CoReCG

Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
21187483	2010	Cell line : - Source : Mayo Clinic Sample Type : CRC tumor and normal tissue No. of Sample : 206 colon tissues, including 74 cancers, 62 adenomas, and 70 normal colon epithelia Stage : -	Methylation-Specific PCR, Real-time Quantitative Methylation-Specific PCR.	Methylation	-	Vimentin genes are commonly methylated in colorectal cancers and adenomas but rarely in normal epithelia.

Gene Details

Chromosome: 10; NC_000010.10 (17270258..17279592)
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Gene Type	protein coding
Gene Family	Intermediate filaments type III
Description	This gene encodes a member of the intermediate filament family. Intermediate filamentents, along with microtubules and actin microfilaments, make up the cytoskeleton. The protein encoded by this gene is responsible for maintaining cell shape, integrity of the cytoplasm, and stabilizing cytoskeletal interactions. It is also involved in the immune response, and controls the transport of low-density lipoprotein (LDL)-derived cholesterol from a lysosome to the site of esterification. It functions as an organizer of a number of critical proteins involved in attachment, migration, and cell signaling. Mutations in this gene causes a dominant, pulverulent cataract.[provided by RefSeq, Jun 2009]
Chromosome	10
Location	10p13
Start	17227935
End	17237593
Strand	+
Gene Sequence	>gi|568815588:17227935-17237593 Homo sapiens chromosome 10, GRCh38.p2 Primary Assembly TTTGTGTTACATAATTGCCTTTCATTTGAACTCATTAATCAAATTGGGGTTTTTAAGCAACACCTAATTA ATTCTTTAACTGGCTCATATTATACCTTTAATGACTTCCACCAGGGTAAAAACCACTGATCACTGAGTTC TATTTTGAAACTACGGACGTCGAGTTTCCTCTTTCACCCAGAATTTTCAGATCTTGTTTAAAAAGTTGGG TGTGGTTTCATGGGGGGAGGGGGAAGAGCGAGAGGAGACCAGAGGGACGGGGGCGGGGACTCTGCAAGAA AAACCTTCCCGGTGCAATCGTGATCTGGGAGGCCCACGTATGGCGCCTCTCCAAAGGCTGCAGAAGTTTC TTGCTAACAAAAAGTCCGCACATTCGAGCAAAGACAGGCTTTAGCGAGTTATTAAAAACTTAGGGGCGCT CTTGTCCCCCACAGGGCCCGACCGCACACAGCAAGGCGATGGCCCAGCTGTAAGTTGGTAGCACTGAGAA CTAGCAGCGCGCGCGGAGCCCGCTGAGACTTGAATCAATCTGGTCTAACGGTTTCCCCTAAACCGCTAGG AGCCCTCAATCGGCGGGACAGCAGGGCGCGGTGAGTCACCGCCGGTGACTAAGCGACCCCACCCCTCTCC CTCGGGCTTTCCTCTGCCACCGCCGTCTCGCAACTCCCGCCGTCCGAAGCTGGACTGAGCCCGTTAGGTC CCTCGACAGAACCTCCCCTCCCCCCAACATCTCTCCGCCAAGGCAAGTCGATGGACAGAGGCGCGGGCCG GAGCAGCCCCCCTTTCCAAGCGGGCGGCGCGCGAGGCTGCGGCGAGGCCTGAGCCCTGCGTTCCTGCGCT GTGCGCGCCCCCACCCCGCGTTCCAATCTCAGGCGCTCTTTGTTTCTTTCTCCGCGACTTCAGATCTGAG GGATTCCTTACTCTTTCCTCTTCCCGCTCCTTTGCCCGCGGGTCTCCCCGCCTGACCGCAGCCCCGAGAC CGCCGCGCACCTCCTCCCACGCCCCTTTGGCGTGGTGCCACCGGACCCCTCTGGTTCAGTCCCAGGCGGA CCCCCCCCTCACCGCGCGACCCCGCCTTTTTCAGCACCCCAGGGTGAGCCCAGCTCAGACTATCATCCGG AAAGCCCCCAAAAGTCCCAGCCCAGCGCTGAAGTAACGGGACCATGCCCAGTCCCAGGCCCCGGAGCAGG AAGGCTCGAGGGCGCCCCCACCCCACCCGCCCACCCTCCCCGCTTCTCGCTAGGTCCCTATTGGCTGGCG CGCTCCGCGGCTGGGATGGCAGTGGGAGGGGACCCTCTTTCCTAACGGGGTTATAAAAACAGCGCCCTCG