Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| USF1 | 7391 | upstream transcription factor 1 | 1 | UEF, MLTFI, bHLHb11 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24173679 | 2014 | Cell line : SW620, ACHN Source : - Sample Type : - No. of Sample : - Stage : - | Chromatin immunoprecipitation | Up-regulation | - | USF1 binding to an E-box element may be critical for basal MVP promoter activation. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Basic helix-loop-helix proteins |
| Description | This gene encodes a member of the basic helix-loop-helix leucine zipper family, and can function as a cellular transcription factor. The encoded protein can activate transcription through pyrimidine-rich initiator (Inr) elements and E-box motifs. This gene has been linked to familial combined hyperlipidemia (FCHL). Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been defined on chromosome 21. [provided by RefSeq, Feb 2013] | Chromosome | 1 |
| Location | 1q22-q23 |
| Start | 161009041 |
| End | 161015769 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 6729 |
| OMIM ID | 191523 |
| HGNC ID | HGNC:12593 |
| Unigene ID | Hs.414880 |
| Ensembl ID | ENSG00000158773 |
| PharmGKB ID | PA37223 |
mRNA Information
| mRNA ID | ?NM_001276373.1 |
|---|---|
| Exon | join(1..122,2620..2712,3098..3147,3310..3394,3763..3864, 4134..4329,4569..4656,5108..5166,5310..5404,5650..5778, 5971..6729) | mRNA Sequence | Download Select all |
| Length | 1799 |
Protein Information
| Protein ID | NP_001263302.1 |
|---|---|
| Protein Name | upstream transcription factor 1 |
| Molecular Wt. (Da) | 78020 |
| Protein Sequence | Download Select all |
| Length | 310 |
| Uniprot ID | Q9UK73 |
| Ensembl Protein ID | ENSP00000307298 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 223 |
| S | Phosphorylation | 164 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 5591 | PRKDC | 2941 | NP_008835.5 | in vitro | 19303849 |
| 8061 | FOSL1 | 643 | NP_005429.1 | in vitro;in vivo;yeast 2-hybrid | 9160889 |
| 9734 | HDAC9 | 5944 | NP_848512.1 | in vivo | 19303849 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00083 | 197-259 | HLH |
| cl00081 | 197-259 | HLH superfamily |
| pfam00010 | 200-255 | HLH |
| smart00353 | 205-259 | HLH |
| PLN03217 | 200-268 | PLN03217 |
| cl14736 | 200-268 | PLN03217 superfamily |
| pfam13851 | 251-307 | GAS |
Ontology Information
| HPRD ID | 9938 |
|---|---|
| Molecular Class | Transcription factor |
| Molecular Function | Transferase activity (GO:0016740) |
| Biological Process | Anti-apoptosis (GO:0006916) |
Drug Information
No matching records could be found.