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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
VNN1 8876 vanin 1  6Tiff66 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
24687856   2014Cell line : -

Source : -

Sample Type : CRC tumor and normal tissue

No. of Sample : 505 colorectal cancer specimens

Stage : -

RT-PCRUp-regulation-VNN1-AB was not present in any of the 43 normal colorectal tissue samples investigated, but in 5 of the 6 polyps, and 102 of the 136 (75%) colorectal cancers.

Novel transcript of the VNN1 gene, with an organ-confined complete specificity for colorectal neoplasia.


Gene Details



Chromosome 6 - NC_000006.12 (132680858..132714055, complement)

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Gene Type protein coding
Gene Family Vanins
Description This gene encodes a member of the vanin family of proteins, which share extensive sequence similarity with each other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. No biotinidase activity has been demonstrated for any of the vanin proteins, however, they possess pantetheinase activity, which may play a role in oxidative-stress response. This protein, like its mouse homolog, is likely a GPI-anchored cell surface molecule. The mouse protein is expressed by the perivascular thymic stromal cells and regulates migration of T-cell progenitors to the thymus. This gene lies in close proximity to, and in the same transcriptional orientation as, two other vanin genes on chromosome 6q23-q24.  
Chromosome 6
Location 6q23-q24
Start 132680858  
End 132714055  
Strand -  
Gene Sequence

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Length 33198  
OMIM ID 603570   
HGNC ID HGNC:12705   
Unigene ID Hs.12114   
Ensembl ID ENSG00000112299   
PharmGKB ID -   

mRNA Information


mRNA ID NM_004666.2
Exon join(1..230,2217..2347,19874..20066,20741..21032, 21472..21833,29551..29721,30734..33198)  
mRNA Sequence

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Length 3844  



CDS Information


   
Location join(21..230,2217..2347,19874..20066,20741..21032, 21472..21833,29551..29721,30734..30916)
CDS Sequence

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CCDS ID CCDS5159.1



Protein Information


      
Protein IDNP_004657.2
Protein Namevanin 1
Molecular Wt. (Da)54682
Protein Sequence

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Length 513  
Uniprot IDP14902
Ensembl Protein ID ENSP00000430950  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SGlycosyl phosphatidyl inositol GPI486
NGlycosylation283

Enzyme Information


   
EC3.5.1.92
Namepantetheine hydrolase
pantetheinase
vanin
vanin-1
ClassHydrolases; Acting on carbon-nitrogen bonds, other than peptide bonds; In linear amides
Sysname(R)-pantetheine amidohydrolase  
Substrate(R)-pantetheine [CPD:C00831]; H2O [CPD:C00001]  
Product(R)-pantothenate [CPD:C00864]; 2-aminoethanethiol [CPD:C01678]  
Reaction (IUBMB)



PPi Information


(Click to view network : Source STRING)      View   

No matching records from HPRD source could be found.

Pathway Information


      
Pathway Name Pathway ID
Pantothenate and CoA biosynthesis hsa00770


Structure Information


PDB ID4CYF
Resolution2.25
MethodX-RAY DIFFRACTION
Chains A, B  
Molecule PANTETHEINASE  
Model View



Domain Information




ID Location Description
cd0756725-330  biotinidase_like
cl1142425-330  nitrilase superfamily
cd0719753-239  nitrilase
cd0757255-216  nit
COG038855-305  YafV
cd0758356-216  nitrilase_5
pfam0079556-237  CN_hydrolase
cd0758155-238  nitrilase_3
cd0757847-239  nitrilase_1_R1
cd0758055-238  nitrilase_2
cd0758455-238  nitrilase_6
cd0757656-239  R-amidase_like
cd0757355-268  CPA
cd0757756-244  Ph0642_like
PLN02798154-216  PLN02798
cd0758554-213  nitrilase_7
cd0757457-216  nitrilase_Rim1_like
cd0756653-243  ScNTA1_like
cd0758245-258  nitrilase_4
cd0756543-194  aliphatic_amidase
cd0756457-178  nitrilases_CHs
PLN0250457-178  PLN02504
cd0756857-223  ML_beta-AS_like


Ontology Information


   
HPRD ID5021
Molecular ClassEnzyme: Hydrolase
Molecular FunctionDNA repair protein (GO:0003685)
Biological ProcessApoptosis (GO:0006915)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO