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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| UBE2C | 11065 | ubiquitin-conjugating enzyme E2C | 20 | UBCH10 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 21514426 | 2011 | Cell line : Colo 320, HCT 15, SW 480 Source : King Faisal Specialist Hospital and Research Centre. Sample Type : CRC Tumor and adjescent tissue No. of Sample : 448 Stage : - | Immunohistochemistry,FISH,Cell Cycle Analysis and Annexin V Staining,Real-Time RT-PCR,MTT | Up-regulation | - | UBE2C and the ubiquitin-proteasome pathway may be potential targets for therapeutic intervention in CRC. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Ubiquitin-conjugating enzymes E2 |
| Description | The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, ubiquitin-conjugating enzymes, and ubiquitin-protein ligases. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is required for the destruction of mitotic cyclins and for cell cycle progression, and may be involved in cancer progression. Multiple transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene have been defined on chromosomes 4, 14, 15, 18, and 19. [provided by RefSeq, Aug 2013] | Chromosome | 20 |
| Location | 20q13.12 |
| Start | 44441255 |
| End | 44445596 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 4342 |
| OMIM ID | 605574 |
| HGNC ID | HGNC:15937 |
| Unigene ID | Hs.93002 |
| Ensembl ID | ENSG00000175063 |
| PharmGKB ID | PA38057 |
Protein Information
| Protein ID | NP_001268670.1 |
|---|---|
| Protein Name | ubiquitin-conjugating enzyme E2C |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 179 |
| Uniprot ID | Q9BYW2 |
| Ensembl Protein ID | ENSP00000386759 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 87 |
| Y | Phosphorylation | 89 |
| S | Phosphorylation | 58 |
| Y | Phosphorylation | 60 |
| S | Phosphorylation | 48 |
| Y | Phosphorylation | 50 |
| S | Phosphorylation | 48 |
| Y | Phosphorylation | 50 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Ubiquitin mediated proteolysis | hsa04120 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00195 | 33-170 | UBCc |
| cl00154 | 33-170 | UBCc superfamily |
| pfam00179 | 34-170 | UQ_con |
| smart00212 | 34-172 | UBCc |
| PTZ00390 | 33-158 | PTZ00390 |
| PLN00172 | 33-175 | PLN00172 |
| smart00591 | 80-125 | RWD |
| cl02687 | 80-125 | RWD superfamily |
| pfam05743 | 54-123 | UEV |
| COG5078 | 33-172 | COG5078 |
Ontology Information
| HPRD ID | 5322 |
|---|---|
| Molecular Class | Ubiquitin proteasome system protein |
| Molecular Function | Protein serine/threonine kinase activity (GO:0004674) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.