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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| VEGFB | 7423 | vascular endothelial growth factor B | 11 | VEGFL |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23684749 | 2013 | Cell line : - Source : - Sample Type : CRC Tumor and normal tissue No. of Sample : 86 Stage : - | Exome sequencing | Mutation | - | Potential mutation hot spots were confirmed in 15 genes; ADAR, DCAF12L2, GLT1D1, ITGA7, MAP1B, MRGPRX4, PSRC1, RANBP2, RPS6KL1, SNCAIP, TCEAL6, TUBB6, WBP5, VEGFB, and ZBTB2. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a member of the PDGF (platelet-derived growth factor)/VEGF (vascular endothelial growth factor) family. The VEGF family members regulate the formation of blood vessels and are involved in endothelial cell physiology. This member is a ligand for VEGFR-1 (vascular endothelial growth factor receptor 1) and NRP-1 (neuropilin-1). Studies in mice showed that this gene was co-expressed with nuclear-encoded mitochondrial genes and the encoded protein specifically controlled endothelial uptake of fatty acids. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Sep 2011] | Chromosome | 11 |
| Location | 11q13 |
| Start | 64002056 |
| End | 64006736 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 4681 |
| OMIM ID | 601398 |
| HGNC ID | HGNC:12681 |
| Unigene ID | Hs.732095 |
| Ensembl ID | - |
| PharmGKB ID | PA37303 |
mRNA Information
| mRNA ID | ?NM_001243733.1 |
|---|---|
| Exon | join(1..310,875..917,1230..1426,1671..1744,2604..2639, 2837..3072,3773..4681) | mRNA Sequence | Download Select all |
| Length | 1822 |
Protein Information
| Protein ID | NP_001230662.1 |
|---|---|
| Protein Name | vascular endothelial growth factor B |
| Molecular Wt. (Da) | 24022 |
| Protein Sequence | Download Select all |
| Length | 207 |
| Uniprot ID | Q99996 |
| Ensembl Protein ID | ENSP00000348573 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 2321 | FLT1 | 1297 | NP_002010.2 | in vivo | 9751730 |
| 7422 | VEGFA | 1889 | NP_001020537.2 | in vivo | 8702615 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| AGE-RAGE signaling pathway in diabetic complications | hsa04933 |
| Cytokine-cytokine receptor interaction | hsa04060 |
| Focal adhesion | hsa04510 |
| Pathways in cancer | hsa05200 |
| PI3K-Akt signaling pathway | hsa04151 |
| Rap1 signaling pathway | hsa04015 |
| Ras signaling pathway | hsa04014 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00135 | 45-127 | PDGF |
| cl00116 | 45-127 | PDGF superfamily |
| smart00141 | 45-126 | PDGF |
| pfam00341 | 47-124 | PDGF |
| PHA02661 | 23-127 | PHA02661 |
| PHA03269 | 108-188 | PHA03269 |
| PRK12270 | 125-190 | kgd |
Ontology Information
| HPRD ID | 5500 |
|---|---|
| Molecular Class | Growth factor |
| Molecular Function | Ubiquitin-specific protease activity (GO:0004843) |
| Biological Process | Protein metabolism (GO:0019538) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P49765 | DB08885 | Aflibercept | BiotechDrug |