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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
TRIM24 8805 tripartite motif containing 24  7hTIF1, Tif1a, RNF82, TIF1A 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
25700357   2014Cell line : HCT116

Source : The Type Culture Collection of the Chinese Academy of Sciences (Shanghai, China).

Sample Type : -

No. of Sample : -

Stage : -

Cell proliferation and colony formationassay,flow cytometry ,Western BlottingUp-regulation-TRIM24 functions as an oncogene in colorectal carcinogenesis.


Gene Details



NC_000007.13 (138145079..138270333)

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Gene Type protein coding
Gene Family Tripartite motif containing / Tripartite motif containing, "RING-type (C3HC4) zinc fingers", "Zinc fingers, PHD-type"
Description The protein encoded by this gene mediates transcriptional control by interaction with the activation function 2 (AF2) region of several nuclear receptors, including the estrogen, retinoic acid, and vitamin D3 receptors. The protein localizes to nuclear bodies and is thought to associate with chromatin and heterochromatin-associated factors. The protein is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains - a RING, a B-box type 1 and a B-box type 2 - and a coiled-coil region. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]  
Chromosome 7
Location 7q32-q34
Start 138145079  
End 138270333  
Strand +  
Gene Sequence

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Length 125255  
OMIM ID 603406   
HGNC ID HGNC:11812   
Unigene ID Hs.490287   
Ensembl ID ENSG00000122779   
PharmGKB ID PA36519   

mRNA Information


mRNA ID ?NM_003852.3
Exon  
mRNA Sequence

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Length  



CDS Information


   
Location
CDS Sequence

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CCDS ID CCDS47720.1



Protein Information


      
Protein IDNP_003843.3
Protein Nametripartite motif containing 24
Molecular Wt. (Da)0
Protein Sequence

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Length 1050  
Uniprot IDQ9NQX1
Ensembl Protein ID ENSP00000264808  



Post-translational Modification Information (Source : HPRD)


Residue Type site
KSumoylation689
KSumoylation707
SPhosphorylation1028;-
SPhosphorylation994;-
SPhosphorylation768;-
SPhosphorylation734;-
SPhosphorylation1025;-
SPhosphorylation1019;-
SPhosphorylation985;-
SPhosphorylation991;-
SPhosphorylation811;-
SPhosphorylation777;-
SPhosphorylation660
SPhosphorylation667
SPhosphorylation685
SPhosphorylation626
SPhosphorylation633
SPhosphorylation651
SPhosphorylation773
SPhosphorylation739
SPhosphorylation808
SPhosphorylation774
KAcetylation185
KAcetylation185
SPhosphorylation687
SPhosphorylation653
SPhosphorylation1042
SPhosphorylation1008
TPhosphorylation818
TPhosphorylation784
TPhosphorylation101
SPhosphorylation110
TPhosphorylation101
SPhosphorylation110
SPhosphorylation771
SPhosphorylation737
TPhosphorylation772
TPhosphorylation738

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                                                                                   
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
367AR2437NP_000035.2in vitro9115274   
2099ESR1589NP_000116.2in vitro;in vivo9   115   274   963   267   610   000   000   
2100ESR23390NP_001428.1in vitro10598587   
2908NR3C1679NP_001019265.1in vivo9115274   
2960GTF2E11799NP_005504.2in vitro9632676   
3172HNF4A2612CAA89989.1in vitro9115274   
3303HSPA1A774NP_005336.3in vitro;in vivo12677068   
5371PML23NP_150241.2in vivo10610177   
6256RXRA1577NP_002948.1in vitro;in vivo1   185   139   691   152   740   000   000   
7026NR2F2139NP_066285.1in vitro9115274   
7421VDR3463NP_000367.1in vivo9115274   
7556ZNF101923NP_056209.2yeast 2-hybrid9016654   
10155TRIM283445NP_005753.1in vitro;in vivo12684500   


Pathway Information


No matching records could be found.

Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd05502900-1007  Bromo_tif1_like
cl02556900-1007  Bromodomain superfamily
cd15622828-870  PHD_TIF1alpha
cl22851828-870  PHD_SF superfamily
cd00021221-259  BBOX
cl00034221-259  BBOX superfamily
cd0016255-82  RING
cl1723855-82  RING superfamily
smart00502266-392  BBC
cl17972266-392  BBC superfamily
smart00297902-1004  BROMO
cd04369904-1001  Bromodomain
cd05509904-1004  Bromo_gcn5_like
cd05503904-998  Bromo_BAZ2A_B_like
cd15624828-873  PHD_TIF1gamma
cd05498926-1000  Bromo_Brdt_II_like
cd05506906-999  Bromo_plant1
pfam00439908-992  Bromodomain
cd15625825-873  PHD_TIF1delta
cd05500926-998  Bromo_BDF1_2_I
cd15541828-870  PHD_TIF1_like
cd05499926-1001  Bromo_BDF1_2_II
cd05504902-1007  Bromo_Acf1_like
cd05497915-1004  Bromo_Brdt_I_like
cd05501902-1005  Bromo_SP100C_like
cd05495921-1001  Bromo_cbp_like
cd05510908-1004  Bromo_SPT7_like
cd05529874-1004  Bromo_WDR9_I_like
cd05512924-993  Bromo_brd1_like
cd05515918-986  Bromo_polybromo_V
cd05505904-1001  Bromo_WSTF_like
cd15539829-870  PHD1_AIRE
cd05511921-1002  Bromo_TFIID
cd05518933-1009  Bromo_polybromo_IV
cd15533829-870  PHD1_PHF12
cd05521918-1006  Bromo_Rsc1_2_I
cd05496905-1004  Bromo_WDR9_II
cd15532829-870  PHD2_CHD_II
cd05522918-1000  Bromo_Rsc1_2_II
smart00336218-259  BBOX
cd05519933-999  Bromo_SNF2
pfam00628828-871  PHD
cd05524933-999  Bromo_polybromo_I
cd05528922-991  Bromo_AAA
cd15559829-870  PHD1_BPTF
cd15523829-870  PHD_PHF21A
cd05517920-986  Bromo_polybromo_II
cd05513909-993  Bromo_brd7_like
cd15527829-870  PHD2_KAT6A_6B
cd15531828-870  PHD1_CHD_II
cd05516933-999  Bromo_SNF2L2
smart00249828-870  PHD
cd15623829-870  PHD_TIF1beta
cd15535829-870  PHD1_Rco1
cd05520933-994  Bromo_polybromo_III
cd15657828-871  PHD4_NSD2
cd05507915-989  Bromo_brd8_like
cd15568828-867  PHD5_NSD
cd15626829-870  PHD_SP110_140
cd15658828-870  PHD4_NSD3
cd15489829-870  PHD_SF
pfam00643223-259  zf-B_box
cd05525915-998  Bromo_ASH1
cd15567828-870  PHD4_NSD
cd15628829-870  PHD_BAZ1B
cd15656828-870  PHD4_NSD1
cd15524828-870  PHD_PHF21B
cd05508923-989  Bromo_RACK7
cd15544829-870  PHD_BAZ1A_like
cd15545829-870  PHD_BAZ2A_like
cd15519829-870  PHD1_Lid2p_like
cd15538829-870  PHD_PRKCBP1
cd11726816-871  ADDz_ATRX
cd05491937-983  Bromo_TBP7_like
cd15515829-870  PHD1_KDM5A_like
cd15629829-870  PHD_BAZ2A
cd15661828-867  PHD5_NSD3
smart00336158-194  BBOX
cl00034158-194  BBOX superfamily
cd15499829-870  PHD1_MTF2_PHF19_like
cd15630828-870  PHD_BAZ2B
cd15540829-870  PHD2_AIRE
cd15627829-870  PHD_BAZ1A
cd15659829-867  PHD5_NSD1
cd15603829-870  PHD1_KDM5B
cd15660829-867  PHD5_NSD2
cd15648829-871  PHD1_NSD1_2
cd04718848-909  BAH_plant_2
cl02608848-909  BAH superfamily
cd15543829-870  PHD_RSF1
cd15510829-870  PHD2_KMT2C_like
cd15566829-868  PHD3_NSD
cd15530829-870  PHD2_d4
cd15604829-870  PHD1_KDM5C_5D
cd15602828-870  PHD1_KDM5A
cd05494904-955  Bromodomain_1
smart0018456-82  RING
cd15537828-870  PHD_BS69
cd15502829-870  PHD_Phf1p_Phf2p_like
pfam1463456-82  zf-RING_5
cd15605829-870  PHD1_Lid_like
cd15595829-870  PHD2_KMT2D
cd15594829-870  PHD2_KMT2C
cd15679829-870  PHD_JADE1
cd15578829-870  PHD1_MTF2
cd15513829-870  PHD5_KMT2C_like
cd05492926-990  Bromo_ZMYND11
cd15500829-870  PHD1_PHF1
COG5076885-1022  COG5076
COG5076932-999  COG5076
pfam07223432-565  DUF1421
pfam09770428-564  PAT1
pfam09770429-572  PAT1
pfam13388486-544  DUF4106
pfam09770435-576  PAT1
pfam09770431-549  PAT1
smart00818490-563  Amelogenin
pfam15240424-555  Pro-rich


Ontology Information


   
HPRD ID5595
Molecular ClassTranscription regulatory protein
Molecular FunctionCysteine-type peptidase activity (GO:0008234)
Biological ProcessProtein metabolism (GO:0019538)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO