCTGGGCGGGGCGGACCGGCGCTGGGCAGCCAGGACAGCCGCGGCAGCCGGGTCCGC AGGGCAGCAGCCGGCCTCTCCCACTGCAGCCCTCCCGCCCGCCTACCGTCCGGCGCGATGGCGGGGAGTA GCTCGCTGGAGGCGGTGCGCAGGAAGATCCGGAGCCTGCAGGAGCAGGCGGACGCCGCTGAGGAGCGCGC GGGCACCCTGCAGCGCGAGCTGGACCACGAGAGGAAGCTGAGGGAGACCGTAAGGGATACACCCATCACC CCGCAGCCCCCAGAGGCGCATCCTCCCGGGGCAGCCCCGCAGGGCCCTCCTGCTTCCCCCCCCGCAGGCC CCGGTCCCTCGTCCCCACGCCTCCAGGGCGCACCTGGCGCACCTGGGCCAGCTGGCGGCGGGCTCTGGGG AGGGGCCCGGCCTGTTCTCCTGAGCCTTTGTTTTCCATCTCGCTGATCCAAAGTAAACGCTCCCAGGGGA AACGGGTGGTGTTGAGAAGGTTCTGGAAGGAGCATTTTCCCAGGAAGGGTCTGTTTCTGGGGTGGTGGCT TTCAGTCGTGTCTGTGCGTCCCCGGGAGGTGCACTTTGCGCTGCTGGCTTGCTTTACTCTGAGAGTGGAG AGGGAGGAGGTCCTTCCTCTTGGAGATCCGTACTTTGAGAAGGGGCGCCGACAGGTCAAGTGGGAGAGGC ACTGTGGACTTGGGGCCCGGGGATGCTACACTCCGCCGTTCCCGTCGACCCTGTGGTTTCCCGGCGGCCT GTGTCTCCGAGGCGGTAGACAGACATTGACAGCTTGACAGCGCCGCGTTCTGCTGGAAGAGCTAAACTAT AGTGCAAAACCCTTAACCCGTCCCTTTTTTCAGCAGTCCTCCTCCCCTTTTCTCTCATACAGATAGATAA TGCTTTGTTACCAAGTCTTGGAAAAAGTTGGCGAAATGTCAACAGTTATTGGGTGTATTCTCTTGCGGGC TTCCCCTCCCCCTTGTTAAATGTAATACCTGGCTTCCTTCCTTTCTTCTAAGGCAAATGTATCCAGCAAA CACGAACAGGATTTCAGAGGTAGTCTAGTATTGGATATTTGTCGATTTTGTGTGTGTGTGTTTTTAATGA AGATACTGAAACAAACACCTTGGGAGTTTTATGACAATTGATAGTATGATGTCCTGCTGTGCTTAATATA CGGGGTTGTTCTGAGTTGAGTAAATCGTTCTAGTTAAGTGTTTGTAAATGGCTGTATGGCTGGCCACAGA AACTTCAAGACCTGAAATGGTCCTCTTCAGAGGAAAGCTCAACTAGAGAAAGTTTCAGATAAAATACAAG CAGGAATAAGGAAATTAATAGGCAAAAGATAATTCTCAGTATTTGCTTTATAGGACGAGTCAGCAAAAGT CCTGTGGATATCCCTGAACTTGGCTGGGTGGTAAACTAATTCCGACTCCCTTACTCGCTAGTAGCTGTCC TTGAACCATTAGAACTATATAGAATATGATGGATAAAAACAAGAACTTTGGACCCAGACTGTCAGAACTT GAATCCTGTCTCCACTACTTACTAGCAGTGGGCAAGTTACTTAATCTCTGTGTTTCAGTTCCCTGTGTGT AAAGTGTGGATAGTAACAGCATCTACCTGTCGGTTAAAGGAGTTACTATGTAAAGACAGTACACTGATGC TTGGCGCAAAAGGGTAAGTGCTGTGTGCCCGCTGTCATTAAAACTGCACAGCCCTGGCAGCCCAGTGCTC CTTCACCTTCAGTTCCCCACCCAGCAAGAGGTCTTAAAGATGGCCTGCTCATTTCATGACATCATAAAAC ACTTCATTTACTGCTTTTAATCAACATTTGTTGGGGCGGGGGGCTTGAATGAAGAGGAAGTGGGCGGGCT GGTAGGCATGTTTGATGGGTTAAAGTGGTATCAGTGGTAGAAGTCTGAGGTCTCCTCACCCTGCTAAGAA AGAGTATGTGTGACCCTATGCAGGAGAGCCTTGTATTGGCTCCTGGCCTAGTGATTGATGTTAGACACAA AAGATAAATTTTATGAAGGGCACATTATTACTTTTATTCTTACCTTCTCTTTTGCACGTCGTTTTTATAA CAGAACTCTTCCTGTGCCAGTTGGCTAAAGATAGTACTTTCGTTCTTTTCACGGCTTTATATCAAAAGTA GTTTAAGTAGTTTCAATTTTTTTAAGTAATCTTTGCAAACAATCTACCTGGGTGATTGATTGAACACAGA ACCTTTTAAGACAGCAACTTGAAGACTGGATCAGACCATTGAAGAGAGACTTTCAGGCTGCAAGTTGTTC CTAACTTCTGAAATTGGAACTTAAATGTAGCTGACTTAGGTATTTAGATGTAGCTTGGGCTGTGAGTTAA GCTAGCAGTAACAGTTTCTTTTGGCAGCAAAGATAAAGGTTTAGTGACAAAACCATGAGCCACTGCAAAA AATATTTGACCAGAGAGTTGGCCTAAATTCAAATACTCAGACTGTAATTAATAGGCCCTATTAAACCAGC CCTTACCTTGGAAAAAGCAGCCATCCCTTACTTCCTCCTAGTCTGTGTTTCCAAGGTGTGTGGATCCTTC AAAATGTTGGAATGAGGCTACTTTGCTTGACATGATTGATTCCAGATCTTGTGACCCACTAGGGTTATGT TTGCTTTTTTTCATTATTTAAAGAAAAAGGCAGGATGAATCTTCCTTTCTGAGTAGTATCCAGCAAACAA GGAGACAGGGAGTTGTGGCCAGAAGGTTCTTAATTAGTAACATGATTAAATCATGGGAAATAACCAATTT ACAAAAATTCCCAGCACTTTCCCTCTTTACACTTGGTAAGTATTTCCGGGATAGGAAAACCGAGGGTGCA TTTTGTGCTTGCATTGGCACTCCCAGAGTGGCTGTTAACTGGAATGTATACTCTCGATTTCCGCTTTCAT ATGTAGGCAAGGCAGAGGCACTACAATGCCTTGTTCATGTCTGTTCTCCCTCATTATACAAATATGCTTC ATAAATTATGGGCTTTGGCACACACAGGAGGTTGTGTTTATCTGTTATCCATGGGAGTGCCCCTTAATGT CATCAGTGTTTTTTTTTTTCCCCCCTTTCCTTACCATATAAGGGCAGAAGTTTAGCTTGGCTGTGGTCAC TTGGCCTTACACAGCAAGTTGGGTGAAACCTTCTTCGTATAACTACAGTTTGCATGAAATAAAAAGACCT GACCTTTGATCATCCCAAGTTCCACTCCAGTTCAGTCAGGACTTTGGAAACATATTCCAGAGGATTGATT TCTAGATTATAATATTCTCCCACCAGTATTTTTTCTTAATAACCTTAACTGGAATACTTTTTTAAAAAGT AAAAGTCACTGCCATTTTTAATTTTCTGTTGTTGTATTGGCTAAAACATCTGGATTTCATGAAAATCTAG GCCTCATAAAAGTTGTTTTTTTTTTTTTTTTTCAAATCTGATTTGGGATAATATTATACTATGGTGGGGT GGGCATGCCCTTGATTTCTATATAGTACCATGTTGGGGTGGGGGAATGGGGTGCATGCCCTTAGAGGAGG GTCATATGCATTGTAAGGCACCTCAAGTACAGAGCACCAGGAAGTTACTTAAAAACATCTGCAGGAGGAC ATTGGTAGCCTTTACTAATACAGCAGTCTCTTTTTTGAGTAGTTCATTGTTAGAACACAATAGCACTTTT GAAATAAAAGAAACTAGCATCCCAGATTGAAAGACTTCACTGGCAGTCAGCACATGGGCTGCTGTTAGAA GAAAGCTAACTTGGCTGGGTGCAGTGGCTCATGCCTGTAATCCCAACACTTTGGGCGGCCGAGACGGGTG GATCACCTGAGGTCAGCAGTTCGAGACTAGCCTAGCCAACATGGCAAAATCCCATCTCTACTAAAAATAC AGCAATTAGCCGAGCATGGTGTCACGTGCCTGTAATCCTAGCTACTGGGGAGGCTGAGGCAGGAGAATCG CTTGAACCCGGGAGGTGGAGGTTGCAGTGAGCCGAGGTCATGCCACTGCACTCCAGCCTGGGAGACAGAG CTAGACTCCATCTCAAAGAAAAAAGAAGAAGAAGAAGAAAGCTAACTCAGTACACTAAGAGTGATTTACA TGCCTGCAAATAATTTGTGTCTGGGGTCTTGACCCTCCCCAAATGCCTTGTTATTTATATCTCTGCTTTT AGATAACAGATGGTCATGTGTCTATGGGCTTGTACCGGCAGAGGCAACAGCAGGTCCTTAAGACTCCCCA GGTGCCATGATGAAAAGAACCTTAGAAAATATTGAAATAAGCTCAAAACTTAAAAAAAAAAATACCAGAA ATAAAAGCTAGTAAAGGTGAGAGGTGTGGGGCTTTTGGAACATAGAGCATAATAAATCAGAATAAAAAGT AAAAATAAGAAAGAGAAAAAAGTGGCCCTGATTAAATTATAAAATTAAGCATATCTTGAATTCTAACGAG CCAAACAAAAATTCTACTAGGCCAGTATAATAGGGCCTGCAGAGCCTGTCATGGGTTCAGGGTTTTCCCA TAAAGATAGGTGTACCTCAGATACTACTCCTAGGTCCTGGCTTTAACCTCAAAGCCCCTCTGCCTGTCCT GCTCTGAAACCTCTGGGGCAGTAGGCATTGACTTCTGGGCTAGGGAGTAAATGTTCCGTGTCCTTATGTG AGCTTCCTATTACCCATTAGCATTGTTTTATGAAGTTTTCAATTTTATATCCTGCCTCATTTCAAAAAGA TTGTGATAATCACTTTAGCAGATGATTTGCATTGCAGCAACTGTTCTCCCAGTCCTGGTTAGGATCTGTG CCTGAGGCCTTTTGTGGGGAGTTGGGGTGGGGGCCGGAGAACATCTCAATCTGATCTCAGGAGAGATAAA GACACAGGAGTGAGAACTGCCAGTTCCAAGGTTTCCGTGATGTTCCGGGAAGCCAGGAGAAGTGACATAG TGGAGAGCCGGCATGCTGGGAGCCTAGTGACTTGGATCTTAATCCTGTCTCACACTGATGGCTGTATGGC CTCCACATACTTCTGTGCCCAGGGTCAGAGTTCCCTCCTGCCGCCTGTTTCTAGTCAAGAGCTAGAAGAA TAGCCAGCTTCTTTGGGTGGTGGCAAAGGGGATTGTTTATTTATAGTACAGATTCCTGCCCTCCCCCTTT GACCTCCTGAATCAGAATCTCTAGGGACACGGCCTGGAAGTTTGATTTTTTTTTTTTTTTTTTTGTTTTT GAGACAAGAGTCTTGCTCTGTCGCCCAGGCTGGAGTGCAGTGGCATGATCTCGGCTCACTGCAGTCTCTG CCTCCCGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGATTACAGGCATGTGCCACCAT GCCTGGCTAATTTTTGTGTTTTTTGTAGAGACGGGGTTTCACCATGTTGGTCAGGCTGGTCTCGAACTCC TGACCTCATGATTGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACAGCGCCCAGCT GAAAGTTTTTTTTTTAATGCTCATCTCTGAGTTGATTCTGACACTCAGCCACTTGTGGGAATTGCTGATC TGGACAATGCCTAGGGATCCTTCTAGCTAAAAAATTGAGACCCTATTTTTTGGATTTACAGGGCCTCCTC AGGAAGGGGCAGCCACTCTCAGGTCTGCTGTGTGTGCCCTACCATTCCTCCCACTATATCACAAACTGGC ACCTAGAAACTGGTCTCCATGCCCAGTCGTTGCTGGGGCACCCTGTATGAAGCCCTGCTGGCTGGTATTC CTGTAGGACATATTCTCTGATGTCCAGGAGTCTGAGGTTCTACAGAATGCCCCTGGGGAAACAAGAGTGG CATTTAGACAACAGCATTCTGTAAACACAGTGCCAAGAGCTAAGGGAAAGAATGGGGGTGGGGGTGATCG GAGGGAAGACACGGATGGATTGGTAGGGGCCCTTTGGGTAGGAAGATCTCATGTGCAAGGCTGGAATGAA CATGAGGTGCTGTTTCCTTCCTTTCTGGTGACTCGGCTGTGTGGGGAGCTGGGGATAGAGACCTGTCACC CAGAGGGTTCTTTCCCCAAAGCATAAACAGTCGTCTTTCTGTGAGTACAAAGTCCTTGAGGTTCAGGCCC AGATCTAAAGCAGAGCAGAGAACTTGGAACTTGGTAGCTACAAAAAAGTTTTGAAAATCTTGCTGGCATT TCTCTAATAGGCCATAGCCTCTGTAACAAGGATATTTGCCATCATATTGAAAATGATAAGAAAGGGGGAA AGAAAAGAAAGTGTACAGTGCTTTTGAGTACATAACCTAGACACTCTATGGAGGCTTTTTGTTGTTGTAG GGCTTTTGGTTTGTGTGCTTGGTTTTTTTGTGTGGCTTTAAATTTTGTTTTGTTTTGTTTGCCCTTTGTT TTTGCTTCCGCTTTGAGTCTCCCCCCCACCCTCAAAAGGAATAGAATTTTACTGGAAAATGAAAATATAG AAAAGTGAAGAAATCTTACCTGACCCAAAAGTATATCCTTAATATATACATCCTTCCAGTAATAGTAATA AAAAAAAAAAGCCTAATGGTTTTTAAAAGACACTTCCCTATAATTGAGAGATTTGTTATCCTATTACCCT CACCCTTCAATACACACACACACCAGAAACAACAGTCATCTGCCAGTAATTCCTAGCTGGGTCCATTTAC CAGCTGTGCACTGATAATGATTTACTTTGTAGGCAGTACAGTTGTAAATGCTCTTCCTCTGATTTATTTC ACATTTGCCCTGCTCCCTGCCTCCATCAACCAATTACTACATTTTTGTCAAGATAAAAGTGTATTTACAT GTTTTTATAGAGTCCTTCACCGTGGTTGGAGATGCCCTACTCACCTCTCTTCCCAGATAAAACTTGGCAT TTAAAATCTTACAAATCTAGGTGAGCAAAGAGCTGAAGGTTCTCAGATTCCTTTGATTAAAGACTATGAC CACAGTTTCTAACTACATTTGCATTTCCAACTCTGTATTGTGGATCCATAAGCTGAGAACGTTGCTTTTA TTAAAATTAGGTTGGTTTTACTCATCTTACTGAGCCCATACTCTGTGCAGAGAACTGTGAGTTCTCTGGA TGTGAGCAGCTTACAGTTCAATGACAAAGACAGGGCTGTGTGTAGAGAAATTTGTTATCCTATTACCATG GGTCCCTAAGTGTGTATTGTAATTTCTAGAAAACTCCTAAGTGTTCTGAAAACCCCACCACCCCTTAGTG AACATACATTCAAAGTGGATGAGGATATTTTACCTGATTAGTAAATTCCATCTCCCACTTCCATGCACAA TATTTAAACAGCCACCAGTGCAAGTGTGTATAATGGACCATCATAGTCTTATAAGTGTTCTGAGGCTCAT AGCAACAATTTCTTATGACAGGAAAAAAATCATTGCCTCTCAAAGAAACCAACATTTTATTTCAGTGACA GATACCAAGTAAAAACAGTACTTGTATTATTTTTCTTTTTAGGAGTTTGATACTTTTCTTGTATTAACCT TGACTTCAAAGAAAAATCATAGGCTTACATCAAAAACACTTGGGAAATTTGTCTTGGCTCTGTTCCAATG AGGCCAGTTATTCTAAAAGGGGTTACTGGATTGTGTTGGGCCTTCATGTGGTGTGTATTTTAGAACCACT GAATTTTAAACTATTTAAGTTCCTTTGTAAGGATCCTATGATAAAGTGGCTTGAAGGAAAGAGTTGAGTG AAACTCTTGAGTCCGATTTCTGGCTGTACTGCTATTGTCTTACATGGCTGAGCCTGGGTAAGTCTTGTCT