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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
TRPV5 56302 transient receptor potential cation channel, subfamily V, member 5  7CaT2 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
26422106   2015Cell line : -

Source : -

Sample Type : CRC tumor and normal tissue

No. of Sample : 93

Stage : -

 Real-time PCRDown-regulation-TRP gene family like TRPV3, TRPV4, TRPV5, TRPM4 and TRPC6 may be thought as potential genes contributing to tumorigenesis as their expression decreases in CRC as compared to normal tissues.


Gene Details



NC_000007.13 (142605648..142630820, complement)

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Gene Type protein coding
Gene Family Voltage-gated ion channels / Transient receptor potential cation channels, "Ankyrin repeat domain containing"
Description This gene is a member of the transient receptor family and the TrpV subfamily. The calcium-selective channel encoded by this gene has 6 transmembrane-spanning domains, multiple potential phosphorylation sites, an N-linked glycosylation site, and 5 ANK repeats. This protein forms homotetramers or heterotetramers and is activated by a low internal calcium level. [provided by RefSeq, Jul 2008]  
Chromosome 7
Location 7q34
Start 142605648  
End 142630820  
Strand -  
Gene Sequence

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Length 25173  
OMIM ID 606679   
HGNC ID HGNC:3145   
Unigene ID Hs.283369   
Ensembl ID ENSG00000127412   
PharmGKB ID PA35045   

mRNA Information


mRNA ID ?NM_019841.6
Exon  
mRNA Sequence

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Length  



CDS Information


   
Location
CDS Sequence

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CCDS ID CCDS5875.1



Protein Information


      
Protein IDNP_062815.3
Protein Nametransient receptor potential cation channel, subfamily V, member 5
Molecular Wt. (Da)0
Protein Sequence

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Length 729  
Uniprot IDQ9BQA1
Ensembl Protein ID ENSP00000235090  



Post-translational Modification Information (Source : HPRD)


Residue Type site
TPhosphorylation685
SPhosphorylation689

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

No matching records from HPRD source could be found.

Pathway Information


      
Pathway Name Pathway ID
Endocrine and other factor-regulated calcium reabsorption hsa04961


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd0020479-202  ANK
cl0252979-202  ANK superfamily
cd00204161-308  ANK
cl02529161-308  ANK superfamily
cd00204117-260  ANK
cd0020446-183  ANK
pfam00023163-193  Ank
pfam00023117-146  Ank
smart00248117-145  ANK
smart00248163-189  ANK
pfam13606162-191  Ank_3
TIGR008702-705  trp
pfam00520397-578  Ion_trans
pfam12796121-202  Ank_2
pfam1279683-193  Ank_2
pfam1279649-146  Ank_2
PHA0309556-261  PHA03095
PHA0309542-221  PHA03095
COG066617-232  ANKYR
COG0666166-253  ANKYR
pfam1279647-105  Ank_2
PHA0287647-208  PHA02876
PHA03100163-222  PHA03100
PHA0287465-205  PHA02874
PHA02878117-202  PHA02878
PHA03100117-222  PHA03100
pfam13637169-220  Ank_4
PHA0287545-221  PHA02875
PHA03100123-263  PHA03100
PHA0309549-198  PHA03095
pfam1363747-98  Ank_4
PHA0309559-145  PHA03095
PHA02741177-259  PHA02741
PHA02736173-212  PHA02736
pfam13857162-202  Ank_5
pfam1363781-137  Ank_4
PHA02878117-221  PHA02878
PHA0287615-201  PHA02876
pfam1385764-124  Ank_5
PHA02859118-202  PHA02859


Ontology Information


   
HPRD ID6403
Molecular ClassMembrane transport protein
Molecular FunctionProtein-hormone receptor activity (GO:0016500)
Biological ProcessFatty acid metabolism (GO:0006631)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO