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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
UGT2B7 7364 UDP glucuronosyltransferase 2 family, polypeptide B7  4UGT2B9 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
19408577   2009Cell line : -

Source : -

Sample Type : CRC tumor and adjacent normal tissue

No. of Sample : 411 CRC and 600 controls

Stage : -

GenotypingPolymorhpism-Frequency of the UGT2B7*2*2 genotype is higher in CRC patients with proximal location of the tumor, especially in males, which suggests that this genotype is associated with an increased risk for proximal CRC


Gene Details



NC_000004.11 (69955190..69978705)

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Gene Type protein coding
Gene Family UDP glucuronosyltransferases
Description The protein encoded by this gene belongs to the UDP-glycosyltransferase (UGT) family. UGTs serve a major role in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This protein is localized in the microsome membrane, and has unique specificity for 3,4-catechol estrogens and estriol, suggesting that it may play an important role in regulating the level and activity of these potent estrogen metabolites. [provided by RefSeq, Sep 2011]  
Chromosome 4
Location 4q13
Start 69955190  
End 69978705  
Strand +  
Gene Sequence

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Length 23516  
OMIM ID 600068   
HGNC ID HGNC:12554   
Unigene ID Hs.654424   
Ensembl ID ENSG00000171234   
PharmGKB ID PA361   

mRNA Information


mRNA ID ?NM_001074.2
Exon join(1..124,1213..1369,4368..4592,4749..4959,5828..6022, 6103..6204,7174..7354,7724..8174)  
mRNA Sequence

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Length 1646  



CDS Information


   
Location381..1310
CDS Sequence

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CCDS ID CCDS3526.1



Protein Information


      
Protein IDNP_001065.2
Protein NameUDP glucuronosyltransferase 2 family, polypeptide B7
Molecular Wt. (Da)0
Protein Sequence

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Length 529  
Uniprot IDQ9Y6N9
Ensembl Protein ID ENSP00000005226  



Post-translational Modification Information (Source : HPRD)


No matching records could be found.

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

No matching records from HPRD source could be found.

Pathway Information


                                                                  
Pathway Name Pathway ID
Ascorbate and aldarate metabolism hsa00053
Chemical carcinogenesis hsa05204
Drug metabolism - cytochrome P450 hsa00982
Drug metabolism - other enzymes hsa00983
Metabolic pathways hsa01100
Metabolism of xenobiotics by cytochrome P450 hsa00980
Pentose and glucuronate interconversions hsa00040
Porphyrin and chlorophyll metabolism hsa00860
Retinol metabolism hsa00830
Starch and sucrose metabolism hsa00500
Steroid hormone biosynthesis hsa00140


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd0378426-449  GT1_Gtf_like
cl1001326-449  Glycosyltransferase_GTB_type superfamily
PLN00164304-416  PLN00164
PLN02554304-450  PLN02554
PLN02448301-402  PLN02448
PLN02167272-417  PLN02167
PLN03004294-445  PLN03004
PLN02207272-448  PLN02207
PLN02534356-399  PLN02534
PLN03007120-399  PLN03007
cd03785376-444  GT1_MurG
pfam04101372-444  Glyco_tran_28_C
PLN02764356-444  PLN02764
PLN02670249-415  PLN02670
pfam0020124-525  UDPGT
PHA033928-507  egt
COG181925-474  YjiC
TIGR0142642-450  MGT
PLN02992252-416  PLN02992
PLN02173294-415  PLN02173
PLN02210294-400  PLN02210
PLN02410265-407  PLN02410
PLN02152269-448  PLN02152
PLN02555266-406  PLN02555
PLN02562234-445  PLN02562
PLN03015289-414  PLN03015
PLN02863300-399  PLN02863
TIGR04516344-447  glycosyl_450act
COG0707372-447  MurG
PLN02208356-450  PLN02208
PRK00726372-447  murG


Ontology Information


   
HPRD ID16889
Molecular ClassEnzyme: Glycosyltransferase
Molecular FunctionMolecular function unknown (GO:0005554)
Biological ProcessApoptosis (GO:0006915)  



SNP Information


View SNP Geneview Report   

Drug Information


Uniprot ID DrugBank ID Name Type
P16662DB00227LovastatinSmallMoleculeDrug
P16662DB00295MorphineSmallMoleculeDrug
P16662DB00313Valproic AcidSmallMoleculeDrug
P16662DB00318CodeineSmallMoleculeDrug
P16662DB00328IndomethacinSmallMoleculeDrug
P16662DB00445EpirubicinSmallMoleculeDrug
P16662DB00495ZidovudineSmallMoleculeDrug
P16662DB00564CarbamazepineSmallMoleculeDrug
P16662DB00586DiclofenacSmallMoleculeDrug
P16662DB00641SimvastatinSmallMoleculeDrug
P16662DB00678LosartanSmallMoleculeDrug
P16662DB00688Mycophenolate mofetilSmallMoleculeDrug
P16662DB00712FlurbiprofenSmallMoleculeDrug
P16662DB00749EtodolacSmallMoleculeDrug
P16662DB00788NaproxenSmallMoleculeDrug
P16662DB00842OxazepamSmallMoleculeDrug
P16662DB00870SuprofenSmallMoleculeDrug
P16662DB00973EzetimibeSmallMoleculeDrug
P16662DB01024Mycophenolic acidSmallMoleculeDrug
P16662DB01050IbuprofenSmallMoleculeDrug
P16662DB01076AtorvastatinSmallMoleculeDrug
P16662DB01095FluvastatinSmallMoleculeDrug
P16662DB01252MitiglinideSmallMoleculeDrug
P16662DB01544FlunitrazepamSmallMoleculeDrug
P16662DB06204TapentadolSmallMoleculeDrug
P16662DB06207SilodosinSmallMoleculeDrug
P16662DB06292DapagliflozinSmallMoleculeDrug
P16662DB06403AmbrisentanSmallMoleculeDrug
P16662DB06695Dabigatran etexilateSmallMoleculeDrug
P16662DB06777Chenodeoxycholic acidSmallMoleculeDrug
P16662DB08860PitavastatinSmallMoleculeDrug

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO