CoReCG

Search results:

General Information

Gene_Symbol	Gene_ID	Gene_Name	Chromosome	Alias
UHRF1	29128	Ubiquitin-like, containing PHD and RING finger domains, 1	19	Np95; hNP95; ICBP90; RNF106; hUHRF1

Evidence
Gene
mRNA
CDS
Protein
PTM
Enzyme
PPi
Pathway
Structural
Domain
Ontology
SNP
Drug
External Links

Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
22219067	2012	Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 144 Stage : -	real time RT-PCR,Iimmunohistochemistry with tissue microarrays	Up-regulation	-	UHRF1 promotes CRC growth and metastasis, likely by repressing p16(ink4a), and thus it may be used as a biomarker or even a therapeutic target for CRC. UHRF1 expression is upregulated in CRC and is associated with the progression of CRC.
22286757	2012	Cell line : - Source : - Sample Type : - No. of Sample : - Stage : -	-	Up-regulation	-	UHRF1 negatively regulates PPARG and is associated with a higher proliferative, clonogenic and migration potential. UHRF1 overexpression, as well as PPARG-silencing, imparts higher growth rate and phenotypic features resembling those occurring in the epithelial-mesenchymal transition. UHRF1 regulates PPARG silencing and both genes appear to be part of a complex regulatory network. 110 sporadic CRC patient sample were included.
23023523	2012	Cell line : - Source : - Sample Type : - No. of Sample : - Stage : -	Immunohistochemical staining,	Up-regulation	-	UHRF1 expression was upregulated in colorectal cancer and binds to methylated promoters of a number of tumor suppressor genes, including p16INK4A and p14ARF, by forming complexes with DNA methyltransferases and HDAC1, resulting in the induction of carcinogenesis. UHRF1 staining was detected in the nucleus of cancer cells, while it was not detected in colonic normal mucosa. UHRF1 may be involved in cellular proliferation and molecular pathogenesis of colorectal cancer in the right hemicolon. 231 colorectal cancer and 40 adenoma specimens were included.

