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General Information
- Evidence
- Gene
- mRNA
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- Protein
- PTM
- Enzyme
- PPi
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 21351261 | 2010 | Cell line : - Source : General Surgery Department of Shanghai Jiao Tong University Affiliated First People's Hospital Sample Type : CRC tumor and normal tissue No. of Sample : 203 Stage : TNM stage II, III | - | Polymorhpism | - | Evaluated 5 putative functional inflammatory pathway polymorphisms in PRODH, PTGS1 and UBD genes. PTGS1 G213G was significantly associated with an increased CRC risk.UBD I68T was significantly associated with advanced stages of CRC and with CRC below 65 years of age . |
| 20808312 | 2010 | Cell line : - Source : German DACHS study Sample Type : Population based case-control study No. of Sample : 1,795 CRC cases and 1,805 controls Stage : - | PCR, tissue microarray, western blotting and immunohistochemistry | Up-regulation | - | UBD may contribute to the progression of colon carcinogenesis and function as a novel prognostic indicator of forecasting recurrence of stage II and III patients after curative operations. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | - | Chromosome | 6 |
| Location | 6p21.3 |
| Start | 29523389 |
| End | 29527702 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 4314 |
| OMIM ID | 606050 |
| HGNC ID | HGNC:18795 |
| Unigene ID | Hs.44532 |
| Ensembl ID | ENSG00000213886 |
| PharmGKB ID | PA38682 |
Protein Information
| Protein ID | NP_006389.2 |
|---|---|
| Protein Name | ubiquitin D |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 165 |
| Uniprot ID | Q9UJU5 |
| Ensembl Protein ID | ENSP00000360157 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 4085 | MAD2L1 | 3274 | NP_002349.1 | in vitro;in vivo;yeast 2-hybrid | 10200259 |
| 51667 | NUB1 | 7450 | NP_057202.2 | in vitro;in vivo | 14757770 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd01769 | 21-76 | UBL |
| cl00155 | 21-76 | UBQ superfamily |
| pfam00240 | 18-79 | ubiquitin |
| pfam00240 | 100-158 | ubiquitin |
| cl00155 | 100-158 | UBQ superfamily |
| cd01803 | 104-165 | Ubiquitin |
| cd01803 | 20-80 | Ubiquitin |
| cd01769 | 100-160 | UBL |
| cd01793 | Nov-81 | Fubi |
| cd01809 | 29-76 | Scythe_N |
| cd00196 | 100-158 | UBQ |
| cd01793 | 102-165 | Fubi |
| cd00196 | 21-76 | UBQ |
| cd01806 | 104-165 | Nedd8 |
| pfam11976 | 100-156 | Rad60-SLD |
| cd01812 | 99-159 | BAG1_N |
| cd01806 | 23-78 | Nedd8 |
| cd01807 | 28-83 | GDX_N |
| pfam14560 | 88-156 | Ubiquitin_2 |
| cd12219 | 25-66 | UBL_TBK1_like |
| cd01811 | Oct-76 | OASL_repeat1 |
| cd01805 | 104-156 | RAD23_N |
| cd01808 | 29-79 | hPLIC_N |
| cd01807 | 90-150 | GDX_N |
| pfam11976 | 20-76 | Rad60-SLD |
| smart00213 | Aug-79 | UBQ |
| smart00213 | 96-160 | UBQ |
Ontology Information
| HPRD ID | 2203 |
|---|---|
| Molecular Class | Ubiquitin proteasome system protein |
| Molecular Function | Catalytic activity (GO:0003824) |
| Biological Process | Metabolism (GO:0008152); Energy pathways (GO:0006091); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.