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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
TSG101 7251 tumor susceptibility 101  11VPS23 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
18600204   2008Cell line : -

Source : -

Sample Type : -

No. of Sample : -

Stage : -

-Up-regulation-TSG101 was reported to be closely related to cancers of the breast, brain and colon, and its overexpression in human papillary thyroid carcinomas and ovarian carcinomas.


Gene Details



NC_000011.9 (18501858..18548503, complement)

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Gene Type protein coding
Gene Family -
Description The protein encoded by this gene belongs to a group of apparently inactive homologs of ubiquitin-conjugating enzymes. The gene product contains a coiled-coil domain that interacts with stathmin, a cytosolic phosphoprotein implicated in tumorigenesis. The protein may play a role in cell growth and differentiation and act as a negative growth regulator. In vitro steady-state expression of this tumor susceptibility gene appears to be important for maintenance of genomic stability and cell cycle regulation. Mutations and alternative splicing in this gene occur in high frequency in breast cancer and suggest that defects occur during breast cancer tumorigenesis and/or progression. [provided by RefSeq, Jul 2008]  
Chromosome 11
Location 11p15
Start 18501858  
End 18548503  
Strand -  
Gene Sequence

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Length 46646  
OMIM ID 601387   
HGNC ID HGNC:15971   
Unigene ID Hs.523512   
Ensembl ID ENSG00000074319   
PharmGKB ID PA38068   

mRNA Information


mRNA ID ?NM_006292.3
Exon join(1..130,652..818,2465..2551,6361..6505,7467..7584, 8261..8309,8709..8834,9170..9243,10812..10938, 12735..12878,13936..14073,14562..14665,15037..15118, 16337..16492,17584..17700,22521..22643,23575..23681, 23849..23999,24306..24428,24914..25048,26265..26454, 27864..27957,28133..28235,28556..28650,29663..29791, 31097..31261,31341..31493,31622..31734,32230..32442, 33660..33863,34501..34623,35760..35881,36293..36780, 37016..37091,37295..37387,38258..38444,38797..38936, 39928..40006,40113..40204,40292..40390,40511..40770)  
mRNA Sequence

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Length 5621  



CDS Information


   
Location 160..5526
CDS Sequence

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CCDS ID CCDS7842.1



Protein Information


      
Protein IDNP_006283.1
Protein Nametumor susceptibility 101
Molecular Wt. (Da)33298
Protein Sequence

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Length 390  
Uniprot IDO14979
Ensembl Protein ID ENSP00000295470  



Post-translational Modification Information (Source : HPRD)


Residue Type site
YPhosphorylation390;-
TPhosphorylation220
SPhosphorylation299
SPhosphorylation300

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                                                     
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
367AR2437NP_000035.2in vitro;yeast 2-hybrid10508170   
1026CDKN1A298NP_510867.1in vivo;yeast 2-hybrid11943869   
1786DNMT1532NP_001124295.1in vivo;yeast 2-hybrid10888872   
2908NR3C1679NP_001019265.1yeast 2-hybrid10508170   
3055HCK796NP_002101.2in vitro12029088   
4193MDM21272NP_002383.2in vivo11172000   
6093ROCK13414NP_005397.1in vitro;yeast 2-hybrid17853893   
7157TP531859NP_000537.3in vivo11172000   
8495PPFIBP24391NP_003612.2yeast 2-hybrid16189514   
8826IQGAP14541NP_003861.1in vitro;yeast 2-hybrid17853893   
55165CEP5512569NP_060601.3in vitro;yeast 2-hybrid1   618   951   417   853   890   


Pathway Information


      
Pathway Name Pathway ID
Endocytosis hsa04144


Structure Information


No matching records could be found.

Domain Information




ID Location Description
pfam0574321-139  UEV
cl0015421-139  UBCc superfamily
pfam09454315-379  Vps23_core
cl09692315-379  Vps23_core superfamily
smart0021223-155  UBCc
pfam07798236-292  DUF1640
cl06708236-292  DUF1640 superfamily
PRK10325241-306  PRK10325
cl03075241-306  GrpE superfamily
cd00179243-313  SynN
cl00143243-313  SynN superfamily
PRK10698223-302  PRK10698
cl22773223-302  PRK10698 superfamily
COG3352242-363  FlaC
cl23430242-363  FlaC superfamily
pfam07106242-317  TBPIP
cl22909242-317  TBPIP superfamily
pfam12325241-298  TMF_TATA_bd
cl22438241-298  TMF_TATA_bd superfamily
pfam12329251-307  TMF_DNA_bd
cl13726251-307  TMF_DNA_bd superfamily
cd00890243-310  Prefoldin
cl09111243-310  Prefoldin superfamily
cd0019532-148  UBCc
pfam06810243-304  Phage_GP20
cl21593243-304  Phage_GP20 superfamily
TIGR02168238-383  SMC_prok_B
pfam11932244-357  DUF3450
pfam04111235-316  APG6
COG1196222-340  Smc
COG1196238-311  Smc
COG1196243-384  Smc
TIGR02168243-382  SMC_prok_B
COG1579244-351  COG1579
COG1196243-382  Smc
COG0419238-388  SbcC
pfam03148248-350  Tektin
PRK03918244-361  PRK03918
TIGR04523230-342  Mplasa_alph_rch
PRK12704243-311  PRK12704
TIGR02169224-369  SMC_prok_A
pfam04111242-310  APG6
TIGR02169241-382  SMC_prok_A
COG1579236-352  COG1579
COG1196222-311  Smc
TIGR04211241-316  SH3_and_anchor
COG1196242-382  Smc
pfam07926232-305  TPR_MLP1_2
TIGR02169216-378  SMC_prok_A
TIGR02977223-303  phageshock_pspA
COG1842236-308  PspA
pfam13863243-342  DUF4200
pfam15346241-310  ARGLU
PRK03918236-306  PRK03918
COG1196229-311  Smc
TIGR00618222-314  sbcc
TIGR03752218-312  conj_TIGR03752
COG1196231-308  Smc
TIGR02169231-342  SMC_prok_A
COG1196241-381  Smc
COG0419233-340  SbcC
pfam00769236-310  ERM
TIGR04523236-319  Mplasa_alph_rch
COG1196220-351  Smc
TIGR03319243-311  RNase_Y
COG1196242-382  Smc
COG1196217-359  Smc
TIGR04523243-342  Mplasa_alph_rch
TIGR02169241-340  SMC_prok_A
PRK03918236-293  PRK03918
pfam04111227-315  APG6
COG4942243-308  EnvC
COG4026242-328  COG4026
COG5187264-365  RPN7
TIGR02168243-382  SMC_prok_B
pfam08614241-313  ATG16
TIGR02350219-305  prok_dnaK
COG2433228-305  COG2433
pfam00769221-310  ERM
TIGR02168216-381  SMC_prok_B
COG0419236-340  SbcC
pfam04156241-342  IncA
TIGR02169231-356  SMC_prok_A
TIGR02169242-347  SMC_prok_A
pfam00769244-310  ERM
pfam13949236-380  ALIX_LYPXL_bnd


Ontology Information


   
HPRD ID4336
Molecular ClassUbiquitin proteasome system protein
Molecular FunctionBinding (GO:0005488)
Biological ProcessRegulation of cell growth (GO:0001558); Signal transduction (GO:0007165)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO