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General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23762846 | 2013 | Cell line : - Source : Shanghai Zhabei District Shibei Hospital, China. Sample Type : CRC Tumor and normal tissue No. of Sample : 40 Stage : TNM staging I to IV. | Western Blotting,Immunohistochemistry | Up-regulation | - | Increased expression of TRPS1 may be involved in the pathogenesis and progression of colon cancer. TRPS1 might be a potential marker to predict the prognosis in colon cancer. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | GATA zinc finger domain containing, "Zinc fingers, C2H2-type" |
| Description | This gene encodes a transcription factor that represses GATA-regulated genes and binds to a dynein light chain protein. Binding of the encoded protein to the dynein light chain protein affects binding to GATA consensus sequences and suppresses its transcriptional activity. Defects in this gene are a cause of tricho-rhino-phalangeal syndrome (TRPS) types I-III. [provided by RefSeq, Jul 2008] | Chromosome | 8 |
| Location | 8q23.3 |
| Start | 116420724 |
| End | 116713299 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 292576 |
| OMIM ID | 604386 |
| HGNC ID | HGNC:12340 |
| Unigene ID | Hs.657018 |
| Ensembl ID | ENSG00000104447 |
| PharmGKB ID | PA37013 |
mRNA Information
| mRNA ID | ?NM_001282902.2 |
|---|---|
| Exon | join(553..1036,45823..45966,49521..50449,64579..65708, 81977..82580,251129..251251,254497..261085) | mRNA Sequence | Download Select all |
| Length | 10003 |
Protein Information
| Protein ID | NP_001269831.1 |
|---|---|
| Protein Name | trichorhinophalangeal syndrome I |
| Molecular Wt. (Da) | 198279 |
| Protein Sequence | Download Select all |
| Length | 1281 |
| Uniprot ID | Q9Y2W1 |
| Ensembl Protein ID | ENSP00000346634 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 1098;- |
| Y | Phosphorylation | 1093;- |
| S | Phosphorylation | 1094;- |
| S | Phosphorylation | 140;- |
| S | Phosphorylation | 905;- |
| S | Phosphorylation | 191 |
| S | Phosphorylation | 170 |
| S | Phosphorylation | 197 |
| S | Phosphorylation | 1079 |
| S | Phosphorylation | 229 |
| Y | Phosphorylation | 242 |
| T | Phosphorylation | 764 |
| S | Phosphorylation | 1054 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 6047 | RNF4 | 4167 | NP_002929.1 | in vitro;in vivo;yeast 2-hybrid | 12885770 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00202 | 895-951 | ZnF_GATA |
| cl00158 | 895-951 | ZnF_GATA superfamily |
| pfam00320 | 896-930 | GATA |
| smart00401 | 891-934 | ZnF_GATA |
| COG5641 | 872-960 | GAT1 |
Ontology Information
| HPRD ID | 6185 |
|---|---|
| Molecular Class | Transcription factor |
| Molecular Function | RNA binding (GO:0003723) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.