Gene Details

Chromosome: 19; NC_000019.9 (4909510..4962165)
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Gene Type	protein coding
Gene Family	RING-type (C3HC4) zinc fingers
Description	This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	19
Location	19p13.3
Start	4903080
End	4962154
Strand	+
Gene Sequence	>gi\|568815579:4903080-4962154 Homo sapiens chromosome 19, GRCh38.p2 Primary Assembly GCAGGGGTGCCATCTTGGCTCACTGCAACCTCCGCCTCATGGGTTCAAGCAATTCTCCTGCCTCAGCCTC CTGAGTAGCTGGGACCACGGGTGCATGCCAGCATGCCCAGCTAATTTTTTGGTAGAGACAGAGTTTCACT GTGTTGGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCCACCCACCTCAGCCTCCCAAAGTGCTGGGA TTGCAGGCGTGAGCCACTGCACCTGGGCTTTTTCTTTTTTTGAGACAAAGTCTCATTCTGTCACCCAGGC TGGAGTGTAGTGGCGCGATCTCGGCTCACTGCCACATCTGCCTCCCGGGTTCAAGCAATTCTCCTGCTTC AGCCTCCTGAGTAGCTGGAATTACAGGCATGCACCATCACCATGCTTTGCTAATTTTTTTTTGGTATTTT TATTTATTTTATTTTTATTTTTTGTGATGGTCTCACTCTGTCAGCCAGACTGGAGTGCAATGGTGTGATC TCGGCTCACTGCAACCTCTGCCTCCTGGGTTCCAGCGATTCTCCCACCTCAGCCCCCCAAGTACCTGAGA TTACAGGCAAGTGCCACTGCAACTAGCTAATTTTTGTATTTTTAGTAGAGACGGGGTTTCACCATGTTGG CCAGGCTGGTCTCGAACTTGTGGCCTCACATGATTCGCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACA GTTGTGAGCCACTGTGCCCAGGTGCATACACACTCATTTTCATCTTAAAGACTCTACATTTATATTGGTC TATATTGGAAAAAACATAGAGATATGGCCAGGACCTGAAATCTGGTGCGCACTGAAGTTGATCAGGGCAG TGTGTGCTTAATCTGAACATCGACACCATCAGGAAGCAGCAACTCCCTGCATGATTGACATTTCTCTTTT TTTTTGAGGTGGAATCTCACTCTGTTGCCCAGGCTGGAGTGCAGTGGCGTGATCTCGGCTCACTGCAACC TCTGCCCCCTGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACGGGCATGGGGGT TACAGGCACCTGCCCCCGTGCCCGGCTAATTTTTGTTCTTTTTGTTTTTGTTTTTGTTTTTTTTTTGAGA TTGGAGTCTCACTTTGTCACCCAGGCTGGAGTGCAGTGGTGCGATCTCGGCTCACTGCAAGCTCCGCCTC CCGTGTTCATGCCATTCTCCTGCCTCAGCTTCCCGAGTAGCTGGGACTACAGGCGTCCGCCACAAATGCC TGGCTAATTTTTTGTATTTTTAGTAGAGACGGGGTTTCATCATGTTAGCCAGGATGGTCTCAATCTCCTG ACCTCGTGATCCGCCCACCTTGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGCACCCAGCCA ATTTTTGTTATTTTTAGTAGAGACAGGGTTTCACCATCTTGGCCAGGCTGATCTTGAACTCCTGACCTCA TGATCCACCCGCCTCACTTGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCTACCACGCCTGGCTGAC ATTTCTCTTTATGCCTGCATCTCCCCCATTGGATGGGAAGTCCCTCCAGGGTGAGACCTTGTCTAAGTGA ACTTTGTGCCCATCAATGTCTGCGTGACCCAGGCAGGATCTGGCTCAGCCAGGAGTGGGTGTGGGGGGTG GAATCAATAAAAGTTTGTTGAATGACTTAATGACCTCTGAGAATGTATCATTTTGCAAAAGGGAAACTGA AGCCCTTTGCACTCTAACAATTATTCCTGGCACCTGATTTGCACATGGTCTGGTGCCTGAGAGGGAGGGA CATTGAATCATAGGAGGGGCTAGGAAGTACCCATTCTCTAGCCTGGCAGGCCTTATTTCTTGTCTTGGCT GTATCTTGCATTATTTTATGTGATAGCTTTTGTGGGCATTGGCCTCTTATTTCCCTAAGTCAAGCTCATC CAACCCCTGACCCACGGGCCACATTTGGCCCAGGATGGAATATGGCTCAACACAAATTCGTAAACTTTCT TTTTTTTTTTTTTTTTTTTTTTTTTGAGACAGAGTCTTGCTCAGTCGCCCAGGCTGGAGTGCAGTGGTGT GATCTCGGCTCACTGCAAGCTCTGCCTCCCAGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCT GGGACTACAGGCATGTGCCACCATGCCCGGCTAATTTTTTTTTGTATTTTTAGTAGAGATGGGGTTTCAC CATGTTAGCCAGGATGGTCTCCATCTCCTGACCTCGTGATCCACCTGCCTCAGCCTCCCAAAGTGCTGGG ATTACAGGTGTGAGCCACCACACCCGGCCACAAATTTGTAGTTTCTTAAAACATTATGAGATTTTTTTGC AATTTTTTTTTTAGCTCATCAGGTATTGTTAGTGTTAGTGTATTTTATTATTTATTTATTTATTTATTTA TTTTTGAGATGGAGTTTTGCTCTTGTTGCCCAGGCTGGAGTTCAGTGGTGCAATCTCGGCTCACTGTAAC CTCCGCCTCCTGGGTTCAAGCAATTCTTCTGCCTCTGCCTCCCGAGTAGCTGGGATTATAGGCACGTGCC ACCACATCTGGCTAATTTTTGTATTTTTAGTAGAGACGGGGTTTCACCGTGTTAGCCAGGCTAGTCTTGA TCTCCTGACCTCAGTGATCCGCCTGCCTTGGCCTCCCAAAGTTCTGGGATTACAGGCGTGAGCCACTGTG CCCGGCCAGTGTTAGTGTATTTTATGTGTGGCCCAAGACAATTCTTCTTCCAATGTGGCCCAGGGAAGCC AAAAGATTGGACACCCCTGCTCTAAGTGACTTGTGAGCTTTTTTTCTGAGACGCCTGGAATAGTTTGTTA CTCATGTTTTTAAATGATTAACTTGAGCAATTATTACTATTTTTTGAGACAGAGTCTCCTTCTGTCACCC AGGCTAGAGTGCAGTGGCGCAAGCATGGCTCACTGTTGCCTTGATCTTCTGGGCTCAAGAGGTCCTCCTG CATCAGTGTCCTGAGTAGCTGGGACTACAGGTGCACACCACCATGCCTGGCTAATTTATTTTTATTTTTT GTAGAGAAGGGTTCTCACTACGTTGCCCAAGCTGGTCTCAAACTCCCGGGCGCAAGAGATCAGCCTTCCT CGGCCTCTCAAAGTGCTGGGATTGCAGGTGTGAGCCACTGCACCCAGCTGGACAATTAACCTGAGCTAAT TTGAAAAATTTTGATGTTCTCAAGATGACTAGGGAACTGGAGCCCTCAATCAACAGTCCTCAGTATCTTT TCTGCAGGGAGGGCTAGATACCTCCTCTGTGACACTTAACTTCCATTATCCAAGGTGCTTAGGCTGTGCC CCTCACCACGTGTACATGAAGAATGCATGCCCAGCCAATCACAGTGGCTCATGCCTGTAATCCCAGCACT TTGGGAAGTCCAGGCGGGCAGATCACCTAAGGTCAGGAGTTTGAGACCAGCCTGGCCAATGTGGTGAAAC CCCATCTCTACTAAAAATAAAAAATTAGCCGGACATGGTGGTGCGGACCTCTAGTTCCTGCTACTGGGGA GGCTGAGGCAGAAGAATTGCTTGAACCCAGGAGGTGGAGGTTGCGGAGAGCCAAGATCATACCACTGCAC TGCAGGCTGGGCACCAAAGCAAGACTCCATCTCAAAAAGAAAAAGAAAAAAAGAAAAAGAAAAATGTATT CCCTCTTTCAGCCACGTTGAGTTTTCGCAACAGCGCTACAAACAGATGATGTGTTCTGATAGAAATAGGC TAGGTTCCTGCAGCAGGTGCTGTCATTTTGGAAGAGCTCAAGCCGTCTCACACCCTCAGGTGGGCCTGCT CATACCTGTGGTGTGGGTTCTACCTGGCTGATGGCTGAGGGTCTAGAATTGTGTGCAGTAGCGTTGATCG TGTACTGAGGTTGCAAACAGTGAACAGCACCATCTGGACATCGTGGATTAGAATGCAGGAGCTTCCCAAG GCTGCTATGACAAAGGACCACAAACTCAGTGGCTGCAAAACACACATTTATTTATTTGTTGATAGAGCCT TGCTCTGTCACCCAGGTGGGAGTACACTGGCTCGATCTTGGCTCACTGCAACCTCCGTCTCCTGGGTTCA AGTGATTCTCCTGCCTCAATCTCCTGAGTAGCTGGGATTATAGGCACACACCACCCTGCCCAGCTAATTT TTTTTTTTGAGACACAGTCTCGCTCTGTTGTCCAGGCTGAAGTGCAGTGGCACGATCTCTGCTCACTGGA ACCTCCGCTTCCCAGGTTCAAGCAATTCTCTGCCTCAGCTTCCCGAGTAGCTGGGATTACAGGCGCCGGC CACCACACCTGGCTAATTTTTGTATTTTTAGTAGAGATGGGGTTTCACCATGTTGACCAGGCTAGTCTGG CGACTCCTGACCTCCAGTTATCTGCCTGCCTCGGCCTCCCAAAGTACTGGGATTACACGTGTGAGCCACC ACGCCCGGCCCACACATTTATCATCTTACAGTTTGGGAGGTCAGAAGTCTGAAATAAATTTTAGGGGCAG GGCGGGTTCTAGGAGTCTTTCTTGCTTTTTCTAGCCACCAGAGGCTGCCCATCTTCCTTGCCTCTTGGCC TGATCTTTTTTTTTTTTTTTTTTTTTTTTTGAGACTGAGTTTTGCTTTTGTTGCCCAGGCTGGAGTGCAA TGGCGCGATCTTGGCTCACCACAACCTCTGCCTCCTGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCGA GTAGCTGGGATTACAGACATGTGCCACCACGCCAGGCTAATTTTGTGTTTTTAGTAGAAACGGGGTTTCT CCATGTTAGTCAGGCTGGTCTCGAACTCCTGACCTCAGGTGATCTGCCTGCCTCGGCCTCCCAAAGTGCT GGGATTACAGGTGTGAGCCAACGCGCCCGGCCCTTGGCCTGATCATTGTAAAGCCTGCTTCCACTTTCCC ATCTCCTTTGACTTTGACCTTTTGTATCCCTTTTTCACTTATTAGGACCTTTTAAGGACATTGTGCCCAC CTGGATCACCCAGGAGACGCTCCCCAACTCAAAATCATTAACTGAATCACACCTGCAAAGTTGCAAAGTC CTTTTAGCTGTGTAAGGCACTGTATTCACAGATCCTGGGGGCGAGGACGTGGGGGTCTAGAGACGCATAT CTTCGGGGGCCATGATCTGTCTCCTATATTAGGGACATAGCAGAAGTCCCACTGACCAGATAGAGGAGAC TTAATAGAGTGACGAAGAAACTGTAAAAAGCTAAGTGGGAACTCAACATTTTTCTGCTCACAGCTCTCAA GGGAAAGACCAAAGTCCTCCCCGGTGGCCTTCAAGGTATTATATATCACCCCTCTGACCTCAACTCCCCC TCCCCTTTGCTCAGTGGGCCCCAACCACACCAGCCCCTTCCTGCTCCCTGGACACCTCTAAGCCTTTTCC GGCCTCTGGGTTTGACTTTCCCTCCTAGACCCATCTGTCCTTGGAGTCTCATCTCCGATTCCAGCTCAAA TGTCATCTTCTCTGAGAGGCCCACCGCAGTGGCCCCAGTGAGAGAGTATCCTCTCTCCCCGCCTCCCACC ACATGGCTGCTGGTCACTCTCCTATAAGGAATCATCTGAAATTATCTGCTTTAGTTATTCATTTCTTGCC TGTCTCCCCCAGATAGGAATTTTCCCTCCCTGAGACCACCAACTGGGTCTGCCATGTACACCGCTGGGTT CTGCAGCTCTGAGCAACCTGTCCGGCTGCTTTGTAGGTGCCCAGCACAGGTCACTCCTGTGCCCGCCAGG ACTGGTCAGAGTGGAACAGACAGGGCGGAGGGGGCAGGGCAGCCCTGCCCGCCTGGACAGCCTGGAGAAG GCGGGAAAACGAGGCGGGAAAAGACAGCAAACAAGCCCTGCGGGTGGGTAGAGTGGGGAGCCCTGGCAGG CCCTGACGCCAGGCAGTGGGGCTTGGGGCGATCGGGCGAGCCATCAGGGTGCAGGTGGTCTCCTAGGGGC CCCCCACATTCCCTCGCAGTATTTACACATTGATTCCGGCCTTCTTAGACCTACTGGTCAATGCGTGCGA GTGGGGGGCTGCGAACGGACTTGGACTTAAGAGTTCAGGGGGTCTGTACCCTGGGGGTCCCCAAGGCTCC TGGGGTGTCCACGTGCGGGGGGTGACCAGGCCCTGCCACGCAGCCCCTTTGCACGCTGGGCGCGCCCAGC AGAGCGCGCAGGGCTGGGCGGAGCCGTGGCCCACTAGGCGGAGGCGCCGTGGACAGAGGCGGGGGCGCCC CCCACCCTCTTTCTCGCTTCCCGCCACTGCGTCGGCCAATCAGGAGGCAGGCGCCCGCCCCCGGCACGGC CTCCTGCGGCCCCGCAACTCCCAAATGCCGAGTTTTCGCGGGAAAAAAATCAGAGCAGCTGGCAGCGCGG CGGGCAGCGTTTGCCGAGCGGGCGCTCCGGGTCGCACGCAAGTCCGCGCGGGGTCCGGGCCACGCACGCG GTTTCATCGCCATCCCCAGCCGGGCCACGCGCGCAGGCAGACAAGCTGTTCGCGGCGACCGGAGAGGTGA GCGGGCGGGCCGGGTCGGGGTGCCAGCCCGGGCCGGGCGCACGGGGCTCGGGAACTTTGCAAAACTTTCC CGCGCGGCCAGCCCGGGCGCACGCATGTCCCGCACTCTGTCCCGGGATCCAGGGCCTCCCCTTCCACCTA ACCCTCGGGAATCGTTCCCCGGCACACATCCGGCTGGAGCCGGGACCAGCGCTGCGTCCCCGGAGCCCGG CGGGGGGTCGAGCGCGCCGGGTGGGGGAGGGCCTGGCGAGCCGCCGGGGAGGATGTCAGGCTCCGCGCCT GCGCGCGGGGCGCCCCGCGATTCAATTGTCGCGCCCGAGCCCGATTTCGCGCGCCCTGAGTTCCCCGGGA GCATCTGGGCCAATGGGGAGCGAGCGGGGCGGGGCGGCCGGGTGCTGCGGAGCCAATAAGAGGCGGCTCA AGTGAAGGGGGGCGGGACTTGACGAGCGGGGGCCCCCTCTGTAGTCCCGGCGGCGGGGGTGGGCGTGGGC TCGCTGGCGCGACCCGCGCGGGCCAGTGGGAGTGCGGGAGGGACGCCGAGGGTCCAGGGTTTGGAGGGGC GCGAGCTGCCGGGGGTTGGAGGTCGAGGTGAGTCGCGGGGCGCGCGCGCTCGCGGGTGGCCGGGACGGGG CGGCCGGTTACCATGGCCACCGCGGGGCGGGCCCGGTCGCGCACGCGCGCGGGGGGGGCCGGCAAGGAGG GGGGGCGTGGGCACCGAGGGGTCCCGGGGTCCGCGGATCTCGGGTGGGGTTTTTCCCTCTCAGTGGCACT TGGTTGAGTTCCCCCGGGACTTCTGAAGTTCCGGCCCGCGCTGGACTTCTGGGATTCCCTCTTCCGTAAA TAGGAATCCGAGGAATGAATGAATCAATGAATGAATGAATAAACGAACCAACTCGGCCACTTGGCCCGGG CCTCCTTTCTCCTCTGGTCGTGGGGAAGGAGGGATGGGTTGGACCTTCTGCTTTTCTTTCAATTCCCTCT TTTCATTCTCCTTCCTCCTCAATCTTCAACACTTGGCTAGTCGTTAATGCCTTAAGTGCTTAATTTGTTG TGTCTGGTCCTGGCCAGGGTCTGGCTGTACAGGAGGACTGGAAGGGCATCCTGGGAGTTTCCTGGTGTCC ACAGGCCGGACAAAAGCAACCCCGACTCCTTAGAGCATGGCATGGCTCAGAGGTGCTGGTAAAACTGATG GGGGTTTTTGCTGTCCCTCCCCTCAGCGCCGACACCATGTGGATCCAGGTTCGGACCATGGACGGGAGGC AGACCCACACGGTGGACTCGCTGTCCAGGCTGACCAAGGTGGAGGAGCTGAGGCGGAAGATCCAGGAGCT GTTCCACGTGGAGCCAGGCCTGCAGAGGCTGTTCTACAGGGGCAAACAGGTACACCCGCCGCCAGCACCT TTGTTCTATGCCTGGTCCAGGCCTCGCGCCTCTGCAGCCACCAGCCGATACTTTCTCCCTCCCACCTCCC CCCCCAACAACCTCGTCCGGTCCCACTTCATCTCTCCCGGAAGGAGAAGTCCACAGAAACCTCAAATGCC TGCGAGAGGAAGGAACAAAGGGAGGACTCACAGATTGACACGCTGGGCTGGCGGCTGGCCCTCGAATCTA TAGGGTCTGGGCTTTTAAACTTCTTTTTTCAAAGCTCCGCCTCAAAATAATGGCTAGAGAAAGAAGTTTT GGAGGTGGCCGATGGAAGGCTGAGGAATTTTCGAGAAAGGGCCCAGGACCATCTGGTAGCTAGGACGGAG GGGACCAGGTTTTCTTTTTTAAACATCCACCACCAATTGCTCTCAGCCTGTACCGGTTAAGCATCAGACC CTGCGAGTGTTTGTTTCTAAAAATTTGGATTAGCTTATTCAGAGTCTGGAGATGGCGCTTGCTAATCAGG AATTTCCGCCACCCTGAGCCTGCTGTGCTGCGGCTGCTGCTGACCTGGGGCGTGTGGTCCCCGAGGGGTC CACCGACCCTCGTCTCTTTCTCTGTTCTGTCTCCAGCCCCTCGTTGCATTTAAAATGTCCCCCTTTGATT TCATAGCTGCCACGTTTGGGGCGCTCCCTCCATTGGCACCTGGGGGTGGAGGTGCTACTTTGGTTGGTGT TTTTGTGGGGGACTGTGGGACCTACTGGGAGTGGGGTTTCCCGGCAGGATGAGACAGTGTGATCGAAGGT GTAGGTCCCATCTGCTGGAGTTGGTTGGACCGTGGGGACGGGCGTAGACTACTGGAACTGGATTAAAAGT CGTCAGTTGAGCTGCGTGTACCCCACTGTGTTGTTGTTGGATTTTGAACCGGGTACTGCTGCCATCTGGT GTCTAGGTTGGAAAATAAACACTGCGCCCGGCCAGGGGTTTTTGGGGGCTGGGAGGATCATGCCTGCTCA CTCCAGATGAGACCTGATGATTAATTTCTCTGGCTTGCATGCCATAGGAGACCTTCATTAGCCCTCTTCC CGTAAGAGACGTGATGACTTGAGTCTTAAGAATCTGAGTTAACCCGCCCTGCCCCGGGAGGAGGCGATCT GGAGAACTTGGGGAGTTGACGGTGCAAGCCGCGTGTGTGCAGAGAAGAGGCAGGGCCGGGCTCGACAGAG GAGCTCCGCCTGGCGCTCTCTTCCTCCCTCCTCCTATGATGCGTGCTCCCTTTGTGGCATCCAAACTGAT TTTGATTTGCCACTCAGCCTATTGGGTCAGCACAGAAGGCTTCATTTCACAAAGAGTTTCTGAAGCCTGC AAGGACCTTCTAAGTTCACAGCGTAGGTCAGTGGCGGGTTGGACTCTCATGCTCCCAAGTTCAGGAGAGG AGATAATGCTGAGTATCCACTCTATGCCAGCCACCGAGCTAGCATTTTAACTTTTGCATTTCAACCATGC AGGAATGGGAAAACACCTAGACACACCTGCCATGTAGATTTCACCATCGGTATTCTGACTTATTAGGTTT