CAGTTCACACTTCAGGCCCCCAGTGAGTGAGGTGGCCGTGATGACGCTCTTGTTTAACAGGCAAGTAAAG CCAGGGTGTTGAACTCTACGGAAGTGGGCCGGGCGCAGTGGCTCACGCCTGTAATCCCAGCACTTTGAGA GGCCAAGGCAGGTGGATAAGGAGGTCAGGAGATTGAGACCATCCTGGCTAACACGGTGAAACCCCGTCTC TACTAAAAATACAAAAAAATTAGCCGGGCGTTGTGGCGGGCGCCTGTAGTCCCAACTACTCGGGAGGCTG AGGCAGGAGAATGGCGTGAATCCAGGAGGCGGAGTTTGCAGTGAGCTGAGATCGTGCCACTGCACCCCAG CCTGGGTGATAGAGCGAGACCCTGTCTCAAAAACAAAACAAAACAAAACAAAAAAATCTACGGAAGAAAG GAACCATGTGAAAGAGCGTTTGCTAATGATCTGTCTGTCTGATGAGAATTGTGTGTATAGATTTGTGTAT ACACAAATATGGATGTTCACTGTATAAATCAATGTGTAAATGTGTCCGAGAACTCCAGAGTTGATGAGGG CTTGTAATGCACTTAAAGGTAGCTCACCACAAGACAGTCTTCCTATCTGAAATCAGCATTGCAGTCCCAG CCATTTCCTGAAGCTACCACCCTCACTTTCTCCCCAACTCTGAAATGCTTTTCACTCTCTACCTAGGCTG AAGCCGACGTAGCTTCTCTGAACAGACGCATCCAGCTGGTTGAGGAAGAGTTGGATCGTGCCCAGGAGCG TCTGGCAACAGCTTTGCAGAAGCTGGAGGAAGCTGAGAAGGCAGCAGATGAGAGTGAGAGGTGAGAATGC CTCATCAGCCATCTTTTGCAGCTGCCTTTCCTGGTGGAATAAACCGGAGGGCTCCTGTGATCTTTGAGGT TTAAGAATTTTTCAGTCCCCTGGTGGTGGGATCATTTCCTCTATTGATCCCAGGTATAACTCGGTTGGTT TTGTTCATTTAGCATTAGTGAAACACCTACTATGTCCAAAGCACTGTCCTAAGCCCTAAGGTTACAAAGA AGAAGATGATCTTGTTCCTGCCCTTACAGAACTCACCATCTAATGAGGGAGACAGACATGTAAAGGAGAA ATGTCAGGGATACAAGTTGGCCCTTTCACTCCTACTGACCACAGAGCAATTGTGCATTTTTTAAAGTGTA ACTTTATTTTATAATATACAAGGAGGCTTAGGTGTAAATAAAGGAACTGTGGACTATCAGTTGTCAAAAT AGCTTAACAAATAGGTGGAAGAAAAAACACAAAGCAGAAACATGGTCTGCAAAAGTAAAATATTTTGGAC TTGGTCTTAGTAATATACACAACACACATGCACACAAATAGTCAGATGCTCGTGTGTTCTGAGCCCACCT CCACTGTAATCTGGCTGTAGCTGAATTATTACTCAGATTCAGCTTTGTGGTAGTAAAGGAAAGCATGGTT CGTATAGACCAGCACAGCCTTGTGTGGTCTAAAAGGCATTTTCCCTTAAGCTCAACTGTTGGAAGTAAGG ATTTGCCATATTGCATAGAAGTACTTCAAGAGAGACTCCATGAGGTGAGAGAGCGTTCTGCCGCTTGAGG GATGGCATAGCATGAAGGGGCTCAGAGCACTGAATGTGTATCTGTCTGTGCTGTGACCTGGGCAAGTGAA TGCAGTCAGTCATCTTGTCCATTTCTTACTCTTTGAAGTGACCCTACCACTAGGTACCAGGTATAAAGAG TGATTTCAGACTTTAGGATTAAAGAAGATTTTTAGCTAAACTTTTTAGGCCATTATTCACCGCTGCTTAG TGTTTCTTCGCTAACCAAGCATTTTGGACTTCTTTAAGATGACTAAGCATCTTACAGTGTACGCATAAGA GCAGTTTTGTGGCTGACTTCTTTCTGAAATATACTTGTTAGTGTACCTTAAAGGCAGTCTGGTAATGTTA GACTTCGGAGTAAAGGGGACTTGGGGATCATTTAGTCCCTTAGTTTTACAAATGAGAAAAGTAGGGCTCA GAGGCTGATGTGACTTGCACCAAGGCTCACAGCATATTTGTGGCTAAGCCAAGACTCCGACCCAGATCTC CTCAACTGTATTCCAATGCTTCATCAAAAGATAGTGGGCCAGATGTGGTGGCTCACACCTGTAATCCCAG CACTTTAGGGGGCCGAGGCGGGCAGATCACTTGAGGCCAGGGATTCGAGACCAGCCTGGCTAACGTGGCA TAACCCCTAAATCTACTAAAAAATAGAAAACTTAGCCAGGCGTGGTGGTGCACACCTGTAATCCCAGCTA CTCGGGAGGCTGAGGCAGAAGAATCGCTTGAACCCAGTAGGTGGAGGTTGCAGTGAGCCAAGATCACACC ACCGCACTCCAACCTGGGTGACAGAGCGAGACTCTGTCTCAAAAAATAAAAATAAAAAAATAGTGGTTCA CTTATACTGCCTACTTAAATTTTGATAAATGAATTCCATTTTACATGACTTGTTATTCCATATATCTGTA AAATATCATAGGTCATTTAGTATTTTTCTGAAACATTACACCACGCTATAGGACCCTAATATACACCATG CCATAGGACCCTAATACACTCAGTGTAGAGGACAGTGTCAGGCCTGTCTCCCAGCATTGCTGTCATGAAA GGGTTCCATTATAGGTAAAACTTAATTTGATGCATTCAGTTGAACCATAAGAAATTGCCATTATTACTTG TCTGAAATGGTCAAATATCAGCATTCTTTGTGGACTTAATAGTTTATTAAATCTAACATTAAGTCTAATA TTTTTGTTTATGGGTGGCAGGGTAAGAAGATTCTTTGTAGAAAGAGGTATATAAAGATAAGTTTGATTTT GTTCTAGCTTTGGTTCATGTGCAAGCTGAGGCTTCCCACAGGAAAGGCAAGAAATCTCATTATCTTTTTA ATAGTAAAGCATATTGGCTTTTCCGGTTTCATACTGCCAAGATTCAGACAGATTCCTGACGTGGTACCTT TCGTCATCATTAATGTTAGATGCCTGATAGTTTCATCAGTACTCAAAGTGAGAGAGTTCATTCACAGTGA ACAGAGAGAAATGTGTCTCTTTTTTCCACCTTTAGCTCTGGAAATTGTTGTTTCCTGGTTTGGAAAATAA AAGTAGCTCTGTGCTCTATTTTGGTCTACCACTTACACTAAGCCTCACAAGCCACAGCAGTGCAGTGTGC ATTTGGGAAGTTCAGCTCTAAATCTTGGGTTTTCTTGCTTGTCTTTCTTTTCAGAGGCATGAAAGTCATT GAGAGTCGAGCCCAAAAAGATGAAGAAAAAATGGAAATTCAGGAGATCCAACTGAAAGAGGCCAAGCACA TTGCTGAAGATGCCGACCGCAAATATGAAGAGGTCAGATCCTGGGGCCCAAAGCCTTGTGGACACCCAGC AGTGGCCTTCAGGAAGCCAGGGAGCAATGTACAGTCTTGATTCCCGAGTGAGGCCATCTGCTTTGTTGGC AGAAATGGGTGGTTTTGAGAAGCAGAGTTCCTTTGTGTCCAGAAAACGGTTCTAATTTTAATCCTGCTAG GGGATCCCAGGCTTTATCAGGAAGCCAATCAGTAGCACTGCGAAGAAGGACCAAAACTCCTCTCCCCCAG CCACAAAGACCCGGACAAAAGATCTTTGGCCGGAAGGGAGAGTTGGGCCCTGTGTCTTGTGAAAGGAGGC TCTCATGCTGTCATGGTGCAAGTCATTTCTTCCCAGAGTGACCTGGCACATCCAGATTGGGCAGCTTAGA GACCACAGACAGTTTCTCAGTGGATTCACAGAGGCCTCTCTCCTCAAGGGTGGTAGAAAACTATTATCAA CGCAGGTTTTCAGCAGAATTTGCTCCTGGTCGTGTCCCCATGAAAACAGCCTCCTGTGATAAGAGGCAAC TTGATTATTAAGGTTTCTGTTTTTTCCTTATTGGATCACATCGTGGCTATCCTGAAACAGCATTGCCCCT CCTTTTTATTACCATTATTACCTTCAGATTACACTATGCTCACAAGTTTTGATCTGCTTCAGAGGCTCCC TTCCTCTCTCTGGTTCTTCCACTAAATACAAATTTGATTTTGTCAGTTATCTCACCAACTTGTCTCACGT TAGTGTCTCTTGTATTCTTCCACTGCAGTAAGGAGGTAGATGCACAGATCAGCCATCAAATTGATGGAGT TCTTAGGTTTACTTTGTTTTCCTGGCAGCCCCCACCTTTTTAGTACATGTCTCATCCTACTGCTGTTTTT GAGATTGTGAATGTGTATTTTATCCCTCCTTCCACATTTTGGTCTGGCTGCCGGTTCACCTAGGTCAGAC TTCCAATTGAGACTGCCCAATCACAGCTAACCATTCTGAGTCAAAGCAGAAGCCTCTGATCTCCTCTCTG CTGGCACTCCTAATAGAGAGTTGCTTCTCTCTGGTCTACCAGAAAGAGGATCATATTGTTTGTAGACAAA ACCCTTAGGGCCTGATGGGATCTGATCTCTACCCCCATGCCCTTCTGTTACACAAAGCTTGCAAGACCCA TGGTGTGTGTGTTGTGTCTTCCTGCTGCAGGTGGCCCGTAAGCTGGTCATCATTGAGAGCGACCTGGAAC GTGCAGAGGAGCGGGCTGAGCTCTCAGAAGGGTAAGCGGGCCCGGCGCCAGGAGGCCACGAATGGGGTGC TGCAGAGCAGTGACTAAACAGCATGACCTTCTGGCAGCTGCACATTACCTGTTTCAGCTCCGGGCTCCTT TTGTGCTCATTTGATGTGGATGAGCCACGAGTATGGAACATGGAGGACTCGTGTGGGGTGTCTTATGTAT GAATGCGTGTATCACTGCATGCCTTACCTGCACACTGATTTTGTGAATGGCCTTGTGCATTTCCTGTGTC CACTAACAGCCAAGTCCGACAGCTGGAAGAACAATTAAGAATAATGGATCAGACCTTGAAAGCATTAATG GCTGCAGAGGATAAGGTACTGATGGCTCGTGTGGTTTTTAGGTTTAACTGCAACCCAGACATCTTTCAGC TTCCAATGCCTCCTGGTTCGTTTGGTATAACGACTGCACCTTCACTTCACCCTCTGCTATTTATATCTTG CCTTAAGTGCTTTCCCTTGGTCCTTTATGCTCCTTTGTTTTCCCTTCATAAATGCTCTTTGGGCAGCCAA AAAAGGAGCCAAATTATCGCACTTCAAAGTTGTTGGATTTGGTCACCCTGCCTTCTGCTGTTGCGAGGTT GGGGGGCAGTGTTCCTGGAAAACCTAAACATTTTAATACCTGATGATTTGGCTACTTTAAGGCAGCCCTT CGTCTCTAGGACTCAGTTTTCATTTTTTCCCATCCCTCTCCTTTTTCTCTCCTCCTTCCTTTGGCTTGTC TCCCACCCTTTCTGCCTCTGATCGAAAACATTAGCAAATGTGCCGAGCTTGAAGAAGAATTGAAAACTGT GACGAACAACTTGAAGTCACTGGAGGCTCAGGCTGAGAAGGTAGGCCAGGAGGATGGTGTGGGGGAAAGG CATCTTTTAAGAGCTGCTCAAAAGAGGCCCTGCCAGAAAGCAACACTTACAGTAGACATTTTAGTAAAAT GGCAATATTGTGAGGTGATTTTTGGAGAGTTACTAGATAACAAATTCTTTTTTTTAACTAGAGAATTTAT TTTATGTTAGGGATATGAGGCATCAATTTAATTTAAACCAAGTGCCAAGTGGATAAGTTATCTTGTTGTT ATCCCATGTAAAACAATAGGCAAGAAAGCAGAGAATGTATTGCAGTGTGCCATTTGATATCAGAGGTTCC ATTACCTCCTAAGAGATCCTTAACATCTGTTGGCTGAGCTGGCGAGTTCTTTGCATGAGAAGCCATGAGT AGATTGAGCTGCAGCCTGACATCTGGAATGCTCTTTCTAATTACAGTACTCGCAGAAGGAAGACAGATAT GAGGAAGAGATCAAGGTCCTTTCCGACAAGCTGAAGGAGGTAATATGAGAGTTGTGGATGAAGCCAACTG GATTTTAAATGAGTTTGTTTTCATGGAACCGGTCAGGGCCTTTTCATTTTAAAGTTCCAATGATCCAAGT CAGGAATATTCAAAGGTCGCCTTGGAGTTTATGTACTGTGCTAACTGCCATTTCTCACAGAGGTGACTGA AACTGACAAGTAGTTTCTGATCCATTTTATAGGTGATGTGCTTCATTTTCATCCTCTAGTTTTCCCTATG TTTGTAGCTACAGGAAACATAAAACTTCCCAACTTTAACTCAAATAAATCATTACAGGCTGAGACTCGGG CTGAGTTTGCGGAGAGGTCAGTAACTAAATTGGAGAAAAGCATTGATGACTTAGAAGGTAAGATCTTAAG TAGTGTTTTTAGTTTAATCCTTATGGTTGAATACCAACCTGGCAAAACAATTTTCCAATTCAAGGGCATC CACATTGATACGCTCCTTTGCACTTGCACATTCTTCCTGTGTGTCCTCTGGGGTTTTTCTCTGTGGCTCT TGAACTCATGAACCTAAGTCTTCTGCTCACGAGGTGACTAGTTAGCCACCAGCCATAGTGGCAAATGCCA TCCAGCTTGACTTCATGCTCATTACAAGTGTGGCAGGTTTATTTTTCACTGTGAGTGAGGTGCTTATTGG TGAGAATGACTCTAGTATATTTTATATCTTTAGTGTTACTTCCTAATTAAATTGGGAATGATGTGGTGAT TGTGGTCTTGTTTTTAGAAGAACCCATCTTCTTCCAAGTATGAATTCAAAGTAAGGATTTAGGGGTTATT TTAAGTCATATATTATCTTAACAAAATACTTTATATCCTGAAGGAGGAGGGAAAAATTATACTTAAGCAT TTCTTCCCTAAGGCACTTAGGTTTTATTTTAGTAATAACCACTCTATCTCACAGATATCCTAAATGTTGA GCTTTGAAGCTTGTGAAGGATTAGCTGTGAACAAGAAAGAAAAAAGACAAATATCTACATCACAGAAGGG ATTAGAGAAGGAACTAGTGTTTGGTGCAGATAATAACCAAAATAGTGGAGAAGAGAGAATGACAAATGGT TGCAAAATGATCTGCCAAAGTGCAGCAAAGTATGAAACCTGCAGCATTACAAAAACTAAGTTGCAGACTT GCCATATAAAGTGTGGCGCCCATTGCTTTTCAAGCCTCCTGGACCAGTAATAGGCAGCTTGAGTGGGAAG ACCACAGGAGTAGCTTAAATGGCACTAAGAAATCGCTATCCCAGTGGTCTAGTGTGGTCAGGAAGTCAGT GGTTTGAAGGTGGAACCAGATAAGGACTACAGGCTGTAGTCACAAATTGTTCTTCCAAAACACTGCCCTT GCATTTTTTTCCCATTGTTTATAGCTGCAGATGCCTGACTACTCCAGTGTAATTAAAATATAGCTCTGCA AAAGAAAGATGTTCCATTAGCCCCTGCCTCCCCTCACCAGGAGACAGCCTTCTGTGGTTTCGTTTACAAT TTAACATGGTTTACTGATATACCTACCATATTTGTTAGGATTTTCATATTGAGTCTTTTTCATTTTATTT TCTAATGGGTTTTGTTCTCTTTGTTTTTGTTTCAATTTACTTAAAACAAAACGCACGCCTCCTGCATTGG CCACCTGCTGCGGCACCAACCCCTTCATGCATTGCCCTTTTCTTGCTGCTGTGTTGGGATGGTGCGCGCA CCACCCTCACTCACCCTCCATTTCTTGATCACTCTCCATGTTCTTGCACCTCTGCCTTCCACTTCCTGGT CATAGACGAGCTGTACGCTCAGAAACTGAAGTACAAAGCCATCAGCGAGGAGCTGGACCACGCTCTCAAC GATATGACTTCCATGTAAACGTTCATCCACTCTGCCTGCTTACACCCTGCCCTCATGCTAATGTAATAAA CTCACCACCATGCCTTCCTTGCTCCCTAATCTCCATCTTTGCACTCTTGTGTTCACCCTTTTTGTCATAA CCTAGAATAGTCATTGTTTTTTCACTTTCTGCTAATATAAAGGCCAATTAGATTAAGTCTGTCTATACAA ACCATTTTCTTTTCAGAATCCGTTTATTTTGTAAACGCTGAACTAGAGCAGTGAACTAGAATGAGTGACC TTGAGCACTGTCCTTTTGGGAAATTAAGCTAAACTCAAGTAAAACTAGAAGGCCATGCCGTTTGTTGTAC AGGAACTTCTCAAAAAATATCAAAATTTGTTTCCTGAAATTCAACTAAGTACAACATAATCATTTTCGTT AAATATAATTTGAAGGAACCCTTAAAGTGTCAGGTTATTGAGAATCTGAGGATAAGGAAATTGGCATGAT CCAATACAGCTTTAACAGTGGTACTACAAAAGATCATCTCTTTTACTTTTAAGAATTCTAGAGTAGGCCG GGCACAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGCGGATCACGAGGTCAGGAG ATTGAGACCATCCTGGCTAACACGGTGAAACCCTGTCTCTACTAAAAATACAAAAAAAATTAGCCGGGCG TGGTGGTGGATGCCTGTAGTCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATGGCATGAACCCGGGAGGT GGAGCTTGCAGTCAGCCGAGATCGCACCACCGCACTCCAGCCTGGACGACAGAGCGAGACTCTGTCTCAA GAAAAAAAAGAATGGTAGAGTAAAAAGAACCCTCTGCTGAGTAACCAAGCCTTTAATTTTGTGTTTTTAT GAAAGGAATTAAAATACCCACGATAAATATTTACCACAACCTGTGTCAAATAAATGGGAAATTAAACACA GATTGTACAATGTGAGCTTGGGAGTTAATGGCCCAGATTTTACTGTTAGGCAGTAAGAGTTGGAGTAGGT AGTCTTGTTATCATGAGAAGAACCTTGAACAGATACAACTAATTTACATATTACTAACCAAACTTAAACA TTAAACTTTTTCTACTACTTTAAATTCTAACCTGGAATGTTTCAGAGTTCTTCATTCTAATATCACCCTG AATTCCATTGAAGCTGGAAATGTCATTTTCCAAGCCCACCTGTCATTCATTTACCCATGCAGAAAAAATG GTAACTTGAAGAGAGTGGCATGTGCCTGCTGCCTTAGAGGTTATAGAATCCCCACAGTCAACAAAAAAGC CTCTAGAGACATGACTGTTGCCATGGAAACCAGAGAAAATGTGTCTTCTCATCCCTCATTTGTAAATGAG GGGGTGGAGCAGATCATCTGTCTCTAAGGTCTTTTTCAGTGCTAAAATGTGGTGATTCTTTGGGAAAAAC TTTTTGCATCAAGTATGATTAAATATTCTGAAAGACGAGTGTAGCTTAAAATTTTTTTTGTTTTTAAATT CTGTTCATGGGTCTTCTTAAAATGGACCCTTGCCGAAAGGCGGCCTGTGACGGCCTCAGGTGGGAAGATG GATGTCCTTCCAAGGGTGTGGCTGGCAGTGGGGTTTGCATGACTGCTTCTTGTCTGTGTTTCAAGTGCTC TCATCTATTGGTTTGGTTTCCTTTCTTTTTTTTTTTTTTCTCATTGTGCCACTTTTTTTTTCCTCCCACC TTTTTATCTTCACGCAGATAAGTTTCTTTGCTTCACTTCTCCCAAGACTCCCTCGTCGAGCTGGATGTCC CACCTCTCTGAGCTCTGCATTTGTCTATTCTCCAGCTGACCCTGGTTCTCTCTCTTAGCATCCTGCCTTA GAGCCAGGCACACACTGTGCTTTCTATTGTACAGAAGCTCTTCGTTTCAGTGTCAAATAAACACTGTGTA AGCTATTTCTGTTTGCTATTCTTTTTACTTCTTATTTATTGACATTTTAGTTTCAACATTGAATAAAACT ACAAAGCTGCTTCACACATATGAGGGTTAGTGTTTGGCTGCTGCTTTTTCTTTTTAAATACTGAACACTA TACAGAATTATATCAGGAGTTTCTAAAGCAGTAGTTCCTTGTTGAACTTCAAAAAAATACCCAGGCCTGC ATTCCCTCTCAGAGTTCTGATTTTCAAAGGTTAGAATGAGGTCTGGACATCTGGGGGGGTTTTGGGGGAA TTGTGATGGCTCTGCTTTGCAGTCTGGGTCACACAGGGGACATTGCTTGTTGAGAGTTGAAAGGTCTGGC TTGATCAGTGTCTTCCTTTGCTGGAGGTTTAGCTCGGGATGTAGTGACCCCTCTGTGTTGATTATTTCGG TGGCCTTACTTGGGAGGACCTGGCTAACTAATGAAAGGCTCATGATGAATGGTTCTGTAGCTGTCCCATA TTACTAGGAAGTTATACATTGAGAAGGGTGAAAAAGAACTTGGATTCAAACAATGTAAGTTTTGGTTATT GTCGATCATCCTTTTATAGCACAAAGAAAAGTTCAAGCTTTTTTGAAGTATATTCATGACTCAGCCACCT TTATTTTGATCATGAAAATGACATCTTAGGTTTTCTAAATATGATTACTCTGTTTAGTCGTGATTTGTTT TGTGCTTTTTAGCACATACTCTTTGGGAGGGATTGTACATAATCTTTGTGTTCAATGGCTGTGTTTTCAT TTGTGGACATTTTTAAAATATAGCAATGAAAGTTTCTTTTTTTTTTTCCCAAAAAGATAGTTGGTGGAAA TTGTTCAGAAGACAATTGTATTTCATTTGGGCTTCTGTTTTATTTCACAAACAGCAATTAAGTGATTTTT TTAAAAAAATACATTGCAAAAAATAGAACTTTAACTAATATGGACTTTAGTGTTATAATTCCCAACATTT CTCCTTCCTCAACAATCTAGCTATATATTTCTCCTGTTTTTTTTTTAACATGGATGATCTGCATGTTTTG TATATAGTTTTTTTAGCCCGAGAGGGCTGATATACCACCATACTCAAATAAATTTGGACAAACTCAGAAG ATAGTGTCATTCTCACTCTACAGAGACTTCAAAGCATAGAGGAAATACTTTTTTTTAAAGAAAGCTGTGA ATTAAAGTATTTTAGTCATAGTATGGTGGAATTTTAGAATCTGGACAATGTCTCTCCCTTGAGTTTATAA AGACTTCCATGATTTCATGCTTTTCTTTTCTTAAGGCTCCTTGGGCCTGCTTCTGACTATGATTCCTTCC TCATTCTTTTTTAAATTCAGAATAAGAGAAGTGTACCCTTCTCTGAGTAAATCCTGCTTCCTGATGTAGA CAAAATGCCAAGTCTGAAAGTTCTGCTGAGCAGATGTTCATGTAATTCTGGAGGCACATCTGTGTTTTGG AAATCCTTCCAGAGACTTTCGCACTTTCTATAAGTACACTCTACAAGGGGAAGTGGGGCACTAATGGACT GGGAGGGCAGGTCAGGAGTAGCCCAAGGTATGCATGTGCAAGAGGAAAACTTGATAAACTCAAGTTTATC AAGAAATTGTTGATTTCTTGTTCAACTGTTGATTTGAACCAGGCTTCTGGTTCAAAGGGCCAGGCCATAG CTACAGCTGCTCTGGTGGGCCAAACCAAAAGCATCACTGAGTTTGGGCACTTGAAGTTTCAGACAGCTGG GAGTCTCCATAGAACCGGAAGGGAAAACACTTCCAAGGATATGAGCATGTCTTGTCCCTGCCTTTGGGCC ACCCATGCACACCAGCTCCACAGCAGCTGAAGCAGAGCAGATCCAGAGGAGGCTGTCGGAGGGACCACTG TCCTTCCTGCTGAATTCATACTGACCCTCTGGATTCTCCAGATTTTCTCCAAAGTTCTTCCATTCTAGCC TGGCCAAACATTTGGGCTCAGCAAACTGAGACAAGCTCCCCACCCATGGCGACACTTCCTATGTCCATAG