Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| TRIB3 | 57761 | tribbles pseudokinase 3 | 20 | dJ1103G7.3, TRB3 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 19904274 | 2009 | Cell line : Caco2, DLD 1, LoVo, HCT116, HT 29, KM12SM, SW480 Source : Kyusyu University and Osaka University Sample Type : CRC tumor and normal tissue No. of Sample : 202 Stage : - | real time RT-PCR,Immunohistochemistry ,Proliferation assay | Up-regulation | - | TRIB3 as a marker for predicting the prognosis of CRC patients, showing a basis for the development of effective treatments for CRC. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The protein encoded by this gene is a putative protein kinase that is induced by the transcription factor NF-kappaB. The encoded protein is a negative regulator of NF-kappaB and can also sensitize cells to TNF- and TRAIL-induced apoptosis. In addition, this protein can negatively regulate the cell survival serine-threonine kinase AKT1. Differential promoter usage and alternate splicing result in multiple transcript variants. [provided by RefSeq, Jul 2014] | Chromosome | 20 |
| Location | 20p13-p12. |
| Start | 356447 |
| End | 378203 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 21757 |
| OMIM ID | 607898 |
| HGNC ID | HGNC:16228 |
| Unigene ID | Hs.516826 |
| Ensembl ID | ENSG00000101255 |
| PharmGKB ID | PA25804 |
Protein Information
| Protein ID | NP_001288117.1 |
|---|---|
| Protein Name | tribbles pseudokinase 3 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 358 |
| Uniprot ID | Q9HCS4 |
| Ensembl Protein ID | ENSP00000282111 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 207 | AKT1 | 1261 | NP_005154.2 | in vitro;in vivo | 12791994 |
| 208 | AKT2 | 1262 | AAA36585.1 | in vitro;in vivo | 12791994 |
| 468 | ATF4 | 6817 | NP_001666.2 | in vitro;in vivo;yeast 2-hybrid | 12743605 |
| 1937 | EEF1G | 11745 | NP_001395.1 | yeast 2-hybrid | 16169070 |
| 5970 | RELA | 1241 | NP_068810.3 | in vitro;in vivo | 12736262 |
| 10980 | COPS6 | 16735 | NP_006824.2 | yeast 2-hybrid | 16169070 |
| 84060 | C7orf64 | 13173 | NP_115496.2 | yeast 2-hybrid | 16169070 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Insulin resistance | hsa04931 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd14024 | 74-315 | PK_TRB3 |
| cl21453 | 74-315 | PKc_like superfamily |
| cd13976 | 74-315 | PK_TRB |
| cd14022 | 74-315 | PK_TRB2 |
| cd14023 | 83-315 | PK_TRB1 |
| cd14003 | 70-314 | STKc_AMPK-like |
| cd05117 | 80-314 | STKc_CAMK |
| cd14081 | 69-315 | STKc_BRSK1_2 |
| cd13974 | 145-310 | STKc_SHIK |
| cd05123 | 131-314 | STKc_AGC |
| cd14663 | 80-314 | STKc_SnRK3 |
| cd14079 | 142-315 | STKc_AMPK_alpha |
| cd14080 | 141-315 | STKc_TSSK-like |
| cd14099 | 141-315 | STKc_PLK |
| cd14078 | 117-315 | STKc_MELK |
| cd14162 | 141-315 | STKc_TSSK4-like |
