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General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
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- Drug
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 19571712 | 2009 | Cell line : - Source : - Sample Type : Serum sample No. of Sample : 161 patients with colorectal cancer and 26 healthy volunteers, 128 tissue samples from cancer patients Stage : - | ELISA | Up-regulation | - | The preoperative level of soluble vascular cell adhesion molecule 1 level reflected disease progression and was a sensitive biomarker for colorectal cancer, especially Stage 2 disease. The mean soluble vascular cell adhesion molecule 1 level in patients was significantly higher than that in control subjects. Elevated serum soluble vascular cell adhesion molecule 1 was significantly associated with clinicopathologic parameters such as tumor size, lymph node metastasis, distant metastasis, and poor prognosis |
| 20491774 | 2010 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | - | Up-regulation | - | The plasma levels of VCAM-1 and PAI-1 together may be a promising biomarker for predicting post-operative recurrence in patients with colorectal cancer. A multivariate logistic regression analysis revealed that the concentrations of vascular cell adhesion molecule 1 (VCAM-1) and plasminogen activator inhibitor-1 (PAI-1) were significantly higher in the post-operative recurrence group. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | CD molecules, "Immunoglobulin superfamily / I-set domain containing", "Immunoglobulin superfamily / C2-set domain containing", "Immunoglobulin superfamily / Immunoglobulin-like domain containing", "Endogenous ligands" |
| Description | This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Three alternatively spliced transcripts encoding different isoforms have been described for this gene. | Chromosome | 1 |
| Location | 1p32-p31 |
| Start | 100719640 |
| End | 100739045 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 19406 |
| OMIM ID | 192225 |
| HGNC ID | HGNC:12663 |
| Unigene ID | Hs.109225 |
| Ensembl ID | ENSG00000162692 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_001078.3 |
|---|---|
| Exon | join(1..285,837..1112,3381..3701,4985..5251,9468..9743, 11559..11879,12779..13045,14863..15129,18484..19406) | mRNA Sequence | Download Select all |
| Length | 3220 |
CDS Information
| Location | join(222..285,837..1112,3381..3701,4985..5251,9468..9743, 11559..11879,12779..13045,14863..15129,18484..18644) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS773.1 |
Protein Information
| Protein ID | NP_001069.1 |
|---|---|
| Protein Name | vascular cell adhesion molecule 1 |
| Molecular Wt. (Da) | 78745 |
| Protein Sequence | Download Select all |
| Length | 739 |
| Uniprot ID | P18510 |
| Ensembl Protein ID | ENSP00000259206 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 3596 | IL13 | 981 | NP_002179.2 | in vitro | 7521694 |
| 3688 | ITGB1 | 628 | NP_391987.1 | in vitro;in vivo | 1 209 782 019 057 840 |
| 7430 | EZR | 475 | NP_003370.2 | in vitro;in vivo | 12082081 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| African trypanosomiasis | hsa05143 |
| AGE-RAGE signaling pathway in diabetic complications | hsa04933 |
| Cell adhesion molecules (CAMs) | hsa04514 |
| HTLV-I infection | hsa05166 |
| Leukocyte transendothelial migration | hsa04670 |
| Malaria | hsa05144 |
| NF-kappa B signaling pathway | hsa04064 |
| TNF signaling pathway | hsa04668 |
Structure Information
| PDB ID | 1IJ9 |
|---|---|
| Resolution | 3 |
| Method | X-RAY DIFFRACTION |
| Chains | A |
| Molecule | VASCULAR CELL ADHESION PROTEIN 1 |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| cd07689 | 116-214 | Ig2_VCAM-1 |
| cl11960 | 116-214 | Ig superfamily |
| cd07689 | 404-502 | Ig2_VCAM-1 |
| cl11960 | 404-502 | Ig superfamily |
| cd00096 | 530-593 | Ig |
| cl11960 | 530-593 | Ig superfamily |
| cd00096 | 242-305 | Ig |
| cl11960 | 242-305 | Ig superfamily |
| cd00096 | 331-397 | Ig |
| cl11960 | 331-397 | Ig superfamily |
| cd00096 | 43-109 | Ig |
| cl11960 | 43-109 | Ig superfamily |
| pfam05790 | 133-220 | C2-set |
| pfam05790 | 421-508 | C2-set |
| pfam13895 | 515-596 | Ig_2 |
| pfam00047 | 239-293 | ig |
| pfam13895 | 226-308 | Ig_2 |
| cd05870 | 238-306 | Ig5_NCAM-2 |
| cd05856 | 527-587 | Ig2_FGFRL1-like |
| cd05851 | 239-309 | Ig3_Contactin-1 |
| cd05732 | 238-308 | Ig5_NCAM-1_like |
| cd05755 | 418-487 | Ig2_ICAM-1_like |
| cd05745 | 526-596 | Ig3_Peroxidasin |
| cd05745 | 238-308 | Ig3_Peroxidasin |
| cd05764 | 527-596 | Ig_2 |
| pfam00047 | 328-385 | ig |
| cd05765 | 239-308 | Ig_3 |
| cd05851 | 507-597 | Ig3_Contactin-1 |
| pfam13927 | 227-295 | Ig_3 |
| cd05731 | 242-309 | Ig3_L1-CAM_like |
| cd04968 | 508-597 | Ig3_Contactin_like |
| pfam13927 | 516-583 | Ig_3 |
| cd04968 | 239-309 | Ig3_Contactin_like |
| cd05725 | 534-596 | Ig3_Robo |
| cd05869 | 223-308 | Ig5_NCAM-1 |
| cd05726 | 527-586 | Ig4_Robo |
| cd04969 | 239-308 | Ig5_Contactin_like |
| cd04983 | 519-579 | IgV_TCR_alpha_like |
| cd05729 | 527-587 | Ig2_FGFR_like |
| cd05731 | 534-589 | Ig3_L1-CAM_like |
| pfam13927 | 328-386 | Ig_3 |
| cd05740 | 227-304 | Ig_CEACAM_D4 |
| cd05725 | 242-308 | Ig3_Robo |
| pfam00047 | 40-97 | ig |
| cd05743 | 527-587 | Ig_Perlecan_D2_like |
| cd05765 | 527-586 | Ig_3 |
| cd05755 | 130-199 | Ig2_ICAM-1_like |
| cd05732 | 604-685 | Ig5_NCAM-1_like |
| cl11960 | 604-685 | Ig superfamily |
| cd05747 | 515-594 | Ig5_Titin_like |
| cd00099 | 525-579 | IgV |
| cd05726 | 239-312 | Ig4_Robo |
| cd04983 | 227-291 | IgV_TCR_alpha_like |
| cd04969 | 527-586 | Ig5_Contactin_like |
| cd05732 | 526-596 | Ig5_NCAM-1_like |
| cd05734 | 242-304 | Ig7_DSCAM |
| cd05876 | 530-589 | Ig3_L1-CAM |
| cd05870 | 526-596 | Ig5_NCAM-2 |
| cd05869 | 322-384 | Ig5_NCAM-1 |
| cd05743 | 239-298 | Ig_Perlecan_D2_like |
| cd05730 | 527-594 | Ig3_NCAM-1_like |
| cd05743 | 40-97 | Ig_Perlecan_D2_like |
| pfam00047 | 527-581 | ig |
| cd05735 | 527-600 | Ig8_DSCAM |
| cd05856 | 239-299 | Ig2_FGFRL1-like |
| cd05730 | 228-308 | Ig3_NCAM-1_like |
| cd05754 | 515-584 | Ig3_Perlecan_like |
| pfam13927 | 29-98 | Ig_3 |
| cd05899 | 519-579 | IgV_TCR_beta |
| cd07706 | 227-291 | IgV_TCR_delta |
| cd05736 | 243-310 | Ig2_Follistatin_like |
| cd05870 | 598-685 | Ig5_NCAM-2 |
| cd05724 | 230-308 | Ig2_Robo |
| cd05735 | 274-312 | Ig8_DSCAM |
| cd05714 | 239-309 | Ig_CSPGs_LP |
| cd05763 | 532-586 | Ig_1 |
| cd05764 | 239-308 | Ig_2 |
| cd05746 | 242-306 | Ig4_Peroxidasin |
| pfam07686 | 226-308 | V-set |
| cd05737 | 236-289 | Ig_Myomesin_like_C |
| cd05728 | 527-594 | Ig4_Contactin-2-like |
| cd05869 | 29-98 | Ig5_NCAM-1 |
| cd05716 | 237-309 | Ig_pIgR |
| cd00099 | 237-291 | IgV |
| pfam13895 | 609-685 | Ig_2 |
| cd05876 | 242-301 | Ig3_L1-CAM |
| cd05867 | 239-295 | Ig4_L1-CAM_like |
| cd05878 | 234-309 | Ig_Aggrecan_like |
| pfam13895 | 327-386 | Ig_2 |
| cd05852 | 239-299 | Ig5_Contactin-1 |
| cd05736 | 531-597 | Ig2_Follistatin_like |
| cd05859 | 537-598 | Ig4_PDGFR-alpha |
| cd05732 | 328-384 | Ig5_NCAM-1_like |
| cd05763 | 244-298 | Ig_1 |
| cd05754 | 228-295 | Ig3_Perlecan_like |
| cd04970 | 651-687 | Ig6_Contactin_like |
| cd05734 | 530-586 | Ig7_DSCAM |
| cd05754 | 603-672 | Ig3_Perlecan_like |
| cd05900 | 234-309 | Ig_Aggrecan |
| cd05771 | 366-434 | IgC_Tapasin_R |
| cd04978 | 527-586 | Ig4_L1-NrCAM_like |
| cd05867 | 527-586 | Ig4_L1-CAM_like |
| cd05759 | 531-598 | Ig2_KIRREL3-like |
| cd05891 | 526-577 | Ig_M-protein_C |
| cd05891 | 236-289 | Ig_M-protein_C |
| cd05869 | 509-587 | Ig5_NCAM-1 |
| smart00408 | 238-298 | IGc2 |
| smart00410 | 33-112 | IG_like |
| pfam07679 | 313-399 | I-set |
| smart00410 | 519-596 | IG_like |
| smart00410 | 609-685 | IG_like |
| smart00409 | 33-112 | IG |
| smart00410 | 321-399 | IG_like |
| smart00409 | 321-399 | IG |
| pfam07679 | 29-112 | I-set |
| smart00410 | 232-308 | IG_like |
| smart00409 | 232-308 | IG |
| smart00409 | 519-596 | IG |
| smart00408 | 526-586 | IGc2 |
| pfam07679 | 233-308 | I-set |
| smart00408 | 327-386 | IGc2 |
| pfam07679 | 511-596 | I-set |
| smart00409 | 609-685 | IG |
| PHA02785 | 521-710 | PHA02785 |
| pfam07679 | 596-685 | I-set |
| smart00408 | 39-98 | IGc2 |
| smart00408 | 615-675 | IGc2 |
Ontology Information
| HPRD ID | 989 |
|---|---|
| Molecular Class | Adhesion molecule |
| Molecular Function | Cytokine activity (GO:0005125) |
| Biological Process | Immune response (GO:0006955) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P19320 | DB00898 | Ethanol | SmallMoleculeDrug |
| P19320 | DB01136 | Carvedilol | SmallMoleculeDrug |