Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| TPX2 | 22974 | TPX2, microtubule-associated | 20 | p100, DIL-2 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24341487 | 2013 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 203 CRC including 24 stage I, 81 stage II, 80 stage III, and 18 stage IV Stage : TNM Stage I-IV | Tissue microarray construction and immunohistochemistry | Up-regulation | - | TPX2 plays an important role in promoting tumorigenesis and metastasis of human colon cancer, and may represent a novel prognostic biomarker and therapeutic target for the disease. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | - | Chromosome | 20 |
| Location | 20q11.2 |
| Start | 30326904 |
| End | 30389605 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 62702 |
| OMIM ID | 605917 |
| HGNC ID | HGNC:1249 |
| Unigene ID | Hs.244580 |
| Ensembl ID | ENSG00000088325 |
| PharmGKB ID | PA25638 |
Protein Information
| Protein ID | NP_036244.2 |
|---|---|
| Protein Name | TPX2, microtubule-associated |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 747 |
| Uniprot ID | Q9UKD2 |
| Ensembl Protein ID | ENSP00000364320 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 738 |
| T | Phosphorylation | 51 |
| T | Phosphorylation | 72 |
| S | Phosphorylation | 125 |
| T | Phosphorylation | 147 |
| S | Phosphorylation | 186 |
| S | Phosphorylation | 293 |
| T | Phosphorylation | 338 |
| S | Phosphorylation | 359 |
| T | Phosphorylation | 369 |
| S | Phosphorylation | 486 |
| S | Phosphorylation | 652 |
| S | Phosphorylation | 654 |
| S | Phosphorylation | 121 |
| T | Phosphorylation | 374 |
| S | Phosphorylation | 542 |
| S | Phosphorylation | 738;- |
| S | Phosphorylation | 634;- |
| T | Phosphorylation | 59 |
| S | Phosphorylation | 257 |
| S | Phosphorylation | 310 |
| S | Phosphorylation | 358 |
| T | Phosphorylation | 361 |
| S | Phosphorylation | 185 |
| T | Phosphorylation | 179 |
| S | Phosphorylation | 94 |
| S | Phosphorylation | 20 |
| S | Phosphorylation | 21 |
| S | Phosphorylation | 33 |
| T | Phosphorylation | 28 |
| S | Phosphorylation | 209 |
| S | Phosphorylation | 250 |
| S | Phosphorylation | 218 |
| T | Phosphorylation | 113 |
| K | Acetylation | 305 |
| T | Phosphorylation | 499 |
| T | Phosphorylation | 386 |
| T | Phosphorylation | 210 |
| S | Phosphorylation | 292 |
| S | Phosphorylation | 646 |
| S | Phosphorylation | 742 |
| T | Phosphorylation | 743 |
| T | Phosphorylation | 316 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 6790 | AURKA | 4066 | NP_003591.2 | in vitro;in vivo | 1 217 704 514 580 330 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam12214 | 360-542 | TPX2_importin |
| cl13625 | 360-542 | TPX2_importin superfamily |
| pfam09041 | Jan-68 | Aurora-A_bind |
| cl07598 | Jan-68 | Aurora-A_bind superfamily |
| pfam06886 | 662-718 | TPX2 |
| cl06100 | 662-718 | TPX2 superfamily |
Ontology Information
| HPRD ID | 6621 |
|---|---|
| Molecular Class | Cell cycle control protein |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Biological_process unknown (GO:0000004) |
Drug Information
No matching records could be found.