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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| UVRAG | 7405 | UV radiation resistance associated | 11 | VPS38 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 26327192 | 2015 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | - | Frameshift Mutation | - | Truncated mutation of UVRAG promotes tumorigenesis, epithelial-to-mesenchymal transition, and metastasis, it appears to sensitize CRC tumors to adjuvant chemotherapy. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PI(3)KC3 complex, promoting autophagy and suppressing the proliferation and tumorigenicity of human colon cancer cells. Chromosomal aberrations involving this gene are associated with left-right axis malformation and mutations in this gene have been associated with colon cancer. [provided by RefSeq, Jul 2008] | Chromosome | 11 |
| Location | 11q13 |
| Start | 75526212 |
| End | 75855282 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 329071 |
| OMIM ID | 602493 |
| HGNC ID | HGNC:12640 |
| Unigene ID | Hs.202470 |
| Ensembl ID | ENSG00000198382 |
| PharmGKB ID | PA37264 |
mRNA Information
| mRNA ID | ?NM_003369.3 |
|---|---|
| Exon | join(1..358,36717..36834,46580..46614,64713..64874, 73663..73737,96788..96873,146278..146383,168221..168347, 188839..188923,192368..192455,193641..193701, 201649..201814,250544..250622,300758..300849, 325545..329072) | mRNA Sequence | Download Select all |
| Length | 5166 |
Protein Information
| Protein ID | NP_003360.2 |
|---|---|
| Protein Name | UV radiation resistance associated |
| Molecular Wt. (Da) | 39699 |
| Protein Sequence | Download Select all |
| Length | 699 |
| Uniprot ID | P56559 |
| Ensembl Protein ID | ENSP00000339754 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| T | Phosphorylation | 518 |
| Y | Phosphorylation | 516 |
| S | Phosphorylation | 498 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 26276 | VPS33B | 10541 | NP_061138.3 | in vivo | 18552835 |
| 55823 | VPS11 | 12258 | NP_068375.3 | in vivo | 18552835 |
| 57617 | VPS18 | 9776 | NP_065908.1 | in vivo | 18552835 |
| 64601 | VPS16 | 12259 | NP_072097.2 | in vivo | 18552835 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00030 | 44-118 | C2 |
| cl14603 | 44-118 | C2 superfamily |
| smart00239 | 44-137 | C2 |
| cd04047 | 48-95 | C2B_Copine |
| cd00276 | 48-115 | C2B_Synaptotagmin |
| cd08688 | 46-99 | C2_KIAA0528-like |
| pfam00168 | 44-94 | C2 |
| cd04040 | 48-114 | C2D_Tricalbin-like |
| pfam10186 | 186-458 | Atg14 |
| COG1196 | 206-305 | Smc |
Ontology Information
| HPRD ID | 4921 |
|---|---|
| Molecular Class | Unclassified |
| Molecular Function | Receptor signaling complex scaffold activity (GO:0030159) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.