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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
UGT1A7 54577 UDP glucuronosyltransferase 1 family, polypeptide A7  2UGT1G 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
22901212   2012Cell line : -

Source : -

Sample Type : CRC tumor and normal tissue

No. of Sample : 68 CRC and 112 controls

Stage : -

PCR-RFLPPolymorhpism- UGT1A6 and UGT1A7 gene polymorphisms are associated with CRC risk in the Japanese population.


Gene Details



NC_000002.11 (234590584..234681945)

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Gene Type protein coding
Gene Family UDP glucuronosyltransferases
Description This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene has moderate glucuronidase activity with phenols. [provided by RefSeq, Jul 2008]  
Chromosome 2
Location 2q37
Start 234590584  
End 234681945  
Strand +  
Gene Sequence

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Length 91362  
OMIM ID 606432   
HGNC ID HGNC:12539   
Unigene ID Hs.554822   
Ensembl ID ENSG00000244122   
PharmGKB ID PA37182   

mRNA Information


mRNA ID ?NM_019077.2
Exon  
mRNA Sequence

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Length  



CDS Information


   
Location
CDS Sequence

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CCDS ID CCDS2506.1



Protein Information


      
Protein IDNP_061950.2
Protein NameUDP glucuronosyltransferase 1 family, polypeptide A7
Molecular Wt. (Da)0
Protein Sequence

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Length 530  
Uniprot IDQ8TAF3
Ensembl Protein ID ENSP00000307491  



Post-translational Modification Information (Source : HPRD)


No matching records could be found.

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

No matching records from HPRD source could be found.

Pathway Information


                                                                  
Pathway Name Pathway ID
Ascorbate and aldarate metabolism hsa00053
Chemical carcinogenesis hsa05204
Drug metabolism - cytochrome P450 hsa00982
Drug metabolism - other enzymes hsa00983
Metabolic pathways hsa01100
Metabolism of xenobiotics by cytochrome P450 hsa00980
Pentose and glucuronate interconversions hsa00040
Porphyrin and chlorophyll metabolism hsa00860
Retinol metabolism hsa00830
Starch and sucrose metabolism hsa00500
Steroid hormone biosynthesis hsa00140


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd0378428-441  GT1_Gtf_like
cl1001328-441  Glycosyltransferase_GTB_type superfamily
PLN02534347-412  PLN02534
PLN00164350-398  PLN00164
PLN03004290-442  PLN03004
PLN02167261-401  PLN02167
PLN02554348-441  PLN02554
PLN02448289-399  PLN02448
PLN02207267-401  PLN02207
pfam04101367-437  Glyco_tran_28_C
PLN03007299-443  PLN03007
PLN02764351-439  PLN02764
PLN02670347-408  PLN02670
cd03785367-448  GT1_MurG
pfam0020126-521  UDPGT
PHA03392264-504  egt
COG181928-440  YjiC
TIGR0142631-440  MGT
PLN02410290-402  PLN02410
PLN02152253-432  PLN02152
PLN03015264-418  PLN03015
PLN02210290-427  PLN02210
PLN02173290-443  PLN02173
PLN02555348-439  PLN02555
PLN02992351-398  PLN02992
TIGR04516345-440  glycosyl_450act
PLN02562299-440  PLN02562
PLN02863347-398  PLN02863
COG0707360-442  MurG
PLN02208351-432  PLN02208
PLN00414298-462  PLN00414
PRK00726367-439  murG
TIGR01133367-437  murG
TIGR00661252-420  MJ1255


Ontology Information


   
HPRD ID18030
Molecular ClassEnzyme: Glycosyltransferase
Molecular FunctionMolecular function unknown (GO:0005554)
Biological ProcessCell growth and/or maintenance (GO:0008151)  



SNP Information


View SNP Geneview Report   

Drug Information


Uniprot ID DrugBank ID Name Type
Q9HAW7DB00688Mycophenolate mofetilSmallMoleculeDrug
Q9HAW7DB01024Mycophenolic acidSmallMoleculeDrug

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO