Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| TWIST2 | 117581 | twist family bHLH transcription factor 2 | 2 | DERMO1, Dermo-1, bHLHa39 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23613636 | 2013 | Cell line : - Source : Eastern Hepatobiliary Surgery Hospital, the Second Military Medical University of China Sample Type : - No. of Sample : 93 CRC patients. Stage : TNM Stage III,IV | Immunohistochemistry | Up-regulation | - | Twist2 is a valuable prognostic biomarker for CRC, particularly for patients in stage III and IV. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Basic helix-loop-helix proteins |
| Description | The protein encoded by this gene is a basic helix-loop-helix type transcription factor and shares similarity with Twist. This protein may inhibit osteoblast maturation and maintain cells in a preosteoblast phenotype during osteoblast development. This gene may be upregulated in certain cancers. Mutations in this gene cause focal facial dermal dysplasia 3, Setleis type. Two transcript variants encoding the same protein have been found. | Chromosome | 2 |
| Location | 2q37.3 |
| Start | 238847934 |
| End | 238910548 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 62615 |
| OMIM ID | 607556 |
| HGNC ID | HGNC:20670 |
| Unigene ID | Hs.422585 |
| Ensembl ID | ENSG00000233608 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | XM_006712242.2 |
|---|---|
| Exon | join(1..800,18811..19173) | mRNA Sequence | Download Select all |
| Length | 1409 |
Protein Information
| Protein ID | NP_001258822.1 |
|---|---|
| Protein Name | twist family bHLH transcription factor 2 |
| Molecular Wt. (Da) | 17993 |
| Protein Sequence | Download Select all |
| Length | 160 |
| Uniprot ID | P06858 |
| Ensembl Protein ID | ENSP00000309757 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 4208 | MEF2C | 2809 | NP_002388.2 | in vivo | 11809751 |
| 6720 | SREBF1 | 1701 | NP_001005291.1 | in vitro;yeast 2-hybrid | 14654692 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Proteoglycans in cancer | hsa05205 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00083 | 66-122 | HLH |
| cl00081 | 66-122 | HLH superfamily |
| pfam00010 | 67-117 | HLH |
| smart00353 | 72-123 | HLH |
Ontology Information
| HPRD ID | 1039 |
|---|---|
| Molecular Class | Transcription factor |
| Molecular Function | Extracellular matrix structural constituent (GO:0005201) |
| Biological Process | Cell growth and/or maintenance (GO:0008151) |
Drug Information
No matching records could be found.