Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| USP14 | 9097 | ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) | 18 | TGT |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 16465409 | 2006 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 99 Stage : - | Immunohistochemistry | Up-regulation | - | USP14/TGT60 kD controls the fate of proteins that regulate tumor invasion and metastasis. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Ubiquitin-specific peptidases |
| Description | This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. Mice with a mutation that results in reduced expression of the ortholog of this protein are retarded for growth, develop severe tremors by 2 to 3 weeks of age followed by hindlimb paralysis and death by 6 to 10 weeks of age. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] | Chromosome | 18 |
| Location | 18p11.32 |
| Start | 158483 |
| End | 213739 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 55257 |
| OMIM ID | 607274 |
| HGNC ID | HGNC:12612 |
| Unigene ID | Hs.464416 |
| Ensembl ID | - |
| PharmGKB ID | PA37238 |
Protein Information
| Protein ID | NP_001032411.1 |
|---|---|
| Protein Name | ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 494 |
| Uniprot ID | Q14644 |
| Ensembl Protein ID | ENSP00000335029 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| Y | Phosphorylation | 136 |
| Y | Phosphorylation | 101 |
| S | Phosphorylation | 143 |
| S | Phosphorylation | 108 |
| T | Phosphorylation | 235 |
| T | Phosphorylation | 200 |
| K | Acetylation | 291 |
| K | Acetylation | 256 |
| K | Acetylation | 313 |
| K | Acetylation | 278 |
| K | Acetylation | 449 |
| K | Acetylation | 414 |
| Y | Phosphorylation | 285 |
| Y | Phosphorylation | 250 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd02657 | 106-481 | Peptidase_C19A |
| cl02553 | 106-481 | Peptidase_C19 superfamily |
| cd02257 | 106-480 | Peptidase_C19 |
| cd02659 | 105-480 | peptidase_C19C |
| cd02661 | 104-480 | Peptidase_C19E |
| cd02660 | 106-480 | Peptidase_C19D |
| cd02668 | 106-480 | Peptidase_C19L |
| cd02663 | 106-480 | Peptidase_C19G |
| cd02664 | 106-480 | Peptidase_C19H |
| cd02667 | 106-441 | Peptidase_C19K |
| cd02674 | 106-480 | Peptidase_C19R |
| cd02671 | 106-466 | Peptidase_C19O |
| cd02666 | 104-477 | Peptidase_C19J |
| cd02658 | 106-480 | Peptidase_C19B |
| cd01813 | May-74 | UBP_N |
| cl00155 | May-74 | UBQ superfamily |
| cd02665 | 392-480 | Peptidase_C19I |
| cd02670 | 311-452 | Peptidase_C19N |
| cd02669 | 238-464 | Peptidase_C19M |
| cd01769 | Jul-74 | UBL |
| cd02673 | 418-469 | Peptidase_C19Q |
| cd02662 | 106-136 | Peptidase_C19F |
| cd02662 | 418-480 | Peptidase_C19F |
| cd01812 | May-91 | BAG1_N |
| pfam00443 | 104-480 | UCH |
| smart00213 | May-74 | UBQ |
| pfam13423 | 106-455 | UCH_1 |
| COG5533 | 75-459 | COG5533 |
| COG5560 | 89-266 | UBP12 |
| COG5207 | 60-480 | UBP14 |
| COG5560 | 208-480 | UBP12 |
| COG5077 | 355-471 | COG5077 |
Ontology Information
| HPRD ID | 12538 |
|---|---|
| Molecular Class | Ubiquitin proteasome system protein |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Biological_process unknown (GO:0000004) |
Drug Information
No matching records could be found.