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General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22295309 | 2011 | Cell line : - Source : - Sample Type : - No. of Sample : 110 patients with CRC and 40 healthy donors Stage : TNM Stage I-IV | ELISA, immunohistochemistry | Up-regulation | - | SVEGF-C may be a biomarker for LNM in CRC. CRC SVEGF-C level (889.0 ? 264.0 pg/mL) significantly exceeded (P = 0.000) the control level (373.2 ? 97.3 ng/L), and was significantly higher in T3, lymph node metastasis (LNM), distant metastasis, and pTNM groups III and IV. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | |
| Description | The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family. The encoded protein promotes angiogenesis and endothelial cell growth, and can also affect the permeability of blood vessels. The proprotein is further cleaved into a fully processed form that can bind and activate VEGFR-2 and VEGFR-3 receptors. | Chromosome | 4 |
| Location | 4q34.3 |
| Start | 176683534 |
| End | 176792745 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 109212 |
| OMIM ID | 601528 |
| HGNC ID | HGNC:12682 |
| Unigene ID | Hs.435215 |
| Ensembl ID | ENSG00000150630 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_005429.4 |
|---|---|
| Exon | join(1..581,63000..63213,64778..64968,81096..81247, 104819..104925,105226..105559,108706..109212) | mRNA Sequence | Download Select all |
| Length | 2103 |
CDS Information
| Location | join(435..581,63000..63213,64778..64968,81096..81247, 104819..104925,105226..105559,108706..108820) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS43285.1 |
Protein Information
| Protein ID | NP_005420.1 |
|---|---|
| Protein Name | vascular endothelial growth factor C |
| Molecular Wt. (Da) | 13104 |
| Protein Sequence | Download Select all |
| Length | 419 |
| Uniprot ID | P60568 |
| Ensembl Protein ID | ENSP00000226730 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 101 |
| T | Phosphorylation | 106 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 2324 | FLT4 | 636 | NP_891555.2 | in vivo | 870 087 216 530 705 |
| 3791 | KDR | 1867 | NP_002244.1 | in vivo | 11332691 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| AGE-RAGE signaling pathway in diabetic complications | hsa04933 |
| Cytokine-cytokine receptor interaction | hsa04060 |
| Focal adhesion | hsa04510 |
| Pathways in cancer | hsa05200 |
| PI3K-Akt signaling pathway | hsa04151 |
| Rap1 signaling pathway | hsa04015 |
| Ras signaling pathway | hsa04014 |
| TNF signaling pathway | hsa04668 |
Structure Information
| PDB ID | 2X1W |
|---|---|
| Resolution | 2.7 |
| Method | X-RAY DIFFRACTION |
| Chains | A,B,C |
| Molecule | VASCULAR ENDOTHELIAL GROWTH FACTOR C |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00135 | 129-214 | PDGF |
| cl00116 | 129-214 | PDGF superfamily |
| pfam00341 | 131-211 | PDGF |
| smart00141 | 129-213 | PDGF |
| PHA02661 | 128-214 | PHA02661 |
Ontology Information
| HPRD ID | 990 |
|---|---|
| Molecular Class | Growth factor |
| Molecular Function | Transmembrane receptor activity (GO:0004888) |
| Biological Process | Signal transduction (GO:0007165); Cell proliferation (GO:0008283); Cell communication (GO:0007154); Immune response (GO:0006955) |
Drug Information
No matching records could be found.