| cd00180 | 80-313 | PKc |
| cd14007 | 117-316 | STKc_Aurora |
| cd14074 | 113-315 | STKc_SNRK |
| cd14073 | 142-315 | STKc_NUAK |
| cd14008 | 153-315 | STKc_LKB1_CaMKK |
| cd14189 | 78-312 | STKc_PLK3 |
| cd14119 | 117-315 | STKc_LKB1 |
| cd14091 | 83-317 | STKc_RSK_C |
| cd14077 | 93-315 | STKc_Kin1_2 |
| cd14092 | 124-341 | STKc_MSK_C |
| cd14166 | 142-315 | STKc_CaMKI_gamma |
| cd14075 | 141-315 | STKc_NIM1 |
| cd14662 | 117-314 | STKc_SnRK2 |
| cd05579 | 132-315 | STKc_MAST_like |
| cd14165 | 142-315 | STKc_TSSK1_2-like |
| cd05580 | 142-316 | STKc_PKA_like |
| cd14665 | 117-314 | STKc_SnRK2-3 |
| cd14095 | 131-314 | STKc_DCKL |
| cd14009 | 142-314 | STKc_ATG1_ULK_like |
| cd14161 | 117-315 | STKc_NUAK2 |
| cd14086 | 84-317 | STKc_CaMKII |
| cd13994 | 140-315 | STKc_HAL4_like |
| cd14169 | 72-318 | STKc_CaMKI_beta |
| cd14084 | 142-315 | STKc_Chk2 |
| cd14118 | 156-314 | STKc_CAMKK |
| cd08215 | 142-313 | STKc_Nek |
| cd14186 | 141-315 | STKc_PLK4 |
| cd14005 | 143-315 | STKc_PIM |
| cd14168 | 72-318 | STKc_CaMKI_delta |
| cd14071 | 117-315 | STKc_SIK |
| cd14089 | 80-314 | STKc_MAPKAPK |
| cd05581 | 141-319 | STKc_PDK1 |
| cd14179 | 142-341 | STKc_MSK1_C |
| cd14098 | 142-314 | STKc_Rad53_Cds1 |
| cd14083 | 156-314 | STKc_CaMKI |
| cd14175 | 84-321 | STKc_RSK1_C |
| cd14070 | 142-315 | STKc_HUNK |
| cd14014 | 142-311 | STKc_PknB_like |
| cd14178 | 84-315 | STKc_RSK3_C |
| cd14094 | 117-331 | STKc_CASK |
| cd14093 | 89-315 | STKc_PhKG |
| cd14164 | 71-315 | STKc_TSSK6-like |
| cd14200 | 148-315 | STKc_CaMKK1 |
| cd14167 | 156-315 | STKc_CaMKI_alpha |
| cd14076 | 117-315 | STKc_Kin4 |
| cd14069 | 154-315 | STKc_Chk1 |
| cd14174 | 90-316 | STKc_Mnk1 |
| cd14172 | 80-315 | STKc_MAPKAPK3 |
| cd14096 | 150-315 | STKc_RCK1-like |
| cd14004 | 131-315 | STKc_PASK |
| cd14106 | 142-315 | STKc_DRAK |
| cd14072 | 85-315 | STKc_MARK |
| cd14188 | 113-312 | STKc_PLK2 |
| cd14121 | 142-314 | STKc_ULK3 |
| cd14090 | 90-314 | STKc_Mnk |
| cd14185 | 142-314 | STKc_DCKL3 |
| cd06632 | 80-315 | STKc_MEKK1_plant |
| cd14087 | 117-315 | STKc_PSKH1 |
| cd05573 | 130-328 | STKc_ROCK_NDR_like |
| cd14209 | 142-316 | STKc_PKA |
| cd14181 | 142-315 | STKc_PhKG2 |
| cd06606 | 142-315 | STKc_MAPKKK |
| cd06623 | 142-317 | PKc_MAPKK_plant_like |
| cd14180 | 142-325 | STKc_MSK2_C |
| cd14173 | 117-315 | STKc_Mnk2 |
| cd14171 | 120-315 | STKc_MAPKAPK5 |
| cd14163 | 117-315 | STKc_TSSK3-like |
| cd14176 | 84-321 | STKc_RSK2_C |
| cd14085 | 140-316 | STKc_CaMKIV |
| cd14097 | 80-315 | STKc_STK33 |
| cd14100 | 143-315 | STKc_PIM1 |
| cd14006 | 83-314 | STKc_MLCK-like |
| cd14170 | 142-331 | STKc_MAPKAPK2 |
| cd14184 | 142-314 | STKc_DCKL2 |
| cd05570 | 130-316 | STKc_PKC |
| cd05584 | 155-325 | STKc_p70S6K |
| cd14088 | 73-315 | STKc_CaMK_like |
| cd14102 | 143-315 | STKc_PIM3 |
| cd05618 | 142-337 | STKc_aPKC_iota |
| cd05616 | 142-304 | STKc_cPKC_beta |
| cd08530 | 142-313 | STKc_CNK2-like |
| cd14183 | 142-318 | STKc_DCKL1 |
| cd14101 | 143-316 | STKc_PIM2 |
| cd08217 | 141-313 | STKc_Nek2 |
| cd14199 | 156-315 | STKc_CaMKK2 |
| cd14010 | 140-314 | STKc_ULK4 |
| cd05590 | 130-317 | STKc_nPKC_eta |
| cd05122 | 142-315 | PKc_STE |
| cd05612 | 80-316 | STKc_PRKX_like |
| cd05587 | 142-316 | STKc_cPKC |
| cd14177 | 84-335 | STKc_RSK4_C |
| cd05611 | 142-316 | STKc_Rim15_like |
| cd08529 | 142-315 | STKc_FA2-like |
| cd05609 | 135-308 | STKc_MAST |
| cd06917 | 80-317 | STKc_NAK1_like |
| cd13997 | 100-313 | PKc_Wee1_like |
| cd13985 | 149-310 | STKc_GAK_like |
| cd05595 | 130-304 | STKc_PKB_beta |
| cd14187 | 147-310 | STKc_PLK1 |
| cd14116 | 133-315 | STKc_Aurora-A |
| cd05577 | 132-316 | STKc_GRK |
| cd05613 | 132-304 | STKc_MSK1_N |
| cd05601 | 130-325 | STKc_CRIK |
| cd05619 | 142-317 | STKc_nPKC_theta |
| cd05572 | 142-314 | STKc_cGK |
| cd14182 | 142-317 | STKc_PhKG1 |
| cd05617 | 142-304 | STKc_aPKC_zeta |
| cd14202 | 142-315 | STKc_ULK1 |
| cd14046 | 162-312 | STKc_EIF2AK4_GCN2_rpt2 |
| cd05571 | 150-316 | STKc_PKB |
| cd14002 | 131-315 | STKc_STK36 |
| cd08218 | 142-315 | STKc_Nek1 |
| cd05614 | 132-316 | STKc_MSK2_N |
| cd05591 | 142-317 | STKc_nPKC_epsilon |
| cd14117 | 142-324 | STKc_Aurora-B_like |
| cd05583 | 132-316 | STKc_MSK_N |
| cd05586 | 153-307 | STKc_Sck1_like |
| cd05582 | 165-306 | STKc_RSK_N |
| cd14201 | 142-315 | STKc_ULK2 |
| cd05588 | 142-317 | STKc_aPKC |
| cd06626 | 150-315 | STKc_MEKK4 |
| cd08219 | 157-310 | STKc_Nek3 |
| cd06629 | 142-315 | STKc_Bck1_like |
| cd05592 | 130-316 | STKc_nPKC_theta_like |
| cd05615 | 142-304 | STKc_cPKC_alpha |
| cd05599 | 142-328 | STKc_NDR_like |
| cd05118 | 131-315 | STKc_CMGC |
| cd14109 | 80-315 | PK_Unc-89_rpt1 |
| cd14105 | 142-315 | STKc_DAPK |
| cd05620 | 130-316 | STKc_nPKC_delta |
| cd14114 | 132-315 | STKc_Twitchin_like |
| cd05621 | 142-353 | STKc_ROCK2 |
| cd06648 | 153-316 | STKc_PAK_II |
| cd05585 | 165-317 | STKc_YPK1_like |
| cd06627 | 142-315 | STKc_Cdc7_like |
| cd08225 | 142-315 | STKc_Nek5 |
| cd14104 | 150-317 | STKc_Titin |
| cd14120 | 142-313 | STKc_ULK1_2-like |
| cd14019 | 141-315 | STKc_Cdc7 |
| cd05597 | 130-328 | STKc_DMPK_like |
| cd08224 | 142-310 | STKc_Nek6_7 |
| cd05576 | 142-306 | STKc_RPK118_like |
| cd08221 | 142-315 | STKc_Nek9 |
| cd06610 | 142-313 | STKc_OSR1_SPAK |
| cd14082 | 141-314 | STKc_PKD |
| cd13987 | 80-314 | STKc_SBK1 |
| cd14115 | 156-314 | STKc_Kalirin_C |
| cd05598 | 132-328 | STKc_LATS |
| cd05610 | 142-325 | STKc_MASTL |
| cd07833 | 165-315 | STKc_CDKL |
| cd14197 | 156-315 | STKc_DRAK1 |
| cd14103 | 156-315 | STKc_MLCK |
| cd05593 | 150-304 | STKc_PKB_gamma |
| cd06605 | 79-317 | PKc_MAPKK |
| cd05622 | 131-353 | STKc_ROCK1 |
| cd14108 | 87-315 | STKc_SPEG_rpt1 |
| cd08222 | 163-315 | STKc_Nek11 |
| cd05594 | 150-304 | STKc_PKB_alpha |
| cd14110 | 57-315 | STKc_obscurin_rpt2 |
| cd07829 | 117-315 | STKc_CDK_like |
| cd05630 | 155-317 | STKc_GRK6 |
| cd06644 | 154-317 | STKc_STK10 |
| cd06631 | 142-315 | STKc_YSK4 |
| cd06659 | 150-321 | STKc_PAK6 |
| cd14194 | 142-315 | STKc_DAPK1 |
| cd14131 | 125-315 | PKc_Mps1 |
| cd05596 | 131-338 | STKc_ROCK |
| cd14107 | 154-315 | STKc_obscurin_rpt1 |
| cd05575 | 147-316 | STKc_SGK |
| cd06622 | 153-318 | PKc_PBS2_like |
| cd08223 | 142-315 | STKc_Nek4 |
| cd06611 | 156-315 | STKc_SLK_like |
| cd14133 | 133-315 | PKc_DYRK_like |
| cd13982 | 155-313 | STKc_IRE1 |
| cd06658 | 153-316 | STKc_PAK5 |
| cd05589 | 174-307 | STKc_PKN |
| cd06609 | 146-317 | STKc_MST3_like |
| cd05624 | 130-309 | STKc_MRCK_beta |
| cd14111 | 225-315 | STKc_SPEG_rpt2 |
| cd06643 | 154-315 | STKc_SLK |
| cd13979 | 142-311 | STKc_Mos |
| cd05604 | 147-306 | STKc_SGK3 |
| cd14198 | 153-315 | STKc_DRAK2 |
| cd07831 | 83-314 | STKc_MOK |
| cd05623 | 142-309 | STKc_MRCK_alpha |
| cd06625 | 164-314 | STKc_MEKK3_like |
| cd06608 | 80-315 | STKc_myosinIII_N_like |
| cd13996 | 80-310 | STKc_EIF2AK |
| cd07845 | 117-324 | STKc_CDK10 |
| cd14048 | 162-312 | STKc_EIF2AK3_PERK |
| cd05606 | 142-324 | STKc_beta_ARK |
| cd05608 | 132-317 | STKc_GRK1 |
| cd05603 | 147-306 | STKc_SGK2 |
| cd07832 | 142-315 | STKc_CCRK |
| cd07830 | 97-315 | STKc_MAK_like |
| cd05625 | 223-348 | STKc_LATS1 |
| cd14113 | 223-315 | STKc_Trio_C |
| cd14012 | 164-313 | PK_eIF2AK_GCN2_rpt1 |
| cd06628 | 142-315 | STKc_Byr2_like |
| cd14036 | 162-310 | STKc_GAK |
| cd05602 | 156-307 | STKc_SGK1 |
| cd05574 | 133-316 | STKc_phototropin_like |
| cd07847 | 141-314 | STKc_CDKL1_4 |
| cd08220 | 154-313 | STKc_Nek8 |
| cd08528 | 146-303 | STKc_Nek10 |
| cd14192 | 147-315 | STKc_MLCK3 |
| cd14196 | 142-315 | STKc_DAPK2 |
| cd13993 | 142-261 | STKc_Pat1_like |
| cd14050 | 152-313 | PKc_Myt1 |
| cd14195 | 142-316 | STKc_DAPK3 |
| cd05578 | 167-315 | STKc_Yank1 |
| cd06637 | 154-319 | STKc_TNIK |
| cd05633 | 142-329 | STKc_GRK3 |
| cd06614 | 153-315 | STKc_PAK |
| cd14190 | 147-315 | STKc_MLCK2 |
| cd14018 | 133-306 | STKc_PINK1 |
| cd06612 | 80-315 | STKc_MST1_2 |
| cd14193 | 131-315 | STKc_MLCK4 |
| cd07840 | 147-314 | STKc_CDK9_like |
| cd05607 | 90-304 | STKc_GRK7 |
| cd14191 | 154-315 | STKc_MLCK1 |
| cd07853 | 101-317 | STKc_NLK |
| cd07837 | 129-314 | STKc_CdkB_plant |
| cd06657 | 153-321 | STKc_PAK4 |
| cd14112 | 90-315 | STKc_Unc-89_rpt2 |
| cd14223 | 142-329 | STKc_GRK2 |
| cd06630 | 224-313 | STKc_MEKK1 |
| cd06619 | 79-317 | PKc_MKK5 |
| cd06642 | 154-315 | STKc_STK25 |
| cd06639 | 114-316 | STKc_myosinIIIB_N |
| cd13986 | 153-312 | STKc_16 |
| cd06641 | 154-331 | STKc_MST3 |
| cd06633 | 152-321 | STKc_TAO3 |
| cd06618 | 147-316 | PKc_MKK7 |
| cd14047 | 158-312 | STKc_EIF2AK2_PKR |
| cd06624 | 225-315 | STKc_ASK |
| cd06656 | 156-316 | STKc_PAK3 |
| cd06655 | 156-316 | STKc_PAK2 |
| cd06640 | 156-315 | STKc_MST4 |
| cd05632 | 156-316 | STKc_GRK5 |
| cd06636 | 80-315 | STKc_MAP4K4_6_N |
| cd05626 | 223-337 | STKc_LATS2 |
| cd06647 | 156-316 | STKc_PAK_I |
| cd08228 | 142-303 | STKc_Nek6 |
| cd07846 | 165-257 | STKc_CDKL2_3 |
| cd06613 | 154-313 | STKc_MAP4K3_like |
| cd06654 | 156-316 | STKc_PAK1 |
| cd14052 | 165-313 | PTKc_Wee1_fungi |
| cd13995 | 80-315 | STKc_MAP3K8 |
| cd07864 | 156-315 | STKc_CDK12 |
| cd14148 | 165-294 | STKc_MLK2 |
| cd06651 | 164-314 | STKc_MEKK3 |
| cd14145 | 224-310 | STKc_MLK1 |
| cd14037 | 149-303 | STKc_NAK_like |
| cd13999 | 141-310 | STKc_MAP3K-like |
| cd14059 | 141-312 | STKc_MAP3K12_13 |
| cd05631 | 156-316 | STKc_GRK4 |
| cd05627 | 142-273 | STKc_NDR2 |
| cd05628 | 142-309 | STKc_NDR1 |
| cd06617 | 153-317 | PKc_MKK3_6 |
| cd05600 | 118-266 | STKc_Sid2p_like |
| cd14063 | 144-266 | PK_KSR |
| cd06653 | 223-314 | STKc_MEKK3_like_u1 |
| cd06638 | 80-315 | STKc_myosinIIIA_N |
| cd13989 | 156-303 | STKc_IKK |
| cd13977 | 142-283 | STKc_PDIK1L |
| cd06607 | 152-317 | STKc_TAO |
| cd13980 | 240-306 | STKc_Vps15 |
| cd05629 | 223-316 | STKc_NDR_like_fungal |
| cd14061 | 224-266 | STKc_MLK |
| cd14038 | 158-275 | STKc_IKK_beta |
| cd05043 | 165-303 | PTK_Ryk |
| cd07857 | 143-315 | STKc_MPK1 |
| cd06621 | 225-315 | PKc_Pek1_like |
| cd13983 | 223-315 | STKc_WNK |
| cd14146 | 149-262 | STKc_MLK4 |
| cd07834 | 143-320 | STKc_MAPK |
| cd07849 | 182-319 | STKc_ERK1_2_like |
| cd13991 | 142-307 | STKc_NIK |
| cd06634 | 152-320 | STKc_TAO2 |
| cd07848 | 133-313 | STKc_CDKL5 |
| cd14147 | 224-262 | STKc_MLK3 |
| cd14057 | 223-303 | PK_ILK |
| cd06620 | 225-306 | PKc_Byr1_like |
| cd06616 | 222-268 | PKc_MKK4 |
| cd05042 | 142-281 | PTKc_Aatyk |
| cd07843 | 143-248 | STKc_CDC2L1 |
| cd06635 | 152-249 | STKc_TAO1 |
| cd07872 | 161-264 | STKc_PCTAIRE2 |
| cd06645 | 142-317 | STKc_MAP4K3 |
| cd14137 | 131-184 | STKc_GSK3 |
| cd13990 | 227-303 | STKc_TLK |
| smart00220 | 80-315 | S_TKc |
| pfam00069 | 80-315 | Pkinase |
| COG0515 | 111-329 | SPS1 |
| PTZ00263 | 142-304 | PTZ00263 |
| PTZ00267 | 142-310 | PTZ00267 |
| PLN00034 | 79-317 | PLN00034 |
| PTZ00283 | 142-313 | PTZ00283 |
| PTZ00426 | 142-315 | PTZ00426 |
| PHA03390 | 132-315 | pk1 |
| PHA03207 | 143-295 | PHA03207 |
| PHA03209 | 117-260 | PHA03209 |
| PLN00009 | 117-316 | PLN00009 |
| PTZ00266 | 153-306 | PTZ00266 |
Ontology Information
| HPRD ID | 6117 |
|---|---|
| Molecular Class | Serine/threonine kinase |
| Molecular Function | Regulator of G-protein signaling activity (GO:0016299) |
| Biological Process | Regulation of cell proliferation (GO:0042127); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.