ATCTTGAAGCGCTCTGTCTTTCTCTCTGCCCGCCAATCCATCTTTTTGGGATGCATTTCAAAGTAAGTTG CAGACACCAGTCCACCTTTCCCTTATTACTGCAGCACACCGTCAGTACCTAGAGCTCAGTATTTGTTTTT GGTTCTGTTTTCATTGATTTTTTTTGTTGTTGTTCCTATTTGAGACAGGATCTCACTCTGCCCAGGCTGT GTTGCAGTGGCACGATCACAGCTCACTATAGCCTCAGCTTCCTGGGCTCAAGCAATCCTCCAGCCTCAGC CTCCCAAGTAGCTAGGACTATAGGCATGCACCACCATGCCTGGCTAGTTTTTGTATCTTTTGTAGAGATG GGGTCTTATTATATTGCCCAGGGTGGTCTCCTGGGCTCAAGTGACCCTCCTGCCTTGGCCTCTCAAAGTT TTGGGGTTACAGGCGTGAGCTACAGTGCCGGACCTAAAAGCTTTGTCTATAGTGAAACAGATGTTAGACA GACTGAATAATTTTGACAAATGTCTACATCCATGCAACCCAAAACCCCTATCTCCCCTCATTTGTAACAT AATACTTGAGTCATACAATAGTGTCTGTCACATTTCTAAGTTTAGTGTGACAATGACAGGAACACGTATG TTAATTAGACATGTACATTGTGCTTTTTTTTTTTTTTTTTTGAGATGGAGTTTCATTCTTGTTGCCCAGG CTGGAGTGCAGTGGCTCGATCTGGGCTCACTGCAACCTTCATCTCCCAAGTTCAAGCGATCCTCCTGCCT TAGCCTCCCAAGTAGCTGGGATTACAGTCACCCACCACCACGCCTGATTAATTTTTTGTATTTTTAGTAG AGACGGAGTTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCCACCTACCTCCGT CTCCCAAAGTGCTGGGATTACAGGTGTGAACCACTGCACCCAGCCACGTACATTGTGCTTTTAATTGTCA GGATGTCCGCAGTGATGACACCTGGCCCTAGCCTTGCCGGAACTCACCCGGACTGAACAGGGAGCTGGGA TTGGAACCTGGGATTTTGGTTTCTGAGACTGGGCTCTCAACACTGAATTTCGTCTCCCAGGTCAGCTCTG GTAGTTATGAAAAGATTCAGTGTTCCTGTGTAACCTTCATAACCGCCTCTTAGTTCCCTTACCCTGTGGC TGTTTCCCATGCAGTAGCTTTTTTTTTTTTTTTTTTTTTTGGAGACAGTTTCGCTCTTATTGCCCAAGGT GGAGTGCAATTGCGTGATCTCGGCTTACCTCAACCTCCACCTCCTGGGTTCCAGCGATTCTTCTGCCTCA GCCTCCCGAGTAGCTGGGATTACAGGTGTGCGCCACCATGCGCAGCTAATTTTTTTTGTATTTTTAGTAG AGATGGGGTTTCTCCATGTTGGTCAGGCTGGTCTCGAACTCCCGACCTCAGGTGATTCACACCCCCCTCC CCCACCTTGGCCTCCCAAAGTGCTGGGATTAGAGGTGTGAACCGTCGCATCCGGCCCCCATGCAGTAGCT TTTAAGAGATCGTGTCGTTGCTTCTGTCTTCCGGGCCACAGAGAGGTGATGCAGTTTCCCCACTTGCATG GCTGGGAAAGTGAGCTGGCAGCAGGGAGGTTTGGACAGTGGCGGGAAGGCGGGACAGAGGCACACAGCAG CACCTCCCAGAGCGTGAAGTCTGCAGGCACCCAGGCTAACGTGATAGAAAGCAACACAGTTCCCGGTGGG CACAAATGGGCAGTTGTCCTTATAGAATGTTCTAGAGTGTTCACAGTCTTTTTTTTTCCCTGTTTAAAGA AACCTGGCCTAGCAGCCCAAGGTCTGCAGTGAAGTTGATGGAGACCCCAGAGCAGAACAGAGTTGGGTCT GTCTCGGAATATGGAGGATCTCGTGGTGGTCTCACTTGGGCTGAATAGGGTGACAGTGATGTCACTTGAT GGGCGGGAACGCAGGGAGCTGATCGAGGGCAGTGACTTTGGGCAGACGGCCCAGCCTAGGCAACGGGAGA GGCATCTGCGGCCCCCACCCCTCAATCTTTTTTTTTTTTTTGGCTGCACATCAAAATAACAATAGCTGTC TTTTGCGGCACCTTTAACCTGCTCGGGTACAACGCTCTGCACTGTACATAATCTTTTCAGCATCCCTGGC CCGCGACTCGCCAGCTCCCACATCATCTTATTTTAGATAGGGCTAATACCCACCACGCTGCAGCGCAGTG CGAATTCAATGAGGTTGTGGATTTGAAGGGCGGAGTGAGCCCTGTGCCAGGCTCACAATGAAAGCGAAAT CAATCTCTTAGCACAGGGCCTGTCCCGCTCTGCACTGTGGATGTTTGGGGCCAGGTCATCCTCTGGCTGG GACCGTCCTGGGCACTGCAGGGTGCGGAGCAGCGTCCCTGGCCTCCACCCACTCCATGCCAGAGCATCCT GCCCTACCAGTCATGACAACCACAAATATTCCCAGAGACTTCCATGCCTCAAAGGCAGGATTAAGGTCAG TCTGATGCCTCAGTTGAAATGGTGGCCCAGGAATGGCCTTGCAAGAGTCACTTGTCACAGTGATGCCTCA GGTGTCCCCACTGGACGGCCCCCTTGCAGAGACCTGCCCTTCTGTCTGCGGGAGGGAGGGTCCCCACCAC CAGCTCCCACCCACTGCGGCATCCCTCCCCCAGGATGGCTCCCTGGTAGAGGGCGCGGCCTCTGTTAGGG TGACTCACCACTGCTGTTGTGGCCCCGAAGCAGCTGTAGACAATCTGTAAACCGGTGGGCGTGGCTTTGT TCCAATAAAACTTGATTTATAAAAACAGGTATGGCGGGGCCCAGTGGCTCATGATTGTAATCCCGGTGCT TTGGGAGGCCAAGGCAGGCGGATCACCTGAGGTCAGGAGTTCTAGAACAGCGTGCCAACATGGTGAAACC CCGTCTCTACTAAAAATACAAAAATTAGCCAGACGTGGTGGCGCATGTCTGTAGTTCCACTTAGGAGGCT GAGGCAGGAGAATCGCTTGAACCTGGGAGGTGGGAGGTTGCAGTGAGCTGAGATCCCACCACTGCACTCC AGCCTGGGCGACAGAGCAAGACTCCGTCTCAAAAAAAAAGCAAAACAAAAAACAAAACCAAAACAAAAGA GGTGCAGGCCAGAATTGTCCCCGTGGACATAGTTGGTCAATTAGATTGCATACTTTAATCCAGCCTCAGT TGGTGTGTCTGGGTTTTCTGGCTAGGAAGAATGCTGCTGTGGAATGTGCTGGAACAGATCCTTACGTGCG CTGTGTTGGAGTCTTTCCAGGTCAGGGGTTCTCAAACGGATTTCAGGACCCTTTACATCATCCAGAATGA TCCAATAGCCCCAGGAGCCTGTGTCTGTGTGGATTATGTCTGCCGGCTGTTAGTGTGTTAGAAGTTGAGG CCAGGCATGGTAGCTCACACCTGTAATCCCAGCACTTTGGGAGGCTGAGGCGAGGATCGCTTGAGGTTGG GAGTTTGAGACCAGCCTGGGCCATGTAGCAAGACCCCGTCTCTACAAAAAATGAAAATTAGCCGGGCATG GTGGCGCATGCCTGTAGTCCTAGCTACTCGGGAGGCCAAGGTGGGAAGATCACTTGAGCCTGAAAGGTTG AGGCTGCAGTGAACCAAGATTGTACCACTGCATTCCAGCCTGGGAGACAGAGCGAGACTTTGTCTCAAAA AAAAAAAAAACCAAATAAATTGAAAGCTGAGAAATTCAGAGCACAAGAAGACAAGCGCGCCCCCTCTTTT AGCTGTCAACATGGCGGAGCCGTCCCTGGTGACGCAGCCTCCAAAGGCCTCCCTGTGCCCTCCTGAGACC GCAAGAGGGAAAGTGGCAGCGACAGTGATCGTGGTGTCTTTGTGGCGGTTGTGTTGACCTCACTGACCCC CGAAGTGCCGCTCTAGGGTCTGTCCTCAGCGGTGACCCGGCCGGGTCGAAGGGCAGAGTTCCGCTGTCAC TAGCCCTCCACCCGTCCTGTGTGCTGGGATGCCCTCGCGGCGCCGTCCACGCCACCGCCGCCCCCTCTTG TGGGTTCTGTCTCCTCCGTGTCTAGGATCCTCCTGCATCCGTTTTTCCTTCCTCCCTTCTCTCCCTCCGT CTGTCTTGCCCGCACCTGAGGTTGTCGCAGAGGCGCTGAGACGGGCCAGCAGGAGCTGTGGCTGCCCCTC AGGAAGGCAGAGCAGTTTCTCACTTCCTTCCCCCCAGGTCCCGTCAGGCCCCTGCAGGCACTCTCTCTTC CGGCTGGAGGTCCCTCCTGATCGAGGCTTACACGGTCTTTGCTGAGCTCCTAAACTTCTGGTTTCTATCC CTAAAGTTGGAGAACCACTGCTCCCCAAACCCGGTGGCATTATCTGCCCTGCTGTGCCGCTAGGCAGTGT TCGGCACCCTGAAAGAGAGCCCCTGAATGTGGCACGAGGGGTAGGAAGTGGGCAGCTCGGTGGGGGGGGG GGGTGCAGTGAGCTTTTAGTCTTAAGTTTTCGTTTTTTTTTTTTTTTTTTTCTTTTTTATAGAGATGGGA TCTCGCTTTTTTCACCAGGCTGGTCTTGAACCCCTGGCCTCAAGTGATCCTCCCATCTTGACTTCCCAAA GTACTGGGTTTACAGGCATGAGCCACCACACTCGGCCCTTTGTCTAAGTTTTCAAAAGGAATCAGCAAAC TTAGTTATCAAGTTGTATTTGTATTTATCTGGACACTTTTTTTTCTTTTCTTTTTTTTGCCTTTAAGGGA GACAGGGTCCACAAGGCCGGGCGTGGTGGCTTACGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGG CGGATCACGAGGTCAAGAGATCGAGACCATGCTGGCCAACATGGTGAAACCCCATCTTTACTAAAGATAC AAAAATTAGCTGGGGATGGTGGTGCACGTCTGTAGTCCCAGCTACTTGGGAGGCTGACGCAGGAGAATTG CTGGAACCCAGGAGGTGGAGGTTGCAGTGAGCCGAGATCACGCCACTGCACTCCAGCTTGGCAACAGAGC GAGACTCCGTCTCAAAAAAAAAAAAAAAAAAAAAAAAAGAGACAAGGTCTTGCTGTCGTCCAGGCTGGAG TGCAGCGGCGTGATCATGGCTTACTGCAACCTCTGTTTTCCAGGCTCAAGCAATCCTCCTACTTCAGCCT CCTGAGTAGCTGGGACTACAGGTGCCTGCCACCACACCCAATATTTAAATTTTTATTAATTGAAAAAACT TTTTTGCAGAGACAGGGTCTTGCCTGGTATCAAACTCCTGGGCTCAAGTGATCCTCCTGCCTCGGCCTTC TGAGTAGTTGGGACTACAAGCATGAGCTATTGGGCCTGGCCTAGCTTTTATACAATGCCCATGTTACAAA ATTCCAAATGTCCAAAAAGCAAGGAGAATATCTTCCACTCTGCCTTGACCTTCAGTTTCCCCCCTGTAGT AACCTGTCTGCTTCCAGAAGTGCTTGAACATGTGTGCGTTTGCTATGGGTTTTTTTTTGTTTGTTTTGTT TTGTTTTTGAGATGGAGTCTCACTCTGTTGCCCAAGCTGGAGTGCAGTGGCGTGATCTTGGCTCACTGCA ACCTCCACCTCCCAGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGGTTACAGGTGCACA CCACCACGTCCGGCTAATTTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCACGTTGGCCAGGTTGGTC TCAAACTCCTGACCTCAGGTGATCCACCCACCTTGGCCTCCCAAAATGCTGGGATTACAAGTATGAGTCA CTGTGCCTGGCCTGTTTTTTTTTTTTTGAGACAGAGTCTTGCTCTGTCGCCAGGCTGGAGTGCGTTGGCT TGATGTCAGCTCACCGCAACCTCCACCTCCCGGGTTCAAGCAATTCTGCGTCAGCCTCCCGAGTAGCTGG GACTACAGGCATGCACCACCATGCCCGGCTAATTTTGTATTTTTAGTAGAGACGAGGTTTCTCCATATTG GTCAGGCTGGTCTCTAACTCCTGACCTCCAGTTATCTGCCGGCCTCAGCCTCCCAAAGTGCTGGGATTAC AGGCGTGAGCTACTGTGCCCAGCTGGTTTTTTTTTTTTTTTTTTTTTTTTAGACAGGCTCTTGCTCTGTT GCCCAGGCTGGAGTACAGTGGCACGATCTTAGCTCACTGCAGCCTCGAATTCCTGAGCTCAAGTGATCCT CCTGCCTCAGCCTCGCAAGTAGCAGGGACTATAGGCTGTATACTACTATACCTGGCTGATTTTAAACATT TTTATAGAGATGGGTTCCTGCCATGTTACCCAGGCTGGTCTTGAACTCCTAGCCTCAAATGATCCTTCTG CCTCAGCTTCCCAAGGTGCTGGGATTATAGACCTGAGCCACTGCTCCTGACCTCATTTTTTTTTTTTTTT TTTTTGAGACAGTGTATCAGTGTCTCCCAGGCTGGAGTGCAGCGGCGCGATCTCGACTCACTGCAACCCC TGCCTCTTGGGCTCAAGCAATCCTCCCACCACAGCCTTCCAGGTAGTTGGGACTAGAGGTAAATTTTATA GTGATGGGTTTTGCCATGTTGCCCAGGTGATCTTCAACTCCTGGACTCAAGTGATCCTCCCGTCTTGGCC TCCCAAATCATACCTGAGATTACAGGCATGAGCCACTGCACACAGCCCCATTTTAACTTTTTTTTTTTTC TGAGGCAGAGTCTCGCTCTGTCACCCAGGCTAGAGTGCAGTGGCGTGGTCTTGGCTCACTGCAAGCTCCA CCTCCTGGGTTCATGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGTGCCCGCCACCTC GCCCAGCTAATTTTTTGTATTTTTAGTAGAGATGGAGTTTCACTGTGTTAGCCAGGATGGTTTCGATCTC CTGACCTCATGATCCACCCGCCTCCGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCGCGCCTAG CCCATTTTATCTTTTCTGATAATGATTTTCCTTTTGCCAAAAACGGCAAGTGGGTTTTAGATTAAGTCAC TCCTTTTACCAGGCACAGTAGGAGACCTTGAGTTAGGGCTGAGGTGGTGTCATTTAATAGGGACATTCAA CTTCACTAGGTTCAATGATAGGAGACTTTACAAATTTCCATAATGGTAAATCTTCTTTCATTTAAATTAT TATTATTGTTAATATTTTTTTTTTTGAGACAGAGTTTTGCTCTTGTTGCCCAAGCTGGAGTGCAGTGGCG TGATCTCAACTCACTGCACCCTCCGCCTCCCGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCGAGTAGC TGGGATTACAGGCACCCACCACCACGCCTGGCTAATTTTGTATTTTTAGTAGAGACGGAGTTTCTCCATG TTGGTCAGGCTGGTCTCGAACTCCTGACCTCAGCTGATCCGTCCGCCTTGGCCTCCCAAGGTGCTGGGAT TACGGGCATGAGCCATCGCACCCGGCCAATCATTTAAATTATTAATGAAGAATAAAAAGAGGCTGGGCGC AGCGGCTCATGCTTGTAATTTCAGCACTTCGGGAGGCTGAGGCAGGCAGATCACCTGAGGTCGGGAGTTA GAGATCAGCCTGGCCAACATGGTGAAACCTCGTCTCTACCAAAGATACAAAGATTAGCTGGGTATGCTGG CATGTGCCTGTACTCTCAGCCATTCGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCGGGAGACGGAGGT TGCAGTGAGCTGAGATTGCGCCACTGCAGTTCAGCCTGGGTGACAGTGAGACTCCGTCTCAAAAAAAAGA AAAAAAAAAGTAAGTCCCACGTAGCCATCACCCTCTGCAGTAGTCATCTGCTGTGTCTGATCTTGTTCAT TTTGCTCATTTCTACCCTACCCACTTACCTCTACCTGACTGGATTGTTTAAGAGATGGGATCTTGCTGTG TTGATCAGGGTGGAGCACAGTGGCTATTCACAGATGTGATCATTTTGCATGAGAACCCCAAACTCCTGGG CTCCCCTGACCCTCCAGCCTCAGTCTGCCAAGCAGCTGGGACTACAGATGTGAGCCACTGTACTGGCTCC TACTGGATCATTTTGAAGTGAGTTACAGATGCCATAACTATAACACAGACATCATAGGTACAGGAATTTC AGTGCATCTTCCCCAGTGGCTCATGGATCACACAGATAGAAAATCGGTCAGGAGGGCCACGCGCGGTGGC TCACACCTGTAATCCCAGCACTTTGGGAGGCCAAGGCGGGTGGATCACGAGGTCAAGAGATCGAAACCAT CCTGGCCAACATGGTGAAACCCTGTCTCTACTAAAAATACAAACATTAGCTGGGCGTGGTGGCATGCACC TGCAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCAGGAGGCGGAGGTCACAGTGA GTCAAGATCGTGCCACTGCACTCCAGCCTGGTGACAGAGGGAGACTCCGTCTCAAAAAAGAAAAAAAAAG AAAGAAAATCGGCCAGGATGCCGGGCACGGTGGCTCAGCCCTATAATTCCAGCACTTCGGGAGGCCAAGG CGGGTGGATCAACTGAGGTGGGGATTTCGAGACCAGCCTGACCAACATGGAGAAACCCCATCTCTACTAA AAATACAAAATTAGCCAGGTATGGTGGCGCATGTCTGTCATCGCAGCTACTCGGGAGGCTGAGGCAGGAG AATTGCTTGAACCTGGGAGGCGGAGGTTGCAGTGAGCCGAGATTACACCACTGCACTCCAGCCTGGGCAA CAAGAGTGAAACTCCGTTTCAAAAAACAAACGAAAAAGGAAAGTTGGTCAGGATGCTGGGCACAGTGGCT GGGTCCTGTAATCCCAGCACTTTGGGAGGCTGAGTCAGAAGGATCAGTTGAGCCCAGGAATTTGAGACCA GCATGGGCAACATGGAGAAACCCTGTCTGTACAAAAAATACAAAAAACTTTCTGGACGTGATGGCCCATG CCTGTAGTCCCAGTTACTTGGAGGGGCCGAGGCGGGAGGGTTGCTTGAGCCCAGGAGGTCGAGGTTGCAG TGAGCCATGGTCGTGCCACTGCCCTCCAGCCTGGGCAACAGGGAGGGAGACCCTGTTTTAAGAAGAAAAA GAAAATTGATAAAGATGTAGATGATTTGAACAACACAAGTAACAGGGTTACCGTAATGACATGGATGGAA TCTGAACCCAGCAAGAGAGAAAACACATTCTTCTCAGGCCACGAGGAGTGCTTAGGGAAACTGACCACAT ACAAGGCAAGTCTTAAAAACTCGATTTTTATTTTTATTTGTATTTACTTATTTTGTTTATTTATTTGAGA CAGTCTCGCTCTGTCGCCTAGGCTGGAGTGCAATGGTGAGATTTCGGCTCACTGCCTCCCAGGTTCAAGC TATTCTCCTGCCTTAGCCTCCTGAGTAGCTGGAATTACAGGCGTGCGCCACCACACCCAGCTAATTTTTG TATTTTTAGTAGAGATGGAGTCTCACCATGTTGGCCAGGCTGGTCTCGAACTCCTGATCTCAAGTGATCT GCCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCGGACCTGGGCTTTTGTTTTTTAT GTTTTCATTTATTTATTTGTTTTTGAGATGGAGTCTTGCTCTGTTGCCCGGACTGGAGTGCAGTGGTGTG ATCTCGGCTCACTGCAAACTCTGCCTCCTGGGTTCAAGCAATTCTTGTGCCACAGCCTCCCCAGTAGCTG GGACTACAGGCGCCCACCACCACGCCCGGGTAATTTTTTGTGTTTTCAGTAGAGATGGGGTTTTGCCATG TTGGCCAGGCTGGTCTCGAACTCCTGACCTCAGGTGATCCATCCGCCCTCGGCCTCCCCAAGTGCTGGGA TTACAGGCGTGCACCACCGTGCCTGACCCTTTACAAATTTAGAACAATTACTGCCTTACTGACCATGTTT TCTCTCACCTGTGGGGTCAGAACTTAACAATAACTAAGCTTCCTCCTTCGCGCTTCGGGTTGTGCAAGCT TCCTCCTGCCTGCTTTGGGGCCTTTCTGCAATGTTCCAGAAGCGGCATCAGGAGGCTGCCCAGCCAGCTC GTGAGTTGTGTTCTGGAGTCAGAGTTTTGTGCCAGCCTGGGCCAGGCCCCATCCCCACTTCCCGCCCCAT TTGCCCCTGTCTACATCATTGTACTGGGAGACACTTCCTGTCCCTCCTACGTAGCCCACGCTAAGCAGGG TGCTTCTATCCACCTCACCTTTCCGATGTGGGAAGGGCCGAAGTCATGGAGGGGCGACCCGTCAGGCCCA GCAAGGGTGGCACAGATGTTGTCCCTAGTAACAGATGAGAGGGGATGGGCTGGGACTGCAGGCCTGGCTC CCCAAGCTGCTCCTGCGGGTCAGGGGCTGCCCATTAGCCTGGCCAGGGCCCCTCATTGGATCCCTCCTGG CCGCCCAGACCACAGCCCTTGCCCCCCTGCCTACCCGCCACCAGTTCTCATTGGCCCTGCCTCCCTGCTT AACTCTGCCGCCTTGGCTTCCCCTCCTCGGTCTGTCTCCTCCCCGACTTGTCCTCTGTCTGAGTCTGGCA GGACAGAGTCCGACCGTCTGGCCCCCTCCTGGCTCCGTCTGCTCCTCCTGCCGCCTCCTGCTGTCGAGGT CACTTGGTTCTTGGCCTGTCTGGCCCCCAGCCACCCTGCTGGCTGCCTGCTCTCCAGGCAGCCCCTCGCC CAGGGCTGCACCTCCGACCTGTCCTCCGTCTTGGGTGGGGCTGGGACTGTATTTTCCATCCTCTGCAGTG GTCTGGTTTCCCTCGTGCGCTGAGGCCCCTCTGCTTGGCTGCCCCTGGCTGCCCCATGCAGCTGAGCCAT GAGCGCGGCCTGTGTGCCCCTCTCCCGCTGGCTGGAGCTCAGGATGCTCACGCCGCTCTGGCAGATATCG CTGCTGCAAACATAGGAGGAGCAGCTGCCCCTCTGCGCACGTGGCCTTCGGACACATGTGAGGGCCGCTC TAGCTTGGGTGCTCACTGCGGGTGATTCCACCCTCCAGGGGACACTGGGGGATGTCTGGGGACATTCATG ACTCGGGCGCTCCTGGCGTGGAGTAGGTGGAGGCCTGGAGTGCTGATTAGCACCCTGCAGGGCCCAGGAA GGCCCCACCCCAGAGAGTGATCAGACCCCAAATGTCAGCTTTGGCAAGAGCAGTGTGCCTGGCCACAGAG GTGCTGGCCCGGATGCAGATGAGTGCCCCATCCATCCCTCTGAGCGCCGTGTGGCTTGTCCCATGCTGCT TTTCCTGACCCAGTGATATTGGGGGCACTTGACTTCTCTCTTTTTAAGACGGAGTCTCATTCTGTCACCC ACGCTGGAGTGCAGTGGCGAGATCCTGGCTCACTGCAACCTCCACCTCCCAGGTTCAAATGATTCTGTTG CCTTAGCCTCTTGAGTATTTGGGATTACAGGCACTAACCACCATGCCTGGCTAATTTTTTAATTAATTTT TAATTTTTTTATTTTTTTGAGACGGAGTCTCGCTCTGTCGCCCAGGCTGCAGTGCAGTGGCGTGATCTCG GCTCACGGCAAGCTCCGCCCCCCGGGTTCATGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTA CAGGTGCCCGCCACCACGCCTGGCTAATTTTTTGTATTTTTAGTAGAGATGGGGTTTCGCCGTGTTAGCC AGGATGGTCTTGATCTCCTGACTTCATGATCCACCCGCCTCGGCCTCCCAAAGTGCTGGGATTATAGGCG TGAGCCACCGCACCCGGCCAATTTTTGTATTTTTAGTGGAGACGGGGTTTGGCAATGTTGCCCAGGCTGG TCTCGAACTCCTGGCCTCAAGTGATCTGCCCACCTCGGCCTCCCAAAATGCTGGGATTACAGAGTAAGCC ACTGTGCCCAGCCCCTTTTTTAGAAAAAATTAATAAACTTTATTTTCTAGAGCAGTTCTAGGTTCACAGC AAAATTGAGCAGAAGGTACGGAGTTCCTATAGACCCCCTGCCCCAACAGGCATAGCCGCCCCCACTGTCA GCCTCCCCCACAGAGCGGTGCATCGGTTACAGTTGATGGCCCGATGGCCCTCTGTGGAGTCATCTTCATC TCTGAGTCCACAGTCTACATACACCAAGGCTTGCCCTTGGTGTTAAGTTTTTTTTTTTTTTTTTTTGAGA CAGTGTCTCACTTGTCGCCCAGGCTGGAATGTAGTGGCGTGATCTCGGCTCACTGTAACCTCTGCCTCCC AGGTTCAAGCGATTCTCCTGCTTCAGCCTCCTGAGTAGCTGGGACTACAGGCGCGTGCCACCACGCCTGG CTAATTTTTGTATTTTTAGTAGAGACGAGGTTTCACCATGTTGGCCAGGCTGGTCTCGAACTCCTGACTT CAAGTGATCCACCTGCCTTGGCCTCCCAGAGTGTTGAGATGACGGGCGTGAGCCACTGTGCCTGGCCTGC TTCATGTTTTAAATAACGGCTTTATTATATCCCTGCAGTTCACCCAGTTAAAGTACACAGTTGAGGTATA TTCATAGTTGTGTAATCATCACTGCAGTCTATTTTAGAACATTTTGTCACCTTGAAAGGAAACCCTGAAC CCTGTCCCAGCTACTGCTTCCTTTTTCTGCATCTCCTCCCGCAGCCCCTGGCACCCTCAAATCCCCTTCC TGCCTCTGTGGCTTGGCCTGTCCTGGAAATTTCATAGAAATGGGATCATGCACTGCGTGGCCTTTTGTGT CTGGTGTTTCTCACTGAGTGTGATGTCCTCAAGGTGCATCCACACTGTGGCCTGGGTCACAGCCTTGCTC CTTTTCATGGCTGAGTCGTATTTTATTTTGCCTTATATTTTATTTATTTTATTTTATTTCTTAAGACAGT CTTGCTCTGTTGCCCAGGCTGGAGTGCAATGGCACAATCTCTGCTTACTGCAACCTCCGTCTCCCAGGTT CAAGCAATTCTCCTGCCTCAGCCTCTGGAGTAGCTAGGATTACAGGCACCCGCCACCACGCCCAGTTAAG TTTTGTATCTTTAGTAGAGACGGGGTTTCACCATGTTGACCAGGGTGGTCTCAAACTCCTGACTTCAGGT GATCTGCCCTCGTTGGCCTCCCAAAGTGCTGGGATGACAGGCGTGAGCCACCGCACGCGGCCTGAGTCAT ATTTTGACACATGGATGGATGGCCACATTGTGTTGATCCTCTCACCTGTTTTTTCTTTTCTTTCTTTCTT TTTTTCTTTCTTTTTGAGACGGAGTTTTGCTCTTTTTGCCCAGGCTGGAGTGCAGTGGTGCAATCTCGGC TCACTGCAACTTCTACCTCCCAGGTTCAAGCAATTGTCCTTCCTCAGCCTCCCGAGTAGCTGGGATTACA GGCACCTGCCACTATGCCCGGCTAATTTTGTATTTTTAGTAGAGACAGGTTTCACCATGTTGGCCAGGCT GGTCTTGAACTCCTGACCTCGTGATCTGCCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGC CACCGCACCCAGCCTCAATCCCCTCACCTGTTGATGGACACCTGGGTTGCTTCCACTCTCAGGCTGTTGC GAGTGATGCCGTGTGAACCTGCGTGTACAGGTTGACGTGCCTCTTCCTCTCCATCCGTGCCACCTCTCCC CAAAGCCAGCTGCTCTGTGCTGGAGAGCTGGCCCTGAGCCTCCTCCTGGCTCCCAGGCAGCGCCTAGCAT GTCAGAGGCACTCACTTCTAGCTGGGAGAACAGAGGGGCTGAAGCGGATATTGGTGGGCCCTCGATGTCC ACGGTGGGTTTCAGAGCAGCCCTTGAAACCCTTGTAGCTGTAGGTGGGTGTGTACATATTCAAACGGGTT TTTCTGATGCTGGTGGATCGCTTGCTTGAGCCCCGGAGTTCAAAACCAGCTTGGGCAAAGCAGCAAGACC TCATCTCTAAAAAAAATTAGCTGGGCATGGGTGATGTGTGCCTGTGGTCCCAGCCACTCAGGAGCCTGAG GCAGGAGGATTACTTGAGCCCAAGGTTCGATGCTGCAGTGAGCTACGATTGCACCACTGCCCTCCATCCT TGGCAACAGAGTGAGATCCTTTCTAAAGGAAAAAAAAAAAAAAGTCCGGGTGCAGTGGCTCACGCCTGTA ATCCCGGCACTTTGGAAGGTTGAGGTGGGCGGATCACGAGGTCAGGAGATCGAGACCATTCTGGCTAACA TGGTGAAACCCCACCTCTACTAAAAATACAAAAATTAGCCGGGCTTGGTGGCGGGTGCCTGTAATCCCCG CTACTTGGGAGGCTGAGGCAGGAGAATGGCGAACCTGGGAGGCGGAGCTTGCAGTGAGCCAAGATCGTGC CACTGCACTCCAGCCTGGGCGACAGAGCAAGATTCCGCCTCAAAACAAAAAACAAAACAAAACAAAACAA AAAAAAACAGGCCGGGTACTGTGGTTCATGCTGTAATCCCAGCTCTTTGGGAGGCCGAGGTGGGTGGATC CCTTCAGCGTAGGAGTTCAAAACCAGCCTGGCCAACATGGCGAGACCCTGTCTCTACTAAAAATACAAAA ATTAGCTGGGTGTGATGGCTCATGCCTATAGTCCCAAGCTACTCAGGAGGCTGAGGCACAAGAATCGCTT GAACCTGGGAGGTGGAGATTGCAGTGAGCTGAGATCACACCCCTACACTCCACCCTGGGCGACAGAGTGA GACTCCATCTCAAAAAAAAAAAAAAAAAAAAAAATTTTTTTCTGGAAAAGATGAGTCAGCCTTTATCAGG TTCTTAGGTTTATGGTGAACAAAGAAAGAAAGCCTGCAGAGAAGGGCCTTGGCCTTCACTGTGACCCCCA TGCTGTTTGCATTTGAACAGCCGTCAGGCCTTGGATCCCCAAGGGGCGAAAGGAGGAAGAGCTGACATTC TATGTATGTCTCTCTCCTCCCTTTTCCTAAGGTCTCTCTCCTCCCTTTTCCTAAGGATGCTCCTGAACCA GGGCATTTCTGCCTCTAGGGGACACATGGTGATGTCTGGGGGACATCGGTTGTTGTCATGACTGGTGGAG GCCAGGGCCGCTGCAGTGCCTCTGCAGTGCCCAGCACGGCCCCACGGTCCAGTGCCCAGAGGGGGAGACC CAGCCCATCCCAGAGTGGTCAGCCCTAATGTCAGCCATGCTTAGGTCGAGAAACCTGTATTAATTACATG GAAACCAACCGAGTCCAATCCTGCTCGCACCAGGCACGGGATAAACTCCTGACGGGGCAGACGTGGAAAC CAGGGGGACCCCCAGCTCCTGGGATTCACCTCCTCTCTCCCTTCCCACTCAGTGTGTGGATTTTAATGCG TGCAGCCTCCTGGGACCTCAGTAGGGCACAGCATCATGGGATAAGGAGTTTCTTGGGGGCCTGTGGAATC CTTCACCAGGGGGTCTCACCCAGGGTGACTTCACACCCCCCCACCCCATACCGTATGATGTCTGGGGACA TTTGTGGTCGTCACAACTACGGGGTGCTCCTGGCATGGAGTAGGTGGAGGCCAGGGACGCTGCTCAGCAC CCTGCAGTGCCCAGGATGGCTCCGCCCCAGAGAATGGTCCAGGACCTGGCCCCAATGTCTGCAGTGCCGG GGGAGAGGAACTTGTTGCCTTGGGGGCATCTAGATGGCAAATCATCAGGAGGGGGGGGTCCTAGATGGCA AACCACCGGGAGAGGGTCCTTGTTGGGTGTTGGTGGAGTGTGAAGGGGCAGCTTCTGACAAAATGCCTCG GCTTCTCCAGCCCCCAGATACAGCTCAGGTGATGAGCTCCTCCTTGCATACCTGCTGAGTCAGGTGACCC GAGGGGCAGGCTGTGGAGCCAGGCCCCAGGGGTTGAGCGCATCAGGATAAAAGCGCACAAAGGGCGGGTG GAGCTGAGGGTCAGAGGAGGTGCCCTGGCAGGCGAGATTGGCGCTGGAGCCTTACCCAGGAAGCTCATAG GAAGCTCATGGATGCTGGCATGTGCCTCTTGCTGTTCAGGTGGGACAGGGTCTCTCTGTCTCGACACTGG ACAGTGGGACCGTCCTGGGCACTGCAGGGTGCCGAGCAGCGTTCCTGGCCTCCACCCACTCCATGCTAGG AGCTTCTCCCAGTGGCGACAACCACAAATGTCCCAGACGTGGCCCAGCGTCCCCCGGGGTCTGAATCATG TTTGGTTGAGAAGCAGTGACAGAGGTGACACATGTTCACTGTCACAAAAGCTGCCGTAAGCACGAAGTAT TAGGAAAAACTCCCAAGACCCCCATGTGTGCGTGGTGCCCCGTGATGATGTTTTGTGCTTCTGGGTGCTT CCTGCATGCAGTGCCAAAAGCCCTCGCTAGAGGGGCCTGAGACCCTGAGGGAAGGGACTGGGGTGCCGCT TGTGAGCGGGACAGCCCCCTGGCATGGCCCAGGTATCATGGCTCTTTACTCTGATGCAGATTGCCCCCCC CCCACAAGGGCTGGGACACAGTGTTTGGTTCATCACTGGTGCCCACAGATGCCCACTTGGCATTTGGTGG CTAAACAGCGTCTGCCTCTGGTGTCCCTGCAGATGGAGGACGGCCATACCCTCTTCGACTACGAGGTCCG CCTGAATGACACCATCCAGCTCCTGGTCCGCCAGAGCCTCGTGCTCCCCCACAGCACCAAGGAGCGGGAC TCCGAGCTCTCCGACACCGACTCCGGCTGCTGCCTGGGCCAGAGTGAGTCAGACAAGTCCTCCACCCACG GTGAGGCGGCCGCCGAGACTGACAGCAGGCCAGCCGATGAGGACATGTGGGATGAGACGGAATTGGGGCT GTACAAGGTGAGCCTCCCCTCCGCAGCTGCTCTGGGGTTGGACGTTCTCCCTGCCATTCTGGTCTTTGCA TACCCAGGGCTCACAGGAGGGGCTTCCCACGCGCCTCTCTAGCTCTGGCTGGGCAGAAATGGCCAAGGGG TGGTTTCCTGCACGTTCCTTGAGGGGAACATGGTACCCTGGGATTCCTTTGTGGACCTCTAGAGCAGAGT CCTGTTCGGGGCCTGCAGGTGTCTTCTCCGTGAAGCTTGCAGTGGCTGTGACGTTTCTGAACTTGCTGCT ACCATGTAAGATCAGGAAATGTCACAGAAAGATCTGGGTTTCCAGCTTTTTTATTTTTTTATTTTTTTTT TGGCAGGGTCTCACTTTGTTGCCCAGCCTGGGGTGCAGCCGTGTGATCACAGCTCACTGTAGCCTCGAAC TCCTGGGCTCAAGTGATCCTCCCACCTCAGCCTCCTGAGTAGCTGATGTTATAGGCATGTGCCACCACGC CCAGCTAATTTTATTTTATTTTATTACTTTTTTAATACATGGTCTCATTCTGTCGCCCAGGCTGGAGTAC AGTGGTGCCATCTCGGCTCATTGCAACCTCCAACTCCTGGGTTCAAGCAATTCTCGTGCCTCAGCCTCCT GAGTAGCTGGGATTACAGGCATGTGCCACCACACCTGGCTAATTTTTGTATTTTTTGTAGAGACGGGATT TCGCCATGTTGGCCAGGCTAGTCTTGAACTCCTGGCCTCAAGTGATCTTCCCGCCGCAGCCTCCCAAAGT GCTGGAATTATAGGTGTGAGCCACTGCACCCAGTCTGTTTTATTTTTTAGTAGACACAGCGTCTTACCAT GTTGCCCAGGCTAGTCTTGAATTCCGGGGCTCAAGCGATCCACCTGCCTCGGCCTCCCAAAGTGCTGGTA TTCCAGGCGTGAGCCACGACGCCCTGCCTGGATTTCCAGCTTCTCTTGACAAATGGGCAGCTCTGGTCTC TCAGGGCCTCCCAGCAGCTGTGGCTGAAGCAGAGCCGCAGGGGCCTTTGTTAAGACAGTCCATGCCCCCT GGCCCCGCATCCCCGTCACCCCTGCCGGGGCTGGTTTCTCATGGTCAGCGGTTCCCAGCCAGGGAGGAGA AACCTCGCTGTGGGCATTCGAGTTTGCGCCCTGGTTCCAGAGCATCCCAGTGTCCGAGAACCAAGGTGGT CTCCCGTCAGTTTTCCTCACCCCGTTGGGATGCCAGACTTCCCTCATTCCTCACAGGTCAATGAGTACGT CGATGCTCGGGACACGAACATGGGGGCGTGGTTTGAGGCGCAGGTGGTCAGGGTGACGCGGAAGGCCCCC TCCCGGGACGAGCCCTGCAGCTCCACGTCCAGGCCGGCGCTGGAGGAGGACGTCATTTACCACGTGAAAT ACGACGAGTGAGTCATGGCAGGTGGGCGGGCCTGGGTATTCAGGCTCTGTGACGCGCATCCTTGGCTGCG GGTGTTCAGGCCAGAGCTTGGCACTGTCTCGAGATGGTGATCAGGATCTGGGGCCCCATCCTCGAATTCC TAACAGCATACGAGGCTGCCCACTTGGGGACTAGCCTGGGGACCCGAAGCCGGCTGCCCCCTCCTGTGTC TCCGCGGAGGGTTCTGCTCGATCAGTGGCTGAAACTGCCACCCCATCAGTTTTTCTGTTTTATTCCATCT TCCGGGTTTGTCATCTCTCCCTCATCCCCACCCCTAACGTCAGTCTCCAGTCTTTGCACAAGTGTTTACT GGGCACTTCCTACCTGCCAAGTTCGGGGTCCACACACCAGTGGACACAGATGGTGGCTGCGTCTGTCCGT GCTGCCATCGTGAGATTTCACAGACGGTGTGGCTTAAACACGGACATTGGTTGACTTGCTCACTGCAACC TCTGCCTCCTGGATTCAAGCGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGTGCCCGCCA CCACACCCAGCTAATGTTTGTATTTTTATTTTATTTTATTTTTATTTTATTTTTTCGAGACAGAGTCTTA CTCTGTCACTCAGGCTAGAGTGCAATGGCGTGGTCTCAGCTCACTGCAACCTCCGCCTCCCAGGTTCAAG CGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGTGTGTGGCCACCACGCCTGGCTAATTTT TGTATTTTCAGAAGAGATGGGGTTTCACTATGTAGGTGAGGCTGGTCTCAAACTTCTGACCTCGTGTTCC GCCCGCCTCAGCCTCCCAGAGTGTTGGGATTACAGGTGTGAGCCACTGTGCCCAGCTTATTTTATTTTTT TGAGACAGTTTCACTCTGTCCCCCAGGCTGGAGTGCAATGGTGTGATCTTGGCTCATTGCACCCTCCATC TCCCGGGTTCAAACGATTCTCCTGCCTCAGCCTCCCAAGTGGCTGGGACTACAGGCGTGCACCACTGCGC CCAGCTAATTTTTGTTTTTGTTTTGTTTTTGAGACAGAGTTTCACTCTTGTTGCCCAGGCTGGCGTCAAT GGCGCGATCTCGGCTCACCGCAACCTCTGCCTCCCGGGTTCAAGCAATTCTGCCTCAGCCTCCCGAGTAG CTGGGATTACAGGCATGCGCCACCACGCCTGGCTAATTTTGTATTTTTAGTAGAGATGGGGTTTCTCCAT GTTGGCTGGTCTCCAACTTCCGACCTCAGATGATCTGCCTGCCTCAGCCTCCCAAAGTGCTGGGATTACA GGCATGAGCCACCGTGCCCGGCCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGGCAGGGTTTCACCGT GTTGGTCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCTTCCCGCTTCGGCCTCCCAAAGTGCTGGGA TTACAGGCGTGGGCCACCTTGCCCGGCCTCTCCTCTTGTTCTAAAGACACCAGTCCTGTTGGATTGGGGC CCACCCTACTGCAGTGTGATCTCATCTTAATATGATTTCATCTGCAAAGGTTCTATCTACAAAGACCCTG