TGTGAATGTAGTAATGGGATATATGTCTTGGAACCCCCAAGCATATGTCACGTGCAAAACACCGTGGGAA GCAGTGGGGGTGTGGTAAAGAGATGGGCTGGAAAGGCTCTTTGTCCTCAATAAGCTGGGCATCTGATGGG GAGATAGAGGAGTGAAGCGAGTCCGAACTAATAGGCATGTGTATTTGGAGGCAACAAGGAAGAGAGAACC ATTCTGACTGGGAGCTCCCTGGAGGAGGTAGCGGACGTTTGACTGGGGTTTGGCATATTCAAAAAATGTG GATGAGCAAAGAGGACAGAGCAGCAGATATTCCAAGCGAGAAAACATAACGAGCATAGCATCCTCCCATG TCCTACCATTTATAAGAGAATGTTAATGTGAGAACTGCTCAGTCTCCTGACAGACCCGGGGGCTGCAGGC ACATTTTCCCTAGGGGTAGGTCTGTTAGCTTTTCAAGATCATGAAGTATTTTTAGGTCCAAGTTGTCACC AGCATTCAAAGCCACCGTGCATCCTCCAGCTGTTCCCAGTGCATACCGGGCTCTTGCTTGTCATAGCTTG GATGTCCCCTGGATCATCAGATACAGACTGACTCCTGCACTTGTTTTCCCCCGTAAGCAGATCACGTGTC AGTGTGTAAAATGTATATCACGCTGGTCTTCATGTAGGTGTTGCAAGTTTCGTTCATTTTATACACATCC ATTAGCACCACACATGAATGCCATCCTCTTCAAGAAGTAAGCAGATAGGGCTGGGCGCGGTGGCTCATGC CTGTAATCCCAGCACTTCGGGAGGCTGAGGCGGGCGGATCATGAGGTCAGGAGATTGAGACCATTCTGGC TAACACGGTGAAACCCCATCTCTACTAAAAAAAATACAAAAAAAATTAGCCAGGCGTGGTGGCGGGCGCC TGTAGTCCCAGCTACTAGGGAGGCTGAGGCAGGAGATTGGCATGAACCCGGGAGGTGGAGCTTGCAGTGA GCTGAGATCACGCCACTGCACTCCACGCTGGGGGACAGAGCGAGACTAAGTCTCAAAAAACAAAAAAAGC AAGCAGATAAATTCTAAATCAGTGTTGAGTGGTGACAAGTGCTTGTTCTTTTGCTGTTTGAATGGATAAC ACTATCAAAGCTAGACAGGAGTCAGAATGTGTACCCTGTATTGTGGTGACTGGGGGAAGGACAGAGACTT AATTCCAAATTTCAAAAAATTTCAGTGCAGCAAAAGCAGTAACCCCCAGTTGGTCCTACCTGAGGGGAAA GCCTGCCCTGTGAACGGAGAGGAAAGGGGTTCTGGAAGAGGTGGGCAGCACTGGGCAGGTTGATGTTTCA CTTAAGTTCAACACTGAGCCCTAGCAAGGGGTGGATGTCACGCTGGGCTCGCCTCCAGCCAGGCCTGCAT TCCCAAATCTATTGCCAGAAACCATGTATGGCTCAGCTCACAAAGTGGTTTAGTGAGGTATAAGAGGAAC ATTCACTCTTCTTCCTCCTCTTATCCTGTTGCTCCTCCTCCCCTCCTTTCCTCACCAAGAGAGAAATTCT GACACTTCCTAAGTCTACCAAGCTTTTTAGGGTCTACCCTTCCTGGATACAGGACAGGTGACTATGGGGT AAGAGTAAACTGCTCAGCAAGTGACCAGTTGCTGTCCTGCTTGAGGTCTCTTTGTGTTCTCTATTAACTG CCTCTCACCAAGTCTGCTAACCTGTCTTCCTTCTGCCTCTTTTCTGCTAACCTGCTTGCTGACCTGTACA GATCAACTCTACCAGCAACTTGAGCAAAATCGCCGCCTCACTAATGAACTAAAGCTGGCCCTGAATGAGG ATTAAACTTAAGAGTGAAAAAACTTGGGCTGAATTCTAGGCGTGGAGCCCATGTGCAGAAAATCTAAGAC TGTCCTACCTTCAACTAATAGAGTTGAAAACAGTTGCTTTCTGCAGAAATGCAAATGCAAGGAATTGGCT GAAAGGCTGGCCTTGCCTGCTTGTTTCTCTATATGGCTGGAATAATTACGTTCTCTTTAATCACAAAACA GCTTTTATGGTAGAATACTTATATCAATTCAGCACTGCTCCTTGAAATAGCAGGTCCTCTTGTTTGAACT GATAAATAATGAGGAGCCCCCCCAAAAAATGTTTTCTATTTCCTGACAGCCATGAGTCCTACTTTAAGTA TGTATATATATATATATATGTGTGTGTGTGTGTGTGTGTATATATTCCTATCAGATACTCATATTCCTAA CTTCTAAATATCTGGTATAGTGTTTGAAATATGATTAAATGTACCTATGCTTGGGCAAAATAGCTTTTGA AAACAGGAACTCATGCCAGAAGCCCCTGGTTGTCTGAAAGGTATGCTTTACTCAGTCTAATGGTGCTGTT GGAGTCTGGGGAGAATGTCATGCTAATAAATAGAACACTATAAAAATATTAAGAGAATGTCCTAATGAAG TGTGCATGAAACATGTTGACAATTTTTTATGAGCAACAGAAATAAATCATTTTAAAAGTTCTCAGAAAAC CTATTTATGTCATCTTTGCTTTTGTGAGTTTGTGTTACCGCACAACTCCCAGACTTTTAACTGCCTGTAC CTTGGAAATGTCTGCTGTTCGTAACTTCTTCAGTTTGTATAACAGTGCTGCAGCTGTATTTGGTTTTTAC CTCTCCCTGTTCCCACGGCACACCGTCAGTGAACCTTCACCAAACCCCACGTGCATTTTATCCTCAGTGA ATTGTTGGTGGAGGTGCACCTGACTGCTCTGTGAGAATCCGTGCCATGGCTCCTTTGGGTCAAAGATGCC CTCCCCTCCGTCTTAGGTTCTTGTCTAGAAATGAGTAATGTCTTACAAGCATGCCTAGTTCTAATCATCT CATCCTGTGTTTGTGATTGATGTTTGCCTGCCTAAATGTACAAACCACCATTGTGTCCAAAGCACAGCTA TTCATGACTTAATTTTCTAATCTCACCACAGAGAAAGTGGCTCATGCCAAAGAAGAAAACCTTAGTATGC ATCAGATGCTGGATCAGACTTTACTGGAGTTAAACAACATGTGAAAACCTCCTTAGCTGCGACCACATTC TTTCGTTTTGTTTTGTTTTGTTTTTAAACACCTGCTTACCCCTTAAATGCAATTTATTTACTTTTACCAC TGTCACAGAAACATCCACAAGATACCAGCTAGGTCAGGGGGTGGGGAAAACACATACAAAAAGGCAAGCC CATGTCAGGGCGATCCTGGTTCAAATGTGCCATTTCCCGGGTTGATGCTGCCACACTTTGTAGAGAGTTT AGCAACACAGTGTGCTTAGTCAGCGTAGGAATCCTCACTAAAGCAGAAGAAGTTCCATTCAAAGTGCCAA TGATAGAGTCAACAGGAAGGTTAATGTTGGAAACACAATCAGGTGTGGATTGGTGCTACTTTGAACAAAA GGTCCCCCTGTGGTCTTTTGTTCAACATTGTACAATGTAGAACTCTGTCCAACACTAATTTATTTTGTCT TGAGTTTTACTACAAGATGAGACTATGGATCCCGCATGCCTGAATTCACTAAAGCCAAGGGTCTGTAAGC CACGCTGCTCTTCCGAGACTTCCATTCCTTTCTGATTGGCACACGTGCAGCTCATGACAATCTGTAGGAT AACAATCAGTGTGGATTTCCACTCTTTTCAGTCCTTCATGTTAAAGATTTAGACACCACATACAACTGGT AAAGGACGTTTTCTTGAGAGTTTTAACTATATGTAAACATTGTATAATGATATGGAATAAAATGCACATT GTAGGACATTTTCTAAA Download Select all
Length	29277
OMIM ID	191010
HGNC ID	HGNC:12010
Unigene ID	Hs.133892
Ensembl ID	ENSG00000140416
PharmGKB ID	-

mRNA Information

mRNA ID	NM_001018020.1
Exon	join(1..305,1068..1193,14347..14480,16925..17042, 18231..18301,18560..18635,19577..19639,19938..20007, 28452..29277)
mRNA Sequence	>7168 GGAAGGGGGGCAGGAGAAAAAAGCTTTTCCAAAAAAGTATTGGCTGTCTTGAGGAATGCGGTCG CCCCCTTGGGAAAGTACATATCTGGGAGAAGCAGGCGGCTCCGCGCTCGCACTCCCGCTCCTCC GCCCGACCGCGCGCTCGCCCCGCCGCTCCTGCTGCAGCCCCAGGGCCCCTCGCCGCCGCCACCA TGGACGCCATCAAGAAGAAGATGCAGATGCTGAAGCTCGACAAGGAGAACGCCTTGGATCGAGC TGAGCAGGCGGAGGCCGACAAGAAGGCGGCGGAAGACAGGAGCAAGCAGCTCGAGGAGGACATC GCGGCCAAGGAGAAGTTGCTGCGGGTGTCGGAGGACGAGCGGGACCGGGTGCTGGAGGAGCTGC ACAAGGCGGAGGACAGCCTCCTGGCCGCCGAAGAGGCCGCCGCCAAGGCTGAAGCCGACGTAGC TTCTCTGAACAGACGCATCCAGCTGGTTGAGGAAGAGTTGGATCGTGCCCAGGAGCGTCTGGCA ACAGCTTTGCAGAAGCTGGAGGAAGCTGAGAAGGCAGCAGATGAGAGTGAGAGAGGCATGAAAG TCATTGAGAGTCGAGCCCAAAAAGATGAAGAAAAAATGGAAATTCAGGAGATCCAACTGAAAGA GGCCAAGCACATTGCTGAAGATGCCGACCGCAAATATGAAGAGGTGGCCCGTAAGCTGGTCATC ATTGAGAGCGACCTGGAACGTGCAGAGGAGCGGGCTGAGCTCTCAGAAGGCCAAGTCCGACAGC TGGAAGAACAATTAAGAATAATGGATCAGACCTTGAAAGCATTAATGGCTGCAGAGGATAAGTA CTCGCAGAAGGAAGACAGATATGAGGAAGAGATCAAGGTCCTTTCCGACAAGCTGAAGGAGGCT GAGACTCGGGCTGAGTTTGCGGAGAGGTCAGTAACTAAATTGGAGAAAAGCATTGATGACTTAG AAGAGAAAGTGGCTCATGCCAAAGAAGAAAACCTTAGTATGCATCAGATGCTGGATCAGACTTT ACTGGAGTTAAACAACATGTGAAAACCTCCTTAGCTGCGACCACATTCTTTCGTTTTGTTTTGT TTTGTTTTTAAACACCTGCTTACCCCTTAAATGCAATTTATTTACTTTTACCACTGTCACAGAA ACATCCACAAGATACCAGCTAGGTCAGGGGGTGGGGAAAACACATACAAAAAGGCAAGCCCATG TCAGGGCGATCCTGGTTCAAATGTGCCATTTCCCGGGTTGATGCTGCCACACTTTGTAGAGAGT TTAGCAACACAGTGTGCTTAGTCAGCGTAGGAATCCTCACTAAAGCAGAAGAAGTTCCATTCAA AGTGCCAATGATAGAGTCAACAGGAAGGTTAATGTTGGAAACACAATCAGGTGTGGATTGGTGC TACTTTGAACAAAAGGTCCCCCTGTGGTCTTTTGTTCAACATTGTACAATGTAGAACTCTGTCC AACACTAATTTATTTTGTCTTGAGTTTTACTACAAGATGAGACTATGGATCCCGCATGCCTGAA TTCACTAAAGCCAAGGGTCTGTAAGCCACGCTGCTCTTCCGAGACTTCCATTCCTTTCTGATTG GCACACGTGCAGCTCATGACAATCTGTAGGATAACAATCAGTGTGGATTTCCACTCTTTTCAGT CCTTCATGTTAAAGATTTAGACACCACATACAACTGGTAAAGGACGTTTTCTTGAGAGTTTTAA CTATATGTAAACATTGTATAATGATATGGAATAAAATGCACATTGTAGGACATTTTCTAAAAAA AAAAA Download Select all
Length	1797

CDS Information

Location	join(192..305,1068..1193,1389..1514,14347..14480, 16925..17042,18231..18301,19075..19150,19577..19639, 19938..20007,28452..28534)
CDS Sequence	>lcl\|NM_001018020.1_cds_NP_001018020.1_1 [gene=TPM1] [protein=tropomyosin alpha-1 chain isoform Tpm1.3sm] [protein_id=NP_001018020.1] [location=192..1046] ATGGACGCCATCAAGAAGAAGATGCAGATGCTGAAGCTCGACAAGGAGAACGCCTTGGATCGAGCTGAGC AGGCGGAGGCCGACAAGAAGGCGGCGGAAGACAGGAGCAAGCAGCTCGAGGAGGACATCGCGGCCAAGGA GAAGTTGCTGCGGGTGTCGGAGGACGAGCGGGACCGGGTGCTGGAGGAGCTGCACAAGGCGGAGGACAGC CTCCTGGCCGCCGAAGAGGCCGCCGCCAAGGCTGAAGCCGACGTAGCTTCTCTGAACAGACGCATCCAGC TGGTTGAGGAAGAGTTGGATCGTGCCCAGGAGCGTCTGGCAACAGCTTTGCAGAAGCTGGAGGAAGCTGA GAAGGCAGCAGATGAGAGTGAGAGAGGCATGAAAGTCATTGAGAGTCGAGCCCAAAAAGATGAAGAAAAA ATGGAAATTCAGGAGATCCAACTGAAAGAGGCCAAGCACATTGCTGAAGATGCCGACCGCAAATATGAAG AGGTGGCCCGTAAGCTGGTCATCATTGAGAGCGACCTGGAACGTGCAGAGGAGCGGGCTGAGCTCTCAGA AGGCCAAGTCCGACAGCTGGAAGAACAATTAAGAATAATGGATCAGACCTTGAAAGCATTAATGGCTGCA GAGGATAAGTACTCGCAGAAGGAAGACAGATATGAGGAAGAGATCAAGGTCCTTTCCGACAAGCTGAAGG AGGCTGAGACTCGGGCTGAGTTTGCGGAGAGGTCAGTAACTAAATTGGAGAAAAGCATTGATGACTTAGA AGAGAAAGTGGCTCATGCCAAAGAAGAAAACCTTAGTATGCATCAGATGCTGGATCAGACTTTACTGGAG TTAAACAACATGTGA Download Select all
CCDS ID	-

Protein Information

Protein ID	XP_005254694.1
Protein Name	Tropomyosin 1 (alpha)
Molecular Wt. (Da)	37322
Protein Sequence	>7168 MDAIKKKMQMLKLDKENALDRAEQAEADKKAAEDRSKQLEEDIAAKEKLLRVSEDERDRVLEEL HKAEDSLLAAEEAAAKLEDELVSLQKKLKGTEDELDKYSEALKDAQEKLELAEKKATDAEADVA SLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKE AKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGKCAELEEELKTVTNNLKSLEAQAEKY SQKEDRYEEEIKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEEKVAHAKEENLSMHQMLDQTL LELNNM Download Select all
Length	326
Uniprot ID	Q12882
Ensembl Protein ID	ENSP00000307107

Post-translational Modification Information (Source : HPRD)

Residue	Type	site
M	Acetylation	1
S	Phosphorylation	283
M	Acetylation	1
M	Acetylation	1
M	Acetylation	1
M	Acetylation	1
M	Acetylation	1
M	Acetylation	1
S	Phosphorylation	252
S	Phosphorylation	252
S	Phosphorylation	252
S	Phosphorylation	252
K	Acetylation	112
K	Acetylation	112
K	Acetylation	112
K	Acetylation	112
K	Acetylation	112
K	Acetylation	76
K	Acetylation	112
K	Acetylation	213
K	Acetylation	213
K	Acetylation	213
K	Acetylation	12
K	Acetylation	12
K	Acetylation	12
K	Acetylation	12
K	Acetylation	12
K	Acetylation	12
S	Phosphorylation	229
S	Phosphorylation	229
S	Phosphorylation	229
S	Phosphorylation	51

Enzyme Information

No matching records could be found.

PPi Information

No STRING Network could be found.

Interactant Gene ID (Source: HPRD)	Gene Symbol	HPRD ID	Ref Seq ID	Technique	References
60	ACTB	32	NP_001092.1	in vivo	9108196
2035	EPB41	558	AAD42222.1	in vitro	11071908
3725	JUN	1302	NP_002219.1	in vivo;yeast 2-hybrid	1631061
5311	PKD2	1437	NP_000288.1	in vitro;in vivo;yeast 2-hybrid	12527301
6273	S100A2	1508	NP_005969.1	in vitro;in vivo	9092943
79036	C19orf50	14526	NP_076974.1	yeast 2-hybrid	16189514

Pathway Information

Pathway Name	Pathway ID
Adrenergic signaling in cardiomyocytes	hsa04261
Cardiac muscle contraction	hsa04260
Dilated cardiomyopathy	hsa05414
Hypertrophic cardiomyopathy (HCM)	hsa05410
MicroRNAs in cancer	hsa05206

Structure Information

No matching records could be found.

Domain Information

ID	Location	Description
pfam12718	7-153	Tropomyosin_1
cl22857	7-153	Tropomyosin_1 superfamily
pfam00261	48-284	Tropomyosin
TIGR02168	37-284	SMC_prok_B
COG1196	21-275	Smc
TIGR02168	11-260	SMC_prok_B
COG1196	1-284	Smc
TIGR02168	4-283	SMC_prok_B
TIGR02169	34-276	SMC_prok_A
TIGR02168	6-256	SMC_prok_B
COG1196	3-262	Smc
PRK02224	2-258	PRK02224
TIGR02168	18-260	SMC_prok_B
TIGR02168	70-284	SMC_prok_B
COG4372	43-258	COG4372
COG1196	1-259	Smc
PRK05771	23-261	PRK05771
COG1196	1-240	Smc
COG1269	6-278	NtpI
TIGR02169	20-246	SMC_prok_A
TIGR02169	2-284	SMC_prok_A
TIGR02168	47-284	SMC_prok_B
TIGR02168	1-239	SMC_prok_B
COG1196	1-260	Smc
TIGR02168	2-270	SMC_prok_B
COG1196	20-275	Smc
COG1196	26-280	Smc
TIGR02169	1-260	SMC_prok_A
COG1196	79-275	Smc
TIGR02169	4-259	SMC_prok_A
PTZ00121	5-258	PTZ00121
COG3206	18-223	GumC
COG1196	89-275	Smc
COG1269	13-284	NtpI
PRK02224	52-260	PRK02224
TIGR02169	19-277	SMC_prok_A
COG1196	4-218	Smc
TIGR03007	21-223	pepcterm_ChnLen
PRK10929	23-233	PRK10929
PTZ00121	6-269	PTZ00121
PTZ00121	5-269	PTZ00121
PTZ00121	14-226	PTZ00121
COG1196	54-277	Smc
TIGR03319	15-165	RNase_Y
pfam04156	23-133	IncA
PTZ00121	1-277	PTZ00121
COG1196	2-201	Smc
COG1566	11-117	EmrA
TIGR00998	1-155	8a0101
PRK02224	13-275	PRK02224
TIGR02169	2-200	SMC_prok_A
PRK02224	15-213	PRK02224
COG4942	28-262	EnvC
PTZ00121	2-259	PTZ00121
TIGR02680	18-197	TIGR02680
COG4372	23-216	COG4372
TIGR02169	82-274	SMC_prok_A
PTZ00121	2-273	PTZ00121
PTZ00121	5-244	PTZ00121
PTZ00121	15-252	PTZ00121
COG4913	56-260	COG4913
COG0419	2-251	SbcC
pfam12128	2-263	DUF3584
PRK04863	15-260	mukB
TIGR02680	82-263	TIGR02680
PRK09039	46-199	PRK09039
TIGR02168	102-275	SMC_prok_B
TIGR04320	2-100	Surf_Exclu_PgrA
PTZ00121	2-258	PTZ00121
TIGR02168	1-184	SMC_prok_B
TIGR04320	14-121	Surf_Exclu_PgrA
TIGR00606	33-284	rad50
COG1196	83-280	Smc
TIGR01845	16-112	outer_NodT
pfam04111	43-144	APG6
pfam13166	33-260	AAA_13
PRK10929	73-264	PRK10929
PRK04863	27-152	mukB
TIGR02169	59-276	SMC_prok_A
pfam01496	35-260	V_ATPase_I
pfam05262	58-219	Borrelia_P83
TIGR02169	14-259	SMC_prok_A
pfam12128	21-275	DUF3584
PRK11448	144-239	hsdR
pfam12128	2-284	DUF3584
COG0419	1-260	SbcC
pfam12128	11-262	DUF3584
TIGR04211	14-142	SH3_and_anchor
PRK00409	90-238	PRK00409
pfam09726	2-260	Macoilin
PRK12704	29-171	PRK12704
PHA02562	10-234	46
TIGR02169	2-149	SMC_prok_A

Ontology Information

HPRD ID	512
Molecular Class	Cytoskeletal associated protein
Molecular Function	Cell adhesion molecule activity (GO:0005194)
Biological Process	Cell growth and/or maintenance (GO:0008151)

SNP Information

View SNP Geneview Report

Drug Information

No matching records could be found.

External Links

ArrayExpress GO
ICGC GO
Cancer3D GO
COSMIC GO
NCG GO
TSGene GO
Tumor Gene Family of Databases GO
CCDB GO
G2SBC GO
Osteosarcoma Database GO
RCDB GO

ArrayExpress	GO
ICGC	GO
Cancer3D	GO
COSMIC	GO
NCG	GO
TSGene	GO
Tumor Gene Family of Databases	GO
CCDB	GO
G2SBC	GO
Osteosarcoma Database	GO
RCDB	GO