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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
TUFM 7284 Tu translation elongation factor, mitochondrial  16P43; EFTU; COXPD4; EF-TuMT 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
21843667   2011Cell line : -

Source : Wakefield Hospital, Wellington, New Zealand.

Sample Type : Case control study

No. of Sample : 10

Stage : TNM Stage I-IV

 Laser capture microdissection and 2-D Gel electrophoresis, western blottingUp-regulation-Specimens of paired colorectal adenocarcinoma (CT) and adjacent normal colon mucosa (NC) were obtained from 10 patients operated on for CRC with synchronous liver metastasis.

22772342   2012Cell line : -

Source : -

Sample Type : Case control study

No. of Sample : 123 CRC case

Stage : -

Immunohistochemistry, Immunoreactivity Up-regulation-TUFM is a potential new prognostic indicator for colorectal carcinoma.

Selective inhibition of TUFM in tumour cells may present a new avenue for the targeted therapy of this cancer.

Immunohistochemical staining was performed in tissue microarrays composed of 123 cases of CRC.


Gene Details



Chromosome: 16; NC_000016.9 (28853732..28857729, complement)

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Gene Type protein coding
Gene Family -
Description This gene encodes a protein which participates in protein translation in mitochondria. Mutations in this gene have been associated with combined oxidative phosphorylation deficiency resulting in lactic acidosis and fatal encephalopathy. A pseudogene has been identified on chromosome 17. [provided by RefSeq, Jul 2008]  
Chromosome 16
Location 16p11.2
Start 28842411  
End 28846511  
Strand +  
Gene Sequence

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Length 4101  
OMIM ID 602389   
HGNC ID HGNC:12420   
Unigene ID Hs.12084    
Ensembl ID ENSG00000178952   
PharmGKB ID PA37082   

mRNA Information


mRNA ID NM_003321.4
Exon join(104..294,406..600,1032..1198,1457..1561,1650..1814, 1961..2093,2178..2282,2411..2562,2657..2776,3364..4101)  
mRNA Sequence

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Length 2089  



CDS Information


   
Location join(243..294,406..600,1032..1198,1457..1561,1650..1814, 1961..2093,2178..2198,2411..2562,2657..2776,3364..3537)
CDS Sequence

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CCDS ID -



Protein Information


      
Protein IDNP_003312.3
Protein NameTu translation elongation factor, mitochondrial
Molecular Wt. (Da)45045
Protein Sequence

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Length 455  
Uniprot IDQ99856
Ensembl Protein ID ENSP00000263620  



Post-translational Modification Information (Source : HPRD)


Residue Type site
KAcetylation82
KAcetylation259
KAcetylation421
KAcetylation91
TPhosphorylation77

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

               
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
4627MYH91177NP_002464.1in vitro12577067   


Pathway Information


No matching records could be found.

Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd0188456-250  EF_Tu
cl2145556-250  P-loop_NTPase superfamily
cd03706347-439  mtEFTU_III
cl02786347-439  Translation_factor_III superfamily
cd03697258-344  EFTU_II
cl02787258-344  Translation_Factor_II_like superfamily
pfam0000955-249  GTP_EFTU
cd0088159-250  GTP_translation_factor
cd0188359-221  EF1_alpha
cd0417160-221  SelB
cd03707347-436  EFTU_III
pfam03143345-440  GTP_EFTU_D3
cd0188858-252  eIF2_gamma
cd0416662-221  CysN_ATPS
cd0189159-250  TypA_BipA
cd0188958-221  SelB_euk
cd03696258-339  selB_II
cd0188764-221  IF2_eIF5B
cd01342258-342  Translation_Factor_II_like
cd01513347-436  Translation_factor_III
pfam03144272-341  GTP_EFTU_D2
cd0416859-205  TetM_like
cd0188559-184  EF2
cd03693255-340  EF1_alpha_II
cd0189059-250  LepA
cd03694258-341  GTPBP_II
cd0417059-185  EF-G_bact
cd0188659-184  EF-G
cd0416759-184  Snu114p
cd0416963-184  RF3
cd03695258-342  CysN_NodQ_II
cd0416559-197  GTPBP1_like
cd0088263-221  Ras_like_GTPase
cd04089257-339  eRF3_II
cd03698257-339  eRF3_II_like
cd09912145-247  DLP_2
cd15491347-436  selB_III
cd03708353-437  GTPBP_III
PRK0004947-441  PRK00049
PRK1273547-441  PRK12735
PRK1273647-441  PRK12736
PLN0312750-441  PLN03127
COG005047-441  TufB
CHL0007147-440  tufA
TIGR0048547-441  EF-Tu
PLN0312641-440  PLN03126
PRK1231753-438  PRK12317
COG525654-436  TEF1
TIGR0048353-436  EF-1_alpha
PTZ0014153-436  PTZ00141
TIGR0047558-434  selB
COG327658-363  SelB
COG525855-440  GTPBP1
TIGR0368056-348  eif2g_arch
COG525756-348  GCD11
PRK0400056-361  PRK04000
PLN0004353-436  PLN00043
PRK1051262-337  PRK10512
COG289553-441  CysN
TIGR0139459-320  TypA_BipA
COG121759-320  TypA
PTZ0032758-361  PTZ00327
TIGR0203462-348  CysN
PRK0512462-447  cysN
PRK1021859-320  PRK10218
PRK0550643-344  PRK05506
COG048059-330  FusA
TIGR0139359-357  lepA
TIGR0049059-330  aEF-2
PRK0756059-353  PRK07560
COG053264-288  InfB
TIGR0048755-288  IF-2
PRK1274063-327  PRK12740
PRK0530662-288  infB
COG048159-330  LepA
PRK1335159-184  PRK13351
CHL0018950-243  infB
PTZ0041654-184  PTZ00416
TIGR0048459-184  EF-G
PLN0011654-184  PLN00116
PRK0543363-289  PRK05433
TIGR0050359-200  prfC
TIGR0023158-184  small_GTP
PRK1273959-184  PRK12739
COG410863-184  PrfC


Ontology Information


   
HPRD ID1355
Molecular ClassTranslation regulatory protein
Molecular FunctionCell adhesion molecule activity (GO:0005194)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO