Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| VPS35 | 55737 | vacuolar protein sorting 35 homolog (S. cerevisiae) | 16 | FLJ10752, MEM3, PARK17 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 21733561 | 2012 | Cell line : - Source : - Sample Type : GC,CRC tumor and normal tissue No. of Sample : 30 gastric cancers with high microsatellite instability, 13 gastric cancers with low microsatellite instability, and 45 gastric cancers with stable microsatellites and 40?colorectal?cancers with high microsatellite instability, 14colorectal?cancers with low microsatellite instability, and 45?colorectal?cancers with stable microsatellites Stage : - | SSCP | Frameshift Mutation | - | Frameshift mutations of VPS genes and losses of expression of Vps13A and Vps35 proteins are common in gastric cancers and colorectal cancers with high microsatellite instability and suggest that these alterations might contribute to development of cancers with high microsatellite instability by deregulating vacuolar protein sorting proteins. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Parkinson disease |
| Description | This gene belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex. [provided by RefSeq, Jul 2008] | Chromosome | 16 |
| Location | 16q12 |
| Start | 46693589 |
| End | 46723144 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 29556 |
| OMIM ID | 601501 |
| HGNC ID | HGNC:13487 |
| Unigene ID | Hs.454528 |
| Ensembl ID | ENSG00000069329 |
| PharmGKB ID | PA37783 |
Protein Information
| Protein ID | NP_060676.2 |
|---|---|
| Protein Name | vacuolar protein sorting 35 homolog (S. cerevisiae) |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 796 |
| Uniprot ID | Q9H7B4 |
| Ensembl Protein ID | ENSP00000419184 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| K | Acetylation | 555 |
| S | Phosphorylation | 7 |
| S | Phosphorylation | 783 |
| T | Phosphorylation | 390 |
| S | Phosphorylation | 391 |
| S | Phosphorylation | 392 |
| S | Phosphorylation | 714 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 6642 | SNX1 | 3171 | NP_003090.2 | in vivo | 11102511 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Endocytosis | hsa04144 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam03635 | 14-754 | Vps35 |
| cl20256 | 14-754 | Vps35 superfamily |
| cd08774 | 694-766 | 14-3-3 |
| cl02098 | 694-766 | 14-3-3 superfamily |
Ontology Information
| HPRD ID | 16696 |
|---|---|
| Molecular Class | Transport/cargo protein |
| Molecular Function | Cell adhesion molecule activity (GO:0005194) |
| Biological Process | Cell adhesion (GO:0007155); Cell-cell adhesion (GO:0016337) |
Drug Information
No matching records could be found.