TTTCCAAAAACAATCCTATTCGTGGGTACTGGGGATCAGCCTTTGAACATCTCTTTTTGCAGGGGACACG GGCAACCCATAACAATTTTGTACCTGGAATGTGCCTTAATATACCTGTGTGTTCTCAACACCAGCATATA AGCCTGTTGGGAGGGGCCTCTGCACACTGTCGGGAGGGGCCGTCCCACCTCGGCTCGTTTCCCATTGAGG GAAGGAGGCTTGGTCTTAGCACGGGGTCTAAGGCCCGGGCTTTCCTCCCAGCTACCCGGAGAACGGCGTG GTCCAGATGAACTCCAGGGACGTCCGAGCGCGCGCCCGCACCATCATCAAGTGGCAGGACCTGGAGGTGG GCCAGGTGGTCATGCTCAACTACAACCCCGACAACCCCAAGGAGCGGGGCTTCTGGTACGACGCGGAGAT CTCCAGGAAGCGCGAGACCAGGACGGCGCGGGAACTCTACGCCAACGTGGTGCTGGGGTGAGCCTCGCGT CCTGGGGCGAGCCCTTCCTCTCTCCTTTCCTCCCCTCCCGGGGCCCCCGGACTGGCTTTGAAGCCGTCCA GCCAGCGCTGTGTGTGCGAGGCCCTTAGCCTCCGGCCTGGCCTTCCTGCCTCCCCTCTGGGGTCTGTTCC TGCTCACTGCTGAGCATCTTTCTAAGACCGACCACCTTGTGCCCCTGAGTGCCTCTGCCCAGGGAACTGT CTCTGACCCCCAGGCCCTGACAGGCAGAGTTGTCAAACTTCCTTTTTCTCATGGTGTTTTTTTTATCGCT CTGTTGCCCAGGCTGGAGTGCAGTGGTTCGATCTCGGTTCACTGCAAGCTCTGCCTCCTGGGTTCATGCC ATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCGTCTACCACCACACCTGGCTAATTTTTTT GTATTTTTAGTAGAGACGGGGTTTCACCGTTAACCAGGATGGTCTCGATCTCCTGACCTCGTGATCTGCC TGCCTCGGCCTCCCAAAGTGCTGGGATTGCAGGCAGTGAGCCACCGTGCCTGGCCTCAAGCTTTCTTTTT CTCTCTTGTTTGTTTCAAATTTGGTGAATAGGTCCCATTCACAGGGTCAAAATAGAAAGCACCCAAGACC ACACATGAAGGTTCTCCCTCCTCTGCCTGGTCACCCAGTTCCCCTTTTTGGCGACATCACTGTTACCAAC TTTCCAGGGACATTCTGTTCATAAACATACACGCCAAACCACACCGCTTAGGAGTTGGCAAACTGCAGTC CACAGGCCTGCTGTGGTCCGCTGCCGGCTTTGACTAATAGTTTTATTGGGACGTGGTCACACCCATTTTT ATCTTATTACCTGTGGTTGCTTTTGTGTTATAAGAGCAGAGTTGTGTAGTTGCAACAGAGACTATGCGGC CTACAAAGCTGAAAATCCTTCCTATTTGGCCATTTGCAGAATCATTTTGCAAAGCCTGTTCTTTCTCCCT TGCCTCTTTGTGTGTGTGTGTGCGTGTGTGTGTGTGTGTGTGTGTGTGATAAAATGTATGTAACAGAAAA TTTACCTTTTTTTTTTTTTTAAAAGACAGAGTCTCCCTCTGTCGCCCAGGCTGGGGTATAGTGGCATGAT CTTGGCTCACTGCAGCCTCCGCCTTCCAGGTTCAGGTGATTCTCCTGCCTCAGCCTCCCAAGTAGTTGGG ATTACAGGCGCCCGCCACCACGTCTGGCTAATTTTTGTATATATATATATATTTAGTAGAGTCTGGGTTT CACCATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAAGTGATTCGCCCGCCTCAGCCTCCCACAGTG CTGGGATTACAGGCATGAGCCACTGCGCCCGGCCAAAAATTTACCATTGGAACCATGTTTAAGCGCACAG TTCGGTGGCATTAAACGCATTTACGTTGTTACGCAACCATCTCCAGCACTTTGTCCTCTTCCCAAACTGA AACTCTGACTCCATGAAACACTCACTCCCTAGCCCCTGACACCTCTGCATCCTACTTTCCATCTCTGTGA ATCTGACAACTCGGGGGACCTCCTAGGAATGGGATCACACAGGATTTGTCCTTTGCATCTGTTCACTGAC GTCACTGAGTGTGATGTCCTTGAGGTGCATCAGGCTGTAGCCTGGTCGGAATTTCCCTCCTTTTTGTGGC CGAGTGATAGTACGTGACGTGTTGTCTATAAACACGAGCATCTTGGCAACGGCGTTCCAAGTACAGGTAC AGCAAGCACGCAGAGGTCCTGGGCTGGGACATTTATGGTGCATCTGTGGCCCGGTAGGGAGGTCAGTGAG CTGCGGGTGATGGAGGGGAGTGGCTGGGGCTGTGGGAGCCTCCTCACTGAGTCTGGGCCTTAAGCGCGTG GCTCGGGTGTGGTGTGGAATTGGTCTTTATTCTCTGCTAGGCGCATTTCTGAATCTGAGATTTTCTGAGA AACTATCTGGATTGTTATATGGAATCTGATTTTTAAATGCTGGTGACTAACTTTTTTTTTTTGAGACAGA GTCTTGCTCTGTCACCCAGGCTGGAATGCAGTGGCAGGATCTCTGCTTACTGCAACCTCCACCTCCCGGG TTCAAGGGATCCTCCTGCCTCACCCTCCTGAGTAGCTGGGACTATAGGTGCCCACCACCAGCTAATTTTT GTATTTTTAGTGGAGACAGAGTTTCACCATGCTGCCCAGGCTGGTCTTGAACTCCTGACCTCAGGCGATC CACCCACCTCAGCCCCTCAAAGTGCTGGGATTACAGGCGTGAGCCACCGCACCCAGCCTATCTGGTTTTA TAAAGGGCAGTTCCCCTGCACACACTCCCTTGCCTGCCGCTGTGTAAGATGTGCCTGTGCTCGTTCACCT TCCACCATGATTGTGAGGCCTCCCCAGCCATGCGGAACTGTGAGTCCATTAAACCTCTTTCCTTTCTAAA TTACCCAGTCTTTATTATTTAGTATGTCTTTATTAGCAACATGAGAACAGACTCATACAACCCCTTCCAA GCTCTTGTGGTGGCTGATATAATCCACTACTTTGCGGTTGAAGGATGGGGGCTTCATTTTTTTTTTTTTA ACTTGGTTCTTGGAGGCCGCCTGCAGTTCCCAGGGCCCACCTGCAGTTCCTTGCCCCATGGGCTTCTCTG ATGTGGCTACTGATGTCAAGCTAGCAAGGGAGGTCTTCAGCTAGTCGGCTAGTAAGATATAGAGCATCGT GTGATGTGTCATCGTCCCAGGAGTGACAGTCCGTCAGCTCTGCTGTATTTTATGGGTTAGGTTTAAGTGA CAGCCCTGTCCATACTTTTATGGGGAGAAACGCCTACAAATGCGTGGTTGCCAGGAGGTGGGGGTTGTGG GGCCACCTTAGGCTCCATCCGCACCAGTTATACACCAGCTGCTGCCCGTTTACCCTGAGACAGATAACCT GCCCAGCCAGCACCCACGGGCTTCCTCCACCTCAGTCCCTCCCCTAGCAGAAGAAAACTGCATTTCTGCA CATTGACTGTCACAAGGCAGGGGTGTCACCAGGCAGGGAAACGAAGATACCTGGCCGACCACACCTTGGG GTGTTTGGGTTCTTCGATTCATTCATGCTTGTGTCCCGAGCCCTCTGGGGATGCAGGAGGCACAGCGGGA AAGGGAACAGGTGCTCGGTCCAGGCGGCCTTGGGGCAGACACTGTCCCTTGCCAGCCCCATGGGAGCTTC CAGGGATGCAGTGAGAGGGTCACGCTGAGCCGAGTTGTGCCTCGCAATGAGTTTGTGATGTGTGCCCATC GTTAGCACCTTCGACTTCTATCATCTGCTGAGTCAGGCATCATACAAGATGAGACAGAGAAACGCGATTG CAGTCCCTGTCTTAGGAGGCACCCAGCCTGGTGTGGGAGACAGATCTGCAGATGACAGACCAGGGAGATG CGTGCTCTGAGACAACACGCGAGGATGGGTGGCAGAGATGGCCGAGTGGACTCTGGGATTGGGAGGCTCA GATAGGTGGCTGAGCCCCAGGTCCTGCTCTGGGCAGTGCTAGGAGCTACCAGCCTTTGCCAGGGCTGACT TCTAAATGCAAGCCCTCTACACTGGTGTCTCTGCAGTGTGGGGGGTCAATTCATTCATCATTCATTTTCA TTAAATTTTACCTTGCATTGTAGATTCACATGCAGTTATAATGTAGAGATGGCTAGGCGCAGTGGCTCAG GCCTGTTGTCCCAGCACTTTGGGAGGCTGAGGTGGGAGGATCGCTTGAGCCTGGGAGGTTGAGGCTGCAG TGAGCCGTGATCACACCACTGCCCTCCAGCCTAGGCAACAGCAAGAGAGTCTGCAAAAAAAAAAAAAAAG TGAAAAGAAAAAAAAACAGGCTGTGTACCCTTTATTCAGTTTCCCCCAGTGGTAACAACTTATATTAATA AACTATACTGTGTTATCACAACTGGAATATTGACATTGATACAGTCAAAAGTGAGTTTCCTCCTCACAAA ATCCTTCTCGTTACCCCTTTTATAGCCAAACCCACCTCCCCATCCCCACCTGGTCCCTGACCCCCGGCAA GCAATAATTTTTTTTTTTGTTGGAGACGGAGTCTCGCTCTCTTTTGTTCTCCATTCATACAATTTTGTAA TTTCAAGGATTTTACAATTTCAACTTTGTAATAAGGATTCCCGTTATATAAATGGAATCACACAGTATGT AACCTTTTGGGATTGATTCTTTTTTTCCCGACTCTCCATAATTACAGATTAATTGAAGTTACCGCATATC AGTAGCTCATTCCTTTTCATCCCTGAGTAGTATTCTGTGGTATAGATGGGCCACTTTTTTTTTTTTTTTT TTTTAACGACCCATTGGATATCTGAGCTGCTTCCAGGATTTTTTGCTGTTTAAGATTTGTTTATTTTTTT GAGACACAGTCTTGCTCTGTTTCCCAGGCTGGAGTGCGGTGATGTGATCTTGGCTCACTGCAACCTCCGC CTCCTGGATTCAAACGATTCTCCTGCCTCAGCCTCTGGAGTAGCTGGGATTACAGGTGCGTATGCCAGCA CACCCAGCTTATTTTTGTATTTTTAGTAGAGGTGGGGTTTCTCCATGTTGGCCAGGCTGATCTTGAACTC CTGACCTCAGGTGATCCGCCCGCCTTGGCCTCCCAAAGTGTTAGGATTATAGGCGTGAGCCACTTCGCCC GGCCAGTTTAGGATTTATTTGAGTAAGTTAATAAGAAACAGTGGTCTGCAATTCTCTTGTTTTGTATGGT CTTTGTTGGTTGGTCAATACCAGCCTTATAATGTGAGCTGGGAAATGTTTATTCCTTTTTCTGTTTTCTG GAAGAGATTGTGTAAAATTTACGTTAATTCTTCTTTAAAGGTTTGATAGAATTCTTTAACGAGACCATAG GCTGGGTGCAGTGGCCGATGCCTGTAATTTCAGCACTTGGAGAGGCGGAGGTGGGCGGATCACTTGAGGT TAGGAGTTTGAGAACAGCCTGGTCAACATGGTGTGAAATCCCCGTCTCTACTAAAAATACAAAAATTAGC TGGGCTTGGTGGTGTGCACCTGCAGCCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCGTTTGAACCTG GGAGGTGGAGGTTGCAGTGAGCTATGATCATGCCATTGCACTCCAGCCTGGATGACAGAGCAAGATTCCG TCTCGGTGGGGTGGGGGAGGAAGGGAAGCTTTACTGAGGCCATGGAGATCTGGAGATGTCTTCTGGAGGA GCTTTTATGAATTGAATTTCTTCTATGCTTATGTGACTGTCTGGACTATCTGTTTCATCATGTTTGAGCT GACATACTTTCTGGGTTTTGGGGAATTAGCCGGTTTCTCTGAGCATAAAGTCATTTGTATTATTTCCTTA TTCTCTGATGCCTGAAGGATCTAGTGAGATCCCTGTTTTATTCTTGGTGTTGGTAATTTATGTTTTCTTT TTATTTTTGTCAGTCTTTACCAATTTTATTTTTGAGGATCTTAGACCTTTCCCTCCCTTCTCATTTATTT GTACAGCAAGAATAAGACAGTTTTTTTTTGTTTGTTTGTTTGTTTTGAGACAAGGTCTCACTCTGTCACC CATGCTGGAGTGCAGTGGCGTGATCTCAGCTCACTGCAACCCCCAGATCCTGGCTTCAAGCGATCCTGAC CTCAGGTGATCCACTCGTCTCGGCCTCTCAAAGTGCTGGGACTACAGGCATGAGCCACTGCACCTGGCAT AAGAGTTTTGTTTTGGTCAGGTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTGAGATAAGGTCTTGCTCT GTTGCCCAGGCTGGAGTGCAATGGCAAGCTCTCAGTTCACTGTAGCCCCAACCTCCTGGGCTCAAGCAAT CCTCCAACCTCAGCCTCCCACGTAGCTGGGACCATAGGCGTGCACCACCATGCCTGACTAATTTTTTTTT TTGTTTTTTGATGAGACAAAGTCTCGCTCTGTCACCCATGGTGGAGTGCAGTGGCACGATCTTGGTTCCC TGCAACCTCCACCTCCCGGGTTCAAGCGATTCTCCTGCTTTAGCCTCCCGAGTAGCTGGGATTACAGGCG TGCTCCACTGCACCTGGCTCATTTTTTTTTGTATTTTCAGTAGAGACAGGGTTTCACCATGTTGGCCAGG CTGGTCTTGAACTCCTGACCTTAGATAATCCACCCGCCTCAGCCTCCCAAAGTGCTAGGATTACAGGCAT GAGCCACTGCACCCGGCCATTTTTTTTTTTTTTTTTTTTTTAATTTTCGGTAGCAATGGGGGTCTGGCTA GATTGGTCTCGAACTTTTGAGTTCAAGTGATACTCCTGCCTCAGCCTCCCAAAAGGTGCTGGGATTATAG GTATGAGCCACTATACCCAGTCTTAGAATATGTTTTTCTTTCTTTTTTTTTGAGACGGAGTCTTGCTGTT TGCTGTCTCACCTAGGCTAGAGTGCAGTGGTGCAATCATAGCTCACTGCAGCCTTGAACTCCTGGGCTGA AGCAATTCTCCTGCCTTAGCCTCCTTTTCCTTAACACTTAATTTGTTGAGGAATCCTGGTCATTTGTCCC AGGAGTTCCAAATGGCTCTATCCAGACTGTAGAGATGACCAGGAGATGTCACTTGCTGTGTGCGTCTGTG CTACCTGTGAGCTGGTAGGTCAGTGTGTTCCCACACTGTCCCATAGCCAAGAGCCACCTGTGCTGTGCTT GAAATGTGGCCAGGAGGAACTGGAATGTACTGTGAGTGTAAAATACACATGGGTGCCAGGCGCAGTGGCT CATGCCTGTAATCCCAGTACTTTGGGGGGCCGAGGTGGGCGGATCACAAGGTCAGGAGATCGAGACCATC CTGGCAAACACGGTGAAACCCCGTCTCTACTAAAAATACAAAAAATTAGCCAGGCGTGGTGGCGGGTGCC TATAGTGCCAGCTACTCAGGAGGCTGAGGCAGGAGAGTGGCGTGAACCCGGGAGGTGGAGCTTGCAGTGA GCCGAGATCGTGCCACTGCACTCCAGCCTGGGCGACAGAGCGAGACTGTCTCAAAAAAAAAAAAAAAAAC ACATGGGCTTTCAGAGACCTGGTACAAAAGAAGAATGTAAAGTAGCTCATTAATAACTTTTTCATATTCA TTCCATGTTGAAATAATCTTTTGTCTACACTGGGTTCTATGGAACATATTCCAATTACTTCCACCTATGT TTACCTCTCAAACGTGCTTATTAGGAAATTTAGAATTACATACACAGCGTGTGTTCAAGTGCTGTTTCCC TCGGACGTTGCTGATGGGGATGTCGGATTATTGATCTCGGGGGATCAGTTTCACTCACAGGAGTTCTTGT ATTTTGATGTAGGCCATTGGATCAAGCGTTGCCTTTATGATTTTTTTTTTTTTTTTTTTTTTTTGAGATG GAGTCTTGCTCTGTCGCCCATGCTGGAGTGCAGTGGCGTGATCATCTCAGCTCCACAACCTCCATTTCCC AGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGCACGGGCCACCATGCCCAG CTAATTCTTGTATTCTTAGTAGAGACGGGGTTTCACTATGTTGGCCATGCTAGTCTCGAAGTCCTGACCC TCGTGATCCACCCACCTTGGCCTCCCAAAGTGCTGGAATTACAGATGTGAGCCACGGTGCCCAACTTGAT TTATTTATATATTTTTTTGATGAGATGGAGTCTCACTCTGTCGCCCAGGCTGGAGTGCAGTGGCACGATC TTGGCTCACTTCAGCGTCTGCCTCCTGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCTGGGTAGCTGGGA TTACAGGTGCGCGCTACCATGCCCAGCTAATTTTTGCATTTTTAGTAGAGACAGGGTTTTACCATGTTGG CCAGGCTGGTCTCGAACTCCTGACCTCAGATGATCGGCCTGCCTCGGTCTCCCAAAGTGTTGGAATTACA GGTCTGAGCTACCATGCCCGGCCAACCTTTATGAGTCTTGCTTGTCGGTTCTTGTGGATTTGGTGCTCCT TAGCCAAAGGTTCAAACTCATTCTTCCCAGGGCATCCTGCAATGAAACTCTGGTTTCTGTGTTTTGTTTT TTTTTTTTTTTTTTTTTTTGAGACTGAGTCTTGCCCTGTCGCCCAGGCTGGAGTGCAGTGGCGCGATCTT GGCTCACTGCAACCTCTGCCTCCCGGGTTCAAGTGATTCTTCTGCCTCAGCCTCCCGAGTAGCTGGGATT ACATGCGCGCTTCTCCAAGCTCAGCTAATTTTTGTATTTTCAGTGGAGGCGGGGGTTCACCATGTTGGCC AGGCTGGTCTCGAACTCCTGACCTCGGCCTCCCAGTGTTGGTATTACAGGCGTGAGCCACTGCGCCCTGT TCCGTTTCATGTTGCTTCTGTGAGTGCAGCTTTGATTGCTAGGGGGCGTAGCTGAGCTGTTGCCCCAGGC ATCCCGAGAACCCGTGGTGTTCAAGTGCTGTGAGTAGATTTAGGGGCCTCGGCAGGCCAGAATGTTCCAG CGTCCTCGTTCCTTGCAGGGATGATTCTCTGAACGACTGTCGGATCATCTTCGTGGACGAAGTCTTCAAG ATTGAGCGGCCGGGTGAAGGGAGCCCCATGGTTGACAACCCCATGAGACGTGAGTTCTGAGCCAGCCTTT CCCCATCTTCCGCGGTGGGCACGGGGCGGGGGCTCTTGTCCCGTCTCTGGCTTGGCCGGGCCCCGCCGGA GCTGACCCTGCCGCCCCGTGCCCAGGGAAGAGCGGGCCGTCCTGCAAGCACTGCAAGGACGACGTGAACA GACTCTGCCGGGTCTGCGCCTGCCACCTGTGCGGGGGCCGGCAGGACCCCGACAAGCAGCTCATGTGCGA TGAGTGCGACATGGCCTTCCACATCTACTGCCTGGACCCGCCCCTCAGCAGTGTTCCCAGCGAGGACGAG TGGTGAGTGCGGCCCTGCCCGCCGCGGGGAGACCAGAGCGCCCCCTACAAATCCCCAGAGGGGCACTGAG GAGATACAGGAGAGGGGCAGGCGCGGGGGCTCACGCCTGCAATCCCAGTGCTTTGGGAGGCCGAGGCGGG AGGATCACTTGAGCTCAGGAGTTCAAGAGCAGCCTGGGCAACACAAGACCAGCCTGGGGGACGTAGAGAC TCTGTTTCTTTTTTTGTTTGTTTTTTTGAGACGGAGTCTTTTTTCTTTTCTTTTTCTTTTCTTTTTTTTT TGCGGCGGAGTCTCGCTGTCTCCCAGGCTGGAGTGCAGTGGCGCGATCTCAGCTCACTGCAAGCTCCGCC TCTCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCGCCCGCCTCCACGC CTGGCTAATTTTTTGTATTTTTAGTAGAGATGGGGTTTCACCTTGTTAGCCAGGATGTTCTTGATCCCCT GACCTCGTGATCCGTCCGTTTCGGCCTCCCAAAGTGCTGGGATTATAGGCGTGAGCCACCTCGCCCAGCC