GCGGGGTCCAGTCCTCTGCCACTCTCGCTCCGAGGTCCCCGCGCCAGAGACGCAGCCGCGCTCCCACCAC CCACACCCACCGCGCCCTCGTTCGCCTCTTCTCCGGGAGCCAGTCCGCGCCACCGCCGCCGCCCAGGCCA TCGCCACCCTCCGCAGCCATGTCCACCAGGTCCGTGTCCTCGTCCTCCTACCGCAGGATGTTCGGCGGCC CGGGCACCGCGAGCCGGCCGAGCTCCAGCCGGAGCTACGTGACTACGTCCACCCGCACCTACAGCCTGGG CAGCGCGCTGCGCCCCAGCACCAGCCGCAGCCTCTACGCCTCGTCCCCGGGCGGCGTGTATGCCACGCGC TCCTCTGCCGTGCGCCTGCGGAGCAGCGTGCCCGGGGTGCGGCTCCTGCAGGACTCGGTGGACTTCTCGC TGGCCGACGCCATCAACACCGAGTTCAAGAACACCCGCACCAACGAGAAGGTGGAGCTGCAGGAGCTGAA TGACCGCTTCGCCAACTACATCGACAAGGTGCGCTTCCTGGAGCAGCAGAATAAGATCCTGCTGGCCGAG CTCGAGCAGCTCAAGGGCCAAGGCAAGTCGCGCCTGGGGGACCTCTACGAGGAGGAGATGCGGGAGCTGC GCCGGCAGGTGGACCAGCTAACCAACGACAAAGCCCGCGTCGAGGTGGAGCGCGACAACCTGGCCGAGGA CATCATGCGCCTCCGGGAGAAGTAAGGCTGCGCCCATGCAAGTAGCTGGGCCTCGGGAGGGGGCTGGAGG GAGAGGGGAACGCCCCCCCGGCCCCCGCGAGAGCTGCCACGCCCTTGGGGATGTGGCCGGGGGGAGGCCT GCCAGGGAGACAGCGGAGAGCGGGGCTGTGGCTGTGGTGGCGCAGCCCCGCCCAGAACCCAGACCTTGCA GTTCGCATTTCCTCCTCTGTCCCCACACATTGCCCAAGGACGCTCCGTTTCAAGTTACAGATTTCTTAAA ACTACCACTTTGTGTGCAGTTGAAGGCCCTTGGGCACAATGAGAGCCAGTCCTCCAAACTTTCAGAAAGT TTCCTGCCCCTTCTGGCAGGCTGCCAATCACCGGGCGGGAGAAGGAAGGAGGGGAAGGCGGTGGAGGGAG CGAGACAAAGGGATGGTCCCTCGGGGGCGGGGATGGCGGGGCTGTCCTGTAGGTCTGTGCGGCCACCGTG ATTGCCCCTCTGCGCGGTGCCCGAAGTCCCGCTGAAACCTGCCGAGGGCAGCAGGTCTGAAAGCTGCAGG CGCTAGTTGCGCGGAGGTGGCGCAGCTGCTCTGGAGGCGCAGAGCGAATACGTGGTGTTTGGGTGTGGCC GCCCCGCCCCTGGCGGTTTCCTCGTTCCCCTTTGGTTAATGCGCAACTGTTTCAGATTGCAGGAGGAGAT GCTTCAGAGAGAGGAAGCCGAAAACACCCTGCAATCTTTCAGACAGGTTTGTAGACTCTCTTCCCACTCG CAGCCGCCTGACCCCACCCAACACAACCCACGAGCAATTCTAAAAGTTGCTTAACTCACGTCTAAAAAGT GCAAAACTTCAGGGCTGCGCGTAAAGCCCTCTAGTGGCGGGAAGACCACAGGTTGGAGCTTCTCATGATT AGAAAAATATTAATAAAACCCCTTGAGCGATTTTTTTTTTTTTTTTGAGACGGAGTCTTACTCTGTCGCC CAGGCTGGAGTGCAGTGGCGAGATCTTGGCTCACTGCATCCTCCGCCTCCCGGGTTCAAGCGATCCTTGA ATGATTTCTAAGCAGTTCCTTGGGACATAAAGAAAAATCTTTTAACTTTTTACTTTGTTTCCCAAATGTT GCACAGTTTTGCAACACATTGACCTTCTGGTTTCGAACGGTTACAATTTTAGATTGTGGTTTGCCAAAGT CAAGTTGCTTAATTTTTACAAGGCCACAAAAAGCGCAATTATGCCCTGCAGTTTAAAATGGAAAACGTGT TGGAAGATAAGAAAACTTAGTTTCCAACTGGAATGGAGCCAGCAAGTTTCTTTTCTTCTTTGCAAATTCT ATTGTGTCATTAAAGTTCGATGGAAGTATCACTATGCACAACTATTTTGTGATCTAATAAGGGTGAAAAG GAGCCATCTGTCCCCTTGGCTAAGGGGTATTAATGGTTTCTATGGGCTTCACTATGGAATGTAGATACAG ACATTCTGGCAAATGTGGTGGCTCTGGACAGAAATAATAGGAGTCTTTGTATTCCCAGGGAAGCTTTGCA ACAGGCTACATTCTTACTGAATATGTAATGATGTAAGCACGGTTCTAATTGGACACAAGTATTTGCTAAC ATCCGTTATCTAATATCTGGCCCAGACTTGAGAAGTAGGTAATGTAAAAAGTTTTTAAAGCTACAAGCAT ACCTCACATTTTAAAAGTCCTTTCTTGATTGGGTTCTTGTGTTCTTTAGCACTCTTGCCATAAAAAATAA TAACAGTAATAAACCCAAGGCTGAAAAACTGAATTTTAACTAAAGGGTTTTTGTGCGTGTTTTTTTTTTT TTTCACCAAAATTAGATGGACTTACAGAATTTTTAACTTAAAATTGGAATCCAAAAGCCAGAAGATCCCC ATTATAGTTTATAGTTGTATTCCCTGGAATATTTACTGGGATTAACTGCAAAGCACTCTCAGATGAATAG TGTAGTATAACATTTTGAAACTGAAATACATTTACCAAATTAATTTAACCACAGCAATGTGTGTGGTTCA TTTTAGTCCTTGAGCATTTTTGATTATCATACCTGTCATGTTTTCTGCAGTGTAGTGAGTTAACATAAAA CAACATCAATACAAAAGATCCTCTGTTTCGAGATTAAGCAAAATTCCTCATTCTCTTCAATGTGATAGAA TACCACATTGATCTTTCTTTGGAGGTTAGTAAAATATCTTTTATGTATTTTTCAGGGCTTAACAAGTAAA AATCAATGTTTTCATCAAGTCTGATCTTTTTGTCACCCACTCTTCATTCATTTTTCCACTAAGGTGATAG AAAAGTCTCAACAGTTTAAGACCGTAAGGCTATGAACTCCAAATATAATTGCTGACAAGATAAGCAATCC TCACGCATCCTTTTGAGAGGAAATAAAATCTTAGTTGCAAGATTACATATTCTGATTTGGAATGCTGAGC TTTTTAAATGGAAATATAGAAGGACGGCTGAATCAGCAAAAATCCTTTATGTAGTTTCATTCTTTGCAAG CTTGACCAGTCATTCTGAAACAGGCTAACTGAACTGATACAGTGGCAAGTGAAAAAGACATGCCTTTACA GGATGAGTCAAAGGAGTTTTAGAAGAAAAATCCACCAGAGAAAGCCAAGCAAATACAGTTCAGAGTTACA TTTCTTTTCCATTTTTTCCTGAACTGAATCTTTGGCATGCATATCCTGAATTGGGTTATTGAATATAAAT CTAGCCTTGTACAATGGATGCCAGATGACTACATATTTGCTTTGGAGCCTAAGGATAAGTTTCAAAAGAT TTGAGTGGAGAAGAAAAGCTAAAACTCTTGAAGCACAAGTTTCTGTTCTCCATGTACTCAAGTGTACATG AAGTTGTGAAAATTTGTCCACCTCTATCATCATGTTATTCCATGAAATTACAAAACAAATCTTAAAAATG TTGTGGCATAGATTTTCTAGATTTAAAAAGTAATTAAATTAAATGAATTACTTTATTTTTTGAGACAGAG TGTCACTCTGTTGCCCAGGCTGGAGTGCAGTGGCACTATGTTGGCTCACTGCAACCTCTGCCTCCTGGGT TGAAGAAATTCTCCTGCCTCAACCTCCCAAGTAGCTGGGACTACAGGCATGTGCCACCACACCCAGCTAA TTTTTGTATTTTTGGTAGAGACGGGGTTTCGCCATGTTGGCTAGGCTGGTCTCGAACTCCTGACCTCAAG TGATCCACCCGTCTCAGCCTCCCAAAGTGCTGGGATTACAGGCATAAGCCACCATGACCAGCCTTAAAAA GTAATTTTAAAATATCACTGGTAAAATGTGGATTCAGTCATGATTGAGTGCAGTTTACCATGTGTGTGGA CATTTATTTATTTTAAAATTGTCTGATCACCACCTTGAGTAAAACACAAGCAGTCACAATTAAAATATAT TAGTGAGCAGGAGAAAGCACAGCATATTATAGCACTGAATGATTTATAAACCTATTCCAGGGTCATAAAA TGTGTCAACGGCTTTTCTATAGTAAGGAGACTAGGTTCAGATGGTTAATCTAAGACAAATAAATGAGATA AGCCATACACTTTTACATCCTCCATGTCCTGTCTTTTCTCTGTTCAAAATAGGATGTTGACAATGCGTCT CTGGCACGTCTTGACCTTGAACGCAAAGTGGAATCTTTGCAAGAAGAGATTGCCTTTTTGAAGAAACTCC ACGAAGAGGTTAGTGGAGTGACTTTCGGGGAATGAATGAGGGTAAGGCAGCCCCCACGGTTGGCAGAGCT GACCGTCTGTCTGTTCTTTTTGCAGGAAATCCAGGAGCTGCAGGCTCAGATTCAGGAACAGCATGTCCAA ATCGATGTGGATGTTTCCAAGCCTGACCTCACGGCTGCCCTGCGTGACGTACGTCAGCAATATGAAAGTG TGGCTGCCAAGAACCTGCAGGAGGCAGAAGAATGGTACAAATCCAAGGTAGGAAACAAATCAGTGCGGCT TCAACCAAAGAAAAGCATTGTGTTCTCAAAACCCCATACCTGTGTGTGATTCCTAAATATCCTCTAGCTC CAATGCAAAGCTGGCTTTGACTTCTTGCTCATATTGTGTTTGCCACCACAGCCTCCCCACCACTCACATC ACCTCCTTTATTTATTTATTTATTTTCTTATTTATTTATGAGACAGAGTCTTGCTCTACTGCCCAGGCTG GAGTGCAGTGGCAACATCTTGGCACACTGCAACCTCCGCCTCCCAGGTTCAAGTGATTCTCCTGCCTCAG CCCCCTAAGAGCTGGAACCACAGGCAAGCACCACCATGCCCGGCTAATTTTTGTATTTTTAGTAGAGATG GGGTTTCACCATGTTGACCAGGCTTCTCTCAAACTCCTGACCTCAGGTGATCCACCCTCCTCAGCCTCCC AAAATGTTGGGATTACAGGCATGCGCCACCACGCCTGGCCACATCACCTCCTTCAGAATAGCAGACTCTC TTCCCCCTAACCTTGCCTCCAAGTAAACCCCAATGCCATACCTTTGACCTCCACTGTGTTGAAATGAGCA CTGTAGAGTGAACTCTGAAAATACTAATGTCAGTACTCCACTGCTCTTTCCCTGGCTTTCAAAACAGAAA TTTAAACCTATACTGGAAGACATTCAGTGAGAAATATGATTTTTTTTTTCTAAGAGAGTCAAAAGACTTG AATGTGAGCAATCTACATTTCTGTTTTCTTCCCAACAGTTTGCTGACCTCTCTGAGGCTGCCAACCGGAA CAATGACGCCCTGCGCCAGGCAAAGCAGGAGTCCACTGAGTACCGGAGACAGGTGCAGTCCCTCACCTGT GAAGTGGATGCCCTTAAAGGAACCGTGAGTACCAACCCTGCAGTAAAAGAGGGAAAATAATGACCCATTC TGCTGACTAGGCTCATGATGATACCTGAACAAAATGTTGAGTGAGTAAAAATGTATATCATAATGCAAAG AAAATGAGTTATCAAGACAGACTCAAAAGGGACTTCATGGAACTCTTGAAGGTTTTAGCTTGCCTATATC ATTGCTTCTAATATGAAGGACTTGGTACTCGCATTCTCCACCTAAAATTAGAGTGGTCGCCATTTGCCGC TAATGGAAATTATTGCAGAAGGTCTGTAAATGGTTCTGGGAACAGCTGGGTTTTTCTGAGAAATAACACC AGACATCTTTCTCACCCCCTGCAGAATGAGTCCCTGGAACGCCAGATGCGTGAAATGGAAGAGAACTTTG CCGTTGAAGCTGCTAACTACCAAGACACTATTGGCCGCCTGCAGGATGAGATTCAGAATATGAAGGAGGA AATGGCTCGTCACCTTCGTGAATACCAAGACCTGCTCAATGTTAAGATGGCCCTTGACATTGAGATTGCC ACCTACAGGAAGCTGCTGGAAGGCGAGGAGAGCAGGTAGGGAACTCAGACTTGGATGCGTGAACTAATGG TGACCATTTGTTAGGCCCTGTGCCACTGGGCTCTAAGCAGTGTCACATTTAATCTTTAGAAAGTTTCTTT GAGGTAACTGCTTTCCACTTTTTGTAGAGGAGGAATTTGAATTGAGAGAGAGTAAGTGACTTGCTGAAAA AGGGTTAATCAACAGCAGAGCTGGGATTTGAACCCATAACTCTGTCAAAGCCTCCACTCCTAACTCCTGT TCATGCTCCTGTGGAGAAAATGCTTGTAGTAACATATTTTAAATGTACTAACAAGACCAGTCATGGGAAA ATGTTTCTGAGACAAATCTCTAGTTTATGATTTAAAACAGTACGTTTTCTTACGTGACGAAAACAAAAAG TGTGTTAATTTGTTCCCAGTGGTTGAAGTTATTTGCCAACAATTTTACTGTTTCTCTTCATCTGTTTATA GGATTTCTCTGCCTCTTCCAAACTTTTCCTCCCTGAACCTGAGGGGTAAGCATTTTATTTCCCTTTAGGA AAAACGTCAGCTGCTTGTAACCACTGTGTTTATGTCAAAGCATTCATTTTTTTTAGGATATCTGAAAAAA TGCCATATAAGAGAAAACTCTATAAAACATCTATAATTTTCGAACCCAAGTACACTCTTGCATTCTATGC TTTAAGTTAAATGCAAACTCCTTTTTCCTTCTTCCTGCTGCAAGTACTATCTCATCCTGATGCTCAAGAG TGTCAGGGCCTGGGTTTCCAAACAGAGACTACCCTAAAATTATTTGGCGAGTAGTACTTTACACAATTGC CTCTCCCCCACAAATCATAATTGTTTCAGTAAAATGGTTACTTGGTTTTTCCAAGAAAAAACTCGTTTTT ACTCATTTTTGGCCTGTTTGTTTATTTAGAAACTAATCTGGATTCACTCCCTCTGGTTGATACCCACTCA AAAAGGACACTTCTGATTAAGACGGTTGAAACTAGAGATGGACAGGTTGGTATCTTTTAAGGAAAAAATA GGGTAATCTCAGACAGGAGTTGATATATTTTAAAATCAGTGAATCTGAATCTCAGATACAGCTGGCTAAT TTGAGAGGTTCAGGTTTCATTCATGCCTACTAAAAAAAGAATAGGCTTCTTCTTCCAGCAGTACACACAG CCAACTAATTATTTGGCTCCTGGATGTGAAGTTGAGATAGCAGTCTTCCTGTGCTCCAGAATTAGTGATT TGCTTTGGTGCTTAATTTGAAGTGGGAGTAAGCTTCCTTAAACCACTTCCTAAAGCAGCTACATGAAACA GCTTCACTAGACTACCTCAATATGAGGAATGTTTTGATCCTGGACATATGGTGTCTTCCTACCTCCATAC TTTATAGATTCCTAAACCCATCTATATAATACAAGCATGTGCCATACGATCATTTAGTTTCTTATTACCT CCCTATGCCAGGAAAGAAATAGTTGCAATTTATTGTAGTCATCATGAAATCTTCCCTTGCACATAAATTT AAAATGTACCTGCTGCACATTTTAATATGTCTTAATTGCTTTTAAACTTGGCTGTATTGTGTACAACTAT TATACCATCTTTTATAAACACAGTTTTTTAAGAAATTTCTTTTTGTAAGTTACAACATTCCACTGGATCC TTATATTGCCTGTAGTGGAAGAGGGTCTTGTGTGTCTGCCCCTTCTAGTTTTCACTCATGCAGAAGCAAC ATAACCTTCTGATTTGCACAATAAATTACATATATTTAGCAGGATTTTTATTTGCCGTGATATATAGGAT AATTTAGTCTTTGGCATGTGGCATTATATTTATTTTGGTTTTTTTTTTTAAACAGGTTATCAACGAAACT TCTCAGCATCACGATGACCTTGAATAAAAATTGCACACACTCAGTGCAGCAATATATTACCAGCAAGAAT AAAAAAGAAATCCATATCTTAAAGAAACAGCTTTCAAGTGCCTTTCTGCAGTTTTTCAGGAGCGCAAGAT AGATTTGGAATAGGAATAAGCTCTAGTTCTTAACAACCGACACTCCTACAAGATTTAGAAAAAAGTTTAC AACATAATCTAGTTTACAGAAAAATCTTGTGCTAGAATACTTTTTAAAAGGTATTTTGAATACCATTAAA ACTGCTTTTTTTTTTCCAGCAAGTATCCAACCAACTTGGTTCTGCTTCAATAAATCTTTGGAAAAACTC 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Length	9659
OMIM ID	193060
HGNC ID	HGNC:12692
Unigene ID	Hs.455493
Ensembl ID	ENSG00000026025
PharmGKB ID	-

mRNA Information

mRNA ID	XM_006717500.1
Exon	join(1..2051,2716..2776,5653..5748,5836..5997,6759..6884, 7235..7455,7912..7955,8360..8445,9296..9659)
mRNA Sequence	>7431 TTTGTGTTACATAATTGCCTTTCATTTGAACTCATTAATCAAATTGGGGTTTTTAAGCAACACC TAATTAATTCTTTAACTGGCTCATATTATACCTTTAATGACTTCCACCAGGGTAAAAACCACTG ATCACTGAGTTCTATTTTGAAACTACGGACGTCGAGTTTCCTCTTTCACCCAGAATTTTCAGAT CTTGTTTAAAAAGTTGGGTGTGGTTTCATGGGGGGAGGGGGAAGAGCGAGAGGAGACCAGAGGG ACGGGGGCGGGGACTCTGCAAGAAAAACCTTCCCGGTGCAATCGTGATCTGGGAGGCCCACGTA TGGCGCCTCTCCAAAGGCTGCAGAAGTTTCTTGCTAACAAAAAGTCCGCACATTCGAGCAAAGA CAGGCTTTAGCGAGTTATTAAAAACTTAGGGGCGCTCTTGTCCCCCACAGGGCCCGACCGCACA CAGCAAGGCGATGGCCCAGCTGTAAGTTGGTAGCACTGAGAACTAGCAGCGCGCGCGGAGCCCG CTGAGACTTGAATCAATCTGGTCTAACGGTTTCCCCTAAACCGCTAGGAGCCCTCAATCGGCGG GACAGCAGGGCGCGGTGAGTCACCGCCGGTGACTAAGCGACCCCACCCCTCTCCCTCGGGCTTT CCTCTGCCACCGCCGTCTCGCAACTCCCGCCGTCCGAAGCTGGACTGAGCCCGTTAGGTCCCTC GACAGAACCTCCCCTCCCCCCAACATCTCTCCGCCAAGGCAAGTCGATGGACAGAGGCGCGGGC CGGAGCAGCCCCCCTTTCCAAGCGGGCGGCGCGCGAGGCTGCGGCGAGGCCTGAGCCCTGCGTT CCTGCGCTGTGCGCGCCCCCACCCCGCGTTCCAATCTCAGGCGCTCTTTGTTTCTTTCTCCGCG ACTTCAGATCTGAGGGATTCCTTACTCTTTCCTCTTCCCGCTCCTTTGCCCGCGGGTCTCCCCG CCTGACCGCAGCCCCGAGACCGCCGCGCACCTCCTCCCACGCCCCTTTGGCGTGGTGCCACCGG ACCCCTCTGGTTCAGTCCCAGGCGGACCCCCCCCTCACCGCGCGACCCCGCCTTTTTCAGCACC CCAGGGTGAGCCCAGCTCAGACTATCATCCGGAAAGCCCCCAAAAGTCCCAGCCCAGCGCTGAA GTAACGGGACCATGCCCAGTCCCAGGCCCCGGAGCAGGAAGGCTCGAGGGCGCCCCCACCCCAC CCGCCCACCCTCCCCGCTTCTCGCTAGGTCCCTATTGGCTGGCGCGCTCCGCGGCTGGGATGGC AGTGGGAGGGGACCCTCTTTCCTAACGGGGTTATAAAAACAGCGCCCTCGGCGGGGTCCAGTCC TCTGCCACTCTCGCTCCGAGGTCCCCGCGCCAGAGACGCAGCCGCGCTCCCACCACCCACACCC ACCGCGCCCTCGTTCGCCTCTTCTCCGGGAGCCAGTCCGCGCCACCGCCGCCGCCCAGGCCATC GCCACCCTCCGCAGCCATGTCCACCAGGTCCGTGTCCTCGTCCTCCTACCGCAGGATGTTCGGC GGCCCGGGCACCGCGAGCCGGCCGAGCTCCAGCCGGAGCTACGTGACTACGTCCACCCGCACCT ACAGCCTGGGCAGCGCGCTGCGCCCCAGCACCAGCCGCAGCCTCTACGCCTCGTCCCCGGGCGG CGTGTATGCCACGCGCTCCTCTGCCGTGCGCCTGCGGAGCAGCGTGCCCGGGGTGCGGCTCCTG CAGGACTCGGTGGACTTCTCGCTGGCCGACGCCATCAACACCGAGTTCAAGAACACCCGCACCA ACGAGAAGGTGGAGCTGCAGGAGCTGAATGACCGCTTCGCCAACTACATCGACAAGGTGCGCTT CCTGGAGCAGCAGAATAAGATCCTGCTGGCCGAGCTCGAGCAGCTCAAGGGCCAAGGCAAGTCG CGCCTGGGGGACCTCTACGAGGAGGAGATGCGGGAGCTGCGCCGGCAGGTGGACCAGCTAACCA ACGACAAAGCCCGCGTCGAGGTGGAGCGCGACAACCTGGCCGAGGACATCATGCGCCTCCGGGA GAAATTGCAGGAGGAGATGCTTCAGAGAGAGGAAGCCGAAAACACCCTGCAATCTTTCAGACAG GATGTTGACAATGCGTCTCTGGCACGTCTTGACCTTGAACGCAAAGTGGAATCTTTGCAAGAAG AGATTGCCTTTTTGAAGAAACTCCACGAAGAGGAAATCCAGGAGCTGCAGGCTCAGATTCAGGA ACAGCATGTCCAAATCGATGTGGATGTTTCCAAGCCTGACCTCACGGCTGCCCTGCGTGACGTA CGTCAGCAATATGAAAGTGTGGCTGCCAAGAACCTGCAGGAGGCAGAAGAATGGTACAAATCCA AGTTTGCTGACCTCTCTGAGGCTGCCAACCGGAACAATGACGCCCTGCGCCAGGCAAAGCAGGA GTCCACTGAGTACCGGAGACAGGTGCAGTCCCTCACCTGTGAAGTGGATGCCCTTAAAGGAACC AATGAGTCCCTGGAACGCCAGATGCGTGAAATGGAAGAGAACTTTGCCGTTGAAGCTGCTAACT ACCAAGACACTATTGGCCGCCTGCAGGATGAGATTCAGAATATGAAGGAGGAAATGGCTCGTCA CCTTCGTGAATACCAAGACCTGCTCAATGTTAAGATGGCCCTTGACATTGAGATTGCCACCTAC AGGAAGCTGCTGGAAGGCGAGGAGAGCAGGATTTCTCTGCCTCTTCCAAACTTTTCCTCCCTGA ACCTGAGGGAAACTAATCTGGATTCACTCCCTCTGGTTGATACCCACTCAAAAAGGACACTTCT GATTAAGACGGTTGAAACTAGAGATGGACAGGTTATCAACGAAACTTCTCAGCATCACGATGAC CTTGAATAAAAATTGCACACACTCAGTGCAGCAATATATTACCAGCAAGAATAAAAAAGAAATC CATATCTTAAAGAAACAGCTTTCAAGTGCCTTTCTGCAGTTTTTCAGGAGCGCAAGATAGATTT GGAATAGGAATAAGCTCTAGTTCTTAACAACCGACACTCCTACAAGATTTAGAAAAAAGTTTAC AACATAATCTAGTTTACAGAAAAATCTTGTGCTAGAATACTTTTTAAAAGGTATTTTGAATACC ATTAAAACTGCTTTTTTTTTTCCAGCAAGTATCCAACCAACTTGGTTCTGCTTCAATAAATCTT TGGAAAAACTC    Download   Select all
Length	3211

CDS Information

   

Location	join(1489..2051,2716..2776,5653..5748,5836..5997, 6759..6884,7235..7455,7912..7955,8360..8445,9296..9337)
CDS Sequence	>lcl|XM_006717500.1_cds_XP_006717563.1_1 [gene=VIM] [protein=vimentin isoform X1] [protein_id=XP_006717563.1] [location=1489..2889] ATGTCCACCAGGTCCGTGTCCTCGTCCTCCTACCGCAGGATGTTCGGCGGCCCGGGCACCGCGAGCCGGC CGAGCTCCAGCCGGAGCTACGTGACTACGTCCACCCGCACCTACAGCCTGGGCAGCGCGCTGCGCCCCAG CACCAGCCGCAGCCTCTACGCCTCGTCCCCGGGCGGCGTGTATGCCACGCGCTCCTCTGCCGTGCGCCTG CGGAGCAGCGTGCCCGGGGTGCGGCTCCTGCAGGACTCGGTGGACTTCTCGCTGGCCGACGCCATCAACA CCGAGTTCAAGAACACCCGCACCAACGAGAAGGTGGAGCTGCAGGAGCTGAATGACCGCTTCGCCAACTA CATCGACAAGGTGCGCTTCCTGGAGCAGCAGAATAAGATCCTGCTGGCCGAGCTCGAGCAGCTCAAGGGC CAAGGCAAGTCGCGCCTGGGGGACCTCTACGAGGAGGAGATGCGGGAGCTGCGCCGGCAGGTGGACCAGC TAACCAACGACAAAGCCCGCGTCGAGGTGGAGCGCGACAACCTGGCCGAGGACATCATGCGCCTCCGGGA GAAATTGCAGGAGGAGATGCTTCAGAGAGAGGAAGCCGAAAACACCCTGCAATCTTTCAGACAGGATGTT GACAATGCGTCTCTGGCACGTCTTGACCTTGAACGCAAAGTGGAATCTTTGCAAGAAGAGATTGCCTTTT TGAAGAAACTCCACGAAGAGGAAATCCAGGAGCTGCAGGCTCAGATTCAGGAACAGCATGTCCAAATCGA TGTGGATGTTTCCAAGCCTGACCTCACGGCTGCCCTGCGTGACGTACGTCAGCAATATGAAAGTGTGGCT GCCAAGAACCTGCAGGAGGCAGAAGAATGGTACAAATCCAAGTTTGCTGACCTCTCTGAGGCTGCCAACC GGAACAATGACGCCCTGCGCCAGGCAAAGCAGGAGTCCACTGAGTACCGGAGACAGGTGCAGTCCCTCAC CTGTGAAGTGGATGCCCTTAAAGGAACCAATGAGTCCCTGGAACGCCAGATGCGTGAAATGGAAGAGAAC TTTGCCGTTGAAGCTGCTAACTACCAAGACACTATTGGCCGCCTGCAGGATGAGATTCAGAATATGAAGG AGGAAATGGCTCGTCACCTTCGTGAATACCAAGACCTGCTCAATGTTAAGATGGCCCTTGACATTGAGAT TGCCACCTACAGGAAGCTGCTGGAAGGCGAGGAGAGCAGGATTTCTCTGCCTCTTCCAAACTTTTCCTCC CTGAACCTGAGGGAAACTAATCTGGATTCACTCCCTCTGGTTGATACCCACTCAAAAAGGACACTTCTGA TTAAGACGGTTGAAACTAGAGATGGACAGGTTATCAACGAAACTTCTCAGCATCACGATGACCTTGAATA A    Download   Select all
CCDS ID	-

Protein Information

      

Protein ID	NP_003371.2
Protein Name	Vimentin
Molecular Wt. (Da)	53521
Protein Sequence	>7431 MSTRSVSSSSYRRMFGGPGTASRPSSSRSYVTTSTRTYSLGSALRPSTSRSLYASSPGGVYATR SSAVRLRSSVPGVRLLQDSVDFSLADAINTEFKNTRTNEKVELQELNDRFANYIDKVRFLEQQN KILLAELEQLKGQGKSRLGDLYEEEMRELRRQVDQLTNDKARVEVERDNLAEDIMRLREKLQEE MLQREEAENTLQSFRQDVDNASLARLDLERKVESLQEEIAFLKKLHEEEIQELQAQIQEQHVQI DVDVSKPDLTAALRDVRQQYESVAAKNLQEAEEWYKSKFADLSEAANRNNDALRQAKQESTEYR RQVQSLTCEVDALKGTNESLERQMREMEENFAVEAANYQDTIGRLQDEIQNMKEEMARHLREYQ DLLNVKMALDIEIATYRKLLEGEESRISLPLPNFSSLNLRETNLDSLPLVDTHSKRTLLIKTVE TRDGQVINETSQHHDDLE    Download   Select all
Length	466
Uniprot ID	P33316
Ensembl Protein ID	ENSP00000370376

Post-translational Modification Information (Source : HPRD)

Residue	Type	site
S	Phosphorylation	10
S	Phosphorylation	25
S	Phosphorylation	26
S	Phosphorylation	34
S	Phosphorylation	39
S	Phosphorylation	42
S	Phosphorylation	7
S	Phosphorylation	9
D	Proteolytic Cleavage	85
D	Proteolytic Cleavage	259
S	Phosphorylation	25
S	Phosphorylation	39
S	Phosphorylation	47
S	Phosphorylation	7
S	Phosphorylation	72
D	Proteolytic Cleavage	85
D	Proteolytic Cleavage	259
D	Proteolytic Cleavage	259
S	Phosphorylation	26
S	Phosphorylation	39
S	Phosphorylation	51
S	Phosphorylation	66
S	Phosphorylation	73
S	Phosphorylation	83
S	Phosphorylation	56
Y	Phosphorylation	61;-
Y	Phosphorylation	117;-
S	Phosphorylation	459;-
S	Phosphorylation	56;-
Y	Phosphorylation	400;-
Y	Phosphorylation	53;-
Y	Phosphorylation	61;-
Y	Phosphorylation	117;-
S	Phosphorylation	27;-
Y	Phosphorylation	30;-
T	Phosphorylation	33;-
S	Phosphorylation	214;-
T	Phosphorylation	458;-
T	Phosphorylation	426;-
S	Phosphorylation	430;-
S	Phosphorylation	412;-
S	Phosphorylation	419;-
S	Phosphorylation	5
S	Phosphorylation	22
T	Phosphorylation	48
S	Phosphorylation	55
S	Phosphorylation	65
S	Phosphorylation	144
S	Phosphorylation	226
S	Phosphorylation	299
T	Phosphorylation	327
S	Phosphorylation	409
S	Phosphorylation	420
T	Phosphorylation	20
T	Phosphorylation	446
T	Phosphorylation	266
S	Phosphorylation	261
S	Phosphorylation	29
K	Acetylation	104
K	Acetylation	373
K	Acetylation	120
K	Acetylation	445
K	Acetylation	139
K	Acetylation	292
K	Acetylation	235
S	Phosphorylation	325
T	Phosphorylation	32
T	Phosphorylation	436
S	Phosphorylation	438
S	Glycosylation	7
T	Glycosylation	33
S	Glycosylation	34
S	Phosphorylation	87
T	Phosphorylation	99
S	Phosphorylation	205
S	Phosphorylation	2

Enzyme Information

   

EC	3.5.2.6
Name	beta-lactamase penicillinase cephalosporinase neutrapen penicillin beta-lactamase exopenicillinase ampicillinase penicillin amido-beta-lactamhydrolase penicillinase I, II beta-lactamase I-III beta-lactamase A, B, C beta-lactamase AME I cephalosporin-beta-lactamase
Class	Hydrolases; Acting on carbon-nitrogen bonds, other than peptide bonds; In cyclic amides
Sysname	beta-lactam hydrolase
Substrate	beta-lactam [CPD:C01866]; H2O
Product	substituted beta-amino acid
Reaction (IUBMB)

PPi Information

(Click to view network : Source STRING)      View   

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             

Interactant Gene ID (Source: HPRD)	Gene Symbol	HPRD ID	Ref Seq ID	Technique	References
293	SLC25A6	2461	NP_001627.2	yeast 2-hybrid	16169070
1822	ATN1	6311	NP_001931.2	yeast 2-hybrid	16169070
1832	DSP	513	NP_004406.2	in vitro;yeast 2-hybrid	9261168
3983	ABLIM1	3819	NP_002304.3	yeast 2-hybrid	16189514
4122	MAN2A2	2994	NP_006113.2	yeast 2-hybrid	16169070
4221	MEN1	564	NP_000235.2	in vitro;in vivo	12169273
4747	NEFL	1206	NP_006149.2	in vitro;yeast 2-hybrid	15383276
4831	NME2	1132	NP_001018146.1	in vivo	11082283
5566	PRKACA	3382	NP_002721.1	in vitro	250   096   611   895   474
5682	PSMA1	4170	NP_683877.1	yeast 2-hybrid	16189514
5713	PSMD7	1147	NP_002802.2	yeast 2-hybrid	15383276
6612	SUMO3	3754	NP_008867.2	yeast 2-hybrid	16169070
6613	SUMO2	4332	NP_008868.3	yeast 2-hybrid	16169070
7518	XRCC4	15951	NP_071801.1	yeast 2-hybrid	16169070
8553	BHLHE40	16050	NP_003661.1	yeast 2-hybrid	16169070
8764	TNFRSF14	4122	NP_003811.2	yeast 2-hybrid	16169070
8880	FUBP1	10349	AAH17247.1	yeast 2-hybrid	16169070
9124	PDLIM1	9326	NP_066272.1	yeast 2-hybrid	16189514
9729	KIAA0408	17187	NP_055517.3	yeast 2-hybrid	16189514
10155	TRIM28	3445	NP_005753.1	yeast 2-hybrid	16169070
10362	HMG20B	5703	NP_006330.2	yeast 2-hybrid	16169070
10567	RABAC1	5375	NP_006414.2	yeast 2-hybrid	16169070
10625	IVNS1ABP	10004	NP_006460.2	yeast 2-hybrid	16169070
10807	SDCCAG3	15307	NP_001034796.1	yeast 2-hybrid	16169070
11078	TRIOBP	11028	NP_001034230.1	yeast 2-hybrid	16169070
11170	FAM107A	9753	NP_009108.1	yeast 2-hybrid	16189514
22827	PUF60	18051	NP_510965.1	yeast 2-hybrid	16169070
22927	HABP4	13628	NP_055097.2	yeast 2-hybrid	16169070
23774	BRD1	6848	NP_055392.1	yeast 2-hybrid	16169070
26135	SERBP1	9570	AAH26916.1	yeast 2-hybrid	16169070
26150	RIBC2	11493	NP_056468.2	yeast 2-hybrid	16189514
26751	SH3YL1	15336	NP_056492.2	yeast 2-hybrid	16169070
27229	TUBGCP4	10616	NP_055259.2	yeast 2-hybrid	16189514
28965	SLC27A6	9173	NP_054750.1	yeast 2-hybrid	16169070
51074	APIP	14725	NP_057041.2	yeast 2-hybrid	16189514
51548	SIRT6	12093	NP_057623.1	yeast 2-hybrid	16169070
51593	SRRT	10665	NP_056992.4	yeast 2-hybrid	16169070
54474	KRT20	12193	NP_061883.1	yeast 2-hybrid	16189514
54544	CRCT1	16635	NP_061933.1	yeast 2-hybrid	16169070
55211	DPPA4	16836	NP_060659.3	yeast 2-hybrid	16169070
55791	C1orf103	17975	NP_060842.3	yeast 2-hybrid	16169070
56992	KIF15	10037	NP_064627.1	yeast 2-hybrid	16169070
57002	C7orf36	16669	NP_064577.1	yeast 2-hybrid	16169070
57120	GOPC	6024	NP_065132.1	yeast 2-hybrid	16189514
60491	NIF3L1	10424	AAH07654.1	yeast 2-hybrid	16189514
65080	MRPL44	14763	NP_075066.1	yeast 2-hybrid	16169070
79050	NOC4L	14543	NP_076983.1	yeast 2-hybrid	16189514
79902	NUP85	1363	NP_079120.1	in vivo	12706117
84260	TCHP	14403	NP_115676.1	yeast 2-hybrid	16189514
129563	DIS3L2	14619	NP_689596.4	yeast 2-hybrid	16169070
151254	ALS2CR11	8687	NP_689738.3	yeast 2-hybrid	16189514

Pathway Information

            

Pathway Name	Pathway ID
Epstein-Barr virus infection	hsa05169
MicroRNAs in cancer	hsa05206

Structure Information

PDB ID	1GK4
Resolution	2.3
Method	X-RAY DIFFRACTION
Chains	A,B,C
Molecule	VIMENTIN
Model	View

Domain Information

ID	Location	Description
pfam04732	14-101	Filament_head
cl04711	14-101	Filament_head superfamily
pfam10240	17-88	DUF2464
cl10925	17-88	DUF2464 superfamily
TIGR03495	290-368	phage_LysB
cl20064	290-368	phage_LysB superfamily
pfam00038	102-410	Filament
TIGR02168	106-341	SMC_prok_B
TIGR02168	95-423	SMC_prok_B
COG1196	122-412	Smc
TIGR02168	137-412	SMC_prok_B
COG1196	106-383	Smc
TIGR02169	58-376	SMC_prok_A
COG1196	95-382	Smc
TIGR02169	149-412	SMC_prok_A
pfam01576	104-384	Myosin_tail_1
TIGR02169	118-383	SMC_prok_A
pfam13514	153-434	AAA_27
pfam14988	162-349	DUF4515
COG0419	106-450	SbcC
COG1196	151-412	Smc
PHA02562	119-400	46
pfam01576	151-407	Myosin_tail_1
TIGR04523	87-412	Mplasa_alph_rch
TIGR04523	92-382	Mplasa_alph_rch
COG2433	80-249	COG2433
TIGR02168	78-274	SMC_prok_B
TIGR01843	148-282	type_I_hlyD
COG4372	153-393	COG4372
TIGR00606	104-466	rad50
pfam05622	94-353	HOOK
COG4942	125-356	EnvC
PRK02224	119-379	PRK02224
TIGR02169	101-388	SMC_prok_A
COG0419	102-350	SbcC
COG1842	151-288	PspA
PLN02939	64-382	PLN02939
PHA02562	104-382	46
TIGR02168	211-428	SMC_prok_B
pfam10186	124-256	Atg14
COG0419	106-374	SbcC
pfam13514	151-333	AAA_27
COG1269	100-258	NtpI
pfam01496	102-406	V_ATPase_I
TIGR02168	78-240	SMC_prok_B
pfam09726	17-298	Macoilin
pfam03962	152-257	Mnd1
TIGR04523	97-375	Mplasa_alph_rch
pfam02463	92-364	SMC_N
pfam01576	106-348	Myosin_tail_1
COG4372	108-249	COG4372
pfam05622	104-351	HOOK
COG0419	87-413	SbcC
PTZ00121	119-373	PTZ00121
pfam05622	115-355	HOOK
PTZ00121	118-368	PTZ00121
COG4942	167-378	EnvC
pfam03999	151-251	MAP65_ASE1
pfam13166	80-401	AAA_13
pfam13166	116-412	AAA_13
PRK04863	151-347	mukB
pfam04111	103-208	APG6
pfam04111	104-237	APG6
pfam12128	156-360	DUF3584
PRK04863	126-357	mukB
PRK01156	92-408	PRK01156
COG1579	151-264	COG1579
TIGR03319	276-387	RNase_Y
TIGR03752	106-197	conj_TIGR03752
TIGR01612	201-388	235kDa-fam
PTZ00121	152-382	PTZ00121
TIGR03752	306-378	conj_TIGR03752
pfam12128	176-411	DUF3584
PRK03918	95-251	PRK03918
pfam04156	102-208	IncA
TIGR04523	91-375	Mplasa_alph_rch
pfam01576	151-396	Myosin_tail_1
pfam09730	234-403	BicD
smart00787	124-250	Spc7
COG3206	88-256	GumC
TIGR01843	187-378	type_I_hlyD
TIGR03345	119-230	VI_ClpV1

Ontology Information

   

HPRD ID	1806
Molecular Class	Cytoskeletal protein
Molecular Function	Transcription factor activity (GO:0003700)
Biological Process	Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)

SNP Information

View SNP Geneview Report