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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 0 | 0 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | - | Mutation | - | Selective induction of TRAF1 in human colon cancer cells through a Ca(2+)-dependent PKC/Raf-1/ERK/NF-kappaB-dependent pathway. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The protein encoded by this gene is a member of the TNF receptor (TNFR) associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from various receptors of the TNFR superfamily. This protein and TRAF2 form a heterodimeric complex, which is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF2 also interacts with inhibitor-of-apoptosis proteins (IAPs), and thus mediates the anti-apoptotic signals from TNF receptors. The expression of this protein can be induced by Epstein-Barr virus (EBV). EBV infection membrane protein 1 (LMP1) is found to interact with this and other TRAF proteins; this interaction is thought to link LMP1-mediated B lymphocyte transformation to the signal transduction from TNFR family receptors. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2010] | Chromosome | 9 |
| Location | 9q33-q34 |
| Start | 123664671 |
| End | 123691451 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 26781 |
| OMIM ID | 601711 |
| HGNC ID | HGNC:12031 |
| Unigene ID | Hs.531251 |
| Ensembl ID | ENSG00000056558 |
| PharmGKB ID | PA36708 |
mRNA Information
| mRNA ID | ?NM_001190945.1 |
|---|---|
| Exon | join(1..60,2486..2624,2873..3238,5382..5469,14874..14939, 15436..15846,17661..17838,19796..19944,23936..26781) | mRNA Sequence | Download Select all |
| Length | 4303 |
Protein Information
| Protein ID | NP_001177874.1 |
|---|---|
| Protein Name | TNF receptor-associated factor 1 |
| Molecular Wt. (Da) | 46033 |
| Protein Sequence | Download Select all |
| Length | 416 |
| Uniprot ID | Q9Y238 |
| Ensembl Protein ID | ENSP00000308597 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| D | Proteolytic Cleavage | 163 |
| D | Proteolytic Cleavage | 163 |
| D | Proteolytic Cleavage | 163 |
| S | Phosphorylation | 66 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 608 | TNFRSF17 | 144 | NP_001183.2 | in vivo | 10903733 |
| 943 | TNFRSF8 | 1074 | NP_001234.2 | in vivo | 862 718 091 688 968 000 000 |
| 958 | CD40 | 178 | NP_001241.1 | in vitro;in vivo | 104 118 887 527 023 |
| 7128 | TNFAIP3 | 1857 | NP_006281.1 | in vivo;yeast 2-hybrid | 8692885 |
| 7132 | TNFRSF1A | 1861 | NP_001056.1 | in vivo | 8565075 |
| 7133 | TNFRSF1B | 1862 | NP_001057.1 | in vitro;in vivo;yeast 2-hybrid | 8069916 |
| 7186 | TRAF2 | 3538 | NP_066961.2 | in vivo;yeast 2-hybrid | 1 474 321 680 699 160 000 000 |
| 8328 | GFI1B | 5088 | NP_004179.3 | yeast 2-hybrid | 16713569 |
| 10758 | TRAF3IP2 | 6129 | NP_671733.1 | in vitro;in vivo | 12089335 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Epstein-Barr virus infection | hsa05169 |
| Herpes simplex infection | hsa05168 |
| NF-kappa B signaling pathway | hsa04064 |
| Pathways in cancer | hsa05200 |
| Small cell lung cancer | hsa05222 |
| TNF signaling pathway | hsa04668 |
| Transcriptional misregulation in cancer | hsa05202 |
| Viral carcinogenesis | hsa05203 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd03779 | 267-413 | MATH_TRAF1 |
| cl02446 | 267-413 | MATH superfamily |
| cd03778 | 249-413 | MATH_TRAF2 |
| cd00270 | 267-413 | MATH_TRAF_C |
| cd03777 | 229-415 | MATH_TRAF3 |
| cd03780 | 267-413 | MATH_TRAF5 |
| cd03781 | 267-413 | MATH_TRAF4 |
| cd03776 | 267-412 | MATH_TRAF6 |
| pfam00917 | 273-414 | MATH |
| cd00121 | 267-413 | MATH |
| smart00061 | 269-388 | MATH |
| cd03771 | 268-370 | MATH_Meprin |
| cd03783 | 268-370 | MATH_Meprin_Alpha |
| TIGR02168 | 170-264 | SMC_prok_B |
| COG1196 | 140-263 | Smc |
| TIGR02168 | 107-257 | SMC_prok_B |
Ontology Information
| HPRD ID | 4868 |
|---|---|
| Molecular Class | Adapter molecule |
| Molecular Function | Growth factor activity (GO:0008083) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.