TTGAGACGGAGTCTAATGGCACGATCTTGGCTCACTGCAACCTCTGCCTCCCGGGTTCAAGCAATTCTCG TGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGTGCCTGCCACCACATCCGGCTAATTTTTGTATTTTTA GTAGAGACGGGGTTTCACCATCTTGGCCAGGCTGGTCTCTTAACTCCTGACCTTAAGTGATCTGCCTGCC TCAGCCTTCCAAAGTGCTGGGATTACAGGTGTGAGCCACCATGCCTGGCCTGGAGACCCCATTTCTACAA AAAATGTAAGAAAATTAGCTGGGCGTGGTGGTGCTCGCCTGTGGTCCCAGCCACTTGGGAGGCCGAGGTA AGAGGATCGGATCGCTGGAGCCCAGGAGGTCGAGGGTGCAGTGAACTGTGATCGCGCCACTGTACTCCAG CCTGGGTGATGGAAGTGAGACCCTATTTCTTTAGAAAAGTAAAAATGAGGTCAGGTGCAGTGGCTCATGC CTGTAATCCCAGGACTTTGGGAGGCTAAGGTGGGTGGATCACGAGGTCAGGAAATTGAGGCCAGCCTGGC CAAGATGGTGAAACCCCGTCTCTACTAAAAATACAAAAAAGTTAGCCAGGCGTGGTGCCACGCGCCTGTA ATCCCAGCTACTCGGGAGGCTGAGGTAGGAGAATCGCTTGAACCTGGGAGGCGGAGGTTGCCGTGAACTG AGATCGCGCCACTGCACTCAAGCCTGGCGACAGAGTGAGACTAAGTCTCAAAAACAAAAAAAAAGGGGGG GTGGTGAGGAAATCTTCCCATGTTGCTTGAGTGGGTGAGACCTGCGGCCAGCCAGGGAACAGAGTGCAGG GGGCTTCACAGCTTCTGTGAGAGGAGGTTTCGTAGCCACTGTGTTCCTGGCGCACATAATGACAATTGCG GATGTGGATGGGGAGGTTGTGATGTGCTAGGCTCGGGTCTGAGGACCTGCCTGTGGTCATTCCTCCAGCA CAGAAGTGGGTGTTGTTGTTGCCCTGCCCCCCCTCCCCACATCGTAGAGATGGGGAAACTGAGTCCACGG CAGTGAGAAGGCACTCATGGAATCTGCACGTGTATTTCCCACATCCCACATTGCGTTCACTCTCACTGTT GCAAGATCCGTGGAATTCTCCGTGGAAGGCCAACAGAGAACCTGCTTTCTTTTTTTTTTGAGATAGAGTC TTGCTCTGTCCTCCAGGCTGGAGTGCAGTGGTGCAACCTCGGCTCACTGCAACCTCTGCCTCCTGGTTTC AAGCGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGTGCCCACCACCATGCCCGGCTAATT TTTGTATTTTTAGTAGAGATGGGGTTTCACCGTGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTG ATCTGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTGTGCCTGGCTTAGTTCGAA TGAATTTAAATGTAAACAGCCTCGTGTGCCAAGCGGCCTGCAATGTGGACAGGGCAGGATGGTAGTGGTG CCAGGCGGGGAGAGCCATGTCCGTGGTGTGTGGGCAGAGGGCACATGTTGGCTGAGACATCTGCCAGGCT AGGCGTGGGCAGTGACAATCCCGACCTCGCAGGTACTGCCCTGAGTGCCGGAATGATGCCAGCGAGGTGG TACTGGCGGGAGAGCGGCTGAGAGAGAGCAAGAAGAAGGCGAAGATGGCCTCGGCCACATCGTCCTCACA GCGGGACTGGGGCAAGGTGAGGCGGGTCCTTCCCACGTGCCCGTGGCCCCTCCCCGCCTGCCAGGGCTCA CGCTGTTGTTCTTTGTGTCTGTGCCTGGGACAGGGCATGGCCTGTGTGGGCCGCACCAAGGAATGTACCA TCGTCCCGTCCAACCACTACGGACCCATCCCGGGGATCCCCGTGGGCACCATGTGGCGGTTCCGAGTCCA GGTACCTGCAGCGTCCCGGGGCTCCAGGGGCCACGCGGGCTCATCCTGCTTTTCTGGGGGCAGTTTCTCC TGGCTTTGGCCAGCCAGGGGTCAGGGTGGTTACCAGTGGTGCCTCGGCTAGCCGAGGAGGGGTGTGGAAA GCCTGCAGGTTTGGGTTTACTCCTTATTTTACCAGGGACCTGCAATGAATCCTTGGGGGTGGGGGCTGCT GCTCTGCTCAGAGACACGTAAGGTCATTCCCAAAGCTCCTGTCCCAGGGAAGGGGTGGCATCTGCTAAGA GGGACCTGTCTCAGCGCTGGTTGTGATCTATCATTGGGGCAGCCCCTGCCTGTGACTGGGTGTTGACAGT GCTGGGCGCTGTCAGCTGTGGGCTGTGTGTCACGGCAGACGAGACACTTTGGCACTAGTGACATTGGAGC CAGATGGTTCTCTGGGGCGGGGCCATCCTGGGCACTGCAGGGTGCTGAGCAGCATCTCTGGCCCCCACCC ACTCCATGTCCTCCCAAGTCATGACAACCAGAAACGTCTGCAGACATGAGTGTCCCCTTGGAGGCAGGAT TGCCCCTGGGTGAGATGCACTGAGCTGGGTGGACAAGCTGGGCCTCATCATGGAGTTCATGGGGCCAGGC GTGCAGGGCTAGGAGCTCCTGGGGCAGCGCTGTATCCCTAGTGCTCAGCGGCCAGCCGGGGCCCCATGCT CAGGCCAGGGCCTCTCAAGGCATTTTGTGGAGTGAGTGGCAGGCTGCACCTCAACCGGCCTAATGAAGGC CGGCTTTTATATCATAACCTCATTTAGAACTCAGTCACCCCCACTTTTATTTTTTTTGAGACGGAGTCTT GCTCTGTTGCCCAGGCTGGAGTGCAGTGGTGCGGTCTTGGCTCACTGCAACCTCCCTCTCCTGGGTTCAA GCGATTCTCCTGCCTCAGCCTCCCCAATAGCTGGGATCACAGGGACATGCCACCACGCCCAGCTAATTTT TGTATTTTTGGTAGAGATGGGGTTTCACCTTGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAAGTGAT CCACCCACCTCGGCCCCCGAAAGTGCTGGGATTACAGGTGTGAGCCACCGTGCCTGGCCGTCACCCCCCA TTTTCTAGAGGCCGAAGAGGAGCATCGGAGATCAGCAGTGAGGATGCCCCGTGCACGCTTGATGGGGCTG GAATTCACGCCAGCTGGTTTTTTTTTTTTTTTTTCCATGGTGCAGCTCAACTCCGGCCGTCTCTAGCCGA GCAGCACACGTAGTAGGTGACTCGCAGGCCTGAGGAGTTTGGTGTAAAAGTGAGGCCGCTGGCTGCTCGG GGTAGGGAGGAGGAGGGCGGTGGAGCTTCTCTGCAGCAGTCATTGCAGAGGACACCATGTATATCTTGGT GGCATCCTCAGGTCAGCGAGTCGGGTGTCCATCGGCCCCACGTGGCTGGCATACACGGCCGGAGCAACGA CGGAGCGTACTCCCTAGTCCTGGCGGGGGGCTATGAGGATGATGTGGTGAGTGTGTGTGTGGGAGGGGTG GGGGAGGGTTGCTCTAGTTTTTTGGATGGTGGTAAAATACATAGAACAAAATTTCCCATCCTAGCCGTTT TTAAATGCTTGGTTCCCGGTGGCGTGAAGTATATTCCCATTGCTATGCAACCATCACCACCACCATCTCC AGAACTTTCTCATCTTCCCAAACTGAAACGTTGTCTCCACGAAGCACTCACTCCCCACCCCCTCCCAGTC CCTGGCACCGCCCAACCTGGTTCCTGCCTCTGTGACTCTGACGACTCTGGAGACCTCCTGGGAGTGGAAT CGCACGGCCTGCGTCCTTGCATGCCTGGCTCCTCTCACTGAGCCCGACGTCCTTGCTTTGTCCATGTTGT CGCATGTGTCCGGATTCCCCTTTTGTTCACGGCTGAGTCCTATTCTGCCGTGCGGAGGGACCATGCTGTG TTGATCTGTCTGTCCGTGGGCACTGGGGTTCCTTCCCCTTTCGACTGCTGTGAATAGATCTGCTACGAAC ACGGCTGTACAAGTATCTCCAGCCCCCGTTTTCCATTCTTTTGGGTGTATATCCAGAAGTGGAATTCAAG ACTCCTGTGATAATTCCATGTTGAGTGTTGTTTTTTTTTTTTCTTTTTTTTGAGACCGAGTCTCATTCTG GCTGGAGTGCAGTGGTGTGATCACAGCTCACTACAGCCACTACCTCCTGGGCTCTAGTGATCCTCCCATG TCAGCCTCCCAAGAAGCTGGGACTACAGGCAGGCACTGCCACGCCAAACTAATTTTTGTATTTTTTTGTG GTGATGGGGTTTCGCCATGTTGCCCAGGCTGATCTCGAACTCCTGGGCTTAAGCGATCCTCCCGCTGCAG CCTCCCAAAGTGCTGGGATTACGGGTGTGAGCCACCATGCCCAGCCCTCTGTTTAAGTTTCTTGAGGACG CACCACACTGTTTGTATAGTCGCTTTGCCATTCTGTAGTCCCACCAACAGTTTACAAAGGGCTCCAATTT CCCCACATTCTCACCAACGCTTGTTATTTTCTGTTTCTTTGAAAGTAGCCATCCTGGGGAGTTTGCTTTC AATGCAGTCTCTTTTTTTTTTTTTGCCTCTGCAGAGGGTTCACCCAGCCTTCTTGTCTGTTTCAGGACCA TGGGAATTTTTTCACATACACGGGTAGTGGTGGTCGAGATCTTTCCGGCAACAAGAGGACCGCGGAACAG TCTTGTGATCAGAAACTCACCAACACCAACAGGTTTGTGGAATCAGCCTTCTTATTTCCTTGCTGATGCA TATCTGCCGAGTCTTGGTTCTGTTTTGGGCCTCATGTCCAGCAAGTGATAGTCTCATTAGGAGCGTGGTA GAACATAGCGAAGCCTGGCATTTGGTTCCTCCCTCTGTCTCCCAAAGTGCTGGGATTACAGGCGTGAGCC ACTGCGCCTGGTCTGGTTCCTCCCGTATGTGTGCCACATACCGTGAGCCATTCAGATGGATGAAAGCAAA CTTCCCTATAAAAGGCCAGATAATAGATATCTTTTTTTTTTTTTTTTTTTTTTTTTTTTTGGGCAGAGTC TCGCTCTGTTGCCCAGGCTAGAGTGCAGTGGTGCACTCTCTGCTCACTGCAACCTCTGCCTCCTGGGCTC AAGCGATTCTCATGCCTCAGCCTCCTGAGTAGCTGGGATTACAGGTGCTTGCCACCTCGCCTGGCTAATT TTTGTATTTTTAGTAGAGATGGGGTTTTGCCATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAGGTG ATCTTCCCTCCTCGGCCTCCCAATATTGGTATTACAGGCATGAGCCACTGCGCCTGGCTGATAGTAGGTA TCTTAATGCTGGGCCTGGTGGCTCACGCCTGTAATTCTCGCGCTTCAGGAGGCCGAGGCTCGAGGATACC TTGAGTTCAGGAGTTCAAGACCAGCCTGGGCAAGGTAGTGAGACAACCCATCTACAAAAAGTAAAAATAA AAAAATTAGCTGGGTGTGTTAGCATGTGCCTATAGTCACAGCTAGTCAGGAGGCTGAGGCAGGAGGATCA CTTGAGCCCAGGAGGTTGAGGCCGCAGTGGGCTGAGATTGCACCACTGCACTCCAGCTTGAGCAACAGAC TGAGATCTTGTCAAAAAAAAAAAAAAAAAAACCCCTCCAAAATAGATTGCTTCAGCTATGCAGGTCACAC AGTCTATTCAGAGAACCTCTTCAGCTCTTGTGTCGTAGCACAAAATCAGCCATAGACCATATGTAAGTGA GTGAGCATGGCTGTGTTTCAGTGAATTTTATTTGCAAAAGTATGTGATAGGCCAGAATTTGCTTGGCCCC TGATTACAGGATGGGGGCGGACTTTTCCAGCATAAAAACCATCATAAAGCCCAAAGGAAAAGACAGATTT GATTATCTAAACATTATAAATATATTACATAAATAAATCCTATAAATTAAAAGGCAGATGACTAGGAGGA GTTCTTGACATGACACATGATGATAGTGTCTTTATCATATAAAGAGCTGTTGCAAATCAACAAGAAACTC ATAGAAGAGCTGGGTGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGAGAGGCCGAGGTAGGTGGTGGA TCACCTGAGGTCAGGAGTTCAAGACTAGCCTGGCCAACATGGTGAAACCCTGTCTCTACTAAAAATACAA AAATTAGCTGGGTGTGGTGGCAGGCACCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGAATTGCTTGA ACCCAGGAGGCGGAGGATGCAGTGAGCCGAAATCATGCCATTGCACTCTTGCACTCTAGCCTGGGTAACA GGAGTGAGACTCTATCTCAAGAAAGAAAGAAACTCGTAGAAGAAAGCAAAGAGGCCAGGCGTGGTGGCTC ACGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGTGGGCGGATCACGATGTCAGGAGATCGAAACCATCC TGGCTAACATGGTGAAACCCCATCTCTACTAAGAATACAAAAAAAAAAAAAAAAAAAAAGCCTGGTATGG TGACAAGTGCCTATAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATGTCATGAACCTGGGAGGCGGA GCTTGCAGTGAGCCAAGATTGCTCCACTGCACTCCAGCCTGGGTGACAGAGCAAAAAAAAAAAAAGAGAA TATGGAAATAATGCACAAAAGAAGTGCAAAGTTGTAATCAAATACAAACTGAGGCTGTGGTGAGATACTA TTTGTTTCCCCTATAAAGTTGGCCAAAAATTCTAAAATGTTGACATAGGTCAGGGGTAAAATAGCATTCC ACTGTTGGTAGAAATACAAATTGGAACCATCTTTCTGGAAATCTCTTCTGCCTGTTTGTATGAAGAGCTT TATAAATGATCTATTCTTGTCACTCTAACTCCGCTTTGAAAAATGTCTTTAGGAGACCTCTGGCTAGGTA AAAATGTAAGATGTAATGTTTTTCATACCATTATCTAAAACAATTGGCACATAGACACACACACACACAC ACACACACACACACACTCTCACAAAGTCAGTAACTAAGTACCTAAAAAAGACATGGGCCATGGGTGGTGT GTCACATGCCTGTCGTTCCAGTACTTTGGGAGGCTGAGGTGGGAGGATTGCTTGAGGCTAGGAGTTTGAG ACCTACTTGTGCAACATAAAATTATGAAAAATTAAAATTACAAAAAAGAATTTCAAAAAAGTTAGCTGGT TATGGTCGTGTGGGCCTATAGTCCCAGCTTGGGAGCCGGAGGTGGGAGGATGGCTTGAGCCCAGGAGGCT GCAGTGAGTAAGGCGTGATCATGCCATTGCATTCCAGCCTGGGTGACAGAGTGAGACACCCTTTCTCTTT TTGTTTGTTTTTTTTTTATATGTGTGTGTGCTTTGTTTTGTTTTTTTTGAGGCAGGGTCTCCCTCTCTTG TCCAGGGTGGAGTGCAGCAGTGTGATCGTAGCTCATTGTAGCCTCCACCTCCTTGGGCTCCACTGATCCT CCCACCTCAGCCTCCAGAGTAGCTGGGACTATAGGTGCATGTTACCACGCCTGGCTATTTTTTTTTTTTT TTGTGGAGATGGGGTTTTGCCACGTTGGCCAGGCTGGTCTTGAACTCCTGGGCTCAGGCAATCCTCCTGC CTTGGCCTCCCAGAGTACTGGGATTAGAGGCGTGAGCCACGGCACCTAGCAACCCTGTCTCAAATAAATA GTAGGCTGGGTGTGGCCTATTTTATAAATTATACATATATAACTTTGAAATATTAAATTTTTTTTTTTTT TTGAGACAGAACCTCACTCTGTCACCCAGGCTGGAGTGCAGTGGCATAATCTCGGCTCACTGCAACCTCT GCCTCCCAGACTCAAGCGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGAATTACAGGCACGCGCCACCA CGCCCGGCTAACTTTTGCATTTTTAGCAGAGACGGGGTTTCACCATGTTGGCCAGGCTGGTCTCGAACTC CTGACTTCAGGCGATCTGCCTACTTCAGCCTCCCAAAGTGCTGGGATTACAGGCCTGAGCCACCACTCCC GGCTCCTGTGTTTCCTTTTTTGGGGGGTACATCCTCACCTATAATGCGTGGGGTCCTGACTCTCCCTGCA GGGCGCTGGCTCTCAACTGCTTTGCTCCCATCAATGACCAAGAAGGGGCCGAGGCCAAGGACTGGCGGTC GGGGAAGCCGGTCAGGGTGGTGCGCAATGTCAAGGGTGGCAAGAATAGCAAGTACGCCCCCGCTGAGGGC AACCGCTACGATGGCATCTACAAGGTGAGTGCCCCTTGAGGAGGCCGGGGGCTCTGTCCCCGCCGGGGCT GCCTCTGATGGAGCTGACGCTGATGCCCGCTCTCTGCAGGTTGTGAAATACTGGCCCGAGAAGGGGAAGT CCGGGTTTCTCGTGTGGCGCTACCTTCTGCGGAGGGACGATGATGAGCCTGGCCCTTGGACGAAGGAGGG GAAGGACCGGATCAAGAAGCTGGGGCTGACCATGCAGGTGTGTCTGGGATGGGGGATGGCACTTTGGGAG GCCAAGGCGGATGGATCACTTACGTTAGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCTCATCTC TACTAAAAATACAAAAATTAGCTGGGTATGGTGGCGGGTGCCTGTAATCCCAGCTACTGAGGTGGCTGAG GCAGGAGAATTGCTTGAACCCAGAAGGTGGAGGTTATAATGAGCTGAGATTGCGCCACTGCACTGCAGCC TGGGTGACAGAATGAGAGTCCATCTCAAAACAGGAGCACTGCCGGGCTCCATGACGGCTCTGACACTTCC CGCCTGGGCACCATGTGTCCTGCTTGGAGGCTGTCATCCTTGAAGGTCATTGTGGGTCACAGAATGGGCC CTGCCTGGGCTTGTGGTGCTCATGTTCTGGACCGCGCTGAACACTCCAGGAGGCCTCCCGTCTCGGGCCC ATGCTTCCCTGGTTTCTCTCTGATCCAGAATAATTTCCAGGGCCCCAGCTGATGGCACCCCCCTAGCTGT CCCATATAAATCCTCCAGCCAGGGGGTGATGGGAACGCGCAGATGACATTTGCTTCTCCGCCTGCCGCAT CTCAGAGTTGAAAACCAGACTTGCTTGTCTTCGTTCTGTTGGTAAAGGGATCGCTGCAGACCAGTCAGGC ATCTGGTGTCTTCTGTTTTCACTTCTTGGCTCATCACAAAAAAAAAAAAAAAAAAGCAGAAACAAACCAA CCAAATTGGTGGATTCCAGAGAGATCTGGACGGAAAAATGGGGAAGATGAATATCCCCGAGCCATCTCTC ACCTCCCTGTGGCGATGGGAACTGCCGAGAACTTACTCAACAAGCGGCGCAGCATTTCAGCACCAGTTAG GATGTGGTCTGTCCATTGCAGGGAGAAGCTTTACAGCAGACGAATCGTGAGACTATTTAAGGAATCTTAA TTGCTGTCGAGAGCCTGATGTCCTCTACCCGAGGGGGTCACTCAGGTTGTCTTTTGAATGGATTTGTACG GTGGGGAATTTCAGAAGCTGAGGAAGTAGAGAGAAAAATAGTAATGGGAGAGACAGCCTCAGCTTCTGTT GGGAGTAGGATTTTTTTTGTTTGTTTGTTTTGAGATGGAGTCTTGCTCTGTCGCCCAGGCTGGAGTGCAG TGGTGGGATCTCGGCTCTCTGCAACCTCTGCCTCCCAGGTTCAAGCCATACTCCTGCCTCAGCCTCCTGA GTAGCTGGGATTACAGGTGCCCACCACCACGCCTGGCTCAGTTTTTGTATTTTTAGTAGAGACGGGGTTT CACCATGTTGGTCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCCACCCGCCTCTGCCTCCCAAAGTG CTGGGATTACAGGCGTAAGCCACCGCTCCCAGCCTTTTTTTTTTTTTTTTTTTGGAGACAGAGTCTCACT CTGTCGCCCAGGCTGGAGTGCAGGCATGATCTCGGCTCATTGCAACCTCCACCTCCCAGGCTCAAGCGAC TCTCTCATCTCAGCCTCCTGCATAGCTGGGATCACAGGTGTGTACCACCATGCCCAGCTATTTTTGTATT TCTAGTAGAGACGGGGTTTCGCCATGTTGGCCAGGCTGGTGACCTCAGGTGATCCACCTGCTTCCACCTC CCAAAGTGCTGGGATTACAGGTGTGAGCCGCTGACCCTGGCCAGGATTTTTTTTTTTTTTATGACTCTCA TCTCCATTGTAACATAAAGAATGTGAAAGGAGCTCAAAGATTTCCTGAGACACTGGAGAGTCAGACGTGA CTTATAGGTACCTTCGAAATGGAGCGATGATGCCCTGTGAGGACAGAGAGGGCCCGAGTCCTCAGAATCA CCAGAGTTTGGCCAGCTAAGGCCCTGGGGTCAGGTGTTCGTAAGTGAAGTTTCTGGGGAAACAGTCATGC TCATTCACTGAAGTAGCCTGCTCTCAGCGCTTGCAGTCCAGACCCATAAGGCTTGAAAACATTCACCCTA GGGTCCCTGGAAGCAAAAGTTTGCCTGCCCTCATGGAAATCGTAAAGACAACGAGATCTTATTGGTGGGA TGTGATGCTGAACACGTCACCCGCGTTCGCTCACATTAAATGCGCTTACCCCGACCCTGCCAGGTGGAGC TTGGCCGATTATCTCCTCTTAGTCTCCTCTTGTTCGTAGTGAAGCTTTGCGATTAGACAGGATTAGCCAT TGGTCGAGGCTCCACAGTTAACGAAGAGCTGAATGCACAGGCGTCCCCCCCTTACCAGGGGGACACTTCG AAGGTCCTCAGCACATGCTTGAAACCAGAGAGTACCAAACCGTTGATGTATAATTTTTTTTCCATACGTT TGGACTGGTGATTAAGTTTAATCTATAAATTAGGCACAGTATGAGATTCACAACCTCTCTTTCGCATCTT AGGCTTCTCTTTAGCATTTCCAAATTGTCAGCATCCCTACTCTTGCACTTTGGGGCCATTATTTTTATTT TTGAGACCAGGTCTCGCTCTGTTGTCCAGGCTGGAGTGTAGTGGTGTGATCATAGCTCACTACAGCCTCA AACTCCTGGGCTCAAGTGATTCTCCTGCCTCAGGCTCCTAAGTAGCTGGGACTACAGATGCACACCACCA GGCTCGGCTAATTTTTTAAATTTTTTTGTAGAGAGGGGATCTTGCTATGTTGCCCAGGCTGGTCTCAAAC TCCTGGGCTCAAGCGATCCCCCTGCCTTGGCTTCCCAAAGTGTTGGGCTTATTTAATAAAAATTAGAATG TTTAATATTAATATTTTATATTTAGCCTGTAATCCCAGCATTTTGGATGACTGAGGCAGGTGGATCACTT GAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAGCCCCATCTCTACTAAAAATACAAAAATTA GCTGGGTGTGGTGGCGGGCACCTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCGAGAAGCTG GACAAAGGGAAGGTTCACATCCCTGTGGGACGATGCAATGTTTCATCATGCAGTGTGCGTGATGTGAGGT GGCTGTAAAGGGGGAGGAAGGGGCCCCGAGCCGAGGGATGCAGCGCCTCTAGACGTTGGACACTTAGAAC AGTGTGCAGTTTACAACTTAGGAATTGTTTCTAGAATATTTCATGTAACATTTTCAGTTGACTTTGGGTC ACTGAAACCTCAGCAAAACTAGATAAGGGAGGACTACCCTGTGCTCTTCAGGGGGATTGGGGGTCAGGTG TGTCTGGAAACCCAGACCTGGCAAGGAGGCTGGAAGAGCGGGCTCTGCATAGCGTGTGGGCCCCAAGCCT GACTCACGGCTGTCCCTCTTCCTCCTGAAGTATCCAGAAGGCTACCTGGAAGCCCTGGCCAACCGAGAGC GAGAGAAGGAGAACAGCAAGAGGGAGGAGGAGGAGCAGCAGGAGGGGGGCTTCGCGTCCCCCAGGACGGG CAAGGGCAAGTGGAAGCGGAAGTCGGCAGGTGAGAATCTCGTGGGTGTGGGGTGAGCGTCTTGTGTGTGG GGGAGCAGGTGGGCATCTCGCGGGTGTGGGGTTGAGGTCGTGTGGACGTGGGAGCCGGTGGCTGTCTCTC CGGCAGCTCGGGCCACGCGCCCCTCCCTCACGCGCCCCACCCTCTTCCAGGAGGTGGCCCGAGCAGGGCC GGGTCCCCGCGCCGGACATCCAAGAAAACCAAGGTGGAGCCCTACAGTCTCACGGCCCAGCAGAGCAGCC TCATCAGAGAGGACAAGAGCAACGCCAAGCTGTGGAATGAGGTCCTGGCGTCACTCAAGGACCGGCCGGC GAGCGGCAGCCCGGTAGGCTCGCACGGCTCACTCGTCGCCCTGATTTGCGTTGACTGCGGTAAAATGTGT GGGGCTTGTTTCCCATGTTCCCCATTTTCAAGTGTACAGCTCAGTCGCACTGAGTACATTCTTGTGGTTG TGCAACCATCACCACCATCACCACCTCCAGAACTTTATCCTCTCCCCAGACTGAAACCCTGGCCCTGAAA CTGTCACTCCCACCCCCTCCCAAGCCTTGGCACTCGCTCCCCAGCCCCGGCAACTGCTCCCCAGCCCCTG CACCCGCTCCCCAGCTCCGGCACCCCCTGCCATCCTACCTTCTGTCTCTGTCTCCCGGGGCTGTTGCAAA GTGACCCCAAGCCTAGGAGTGCAAAGCGACTCACATCTCACAGCTCTGGGGCTGGGAGCCCGACATGGGC CTTGCTGGGCTAAAGTCAGGGCAGGGATAGGGCTGGGCCCTCCTGGGGGCTCCAGGGGAGAACCAGATTT CTGCCTTTCCCAAGGTCTAGAGGCACTGTATCCCTCGGCTCGGGGCCCCTTCCTCCCCCTTTACAGCCAC AGCGCATCTTCTTCCAGTCTCTGAGTCTCACTCTCCCGCCCTCTCTCGGGAGGACCTCGGGGTGACATCA GGCCCCCCGCCTCACCCAGGATGCTTTCCCAGCTCCAGGTCCTTCACTCAGTCCCACCTGCCATTTCTCC TCTGCTGTGGATGGTGACGTCTCAGGATGGTGCAGGTCTCAGGATTCAGCTGTGGCCGAGGCCATCTCAG TGGTCCCTCTCTTCCCATTTCCTTCAGGCCACATTCTTCCCAGGGCTTTCTCCCCAGCTCCCACCCTACG CTGGGGCAGCCCCTTGCCCCTAGACCTTCACTTGTGTCTCTTTGGTCCCCGCACTTAGCTCCAAGCAGGA GGAGGTGTCTTTCGAGTCATCCGAGGCTGGGCTCCTGGTGGCCCGTGTACTCAGTATGCATTGTGTCAGT GGACACCATGCCTCTAAATTTTTTTGGTGACAGGAGCTCACCCTGTCACCCAGGCTGGAGTGCGGTGGCA TGGACAAAGGTCACTGCCTCCTTGAACTCCCAACTCCCAGGCCACGCCTATGTTTTTAATTTATTTTGTT TATTTTTATTATTTTTTTTTGAGATGGAGTTTTGCTCTCGTTGCCCGGGCTGGAGTGTGCAATGGCATGA TCTTGGATCACTGCAACCTCCACCTTCCAGGTTCAAGTGAGTCTCCTGTCTCAGCCTCCCAAGTACCTGG GATTACAGGCACCCACCACGCCTGGCTAATCTTGTATTTTTAGTAGGGATGGGATTTCACCGTGTTGGTC AGGCTGGTCTCGAACTCCTGACCTTAGGTGATCTGCTCACCTCAGCCTCCCAAAGTACTGGGATTACAGG CGTGAGCCACCATGCCCGGCCTATTTTTTAATTTTTTGTAGAGATGGGGGTCTCACTGTATTGCCGGGCT GGTCTTGAACACCTGGCTCAAGCGATCCTCTTGTCTTGGCCTTCCAAAGTTCTGGGATGACAGGCGTGAG CTGCCGCTCCCAGCCAGGAACCTCTCCTAAAGCCCTGTCTTGACTCAGTGCAGGGTGTGCTTGGTGGTGC CAGCTGGTCATATCTGGGTCCTGCCCAGCATCATTGAGGCTGGCGCCCTTGTACTGGCTCCGCCTCATCC TCCCCACCTTGCCACTTGGGGTGTTGGGGACTTCAGGTGAGGCTCATGCCTGTTGGGCCTCTGTTTTTCT CAGAACGGGGACGATCATGGCCCCCGCCTCCTGGAGTGAAGGCTGGGGACAGAATTAGAGGACCCAGGTA CATGCTCAGCAGGAAGCCACTGATCTGTGGGAGCCCTGGTCCCGGTGTCTTTGCCGGCCTCACACCCGCT TCCCTCTAGTTCCAGTTGTTCCTGAGTAAAGTGGAGGAGACGTTCCAGTGTATCTGCTGTCAGGAGCTGG TGTTCCGGCCCATCACGACCGTGTGCCAGCACAACGTGTGCAAGGTGAGTAGAGATGGCCGCGGGAGCCG GGTGGAAGGTTCTGGAAGGATGACCTGACCTCCCGTTCCCACATGCCTGCCACTACAGACAGAGGCTTGT TGGCTTTGCTCCGCTCACTCTGCAGCTTTTCTCGGGGCCCTGTTGACTGCTTTCTGGGCAGCCTGTATTA CCACGGAGGCCTATAACATTCTCCCCCAAGTCCTGTATGGTCAAGGGGCCAGGGTGGGAGAGGATGGGCC ACAGTCTTGGCCTAAGGTCTGGAGAGGAGGTGCACATCCCCTAGGGGTCAGGAAAGAAGGCTTCTTGGAG GAGGTGGTGTTACCAGGCAGCATCCCTTGTACCTGGGACAGCAGGTGAAGAAGCCTGGGTGGGAAGTCAG CAGCTGGGGCCTGCAGTGGCTCTGGGCACTGGGGTGGTGGCCTGCCATGGGCTTTAAACTCAGGACAAGT GGTCAGTCGTAGGAGGGACACAAGATCCCAGCTGATGGTTTTTTTTTTTTTTTTTTTTTTTTTTTCTGAG ACAGAGTCTCGCTCTGTTGCCCATGCTGGAGTGCAGTGGCGCAGTCTCCACTCACTGCAAGCTCTGCCTC CCGGGTTCACGCCATTCTCCCACCTCAGCCTCCCGAGTAGCTGGGACTACAGGCGCCCGCCACCGTGCCC GGCTAATTTTTTGTATTTTTAGTAGAGATGGGGTTTCACCGTGTTAGCCAGGATGGTTTCGATCTCCTGA CCTTGTCATCCACCCGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGTGTAAGCCACCGCGCCCACCCCG CAGCTGATGGTTTTCAAACCGATTGGTTTGGGGCCAGGACAGGGTCTCTTCCCCCCTGTGCTGTGGGCCT TGGGGCTGGATCATTGTCTGGGGTGGGGCCGTCCTGGGCACTGCAGGGTGCTGAGCAGCATCCCCGGCCC CCACCCACTCCATGCCAGGAGCTCCCTGCCTAGTCGAGACAATCACAGACATCCCCAGACACCTTCCAGT GTCCCCTGGGGGCAGAACTGCCCAGGTGGGCAGTGTGGGTCTGGGTGATGGTTTCTCTGCTGCAACCTCT GGCCAGAGCCGGCAGTCCCGGTGGACAGGTGTGGAAGGGACTGACCCTGCCACCCCACGGATCTCCCCAG GCTTCTGAGTTGCTGGCGGTTTTCCTTCCAACTGCAGTCCCGCAGTCCTCTCAGCCATGGGCCACACCCC CGGGTCTCAGACCCCGTGTTTGTTTTCATGCCAGGAGGCAGCTCAGGGAAGGTCAGGAGATGGGGTGTTC CCAGTCATGCCCATGGCATCTCTGCCTCCTCGGGCCCCACCTGCCTCGCCCTGTGGCCTGAGTCCCTTCA GCTGTGTGGGCCTCCCTGAGTGCCCTGAGTGAGGTGGCAGAAGGGGTGAGAGGCCATGGTGTCTTTGGGG CTGGTGGTCCGGGTCTGGCCATCTGTCACCTCTCAGGCGTGCAGGCACTAATCCCTCCAAGCCTCAGTTG GCCACAGTGAGAAGGGGCCTGGTAACACTGTCCTGGATGCCAGGTTGTTGTGAAGGTCCCGGCTTAGCCT CTGGCAGGAAGGAGGTGCTCAGGAGGTGGGCACAGGCAGAGGGCTGGCTGTGGGGGGCTATTGGAAGAGG GAGGCCTGGGAGCCCCGTGGCGGTAGGAAGGACTGTGGGGACATTGGAAACCATCTGTCCTGTGCATCGG TGTGAAGGCGCGGAAGCGCTGAGGATGTGAAGGAAGGGGCTAACCAGCATCACGGTGTCCCCACAATCTG TCCTTGTTGCTCTGTTCCAACTTGGGAAGCTCAGCATCGGAGGGGTTCTGGGAAACAGGCTGTGACCTTC CACCTTGATCTTTTTAAATTATAAACTTGAGGCCAGCCGTGGTGGCTAATGCCTGTAATCCCAGCACTTG GGGAGGCTGAGGTGGGAGGATCACTTGAGGTCAGGAGTTTGAGACCAGCCCGGGCAACATGGTGAAACCC CATCTCTACTAAAAATTAAAACAAAATTAGCTGGGTGAGGTGACAGGTGCTACTCAGGAGACTGAGGTGG TAGAATCGCTTGAACCTGGGAGGTACAGGTTGCGGTGAGCTGAGATCGCGCCATTGTACTCCAGCCTGGG CGTCAGAGCAAGATTCTGTCTCAAAAAAAAAAAAAAAAAATTGAAAAAAACATTCAGAGACAGCATCTCA CTCTGTCGCCCAGGCTGGAGTGCAGTGGTGCCATCATAGCTCATCGCAGCCTTGAACTCCTCGCGGGGCT AAAGAGATCCTCCTGCCTTAGCCTCCTGAGTAGCTGGGGCTACAGGCATACACCACCATGGCCAACATGA TGAAACCCTGTCTCTACTAAAAATACAAAAATTAGCCAGGTGTGCTGGTGGGCGCCTGTAATCCCAGCTA CTCAGGAGGCTGAGACACGAGAATCCCTTGAACCCGGGAGGTGGAGGTTGCAGTGAGCCAAGATCACGCC ACTGCACTCCAGCCTGGGCGACAGAGCGAGACTCTATCTTAAAAAAAAACAACAAAAACAAAAGCCACAG GCTGCCTGGGGCAGGTGACTGTGCTGTGGTCACCAGGCCTCTCCCCCATGTGGTCACCGCCCTCGCCCAG CTGTGTGACGACATGCTGCAGACATGTGCCCCCTGCGTAGGCATCTGTGCACCTGTGTACGGCGTGTCAC TCCTCCCTGGCGTGCAGCCAGCCCGGTGGCATCTTCCCTGTTTGTCTGCTTGGGAAGTGGAGACTCCAGG CCTCTCAGCTCTGTCTTCTCCTGGCTTTCTTCCCCAGGCACGACTTGGTTGATTGAGCTTGAAGTTAGGA ATCTGAATCCACCAGACTTGGTTCCTTCCTCCTTTTCCCCTTTCTTCTCATTGACGTGTATGTTTATTTT TTATTTTTTTCGAGACAAGGTCTTGCTTTGTCGCTCAGGCTGGAGTGCAATGGCGTGATCATGGCTCACT GCAGCCTCAGCCTGCCTCCCTGGGTTCAGGTGATCCTCCCACTTCAGCCTCCGGAGTAGCCACGCCCGGC TAATTTTTTTGTTTTTGTTTTTTCTTTGAGACGCAGAGTCTTGCCCTGTCACCCAGGCTGGAGTGCAATG GCGTGATCTCAGCTCACTGCAACCTCCGCCTCCCGGGTTCAAGCCATTCTCTTGCCTTAGCCTCCCAGGT AGCTGGGATTACAGGCATGTGCCTGGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCACCATGTTGG CCAGGCTGGTCTTGAACTCCTGACCTCAAGTGATCTGCCCCCCTCGGCCTCCCAGAGTGCTGGGATTACA GGCATGAGCCACGATGCTTGGCCTGATGTGTGTGTTTATTAAGCATCTACTGTATACACTGTGCTTGGTG TTGAGAGAGAACACAGCCTCAAAGCTCAGGGAGCATCTGCCCTGTTGTAGATAAGATAAGCACATTAATA ATATATAACACGGCTCCACAGGTGGAAGGAGAGGTGCCGTCTTGAAGGCAGATGGGGTGAGGGGATGGGA CTGCCTCTAGGGAGGTGTCAGGGAAGGCCCCATAAGGGAGGTGACTTGAGCTGAGCTGTGAGTGATGAGA GCCGGGGGACCGAGCTGTTAAGCTGCATGACCTGCCAGGGACAAAAGCCTGGAGGCCGGGTGAGCTTGGA ATCTTTGAGGGCCCCTAGGGGGGCCAGGCTGGTGATGGGCAGCAGGTGGAAAGTGAGACTGAAGGTCAGA GGGGCCTCTGGACCTGGTGAGACTGTCCCCACAGTCCTGGGAGAGGTGGCCAGGAGCAAACCTGATGGTG TGGATGGCACTTCTCACGCGCCTGCTGTGTCTTACAGGACTGCCTGGACAGATCCTTTCGGGCACAGGTG TTCAGCTGCCCTGCCTGCCGCTACGACCTGGGCCGCAGCTATGCCATGCAGGTGAACCAGCCTCTGCAGA CCGTCCTCAACCAGCTCTTCCCCGGCTACGGCAATGGCCGGTGATCTCCAAGCACTTCTCGACAGGCGTT TTGCTGAAAACGTGTCGGAGGGCTCGTTCATCGGCACTGATTTTGTTCTTAGTGGGCTTAACTTAAACAG GTAGTGTTTCCTCCGTTCCCTAAAAAGGTTTGTCTTCCTTTTTTTTTTTATTTTTATTTTTCAAATCTAT ACATTTTCAGGAATTTATGTATTCTGGCTAAAAGTTGGACTTCTCAGTATTGTGTTTAGTTCTTTGAAAA CATAAAAGCCTGCAATTTCTCGACAAAACAACACAAGATTTTTTAAAGATGGAATCAGAAACTACGTGGT GTGGAGGCTGTTGATGTTTCTGGTGTCAAGTTCTCAGAAGTTGCTGCCACCAACTCTTTAAGAAGGCGAC AGGATCAGTCCTTCTCTCGGGTTCTGGCCCCCAAGGTCAGAGCAAGCATCTTCCTGACAGCATTTTGTCA TCTAAAGTCCAGTGACATGGTTCCCCGTGGTGGCCCGTGGCAGCCCGTGGCATGGCGTGGCTCAGCTGTC TGTTGAAGTTGTTGCAAGGAAAAGAGGAAACATCTCGGGCCTAGTTCAAACCTTTGCCTCAAAGCCATCC CCCACCAGACTGCTTAGCGTCTGAGATCCGCGTGAAAAGTCCTCTGCCCACGAGAGCAGGGAGTTGGGGC CACGCAGAAATGGCCTCAAGGGGACTCTGCTCCACGTGGGGCCAGGCGTGTGACTGACGCTGTCCGACGA AGGCGGCCACGGACGGACGCCAGCACACGAAGTCACGTGCAAGTGCCTTTGATTCGTTCCTTCTTTCTAA AGACGACAGTCTTTGTTGTTAGCACTGAATTATTGAAAATGTCAACCAGATTCTAGAAACTGCGGTCATC CAGTTCTTCCTGACACCGGATGGGTGCTTGGGAACCGTTTGAGCCTTATAGATCATTTACATTCAATTTT TTTAACTCAGCAAGTGAGAACTTACAAGAGGGTTTTTTTAAAATTTTTTTTTCTCTTAATGAACACATTT TCTAAATGAATTTTTTTTGTAGTTACTGTATATGTACCAAGAAAGATATAACGTTAGGGTTTGGTTGTTT TTGTTTTTGTATTTTTTTTCTTTTGAAAGGGTTTGTTAATTTTTCTAATTTTACCAAAGTTTGCAGCCTA TACCTCAATAAAACAGGGATATTTTAAATCACATACCTGCAGACAAACTGGAGCAATGTTATTTTTAAAG GGTTTTTTTCACCTCCTTATTCTTAGATTATTAATGTATTAGGGAAGAATGAGACAATTTTGTGTAGGCT TTTTCTAAAGTCCAGTACTTTGTCCAGATTTTAGATTCTCAGAATAAATGTTTTTCACAGATAGA Download Select all
Length	59075
OMIM ID	607990
HGNC ID	HGNC:12556
Unigene ID	Hs.108106
Ensembl ID	ENSG00000034063
PharmGKB ID	-

mRNA Information

mRNA ID	XM_011528182.1
Exon	complement(12259..13741)
mRNA Sequence	>29128 GCAGGGGTGCCATCTTGGCTCACTGCAACCTCCGCCTCATGGGTTCAAGCAATTCTCCTGCCTC AGCCTCCTGAGTAGCTGGGACCACGGGTGCATGCCAGCATGCCCAGCTAATTTTTTGGTAGAGA CAGAGTTTCACTGTGTTGGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCCACCCACCTCAG CCTCCCAAAGTGCTGGGATTGCAGGCGTGAGCCACTGCACCTGGGCTTTTTCTTTTTTTGAGAC AAAGTCTCATTCTGTCACCCAGGCTGGAGTGTAGTGGCGCGATCTCGGCTCACTGCCACATCTG CCTCCCGGGTTCAAGCAATTCTCCTGCTTCAGCCTCCTGAGTAGCTGGAATTACAGGCATGCAC CATCACCATGCTTTGCTAATTTTTTTTTGGTATTTTTATTTATTTTATTTTTATTTTTTGTGAT GGTCTCACTCTGTCAGCCAGACTGGAGTGCAATGGTGTGATCTCGGCTCACTGCAACCTCTGCC TCCTGGGTTCCAGCGATTCTCCCACCTCAGCCCCCCAAGTACCTGAGATTACAGCGCCGACACC ATGTGGATCCAGGTTCGGACCATGGACGGGAGGCAGACCCACACGGTGGACTCGCTGTCCAGGC TGACCAAGGTGGAGGAGCTGAGGCGGAAGATCCAGGAGCTGTTCCACGTGGAGCCAGGCCTGCA GAGGCTGTTCTACAGGGGCAAACAGATGGAGGACGGCCATACCCTCTTCGACTACGAGGTCCGC CTGAATGACACCATCCAGCTCCTGGTCCGCCAGAGCCTCGTGCTCCCCCACAGCACCAAGGAGC GGGACTCCGAGCTCTCCGACACCGACTCCGGCTGCTGCCTGGGCCAGAGTGAGTCAGACAAGTC CTCCACCCACGGTGAGGCGGCCGCCGAGACTGACAGCAGGCCAGCCGATGAGGACATGTGGGAT GAGACGGAATTGGGGCTGTACAAGGTCAATGAGTACGTCGATGCTCGGGACACGAACATGGGGG CGTGGTTTGAGGCGCAGGTGGTCAGGGTGACGCGGAAGGCCCCCTCCCGGGACGAGCCCTGCAG CTCCACGTCCAGGCCGGCGCTGGAGGAGGACGTCATTTACCACGTGAAATACGACGACTACCCG GAGAACGGCGTGGTCCAGATGAACTCCAGGGACGTCCGAGCGCGCGCCCGCACCATCATCAAGT GGCAGGACCTGGAGGTGGGCCAGGTGGTCATGCTCAACTACAACCCCGACAACCCCAAGGAGCG GGGCTTCTGGTACGACGCGGAGATCTCCAGGAAGCGCGAGACCAGGACGGCGCGGGAACTCTAC GCCAACGTGGTGCTGGGGGATGATTCTCTGAACGACTGTCGGATCATCTTCGTGGACGAAGTCT TCAAGATTGAGCGGCCGGGTGAAGGGAGCCCCATGGTTGACAACCCCATGAGACGGAAGAGCGG GCCGTCCTGCAAGCACTGCAAGGACGACGTGAACAGACTCTGCCGGGTCTGCGCCTGCCACCTG TGCGGGGGCCGGCAGGACCCCGACAAGCAGCTCATGTGCGATGAGTGCGACATGGCCTTCCACA TCTACTGCCTGGACCCGCCCCTCAGCAGTGTTCCCAGCGAGGACGAGTGGTACTGCCCTGAGTG CCGGAATGATGCCAGCGAGGTGGTACTGGCGGGAGAGCGGCTGAGAGAGAGCAAGAAGAAGGCG AAGATGGCCTCGGCCACATCGTCCTCACAGCGGGACTGGGGCAAGGGCATGGCCTGTGTGGGCC GCACCAAGGAATGTACCATCGTCCCGTCCAACCACTACGGACCCATCCCGGGGATCCCCGTGGG CACCATGTGGCGGTTCCGAGTCCAGGTCAGCGAGTCGGGTGTCCATCGGCCCCACGTGGCTGGC ATACACGGCCGGAGCAACGACGGAGCGTACTCCCTAGTCCTGGCGGGGGGCTATGAGGATGATG TGGACCATGGGAATTTTTTCACATACACGGGTAGTGGTGGTCGAGATCTTTCCGGCAACAAGAG GACCGCGGAACAGTCTTGTGATCAGAAACTCACCAACACCAACAGGGCGCTGGCTCTCAACTGC TTTGCTCCCATCAATGACCAAGAAGGGGCCGAGGCCAAGGACTGGCGGTCGGGGAAGCCGGTCA GGGTGGTGCGCAATGTCAAGGGTGGCAAGAATAGCAAGTACGCCCCCGCTGAGGGCAACCGCTA CGATGGCATCTACAAGGTTGTGAAATACTGGCCCGAGAAGGGGAAGTCCGGGTTTCTCGTGTGG CGCTACCTTCTGCGGAGGGACGATGATGAGCCTGGCCCTTGGACGAAGGAGGGGAAGGACCGGA TCAAGAAGCTGGGGCTGACCATGCAGTATCCAGAAGGCTACCTGGAAGCCCTGGCCAACCGAGA GCGAGAGAAGGAGAACAGCAAGAGGGAGGAGGAGGAGCAGCAGGAGGGGGGCTTCGCGTCCCCC AGGACGGGCAAGGGCAAGTGGAAGCGGAAGTCGGCAGGAGGTGGCCCGAGCAGGGCCGGGTCCC CGCGCCGGACATCCAAGAAAACCAAGGTGGAGCCCTACAGTCTCACGGCCCAGCAGAGCAGCCT CATCAGAGAGGACAAGAGCAACGCCAAGCTGTGGAATGAGGTCCTGGCGTCACTCAAGGACCGG CCGGCGAGCGGCAGCCCGTTCCAGTTGTTCCTGAGTAAAGTGGAGGAGACGTTCCAGTGTATCT GCTGTCAGGAGCTGGTGTTCCGGCCCATCACGACCGTGTGCCAGCACAACGTGTGCAAGGACTG CCTGGACAGATCCTTTCGGGCACAGGTGTTCAGCTGCCCTGCCTGCCGCTACGACCTGGGCCGC AGCTATGCCATGCAGGTGAACCAGCCTCTGCAGACCGTCCTCAACCAGCTCTTCCCCGGCTACG GCAATGGCCGGTGATCTCCAAGCACTTCTCGACAGGCGTTTTGCTGAAAACGTGTCGGAGGGCT CGTTCATCGGCACTGATTTTGTTCTTAGTGGGCTTAACTTAAACAGGTAGTGTTTCCTCCGTTC CCTAAAAAGGTTTGTCTTCCTTTTTTTTTTTATTTTTATTTTTCAAATCTATACATTTTCAGGA ATTTATGTATTCTGGCTAAAAGTTGGACTTCTCAGTATTGTGTTTAGTTCTTTGAAAACATAAA AGCCTGCAATTTCTCGACAAAACAACACAAGATTTTTTAAAGATGGAATCAGAAACTACGTGGT GTGGAGGCTGTTGATGTTTCTGGTGTCAAGTTCTCAGAAGTTGCTGCCACCAACTCTTTAAGAA GGCGACAGGATCAGTCCTTCTCTCGGGTTCTGGCCCCCAAGGTCAGAGCAAGCATCTTCCTGAC AGCATTTTGTCATCTAAAGTCCAGTGACATGGTTCCCCGTGGTGGCCCGTGGCAGCCCGTGGCA TGGCGTGGCTCAGCTGTCTGTTGAAGTTGTTGCAAGGAAAAGAGGAAACATCTCGGGCCTAGTT CAAACCTTTGCCTCAAAGCCATCCCCCACCAGACTGCTTAGCGTCTGAGATCCGCGTGAAAAGT CCTCTGCCCACGAGAGCAGGGAGTTGGGGCCACGCAGAAATGGCCTCAAGGGGACTCTGCTCCA CGTGGGGCCAGGCGTGTGACTGACGCTGTCCGACGAAGGCGGCCACGGACGGACGCCAGCACAC GAAGTCACGTGCAAGTGCCTTTGATTCGTTCCTTCTTTCTAAAGACGACAGTCTTTGTTGTTAG CACTGAATTATTGAAAATGTCAACCAGATTCTAGAAACTGCGGTCATCCAGTTCTTCCTGACAC CGGATGGGTGCTTGGGAACCGTTTGAGCCTTATAGATCATTTACATTCAATTTTTTTAACTCAG CAAGTGAGAACTTACAAGAGGGTTTTTTTAAAATTTTTTTTTCTCTTAATGAACACATTTTCTA AATGAATTTTTTTTGTAGTTACTGTATATGTACCAAGAAAGATATAACGTTAGGGTTTGGTTGT TTTTGTTTTTGTATTTTTTTTCTTTTGAAAGGGTTTGTTAATTTTTCTAATTTTACCAAAGTTT GCAGCCTATACCTCAATAAAACAGGGATATTTTAAATCACATACCTGCAGACAAACTGGAGCAA TGTTATTTTTAAAGGGTTTTTTTCACCTCCTTATTCTTAGATTATTAATGTATTAGGGAAGAAT GAGACAATTTTGTGTAGGCTTTTTCTAAAGTCCAGTACTTTGTCCAGATTTTAGATTCTCAGAA TAAATGTTTTTCACAGATAGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA Download Select all
Length	4339

CDS Information

Location	join(7768..7959,26143..26397,27637..27797,29662..29877, 38449..38549,38666..38852,41053..41176,41264..41371, 42782..42886,44026..44132,47532..47694,47780..47917, 51271..51409,51571..51743,53630..53734,57578..57724)
CDS Sequence	>lcl\|NM_001290050.1_cds_NP_001276979.1_1 [gene=UHRF1] [protein=E3 ubiquitin-protein ligase UHRF1 isoform 1] [protein_id=NP_001276979.1] [location=577..2958] ATGTGGATCCAGGTTCGGACCATGGACGGGAGGCAGACCCACACGGTGGACTCGCTGTCCAGGCTGACCA AGGTGGAGGAGCTGAGGCGGAAGATCCAGGAGCTGTTCCACGTGGAGCCAGGCCTGCAGAGGCTGTTCTA CAGGGGCAAACAGATGGAGGACGGCCATACCCTCTTCGACTACGAGGTCCGCCTGAATGACACCATCCAG CTCCTGGTCCGCCAGAGCCTCGTGCTCCCCCACAGCACCAAGGAGCGGGACTCCGAGCTCTCCGACACCG ACTCCGGCTGCTGCCTGGGCCAGAGTGAGTCAGACAAGTCCTCCACCCACGGTGAGGCGGCCGCCGAGAC TGACAGCAGGCCAGCCGATGAGGACATGTGGGATGAGACGGAATTGGGGCTGTACAAGGTCAATGAGTAC GTCGATGCTCGGGACACGAACATGGGGGCGTGGTTTGAGGCGCAGGTGGTCAGGGTGACGCGGAAGGCCC CCTCCCGGGACGAGCCCTGCAGCTCCACGTCCAGGCCGGCGCTGGAGGAGGACGTCATTTACCACGTGAA ATACGACGACTACCCGGAGAACGGCGTGGTCCAGATGAACTCCAGGGACGTCCGAGCGCGCGCCCGCACC ATCATCAAGTGGCAGGACCTGGAGGTGGGCCAGGTGGTCATGCTCAACTACAACCCCGACAACCCCAAGG AGCGGGGCTTCTGGTACGACGCGGAGATCTCCAGGAAGCGCGAGACCAGGACGGCGCGGGAACTCTACGC CAACGTGGTGCTGGGGGATGATTCTCTGAACGACTGTCGGATCATCTTCGTGGACGAAGTCTTCAAGATT GAGCGGCCGGGTGAAGGGAGCCCCATGGTTGACAACCCCATGAGACGGAAGAGCGGGCCGTCCTGCAAGC ACTGCAAGGACGACGTGAACAGACTCTGCCGGGTCTGCGCCTGCCACCTGTGCGGGGGCCGGCAGGACCC CGACAAGCAGCTCATGTGCGATGAGTGCGACATGGCCTTCCACATCTACTGCCTGGACCCGCCCCTCAGC AGTGTTCCCAGCGAGGACGAGTGGTACTGCCCTGAGTGCCGGAATGATGCCAGCGAGGTGGTACTGGCGG GAGAGCGGCTGAGAGAGAGCAAGAAGAAGGCGAAGATGGCCTCGGCCACATCGTCCTCACAGCGGGACTG GGGCAAGGGCATGGCCTGTGTGGGCCGCACCAAGGAATGTACCATCGTCCCGTCCAACCACTACGGACCC ATCCCGGGGATCCCCGTGGGCACCATGTGGCGGTTCCGAGTCCAGGTCAGCGAGTCGGGTGTCCATCGGC CCCACGTGGCTGGCATACACGGCCGGAGCAACGACGGAGCGTACTCCCTAGTCCTGGCGGGGGGCTATGA GGATGATGTGGACCATGGGAATTTTTTCACATACACGGGTAGTGGTGGTCGAGATCTTTCCGGCAACAAG AGGACCGCGGAACAGTCTTGTGATCAGAAACTCACCAACACCAACAGGGCGCTGGCTCTCAACTGCTTTG CTCCCATCAATGACCAAGAAGGGGCCGAGGCCAAGGACTGGCGGTCGGGGAAGCCGGTCAGGGTGGTGCG CAATGTCAAGGGTGGCAAGAATAGCAAGTACGCCCCCGCTGAGGGCAACCGCTACGATGGCATCTACAAG GTTGTGAAATACTGGCCCGAGAAGGGGAAGTCCGGGTTTCTCGTGTGGCGCTACCTTCTGCGGAGGGACG ATGATGAGCCTGGCCCTTGGACGAAGGAGGGGAAGGACCGGATCAAGAAGCTGGGGCTGACCATGCAGTA TCCAGAAGGCTACCTGGAAGCCCTGGCCAACCGAGAGCGAGAGAAGGAGAACAGCAAGAGGGAGGAGGAG GAGCAGCAGGAGGGGGGCTTCGCGTCCCCCAGGACGGGCAAGGGCAAGTGGAAGCGGAAGTCGGCAGGAG GTGGCCCGAGCAGGGCCGGGTCCCCGCGCCGGACATCCAAGAAAACCAAGGTGGAGCCCTACAGTCTCAC GGCCCAGCAGAGCAGCCTCATCAGAGAGGACAAGAGCAACGCCAAGCTGTGGAATGAGGTCCTGGCGTCA CTCAAGGACCGGCCGGCGAGCGGCAGCCCGTTCCAGTTGTTCCTGAGTAAAGTGGAGGAGACGTTCCAGT GTATCTGCTGTCAGGAGCTGGTGTTCCGGCCCATCACGACCGTGTGCCAGCACAACGTGTGCAAGGACTG CCTGGACAGATCCTTTCGGGCACAGGTGTTCAGCTGCCCTGCCTGCCGCTACGACCTGGGCCGCAGCTAT GCCATGCAGGTGAACCAGCCTCTGCAGACCGTCCTCAACCAGCTCTTCCCCGGCTACGGCAATGGCCGGT GA Download Select all
CCDS ID	CCDS74262.1

Protein Information

Protein ID	NP_037414.3
Protein Name	Ubiquitin-like, containing PHD and RING finger domains, 1
Molecular Wt. (Da)	90970
Protein Sequence	>29128 MGVFAVPPLSADTMWIQVRTMDGRQTHTVDSLSRLTKVEELRRKIQELFHVEPGLQRLFYRGKQ MEDGHTLFDYEVRLNDTIQLLVRQSLVLPHSTKERDSELSDTDSGCCLGQSESDKSSTHGEAAA ETDSRPADEDMWDETELGLYKVNEYVDARDTNMGAWFEAQVVRVTRKAPSRDEPCSSTSRPALE EDVIYHVKYDDYPENGVVQMNSRDVRARARTIIKWQDLEVGQVVMLNYNPDNPKERGFWYDAEI SRKRETRTARELYANVVLGDDSLNDCRIIFVDEVFKIERPGEGSPMVDNPMRRKSGPSCKHCKD DVNRLCRVCACHLCGGRQDPDKQLMCDECDMAFHIYCLDPPLSSVPSEDEWYCPECRNDASEVV LAGERLRESKKKAKMASATSSSQRDWGKGMACVGRTKECTIVPSNHYGPIPGIPVGTMWRFRVQ VSESGVHRPHVAGIHGRSNDGAYSLVLAGGYEDDVDHGNFFTYTGSGGRDLSGNKRTAEQSCDQ KLTNTNRALALNCFAPINDQEGAEAKDWRSGKPVRVVRNVKGGKNSKYAPAEGNRYDGIYKVVK YWPEKGKSGFLVWRYLLRRDDDEPGPWTKEGKDRIKKLGLTMQYPEGYLEALANREREKENSKR EEEEQQEGGFASPRTGKGKWKRKSAGGGPSRAGSPRRTSKKTKVEPYSLTAQQSSLIREDKSNA KLWNEVLASLKDRPASGSPFQLFLSKVEETFQCICCQELVFRPITTVCQHNVCKDCLDRSFRAQ VFSCPACRYDLGRSYAMQVNQPLQTVLNQLFPGYGNGR Download Select all
Length	806
Uniprot ID	P49327
Ensembl Protein ID	ENSP00000304592

Post-translational Modification Information (Source : HPRD)

Residue	Type	site
S	Phosphorylation	300;-
S	Phosphorylation	287;-
S	Phosphorylation	652;-
S	Phosphorylation	639;-
S	Phosphorylation	184;-
S	Phosphorylation	171;-
T	Phosphorylation	106;-
S	Phosphorylation	108;-
T	Phosphorylation	93;-
S	Phosphorylation	95;-
S	Phosphorylation	101;-
S	Phosphorylation	88;-
T	Phosphorylation	122;-
T	Phosphorylation	109;-
S	Phosphorylation	89
S	Phosphorylation	76
S	Phosphorylation	104
S	Phosphorylation	91
S	Phosphorylation	720
S	Phosphorylation	707
K	Acetylation	412
K	Acetylation	399
K	Acetylation	559
K	Acetylation	546
S	Phosphorylation	674
S	Phosphorylation	661
S	Phosphorylation	31
S	Phosphorylation	18
T	Phosphorylation	441
T	Phosphorylation	428

Enzyme Information

No matching records could be found.

PPi Information

No STRING Network could be found.

Interactant Gene ID (Source: HPRD)	Gene Symbol	HPRD ID	Ref Seq ID	Technique	References
8350	HIST1H3A	4155	NP_003520.1	in vitro;in vivo	14993289

Pathway Information

No matching records could be found.

Structure Information

PDB ID	2FAZ
Resolution	2
Method	X-RAY DIFFRACTION
Chains	A,B
Molecule	Ubiquitin-like containing PHD and RING finger domains protein 1
Model	View

Domain Information

ID	Location	Description
cd01797	Jan-78	NIRF_N
cl00155	Jan-78	UBQ superfamily
cd15616	317-363	PHD_UHRF1
cl22851	317-363	PHD_SF superfamily
cd00162	724-766	RING
cl17238	724-766	RING superfamily
pfam02182	416-586	SAD_SRA
cl02620	416-586	SAD_SRA superfamily
smart00466	414-586	SRA
pfam12148	140-236	DUF3590
cl13567	140-236	DUF3590 superfamily
cd15525	317-363	PHD_UHRF1_2
cd15617	317-363	PHD_UHRF2
cd15543	317-363	PHD_RSF1
cd01769	Apr-74	UBL
cd15627	318-363	PHD_BAZ1A
pfam00240	Jun-76	ubiquitin
cd15519	318-363	PHD1_Lid2p_like
cd15544	317-363	PHD_BAZ1A_like
cd15536	318-363	PHD_PHRF1
pfam00628	318-366	PHD
cd15515	317-363	PHD1_KDM5A_like
smart00249	318-363	PHD
cd15513	318-363	PHD5_KMT2C_like
cd15527	317-363	PHD2_KAT6A_6B
cd15605	318-363	PHD1_Lid_like
cd15628	318-363	PHD_BAZ1B
cd15545	318-363	PHD_BAZ2A_like
cd15603	317-363	PHD1_KDM5B
cd01803	Jan-74	Ubiquitin
cd15489	318-363	PHD_SF
cd15530	318-363	PHD2_d4
cd15602	318-363	PHD1_KDM5A
cd15532	313-363	PHD2_CHD_II
cd15604	318-363	PHD1_KDM5C_5D
cd15534	318-361	PHD2_PHF12_Rco1
cd15504	314-363	PHD_PRHA_like
cd15562	318-363	PHD2_PHF14
cd00196	Apr-74	UBQ
cd15539	318-363	PHD1_AIRE
cd15529	318-363	PHD2_PHF10
cd15523	331-363	PHD_PHF21A
cd15594	318-363	PHD2_KMT2C
cd15595	318-363	PHD2_KMT2D
cd15510	317-363	PHD2_KMT2C_like
cd15499	318-363	PHD1_MTF2_PHF19_like
cd15535	318-363	PHD1_Rco1
cd01809	Mar-74	Scythe_N
cd15629	318-363	PHD_BAZ2A
cd15531	318-363	PHD1_CHD_II
smart00184	724-762	RING
cd15630	318-363	PHD_BAZ2B
cd01806	Jan-73	Nedd8
cd15533	301-363	PHD1_PHF12
cd15509	318-363	PHD1_KMT2C_like
cd15563	318-363	PHD3_PHF14
cd01805	Jan-76	RAD23_N
cd15497	318-363	PHD1_Snt2p_like
cd15559	313-363	PHD1_BPTF
pfam13639	724-763	zf-RING_2
cd01807	Jan-74	GDX_N
cd15590	318-363	PHD2_KMT2A
cd15507	318-363	PHD2_KMT2A_like
cd15502	312-363	PHD_Phf1p_Phf2p_like
cd15541	313-363	PHD_TIF1_like
PTZ00044	Jan-74	PTZ00044
pfam11976	Mar-73	Rad60-SLD
pfam13923	724-762	zf-C3HC4_2
pfam00097	724-762	zf-C3HC4
cd15524	333-363	PHD_PHF21B
cd01812	Mar-58	BAG1_N
cd04718	340-383	BAH_plant_2
cl02608	340-383	BAH superfamily
cd15625	316-365	PHD_TIF1delta
cd15610	332-363	PHD3_KDM5A_like
cd15538	318-363	PHD_PRKCBP1
cd15623	313-363	PHD_TIF1beta
pfam14634	725-763	zf-RING_5
cd15522	318-363	PHD_TAF3
cd16039	320-363	PHD_SPP1
cd01800	Aug-75	SF3a120_C
cd15517	315-363	PHD_TCF19_like
cd15591	318-363	PHD2_KMT2B
smart00213	Mar-74	UBQ
COG5432	715-765	RAD18
TIGR00599	715-763	rad18

Ontology Information

HPRD ID	1973
Molecular Class	DNA binding protein
Molecular Function	Hydrolase activity (GO:0016787)
Biological Process	Metabolism (GO:0008152); Energy pathways (GO:0006091)

SNP Information

View SNP Geneview Report

Drug Information

No matching records could be found.

External Links

ArrayExpress GO
ICGC GO
Cancer3D GO
COSMIC GO
NCG GO
TSGene GO
Tumor Gene Family of Databases GO
CCDB GO
G2SBC GO
Osteosarcoma Database GO
RCDB GO

ArrayExpress	GO
ICGC	GO
Cancer3D	GO
COSMIC	GO
NCG	GO
TSGene	GO
Tumor Gene Family of Databases	GO
CCDB	GO
G2SBC	GO
Osteosarcoma Database	GO
RCDB	GO

Mechanism	Up-regulation
Biomarker	22219067
Drug Target	22219067
Biological Process	Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism