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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| UBA52 | 7311 | ubiquitin A-52 residue ribosomal protein fusion product 1 | 19 | RPL40, CEP52, HUBCEP52, MGC57125, MGC126879, MGC126881, L40 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 8541345 | 1995 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 24 Stage : - | Northern hybridization | Up-regulation | - | UbA80 and UbA52 are overexpressed in colon cancer, but not in gastric cancer. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | L ribosomal proteins |
| Description | Ubiquitin is a highly conserved nuclear and cytoplasmic protein that has a major role in targeting cellular proteins for degradation by the 26S proteosome. It is also involved in the maintenance of chromatin structure, the regulation of gene expression, and the stress response. Ubiquitin is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin moiety fused to an unrelated protein. This gene encodes a fusion protein consisting of ubiquitin at the N terminus and ribosomal protein L40 at the C terminus, a C-terminal extension protein (CEP). Multiple processed pseudogenes derived from this gene are present in the genome. [provided by RefSeq, Jul 2008] | Chromosome | 19 |
| Location | 19p13.1-p1 |
| Start | 18674576 |
| End | 18688270 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 13695 |
| OMIM ID | 191321 |
| HGNC ID | HGNC:12458 |
| Unigene ID | Hs.5308 |
| Ensembl ID | ENSG00000221983 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | ?NM_001033930.1 |
|---|---|
| Exon | join(<1104..1256,3367..3413,4637..5622) | mRNA Sequence | Download Select all |
| Length | 1496 |
Protein Information
| Protein ID | NP_001029102.1 |
|---|---|
| Protein Name | ubiquitin A-52 residue ribosomal protein fusion product 1 |
| Molecular Wt. (Da) | 24693 |
| Protein Sequence | Download Select all |
| Length | 128 |
| Uniprot ID | Q13111 |
| Ensembl Protein ID | ENSP00000301280 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| K | Acetylation | 88 |
| K | Acetylation | 88 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 7251 | TSG101 | 3229 | NP_006283.1 | in vitro | 11916981 |
| 9146 | HGS | 5085 | NP_004703.1 | in vitro | 11916981 |
| 10657 | KHDRBS1 | 3926 | NP_006550.1 | in vitro;in vivo;yeast 2-hybrid | 8702753 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Ribosome | hsa03010 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd01803 | Jan-76 | Ubiquitin |
| cl00155 | Jan-76 | UBQ superfamily |
| pfam00240 | Jun-74 | ubiquitin |
| cd01806 | Jan-76 | Nedd8 |
| cd01769 | Apr-72 | UBL |
| PTZ00044 | Jan-76 | PTZ00044 |
| pfam01020 | 77-128 | Ribosomal_L40e |
| cl00671 | 77-128 | Ribosomal_L40e superfamily |
| cd01802 | Jan-76 | AN1_N |
| pfam11976 | Jan-71 | Rad60-SLD |
| cd01805 | Jan-61 | RAD23_N |
| cd01793 | Jan-76 | Fubi |
| cd01809 | Jan-72 | Scythe_N |
| cd01798 | Mar-72 | parkin_N |
| cd00196 | Apr-72 | UBQ |
| COG5272 | Jan-57 | UBI4 |
| cd01807 | Jan-72 | GDX_N |
| COG1552 | 80-128 | RPL40A |
| cd01797 | Jan-72 | NIRF_N |
| cd01800 | Aug-76 | SF3a120_C |
| cd01810 | Mar-76 | ISG15_repeat2 |
| cd01796 | Oct-72 | DDI1_N |
| cd01812 | May-70 | BAG1_N |
| PRK04136 | 80-126 | rpl40e |
| cd01808 | Jan-72 | hPLIC_N |
| cd01794 | May-71 | DC_UbP_C |
| cd01804 | Jan-78 | midnolin_N |
| pfam14560 | 19-70 | Ubiquitin_2 |
| cd01792 | May-72 | ISG15_repeat1 |
| cd01799 | Dec-62 | Hoil1_N |
| pfam13881 | 18-72 | Rad60-SLD_2 |
| cd01815 | 26-72 | BMSC_UbP_N |
| cd12219 | 17-52 | UBL_TBK1_like |
| smart00213 | Jan-72 | UBQ |
| TIGR00601 | Jan-61 | rad23 |
| pfam13019 | Jan-76 | Telomere_Sde2 |
Ontology Information
| HPRD ID | 5099 |
|---|---|
| Molecular Class | Ribosomal subunit |
| Molecular Function | Growth factor activity (GO:0008083) |
| Biological Process | Biological_process unknown (GO:0000004) |
Drug Information
No matching records could be found.