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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| TRRAP | 8295 | transformation/transcription domain-associated protein | 7 | TR-AP, PAF400, Tra1 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 20051959 | 2010 | Cell line : SW480, HCT116 Source : Cells obtained from the American Type Culture Collection. Sample Type : - No. of Sample : - Stage : - | q PCR, immunohistochemical analyses,Northern blotting, Flow cytometry. | Up-regulation | - | MRGBP has an important function in proliferation of cancer cells through the regulation of BRD8 and that MRGBP should be a novel therapeutic target for colorectal cancer. |
| 21535316 | 2011 | Cell line : HCT116, HCT 15, SW480, SW620, DLD 1, Caco 2, LS174T, HT 29 Source : Institute of Medical Science, The University of Tokyo, Tokyo, Japan. Sample Type : CRC tumor No. of Sample : 22 Adenoma and 47 CRC Carcinoma Stage : TNM Stage I-IV | Immunohistochemistry,real time RT-PCR | Up-regulation | - | Immunohistochemical staining of 22 adenomas and 47 carcinomas in the colon and rectum showed that high levels of MRGBP expression were observed more frequently in carcinomas (45%) than adenomas (5%), linking its role to malignant properties of colorectal tumors. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a large multidomain protein of the phosphoinositide 3-kinase-related kinases (PIKK) family. The encoded protein is a common component of many histone acetyltransferase (HAT) complexes and plays a role in transcription and DNA repair by recruiting HAT complexes to chromatin. Deregulation of this gene may play a role in several types of cancer including glioblastoma multiforme. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011] | Chromosome | 7 |
| Location | 7q21.2-q22 |
| Start | 98476113 |
| End | 98610866 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 134754 |
| OMIM ID | 603015 |
| HGNC ID | HGNC:12347 |
| Unigene ID | Hs.203952 |
| Ensembl ID | ENSG00000196367 |
| PharmGKB ID | PA37020 |
mRNA Information
| mRNA ID | ?NM_001244580.1 |
|---|---|
| Exon | join(1..148,2601..2761,3486..3535,11846..11956, 13935..14039,15309..15392,17275..17331,19252..19377, 20933..21010,21190..21278,22135..22231,24890..25028, 27688..27766,30239..30473,31567..31930,32021..32118, 32588..32782,33533..33724,37234..37399,38934..39190, 43264..43464,46623..46774,48678..48877,51500..51717, 52144..52341,52916..53176,54752..54913,57090..57186, 58667..58788,59161..59331,64460..64528,67258..67311, 69732..69851,70077..70196,70928..71092,71171..71352, 71575..71773,72387..72515,74678..74944,76609..76815, 77657..77815,77910..78044,79492..79602,80855..81001, 82772..82985,83813..83938,86140..86286,87207..87406, 88552..88673,88996..89209,91623..91802,93310..93456, 97660..97779,97994..98281,98450..98587,997 | mRNA Sequence | Download Select all |
| Length | 12695 |
Protein Information
| Protein ID | NP_001231509.1 |
|---|---|
| Protein Name | transformation/transcription domain-associated protein |
| Molecular Wt. (Da) | 61262 |
| Protein Sequence | Download Select all |
| Length | 3859 |
| Uniprot ID | O76038 |
| Ensembl Protein ID | ENSP00000367197 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 2033 |
| S | Phosphorylation | 2057 |
| S | Phosphorylation | 2059 |
| K | Acetylation | 3049 |
| K | Acetylation | 2525 |
| S | Phosphorylation | 1610 |
| T | Phosphorylation | 2583 |
| T | Phosphorylation | 2315 |
| T | Phosphorylation | 1441 |
| S | Phosphorylation | 1534 |
| T | Phosphorylation | 1615 |
| T | Phosphorylation | 2114 |
| T | Phosphorylation | 2383 |
| Y | Phosphorylation | 3154 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1869 | E2F1 | 1806 | NP_005216.1 | in vivo | 9708738 |
| 1874 | E2F4 | 2806 | NP_001941.2 | in vivo | 11418595 |
| 2099 | ESR1 | 589 | NP_000116.2 | in vitro | 1 193 176 316 260 770 |
| 4149 | MAX | 1113 | NP_002373.3 | in vitro | 10611234 |
| 4609 | MYC | 1818 | NP_002458.2 | in vitro;in vivo | 9708738 |
| 10902 | BRD8 | 4166 | NP_631938.1 | in vitro;in vivo | 12963728 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| HTLV-I infection | hsa05166 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd05163 | 3496-3783 | PIKK_TRRAP |
| cl21453 | 3496-3783 | PKc_like superfamily |
| cd05164 | 3496-3776 | PIKKc |
| smart00146 | 3539-3746 | PI3Kc |
| pfam00454 | 3525-3737 | PI3_PI4_kinase |
| cd00892 | 3496-3783 | PIKKc_ATR |
| cd05169 | 3496-3732 | PIKKc_TOR |
| cd05172 | 3496-3783 | PIKKc_DNA-PK |
| cd05170 | 3496-3755 | PIKKc_SMG1 |
| pfam02260 | 3832-3859 | FATC |
| cl03505 | 3832-3859 | FATC superfamily |
| pfam02259 | 2851-3204 | FAT |
| COG5032 | 2545-3859 | TEL1 |
Ontology Information
| HPRD ID | 12295 |
|---|---|
| Molecular Class | Transcription regulatory protein |
| Molecular Function | Cell adhesion molecule activity (GO:0005194) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.