Search results:
General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24687856    | 2014 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 505 colorectal cancer specimens Stage : - | RT-PCR | Up-regulation | - | VNN1-AB was not present in any of the 43 normal colorectal tissue samples investigated, but in 5 of the 6 polyps, and 102 of the 136 (75%) colorectal cancers. Novel transcript of the VNN1 gene, with an organ-confined complete specificity for colorectal neoplasia. |
Gene Details

| Gene Type | protein coding |
|---|---|
| Gene Family | Vanins |
| Description | This gene encodes a member of the vanin family of proteins, which share extensive sequence similarity with each other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. No biotinidase activity has been demonstrated for any of the vanin proteins, however, they possess pantetheinase activity, which may play a role in oxidative-stress response. This protein, like its mouse homolog, is likely a GPI-anchored cell surface molecule. The mouse protein is expressed by the perivascular thymic stromal cells and regulates migration of T-cell progenitors to the thymus. This gene lies in close proximity to, and in the same transcriptional orientation as, two other vanin genes on chromosome 6q23-q24.   | Chromosome | 6 |
| Location | 6q23-q24 |
| Start | 132680858   |
| End | 132714055   |
| Strand | -   |
| Gene Sequence |    Download   Select all |
| Length | 33198   |
| OMIM ID | 603570    |
| HGNC ID | HGNC:12705    |
| Unigene ID | Hs.12114    |
| Ensembl ID | ENSG00000112299    |
| PharmGKB ID | -    |
mRNA Information
| mRNA ID | NM_004666.2 |
|---|---|
| Exon | join(1..230,2217..2347,19874..20066,20741..21032, 21472..21833,29551..29721,30734..33198)   | mRNA Sequence |    Download   Select all |
| Length | 3844   |
CDS Information
| Location | join(21..230,2217..2347,19874..20066,20741..21032, 21472..21833,29551..29721,30734..30916) |
|---|---|
| CDS Sequence |    Download   Select all |
| CCDS ID | CCDS5159.1 |    
Protein Information
| Protein ID | NP_004657.2 |
|---|---|
| Protein Name | vanin 1 |
| Molecular Wt. (Da) | 54682 |
| Protein Sequence |    Download   Select all |
| Length | 513   |
| Uniprot ID | P14902 |    
| Ensembl Protein ID | ENSP00000430950   |    
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Glycosyl phosphatidyl inositol GPI | 486 |
| N | Glycosylation | 283 |
Enzyme Information
| EC | 3.5.1.92 |    
|---|---|
| Name | pantetheine hydrolase pantetheinase vanin vanin-1 |
| Class | Hydrolases; Acting on carbon-nitrogen bonds, other than peptide bonds; In linear amides |
| Sysname | (R)-pantetheine amidohydrolase   |
| Substrate | (R)-pantetheine [CPD:C00831]; H2O [CPD:C00001]   |
| Product | (R)-pantothenate [CPD:C00864]; 2-aminoethanethiol [CPD:C01678]   |
| Reaction (IUBMB) | ![]() |
PPi Information
(Click to view network : Source STRING)      View   
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Pantothenate and CoA biosynthesis |    hsa00770 |    
Structure Information
| PDB ID | 4CYF |
|---|---|
| Resolution | 2.25 |
| Method | X-RAY DIFFRACTION |
| Chains | A, B   |
| Molecule | PANTETHEINASE   |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| cd07567 | 25-330  | biotinidase_like |
| cl11424 | 25-330  | nitrilase superfamily |
| cd07197 | 53-239  | nitrilase |
| cd07572 | 55-216  | nit |
| COG0388 | 55-305  | YafV |
| cd07583 | 56-216  | nitrilase_5 |
| pfam00795 | 56-237  | CN_hydrolase |
| cd07581 | 55-238  | nitrilase_3 |
| cd07578 | 47-239  | nitrilase_1_R1 |
| cd07580 | 55-238  | nitrilase_2 |
| cd07584 | 55-238  | nitrilase_6 |
| cd07576 | 56-239  | R-amidase_like |
| cd07573 | 55-268  | CPA |
| cd07577 | 56-244  | Ph0642_like |
| PLN02798 | 154-216  | PLN02798 |
| cd07585 | 54-213  | nitrilase_7 |
| cd07574 | 57-216  | nitrilase_Rim1_like |
| cd07566 | 53-243  | ScNTA1_like |
| cd07582 | 45-258  | nitrilase_4 |
| cd07565 | 43-194  | aliphatic_amidase |
| cd07564 | 57-178  | nitrilases_CHs |
| PLN02504 | 57-178  | PLN02504 |
| cd07568 | 57-223  | ML_beta-AS_like |
Ontology Information
| HPRD ID | 5021 |    
|---|---|
| Molecular Class | Enzyme: Hydrolase |
| Molecular Function | DNA repair protein (GO:0003685) |
| Biological Process | Apoptosis (GO:0006915)   |
Drug Information
No matching records could be found.
External Links
| ArrayExpress | GO |    
|---|---|
| ICGC | GO |    
| Cancer3D | GO |    
| COSMIC | GO |    
| NCG | GO |    
| TSGene | GO |    
| Tumor Gene Family of Databases | GO |    
| CCDB | GO |    
| G2SBC | GO |    
| Osteosarcoma Database | GO |    
| RCDB | GO |    

