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General Information
- Evidence
- Gene
- mRNA
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- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25202077 | 2014 | Cell line : - Source : - Sample Type : Formalin-fixed paraffin-embedded and fresh-frozen tumor tissue No. of Sample : 96 formalin-fixed paraffin-embedded and 30 fresh-frozen tumor tissue samples were evaluated . Stage : TNM Stage I-IV. | Immunohistochemistry, qRT-PCR and microarray gene expression profiling. | Up-regulation | - | TYMS mRNA expression highlight a cluster of genes associated with nodal metastases that warrant further investigation in a larger cohort of patients with colorectal cancer treated with 5-FU-based adjuvant chemotherapy. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes an angiogenic factor which promotes angiogenesis in vivo and stimulates the in vitro growth of a variety of endothelial cells. It has a highly restricted target cell specificity acting only on endothelial cells. Mutations in this gene have been associated with mitochondrial neurogastrointestinal encephalomyopathy. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Apr 2012] | Chromosome | 22 |
| Location | 22q13 |
| Start | 50964181 |
| End | 50968514 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 4334 |
| OMIM ID | 131222 |
| HGNC ID | HGNC:3148 |
| Unigene ID | Hs.180903 |
| Ensembl ID | ENSG00000025708 |
| PharmGKB ID | PA162407502 |
mRNA Information
| mRNA ID | NM_001169109.1 |
|---|---|
| Exon | 3647..3840 | mRNA Sequence | Download Select all |
| Length | 1051 |
Protein Information
| Protein ID | NP_001162580.1 |
|---|---|
| Protein Name | thymidine phosphorylase |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 266 |
| Uniprot ID | O00592 |
| Ensembl Protein ID | ENSP00000319782 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| T | Phosphorylation | 271 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Bladder cancer | hsa05219 |
| Drug metabolism - other enzymes | hsa00983 |
| Metabolic pathways | hsa01100 |
| Pyrimidine metabolism | hsa00240 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam00591 | 109-340 | Glycos_transf_3 |
| cl02901 | 109-340 | Glycos_transf_3 superfamily |
| pfam02885 | 35-99 | Glycos_trans_3N |
| cl03761 | 35-99 | Glycos_trans_3N superfamily |
| smart00941 | 389-462 | PYNP_C |
| cl06734 | 389-462 | PYNP_C superfamily |
| pfam07831 | 388-462 | PYNP_C |
| TIGR02644 | 37-446 | Y_phosphoryl |
| PRK05820 | 37-470 | deoA |
| COG0213 | 37-471 | DeoA |
| TIGR02643 | 38-471 | T_phosphoryl |
| PRK06078 | 38-441 | PRK06078 |
| PRK04350 | 29-466 | PRK04350 |
| TIGR03327 | 29-443 | AMP_phos |
| TIGR02645 | 29-443 | ARCH_P_rylase |
| PRK14607 | 46-350 | PRK14607 |
| COG0547 | 33-181 | TrpD |
| TIGR01245 | 45-183 | trpD |
| PRK09522 | 49-185 | PRK09522 |
| PLN02641 | 33-181 | PLN02641 |
| PRK00188 | 45-183 | trpD |
Ontology Information
| HPRD ID | 7177 |
|---|---|
| Molecular Class | Growth factor |
| Molecular Function | DNA-directed DNA polymerase activity (GO:0003887) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P19971 | DB00322 | Floxuridine | SmallMoleculeDrug |
| P19971 | DB00369 | Cidofovir | SmallMoleculeDrug |
| P19971 | DB00432 | Trifluridine | SmallMoleculeDrug |
| P19971 | DB00544 | Fluorouracil | SmallMoleculeDrug |
| P19971 | DB01101 | Capecitabine | SmallMoleculeDrug |